Publications – Schneider

  1. Leimkühler NB*, Gleitz HFE*, Ronghui L*, Snoeren IAM , Fuchs SNR, Nagai JS, Banjanin B, Lam KH, Vogl T, Kuppe C, Stalmann USA, Buesche G, Kreipe H, Gütgemann I, Krebs P, Banz Y, Boor P, Wing-Ying E, Brümmendorf TH, Koschmieder S, Crysandt M, Bindels E, Kramann R, CostaIG and Schneider RK. Heterogeneous bone marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis; Cell Stem Cell 2020 Dec 9;S1934-5909(20)30542-7. doi: 10.1016/j.stem.2020.11.004. [IF 20.869]
     
  2. Gleitz H*, Dugourd AJF*, Leimkühler NB*, Snoeren IAM, Fuchs SNR, Menzel S, Ziegler S, Kroeger N, Triviai I, Büsche G, Kreipe H, Banjanin B, Pritchard J, Hoogenboezem R, Bindels E, Schumacher N, Rose-John S, Elf S, Saez-Rodriguez J, Kramann R, Schneider RK. Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN. Blood. 2020 Jul 29:blood.2019004095. doi: 10.1182/blood.2019004095. [IF 17.543]
     
  3. RibezzoF*, SnoerenIAM*, Ziegler S, StoelbenJ, OlofsenPA, HenicA, Ventura FerreiraM, ChenS, StalmannUSA, BuescheG, HoogenboezemRM, KramannR, PlatzbeckerU, RaaijmakersMHGP, EbertBL and SchneiderRK. Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome. Leukemia, 2019 Jul;33(7):1759-1772. doi: 10.1038/s41375-018-0350-3. [IF 10.023]
     
  4. Schneider RK#, Mullally A, Dugourd A, Peisker F, Hoogenboezem R, Van Strien PMH, Bindels EM, Heckl D, Büsche G, Fleck D, Müller-Newen G, Wongboonsin J, Ventura Ferreira MS, Puelles V-G, Saez-Rodriguez J, Ebert BL, Humphreys BD, Kramann R#. Gli1+ mesenchymal stromal cells are a key driver of bone marrow fibrosis and an important cellular therapeutic target. Cell Stem Cell. 2017; 2018 Aug 2;23(2):308-309. #corresponding author. [IF 20.869]
     
  5. Schneider RK, Schenone M, Ventura Ferreira M, Kramann R, Joyce CE, Hartigan C Beier F, Brümmendorf TH, Germing U, Platzbecker U, Büsche G, Knüchel R, Chen MC, WatersCS, Chen E, Chu LP, NovinaCD, LindsleyRC, Carr SA, Ebert BL. Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8/S100A9. Nature Medicine 2016 Mar;22(3):288-97. [IF 36.130]
     
  6. Schneider RK, Ademà V, Heckl D, Järås M, Mallo M, Lord AM, Chu LP, McConkey ME, Kramann R, Mullally A, Bejar R, Solé F, Ebert BL. Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS. Cancer Cell. 2014 Oct 13;26(4):509-20. [IF 26.620]
     
  7. Schneider RK, Ziegler S, Leisten I, Ferreira MSV, Schumacher A, Rath B, Fahrenkamp D, Muller-Newen G, Crysandt M, Wilop S, Jost E, Koschmieder S, Knuchel R, Brummendorf TH, Ziegler P. Activated fibronectin-secretory phenotype of mesenchymal stromal cells in pre-fibrotic myeloproliferative neoplasms. Journal of Hematology and Oncology. 2014 Dec 14;7:92. [IF 11.059]
     
  8. Leisten I, Kramann R, Ventura Ferreira MS, Ziegler P, Wagner W, Neuss S, Knüchel R and Schneider RK. 3D co-culture of hematopoietic stem and progenitor cells and mesenchymal stem cells in collagen scaffolds as a model of the hematopoietic niche. Biomaterials. 2012 Feb;33(6):1736-47. [IF 10.317]
     
