Publications

2020

2019

2018

2017

  • Schmidt A, Rossetti G, Joussen S, Gründer S
    Diminazene Is a Slow Pore Blocker of Acid-Sensing Ion Channel 1a (ASIC1a).
    Mol Pharmacol. 2017 Dec;92(6):665-675. doi: 10.1124/mol.117.110064. Epub 2017 Oct 12.
  • Frank J.P. Kühn, Mathis Winking, Cornelia Kühn, Daniel C. Hoffmann and Andreas Lückhoff (2017).
    Modulation of activation and inactivation by Ca2+ and 2-APB in the pore of an archetypal TRPM channel from Nematostella vectensis.
    Sci Rep. 7:7245.
  • Frank J.P. Kühn
    New insights into the interaction between ADP-ribose and human TRPM2 channel.
    Biotarget 1:14 (invited Editorial).
  • Reimers C, Lee CH, Kalbacher H, Tian Y, Hung CH, Schmidt A, Prokop L, Kauferstein S, Mebs D, Chen CC, Gründer S
    Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain
    PNAS April 25, 2017 vol. 114 no. 17 E3507-E3515
  • Tian Y, Bresenitz P, Reska A, El Moussaoui L, Beier CP, Gründer S
    Glioblastoma cancer stem cell lines express functional acid sensing ion channels ASIC1a and ASIC3
    Scientific Reports 7, Article number: 13674 (2017) doi:10.1038/s41598-017-13666-9
  • Kühn Frank JP, Kühn Cornelia, Lückhoff Andreas
    Different Principles of ADP-Ribose-Mediated Activation and Opposite Roles of the NUDT9 Homology Domain in the TRPM2 Orthologs of Man and Sea Anemone
    Frontiers in Physiology / 8: 879 / DOI:10.3389/fphys.2017.00879
  • Kist AM, Lampert A, O'Reilly AO.
    DIsulfide Mapping PLanner Software Tool.
    J Comput Biol. 2017 Aug 17. doi: 10.1089/cmb.2017.0129. [Epub ahead of print]
  • O'Reilly AO, Lattrell A, Miles AJ, Klinger AB, Nau C, Wallace BA, Lampert A.
    Mutagenesis of the NaChBac sodium channel discloses a functional role for a conserved S6 asparagine.
    Eur Biophys J. 2017 Aug 20. doi: 10.1007/s00249-017-1246-2. [Epub ahead of print]
  • Dreser A, Vollrath JT, Sechi A, Johann S, Roos A, Yamoah A, Katona I, Bohlega S, Wiemuth D, Tian Y, Schmidt A, Vervoorts J, Dohmen M, Beyer C3, Anink J, Aronica E, Troost D, Weis J, Goswami A.
    The ALS-linked E102Q mutation in Sigma receptor-1 leads to ER stress-mediated defects in protein homeostasis and dysregulation of RNA-binding proteins.
    Cell Death Differ. 2017 Jun 16. doi: 10.1038/cdd.2017.88. [Epub ahead of print]
  • Bosch TC, Klimovich A, Domazet-Lošo T, Gründer S, Holstein TW, Jékely G, Miller DJ, Murillo-Rincon AP, Rentzsch F, Richards GS, Schröder K, Technau U, Yuste R
    Back to the Basics: Cnidarians Start to Fire.
    Trends Neurosci. 2017 Feb;40(2):92-105. doi: 10.1016/j.tins.2016.11.005. Epub 2016 Dec 30.
  • Meents JE, Fischer MJ, McNaughton PA.
    Sensitization of TRPA1 by Protein Kinase A.
    PLoS ONE. 2017 Jan 11; 12(1): e0170097

