Inhalt

Dr. rer. nat. Patrick Ziegler

pziegler@remove-this.ukaachen.de 
Pauwelsstraße 30, 52074 Aachen
Raum 1 (Etage 5, Aufzug D1, Gang D, Flur 41)
Tel.: 0241 80-88883
Fax: 0241 80-82587

Weitere Informationen

Kurzbiographie

Ausbildung

1999-2002  Dr. rer. nat. Ernst-Moritz-Arndt Universität Greifswald.

1993-1998 Studium Diplom-Biologie Eberhard-Karls Universität Tübingen und Ernst-Moritz-Arndt Universität Greifswald.

Beruflicher Werdegang

Seit 2015  Leiter der Arbeitsgruppe molekulare Arbeitsmedizin am Institut für Arbeits- und Sozialmedizin der RWTH Aachen.

2010-2015 Leiter der Arbeitsgruppe mesenchymale Stammzellen und inflammatorische Hämatopoese an der Klinik für Hämatologie, Onkologie, Hämostaseologie und Stammzelltransplantation der RWTH Aachen.

2006-2009  Postdoc am Institute For Research in Biomedicine in Bellinzona, Schweiz.

2003-2005 Wissenschaftlicher Assistent experimentelle Hämatologie an der Klinik für Onkologie, Hämatologie, Klinische Immunologie, Rheumatologie und Pulmologie der Eberhard-Karls Universität Tübingen.

Forschungsschwerpunkte

  • Immunsupprimierende Wirkung polychlorierter Biphenyle
  • Interferenz von Microplastic auf Ebene der zellulären Signaltransduktion

Publikationen

Lisa Rauschenberger, Doreen Staar, Kathleen Thom, Christian Scharf, Simone Venz, Georg Homuth, Rabea Schlüter, Lars-Ove Brandenburg, Patrick Ziegler, Uwe Zimmermann, Werner Weitschies, Uwe Völker, Uwe Lendeckel, Reinhard Walther, Martin Burchardt, Matthias B Stope: Exosomal particles secreted by prostate cancer cells are potent mRNA and protein vehicles for the interference of tumor and tumor environment. The Prostate 12/2015; 76(4). DOI:10.1002/pros.23132

Patrick Ziegler, Steffen Boettcher, Hitoshi Takizawa, Manz MG, Brümmendorf TH: LPS-stimulated human bone marrow stroma cells support myeloid cell development and progenitor cell maintenance. Annals of Hematology 11/2015;  DOI:10.1007/s00277-015-2550-5

Sebastian Hummel, Ventura Ferreira MS, Daniel Heudobler, Elisabeth Huber, Dirk Fahrenkamp, Felix Gremse, Karin Schmid, Gerhard Müller-Newen, Patrick Ziegler, Edgar Jost, Maria A Blasco, Brümmendorf TH, Ernst Holler, Fabian Beier: Telomere shortening in enterocytes of patients with uncontrolled acute intestinal graft versus host disease. Blood 10/2015; 126(22). DOI:10.1182/blood-2015-03-633289

Fabian Beier, Masouleh BK, Guntram Buesche, Ventura Ferreira MS, Schneider RK, Patrick Ziegler, Stefan Wilop, Lucia Vankann, Norbert Gattermann, Uwe Platzbecker, Aristoteles Giagounidis, Götze KS, Florian Nolte, Hofmann WK, Detlef Haase, Hans Kreipe, Jens Panse, Maria A Blasco, Ulrich Germing, Brümmendorf TH: Telomere dynamics in patients with del (5q) MDS before and under treatment with lenalidomide. Leukemia Research 09/2015; 39(11). DOI:10.1016/j.leukres.2015.09.003

Wenn K, Tomala L, Wilop S, Vankann L, Hasenbank C, Frank O, Hochhaus A, Giles FJ, Lange T, Müller MC, Koschmieder S, Beier F, Ziegler P+, Brümmendorf TH+: Telomere length at diagnosis of chronic phase chronic myeloid leukemia (CML-CP) identifies a subgroup with favourable prognostic parameters and molecular response according to the ELN criteria after 12 months of treatment with nilotinib. Leukemia 09/2015;  DOI:10.1038/leu.2015.245.+ equal contribution

Martin Weiss, Denis Gümbel, Nadine Gelbrich, Lars-Ove Brandenburg, Robert Mandelkow, Uwe Zimmermann, Patrick Ziegler, Martin Burchardt, Matthias B Stope: Inhibition of Cell Growth of the Prostate Cancer Cell Model LNCaP by Cold Atmospheric Plasma. In vivo (Athens, Greece) 09/2015; 29(5):611-616.