  9. Schneider RK, Anraths J, Kramann R, Bornemann J, Bovi M, Knüchel R, Neuss S. The role of biomaterials in the direction of mesenchymal stem cell properties and extracellular matrix remodelling in dermal tissue engineering. Biomaterials. 2010. Nov;31(31):7948-59. [IF 10.317]
     
  10. Schneider RK, Puellen A, Kramann R, Raupach K, Bornemann J, Knuechel R, Pérez-Bouza A, Neuss S. The osteogenic differentiation of adult bone marrow and perinatal umbilical mesenchymal stem cells and matrix remodelling in three-dimensional collagen scaffolds. Biomaterials. 2010 Jan;31(3):467-80. [IF 10.317]
  1. Kuppe C, Ibrahim MM, Kranz J, Zhang X, Ziegler S, Perales-Patón J, Jansen J, Reimer KC, Smith JR, Dobie R, Wilson-Kanamari JR, Halder M, Xu Y, Kabgani N, Kaesler N, Klaus M, Gernhold L, Puelles VG, Huber TB, Boor P, Menzel S, Hoogenboezem RM, Bindels EMJ, Steffens J, Floege J, Schneider RK, Saez-Rodriguez J, Henderson NC, Kramann R: Decoding myofibroblast origins in human kidney fibrosis. Nature 2021 Available from: dx.doi.org/10.1038/s41586-020-2941-1
     
  2. Kramann R, Schneider RK. The identification of fibrosis-driving myofibroblast precursors reveals new therapeutic avenues in myelofibrosis. Blood. 2018 May 10;131(19):2111-2119.
     
  3. Gleitz HF, Kramann R, Schneider RK. Understanding deregulated cellular and molecular dynamics in the haematopoietic stem cell niche to develop novel therapeutics for bone marrow fibrosis. Journal of Pathology. 2018 Jun;245(2):138-146.
     
  4. Obeng EA, Chappell RJ,Seiler M, Chen MC, Campagna D, Schmidt PJ, Schneider RK,Yu L, Lord AM, McConkey ME,Ali AM, Raza A, Buonamici S, Smith PG, Mullally A, Wu CJ, Fleming MD and Ebert BL. Physiologic expression of Sfb1K700E causes impaired erythropoiesis, aberrant splicing, and sensitivity to a spliceosome inhibitor. Cancer Cell. 2016 Sep 12;30(3):404-17.
     
  5. Puram RV, Kowalczyk MS, de Boer CG, Schneider RK, Miller PG, McConkey M, Tothova Z, Tejero H, Heckl D, Järås M, Chen M, Li H, Tamayo A, Cowley GS, Rozenblatt-Rosen O, Al-Shahrour F, Regev A, Ebert BL. Core circadian clock genes regulate leukemia stem cells in AML. Cell. 2016 Apr 7;165(2):303-16.
     
  6. Ventura Ferreira MS, Bergmann C, Bodensik I, Peukert K, Abert J, Kramann, R, Kachel, P, Rath B, Rütten S, Knuchel R, Ebert BL, Fischer H, Brümmendorf T, Schneider RK. An engineered multicomponent bone marrow niche for the recapitulation of hematopoiesis at ectopic transplantation sites. Journal of Hematology and Oncology, 2016 Jan 25;9:4.  
     
  7. Kowalczyk MS, Tirosh I, Heckl D, Nageswara Rao T, Dixit A, Haas BJ, Schneider RK, Wagers AJ, Ebert BL, Regev A. Single cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells. Genome Res. 2015 Dec;25(12):1860-72.
     
  8. Krönke J*, FinkEC*, HollenbachPW, MacBeth KJ, HurstSN, UdeshiND,  ChamberlainPP, ManiDR,  Wah ManH, GandhiAK, SvinkinaT, Schneider RK, McConkey M, Järås M, Griffiths E, Wetzler M, Bullinger L, Cathers BE, Carr SA, Chopra R, and Ebert BL. Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Nature. 2015 July 9;523(7559):183-8.
     