2016

  • Schmidt A, Löhrer D, Alsop RJ, Lenzig P, Oslender-Bujotzek A, Wirtz M, Rheinstädter MC, Gründer S, Wiemuth D.
    A Cytosolic Amphiphilic α-Helix Controls the Activity of the Bile Acid-sensitive Ion Channel (BASIC).
    J Biol Chem. 2016 Nov 18;291(47):24551-24565.
  • Hendriks CM, Penning TM, Zang T, Wiemuth D, Gründer S, Sanhueza IA, Schoenebeck F, Bolm C.
    Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities.
    Bioorg Med Chem Lett. 2015 Oct 15;25(20):4437-40. doi: 10.1016/j.bmcl.2015.09.012.
  • Daniel Komnig, Silke Imgrund, Arno Reich, Stefan Gründer, Björn H. Falkenburger
    ASIC1a Deficient Mice Show Unaltered Neurodegeneration in the Subacute MPTP Model of Parkinson Disease.
    PLos Published: November 7, 2016
  • Kist, A.M., D. Sagafos, A. M. Rush, C. Neacsu, E. Eberhardt, R. Schmidt, L. K. Lunden, K. Ørstavik, L. Kaluza, J. Meents, Z. Zhang, T. H. Carr, H. Salter, D. Malinowsky, P. Wollberg, J. Krupp, I. P. Kleggetveit, M. Schmelz, E. Jørum*, A. Lampert*, B. Namer*
    SCN10A Mutation in a patient with Erythromelalgia enhances C-fiber activity dependent slowing.
    PLoS One. 2016 Sep 6;11(9)
  • Mishra HK, Prots I, Havlicek S, Kohl Z, Perez-Branguli F, Boerstler T, Anneser L, Minakaki G, Wend H, Hampl M, Leone M, Brückner M, Klucken J, Reis A, Boyer L, Schuierer G, Behrens J, Lampert A, Engel FB, Gage FH, Winkler J, Winner B.
    GSK3ß-dependent dysregulation of neurodevelopment in SPG11-patient iPSC model.
    Ann Neurol. 2016 Mar 11.
  • Fischer TM.
    Creep and stress relaxation of human red cell membrane.
    Biomech Model Mechanobiol. 2016 Aug 11. [Epub ahead of print]
  • Joeres N, Augustinowski K, Neuhof A, Assmann M, Gründer S.
    Functional and pharmacological characterization of two different ASIC1a/2a heteromers reveals their sensitivity to the spider toxin PcTx1.
    Sci Rep. 2016 Jun 9;6:27647. doi: 10.1038/srep27647.
  • Schmidt A, Löhrer D, Alsop RJ, Lenzig P, Oslender-Bujotzek A, Wirtz M, Rheinstädter MC, Gründer S, Wiemuth D.
    A cytosolic amphiphilic alpha helix controls the activity of the bile acid-sensitive ion channel BASIC.
    J Biol Chem. 2016 Sep 27. pii: jbc.M116.756437. [Epub ahead of print]
  • Bressan E, Touska F, Vetter I, Kistner K, Kichko TI, Teixeira NB, Picolo G, Cury Y, Lewis RJ, Fischer MJ, Zimmermann K, Reeh PW.
    Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia.
    Pain. 2016 Jul 18. [Epub ahead of print]
  • Kühn FJP, Kühn C, Winking M, Hoffmann DC, Lückhoff A.
    ADP-Ribose activates the TRPM2 channel from the sea anemone Nematostella vectensis independently of the NUDT9H Domain.
    PLoS ONE 11(6): e0158060. doi:10.1371 (2016)
  • Meents, JE, Fischer MJ, McNaughton PA.
    Agonist-induced sensitisation of the irritant receptor ion channel TRPA1.
    J Physiol. 2016 Nov 15;594(22):6643-6660
  • Hampl* M., Eberhardt* E., O'Reilly AO, Lampert A.
    Sodium channel slow inactivation interferes with open channel block.
    Sci Rep. 2016, May 13;6:25974
  • E. Shahbazi, S. Moradi, S. Nemati, L. Satarian, M. Basiri, H. Gourabi, N. Z. Mehrjardi, P. Günther, A. Lampert, K. Händler, M. Molcanyi, D. Schmidt, F. Hatay, J. Hescheler, J. L. Schultze, T. Šarić, H. Baharvand.
    Generation of Stably Self-Renewing Neural Stem Cells by Conversion of Human Fibroblasts with a Single Zinc-Finger Transcription Factor.
    Stem Cell Reports, 2016 Apr 12;6(4):539-51.
  • Meents, J. E. und A. Lampert.
    Studying sodium channel gating in heterologous expression systems.
    Patch-Clamp Analysis: Advanced Techniques, Third Edition, Volume 113 of the series Neuromethods, pp 37-65

