Organ Fibrosis:
From Mechanisms of Injury to Modulation of Disease 

• Sprecher
  Univ.-Prof. Dr. med. Christian Trautwein
  Medizinische Klinik III, Universitätsklinikum Aachen, RWTH Aachen
  E-Mail: ctrautwein@ukaachen.de

• Vize-Sprecher
  Univ.-Prof. Dr. med. Tilman Sauerbruch
  Medizinische Klinik I, Universitätsklinikum Bonn, Universität Bonn
  E-Mail: sauerbruch@uni-bonn.de

• Wissenschaftlicher Sekretär
  Univ.-Prof. Dr. rer. nat. Ralf Weiskirchen
  Institut für Klinische Chemie und Pathobiochemie, Universitätsklinikum Aachen, RWTH Aachen
  E-Mail: rweiskirchen@ukaachen.de

• Sekretariat
  Frau Heike Schrinner
  Tel.: +49 241 80-88895, Fax: +49 241 80-82129, E-Mail: sfbtrr57@ukaachen.de

Weitere Informationen auf der externen Webseite: www.sfbtrr57.rwth-aachen.de*

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 * External links open in separate window.

P01: Identification and characterisation of complement factor C5 as quantitative trait gene that modifies liver fibrogenesis in mono- and polygenic mouse models
Frank Lammert and Volker Schmitz, University Hospital Bonn

P02: Functional and structural characterisation of the PKHD1 protein polyductin in the etiology of liver fibrosis
Carsten Bergmann and Klaus Zerres, University Hospital Aachen

P03: Collagen gene regulation in patients with progressive organ fibrosis due to diabetic nephropathy or IgA nephritis
Peter R. Mertens, University Hospital Aachen

P04: The role of E-type cyclins and G1-S phase cell cycle transition in initiation and progression of murine liver fibrosis
Christian Liedtke and Christian Trautwein, University Hospital Aachen

P05: The impact of the LIM domain proteins FHL2 and CRP2 on hepatic stellate cell activation and its crosstalk with TGF- signalling pathways in hepatic fibrogenesis
Ralf Weiskirchen, University Hospital Aachen and Reinhard Büttner, University Hospital Bonn

P06: The role of the NF- B signalling pathway in liver fibrosis
Tom Lüdde and Christian Trautwein, University Hospital Aachen

P07: The molecular mechanism of MIF and CXCR2 in liver fibrosis - analysis of the MIF/CXCR2 axis and the MIF/JAB1/Smad signalling pathway
Jürgen Bernhagen, Hermann E. Wasmuth and Christian Weber, University Hospital Aachen

P08: The CXCR3/CXCL9 chemokine system as an antifibrotic target in murine liver fibrosis
Hermann E. Wasmuth, University Hospital Aachen

P09: Role of monocyte subsets in liver fibrogenesis
Frank Tacke, University Hospital Aachen

P10: Role of dendritic cells in immune-mediated glomerular damage and renal fibrosis
Christian Kurts, University Hospital Bonn

P11: Role of liver antigen presenting cell immune function in liver fibrosis
Percy A. Knolle, University Hospital Bonn

P12: Regulation of natural killer cells by CC chemokines as a pivotal factor of hepatic fibrogenesis in viral hepatitis
Jacob Nattermann and Ulrich Spengler, University Hospital Bonn

P13: Exogenous and endogenous modulators of PDGF/TGF- signalling in liver fibrogenesis and their therapeutic application
Ralf Weiskirchen, University Hospital Aachen

P14: Molecular mechanisms of renal fibrosis: analysis of the pathophysiological role of Platelet Derived Growth Factor-C (PDGF-C)
Frank Eitner and Tammo Ostendorf, University Hospital Aachen

P15: The role of endocannabinoids in hepatic injury and fibrosis
Sören V. Siegmund University, Hospital Mannheim and Andreas Zimmer, University Hospital Bonn

P16: Defining c-Met-dependent cellular interactions in a mouse model of hepatocyte transplantation
Konrad L. Streetz, University Hospital Aachen

P17: Prevention of renal fibrosis by replacing podocytes
Marcus J. Möller and Jürgen Floege, University Hospital Aachen

P18: Angiotensin-stimulated hepatic fibrogenesis and portal hypertension: Receptor regulation and intracellular signalling
Jonel Trebicka and Tilman Sauerbruch, University Hospital Bonn

P19: Mesenchymal stem cells in renal fibrosis: Benefits and risks
Uta Kunter and Jürgen Floege, University Hospital Aachen

Q1: Histopathological analysis and quantification of hepatic and renal fibrosis
Hans-Peter Fischer and Frank Eitner, University Hospital Aachen, and Reinhard Büttner, University Hospital Bonn

Q2: Central animal resource project
Institute for Laboratory Animal Science (ILAS), Aachen, & House of Experimental Therapy (HET), Bonn
René Tolba, University Hospital Aachen

Q3: FACS-based cell sorting of parenchymal and non-parenchymal cells from liver and kidney
Frank Tacke and Ralf Weiskirchen, University Hospital Aachen

Z: Administrative Project
Christian Trautwein, University Hospital Aachen

Participating university departments and institutes

RWTH University of Aachen

• Department of Internal Medicine II, University Hospital Aachen
• Department of Internal Medicine III, University Hospital Aachen
• Department of Human Genetics, University Hospital Aachen
• Institute of Clinical Chemistry and Pathobiochemistry, University Hospital Aachen
• Institute of Biochemistry, University Hospital Aachen
• Institute of Molecular Cardiovascular Research, University Hospital Aachen
• Institute for Laboratory Animal Science, University Hospital Aachen

University of Bonn

• Department of Internal Medicine I, University of Bonn
• Institute for Molecular Medicine and Experimental Immunology, University of Bonn
• Institute of Pathology, University of Bonn
• Institute of Molecular Psychiatry, University of Bonn

Saarland University

• Department of Internal Medicine II, University Homburg

University of Heidelberg

• Department of Internal Medicine II, University Hospital Mannheim