  9. Kramann R, SchneiderRK, DiRocco DP, Machado F, Fleig S, Bondzie PA, Henderson JM, Ebert BLand Humphreys BD. Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis.Cell Stem Cell. 2015 Jan 8;16(1):51-66. doi: 10.1016/j.stem.2014.11.004.
     
  10. Chen E, Schneider RK, Breyfogle LJ, Rosen EA, Poveromo L, Elf S, Ko A, Brumme K, Levine R, Ebert BL, Mullally A. Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice combine to promote disease progression in myeloproliferative neoplasms. Blood. 2014 Jan 8;125(2):327-35.
     
  11. Losman JA, Looper R, Koivunen P, Lee S, Schneider RK, McMahon C, Cowley G, Root D, Ebert BL, Kaelin WG Jr. (R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible. Science. 2013, March 29;339(6127):1621-5.
     
  12. Kramann R, Kunter U, Brandenburg VM, Leisten I, Ehling J, Klinkhammer B, Knüchel R, Floege J and Schneider RK. Osteogenesis of heterotopically transplanted mesenchymal stromal cells in rat models of chronic kidney disease. Journal of Bone and Mineral Research. 2013 December;28(12):2523-34.
     
  13. Kramann R, Brandenburg VM, Schurgers LJ, Ketteler M, Westphal S, Leisten I, Bovi M, Jahnen-Dechent W, Knüchel R, Floege J and Schneider RK. Novel insights into osteogenesis and matrix remodelling associated with calcific uraemic arteriolopathy. Nephrology Dialysis Transplantation. 2013 March; 28(4): 856-868.
     
  14. Kramann R, Couson S, Neuss S, Floege J, Knuechel R and Schneider RK. Exposure to uremic serum disrupts the vascular niche in a three-dimensional co-culture system of human mesenchymal stem cells and human umbilical cord endothelial cells. Nephrology Dialysis Transplantation. 2012 Jul;27(7):2693-702.
     
  15. van de Kamp J, Kramann R, Anraths J, Schöler HR, Ko K, Knüchel R, Zenke M, Neuss S and Schneider RK. Epithelial morphogenesis of germline-derived pluripotent stem cells on organotypic skin equivalents in vitro. Differentiation. 2012 Mar; 83(3):138-47.
     
  16. Kramann R, Couson SK, Neuss S, Kunter U, Bovi M, Bornemann J, Knüchel R, Jahnen-Dechent W, Floege J and Schneider RK. Exposure to uremic serum induces a procalcific phenotype in human mesenchymal stem cells. Arteriosclerosis Thrombosis Vascular Biology. 2011 Sep;31(9):e45-54.
     
  17. Ko K, Araúzo-Bravo MJ, Tapia N, Kim J, Lin Q, Bernemann C, Han DW, Gentile L, Reinhardt P, Greber B, Schneider RK, Kliesch S, Zenke M, Schöler HR. Human adult germline stem cells in question. Nature. 2010 June 24;465(7301).
     
  18. Schneider RK, Püllen A, Kramann R, Bornemann J, Knüchel R, Neuss S, Perez-Bouza A. Long-term survival and characterisation of human umbilical cord-derived mesenchymal stem cells on dermal equivalents. Differentiation.  2010. Mar;79(3):182-93.
     
  19. Schneider RK, Neuss S, Stainforth R, Laddach N, Bovi M, Knuechel R, Perez-Bouza A. Three-dimensional epidermis-like growth of human mesenchymal stem cells on dermal equivalents: contribution to tissue organization by adaptation of myofibroblastic phenotype and function. Differentiation. 2008 Feb;76(2):156-67.
     
  20. Kramann R, Couson SK, Neuss S, Kunter U, Bovi M, Bornemann J, Knüchel R, Jahnen-Dechent W, Floege J and Schneider RK. Exposure to uremic serum induces a procalcific phenotype in human mesenchymal stem cells. Arteriosclerosis Thrombosis Vascular Biology. 2011 Sep;31(9):e45-54