2015

  • Salehi-Nik, N., Amoabediny, G., Shokrgozar, M. A., Mottaghy, K., Klein-Nulend, J., & Zandieh-Doulabi, B.
    Surface modification of silicone tubes by functional carboxyl and amine.
    Biomed Mater. 2015 Mar 2;10(1):015024. doi: 10.1088/1748-6041/10/1/015024.
  • Schwartz V, Friedrich K, Polleichtner G, Gründer S.
    Acid-sensing ion channel (ASIC) 4 predominantly localizes to an early endosome-related organelle upon heterologous expression.
    Sci Rep. 2015 Dec 15;5:18242.
  • Hendriks CM, Penning TM, Zang T, Wiemuth D, Gründer S, Sanhueza IA, Schoenebeck F, Bolm C. Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities.
    Bioorg Med Chem Lett. 2015 Oct 15;25(20):4437-40.
  • Lampert, A., W. Stühmer, S. G. Waxman.
    Sodium channels.
    eLS (encyclopedia of Life Sciences) – Wiley Online Library, 2015
    (DOI: 10.1002/9780470015902.a0000127.pub2)
  • Tigerholm J., M.E. Petersson, O. Obreja, E. Eberhardt, B. Namer, C. Weidner, A.  Lampert, R. W. Carr, M. Schmelz, E. Fransén.
    C-fiber recovery cycle supernormality depends on ion concentration and ion channel permeability.
    Biophysical Journal, 2015 Mar 10;108(5):1057-71.
  • Esther Eberhardt*, Steven Havlicek*, Diana Schmidt*, Andrea S. Link, Cristian Neacsu, Zacharias Kohl, Martin Hampl, Andreas M. Kist, Alexandra Klinger, Carla Nau, Jürgen Schüttler, Christian Alzheimer, Jürgen Winkler, Barbara Namer, Beate Winner, Angelika Lampert.
    Pattern of functional TTX-resistant sodium channels reveals developmental stage of human iPS- and ES cell-derived nociceptors.
    Stem Cell Reports, 2015 Sep 8;5(3):305-13.
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  • Gründer S, Assmann M.
    Peptide-gated ion channels and the simple nervous system of Hydra.
    J Exp Biol. 2015 Feb 15;218(Pt 4):551-561.
  • Gründer S & Pusch M.
    Biophysical properties of acid-sensing ion channels (ASICs).
    Neuropharmacol. 2015 Jan 10. pii: S0028-3908(14)00467-5 (in press).
  • Stadler T.S., A.O. O’Reilly, A. Lampert.
    Erythromelalgia Mutation Q875E Stabilizes The Activated State Of Sodium Channel Nav1.7.
    Journal of Biological Chemistry; 2015 Mar 6;290(10):6316-25.
  • Frank J.P. Kühn, Cornelia Kühn and Andreas Lückhoff.
    Functional Characterisation of a TRPM2 orthologue from the sea anemone Nematostella vectensis in human cells.
    Sci Rep. 2015 Jan 26;5:8032

2014

  • Assmann M, Kuhn A, Dürrnagel S, Holstein TW und Gründer S.
    The comprehensive analysis of DEG/ENaC subunits in Hydra reveals a large variety of peptide-gated channels, potentially involved in neuromuscular transmission.
    BMC Biology 2014 Oct 14;12(1):84.
  • Schmidt A, Lenzig P, Oslender-Bujotzek A, Gründer S und Wiemuth D.
    The bile acid-sensitive ion channel (BASIC) is activated by alterations of its membrane environment.
    PLOS ONE 2014 Oct 31;9(10):e111549
  • Mirjam Eberhardt, Maria Dux, Barbara Namer, Jan Miljkovic, Nada Cordasic, Christine Will, Tatjana I. Kichko, Jeanne de la Roche, Michael Fischer, Sebastián A. Suárez, Damian Bikiel, Karola Dorsch, Andreas Leffler, Alexandru Babes, Angelika Lampert, Jochen K. Lennerz, Johannes Jacob5, Marcelo A. Martí, Fabio Doctorovich, Edward D. Högestätt, Peter M. Zygmunt, Ivana Ivanovic-Burmazovic, Karl Messlinger, Peter Reeh, Milos R Filipovic.
    H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway.
    Nature Communications 2014 Jun 12; 5:4381.
  • Eberhardt M, Nakajima J, Klinger AB, Neacsu C, Hühne K, O'Reilly AO, Kist AM, Lampe AK, Fischer K, Gibson J, Nau C, Winterpacht A, Lampert A.
    Inherited Pain: Sodium Channel Nav1.7 A1632T Mutation Causes Erythromelalgia Due to a Shift of Fast Inactivation.
    J Biol Chem. 2014 Jan 24;289(4):1971-80.
    Dr. Mirjam Eberhardt hat aufgrund dieser Publikation den “EFIC- IBSA Foundation Publication Award“ gewonnen.
  • Bartoi T, Augustinowski K, Polleichtner G, Gründer S, Ulbrich MH.
    Acid-sensing ion channel (ASIC) 1a/2a heteromers have a flexible 2:1/1:2 stoichiometry.
    Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8281-6.
  • Havlicek S., Z. Kohl, H.K. Mishra, I. Prots, E. Eberhardt, N. Denguir, H. Wend, S. Plötz, L. Boyer, M.C. Marchetto, S. Aigner, H. Sticht, T.W. Groemer, U. Hehr, A. Lampert, U. Schlötzer-Schrehardt, J. Winkler, F.H. Gage, B. Winner.
    Gene dosage dependent rescue of HSP neurite defects in SPG4 patients’ neurons.
    Hum Mol Genet. 2014 May 15;23(10):2527-41.
  • Lampert A, Eberhardt M, Waxman SG.
    Altered sodium channel gating as molecular basis for pain: contribution of activation, inactivation, and resurgent currents.
    Handb Exp Pharmacol. 2014;221:91-110.
  • Lampert A, Korngreen A.
    Markov modeling of ion channels: implications for understanding disease.
    Prog Mol Biol Transl Sci. 2014;123:1-21.
  • Lefèvre CM, Diakov A, Haerteis S, Korbmacher C, Gründer S, Wiemuth D.
    Pharmacological and electrophysiological characterization of the human bile acid-sensitive ion channel (hBASIC).
    Pflugers Arch. 2014 Feb;466(2):253-63.
  • O’Reilly, A. O., A. R. Cole, J. L. Lopes, A. Lampert, B. A. Wallace.
    Chaperone-mediated Native Folding of a β-scorpion Toxin in the Periplasm of E.coli.
    Biochim Biophys Acta. 2014 Jan;1840(1):10-5.
  • Petersson M.E., O. Obreja, A. Lampert, R.W. Carr, M. Schmelz, E. Fransén.
    Differential axonal conduction patterns of mechano-sensitive and mechano-insensitive nociceptors--a combined experimental and modelling study.
    PLoS ONE, 2014 Aug; 9(8): e103556.
  • Schulze, V., C.Stoetzer, A.O. O´Reilly, E. Eberhardt, N. Foadi, J. Ahrens, F. Wegner, A. Lampert, J. de la Roche, A. Leffler.
    The opioid methadone induces a local anesthetic like inhibition of the cardiac Na+ channel Nav1.5.
    British Journal of Pharmacology, 2014 Jan;171(2):427-37.
  • Tigerholm, J. M. Petersson, O. Obreja, A. Lampert, R. Carr, M. Schmelz, and E. Fransen.
    Modelling activity-dependent changes of axonal spike conduction in primary afferent C-nociceptors.
    Journal of Neurophysiology, 2014 May;111(9):1721-35.
  • Vollrath JT, Sechi A, Dreser A, Katona I, Wiemuth D, Vervoorts J, Dohmen M, Chandrasekar A, Prause J, Brauers E, Jesse CM, Weis J, Goswami A.
    Loss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbances.
    Cell Death Dis. 2014 Jun 12;5:e1290.
  • Wiemuth D, Assmann M, Gründer S.
    The bile acid-sensitive ion channel (BASIC), the ignored cousin of ASICs and ENaC.
    Channels 2014 Jan 1; 8(1): 29–34.
  • Wiemuth D, Lefèvre CM, Heidtmann H, Gründer S.
    Bile acid increase the activity of the epithelial Na+ channel.
    Pflügers Archive  2014 Sep;466(9):1725-33.

2013

  • Forschungsbericht 2013
  • Thomas M. Fischer and Rafal Korzeniewski
    Threshold shear stress for the transition between tumbling and tank-treading of red blood cells in shear flow: dependence on the viscosity of the suspending medium
    Journal of Fluid Mechanics / Volume 736 / December 2013, pp 351 - 365 
    Published online: 06 November 2013
  • Frank J.P. Kühn, Mathis Winking, Cornelia Kühn, Daniel C. Hoffmann and Andreas Lückhoff
    Surface expressions and channel function of TRPM8 are cooperatively controlled by transmembrane segments S3 and S4*
    Pflügers Archive - European Journal of Physiology 2013 (in press)
  • J. Prause, A. Goswami, I. Katona, A. Roos, M. Schnizler, E. Bushuven, A. Dreier, S. Buchkremer, S. Johann, C. Beyer, M. Deschauer, D. Troost and J. Weis 
    Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis
    Hum. Mol. Genet. (2013) doi: 10.1093/hmg/ddt008 
  • Wiemuth D, Sahin H, Lefèvre CM, Wasmuth H, Gründer S.
    Strong activation of bile acid-sensitive ion channel (BASIC) by ursodeoxycholic acid.
    Channels 7:1, 38–42; January/February 2013