Anne Schumacher, Bernd Denecke, Till Braunschweig, Jasmin Stahlschmidt, Susanne Ziegler, Brandenburg LO, Stope MB, Antons Martincuks, Michael Vogt, Dieter Görtz, Annalisa Camporeale, Valeria Poli, Gerhard Müller-Newen, Brümmendorf TH, Patrick Ziegler: Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after myelosuppressive therapy. Journal of Hematology & Oncology 06/2015;  DOI:10.1186/s13045-015-0152-2

Christoph Emontzpohl, Andreas Goetzenich, David Simons, Sandra Kraemer, Manfred Dewor, Hongqi Lue, Luise Hammer, Denise Jacobs, Gerrit Grieb, Patrick Ziegler, Jens Panse, Rolf Rossaint, Jürgen Bernhagen, Christian Stoppe: Key role of MIF in the migration of endothelial progenitor cells in patients during cardiac surgery. International Journal of Cardiology 12/2014; 181C:284-287. DOI:10.1016/j.ijcard.2014.11.226

Rebekka K. Schneider, Susanne Ziegler, Isabelle Leisten, Monica S. V. Ferreira, Anne Schumacher, Björn Rath, Dirk Fahrenkamp, Gerhard Müller-Newen, Martina Crysandt, Stefan Wilop, Edgar Jost, Steffen Koschmieder, Ruth Knüchel, Tim H. Brümmendorf, Patrick Ziegler: Activated fibronectin-secretory phenotype of mesenchymal stromal cells in pre-fibrotic myeloproliferative neoplasms. Journal of Hematology & Oncology 12/2014; 7(1). DOI:10.1186/s13045-014-0092-2

Weidner CI, Ziegler P, Hahn M, Brümmendorf TH, Ho AD, Dreger P, Wagner W: Epigenetic aging upon allogeneic transplantation: The hematopoietic niche does not affect age-associated DNA methylation. Leukemia 11/2014; 29(4). DOI:10.1038/leu.2014.323

Matthias B Stope, Christian Stender, Tina Schubert, Stefanie Peters, Martin Weiss, Patrick Ziegler, Uwe Zimmermann, Reinhard Walther, Martin Burchardt: Heat-shock Protein HSPB1 Attenuates MicroRNA miR-1 Expression Thereby Restoring Oncogenic Pathways in Prostate Cancer Cells. Anticancer research 07/2014; 34(7):3475-80.

Michael Heuser, Carola Schlarmann, Vera Dobbernack, Victoria Panagiota, Lutz Wiehlmann, Carolin Walter, Fabian Beier, Patrick Ziegler, Haiyang Yun, Sofia Kade, Aylin Kirchner, Liu Huang, Christian Koenecke, Matthias Eder, Tim H Brümmendorf, Martin Dugas, Arnold Ganser, Felicitas Thol: Genetic characterization of acquired aplastic anemia by targeted sequencing. Haematologica 06/2014; 99(9). DOI:10.3324/haematol.2013.101642

Carola Ingrid Weidner, Qiong Lin, Carmen Maike Koch, Lewin Eisele, Fabian Beier, Patrick Ziegler, Dirk Olaf Bauerschlag, Karl-Heinz Jöckel, Raimund Erbel, Thomas Walter Mühleisen, Martin Zenke, Tim Henrik Brümmendorf, Wolfgang Wagner: Aging of blood can be tracked by DNA methylation changes at just three CpG sites. Genome biology 02/2014; 15(2):R24. DOI:10.1186/gb-2014-15-2-r24

Ilona Hauber, Helga Hofmann-Sieber, Jan Chemnitz, Danilo Dubrau, Janet Chusainow, Rolf Stucka, Philip Hartjen, Axel Schambach, Patrick Ziegler, Karl Hackmann, Evelin Schröck, Udo Schumacher, Christoph Lindner, Adam Grundhoff, Christopher Baum, Markus G Manz, Frank Buchholz, Joachim Hauber: Highly Significant Antiviral Activity of HIV-1 LTR-Specific Tre-Recombinase in Humanized Mice. PLoS Pathogens 09/2013; 9(9):e1003587. DOI:10.1371/journal.ppat.1003587

Fabian Beier, Andreas Böhmler, Tim H. Brümmendorf, Patrick Ziegler: Quantifizierung der Telomerlängen in Granulozyten und Lymphozyten. BioSpektrum 05/2013; 19(3). DOI:10.1007/s12268-013-0310-4

Carmen M Koch, Kristina Reck, Kaifeng Shao, Qiong Lin, Sylvia Joussen, Patrick Ziegler, Gudrun Walenda, Wolf Drescher, Bertram Opalka, Tobias May, Tim Hendrik Brummendorf, Martin Zenke, Tomo Saric, Wolfgang Wagner: Pluripotent stem cells escape from senescence-associated DNA methylation changes. Genome Research 10/2012; 23(2). DOI:10.1101/gr.141945.112

N Chatain, P Ziegler, D Fahrenkamp, E Jost, R Moriggl, H Schmitz-Van de Leur, G Müller-Newen: Src family kinases mediate cytoplasmic retention of activated STAT5 in BCR-ABL-positive cells. Oncogene 08/2012; 32(31). DOI:10.1038/onc.2012.369

Steffen Boettcher+, Patrick Ziegler+, Michael A Schmid, Hitoshi Takizawa, Nico van Rooijen, Manfred Kopf, Mathias Heikenwalder, Markus G Manz: Cutting Edge: LPS-Induced Emergency Myelopoiesis Depends on TLR4-Expressing Nonhematopoietic Cells. The Journal of Immunology 05/2012; 188(12):5824-8. DOI:10.4049/jimmunol.1103253.+Equal contribution.

Patrick Ziegler, Hubert Schrezenmeier, Jamil Akkad, Ute Brassat, Lucia Vankann, Jens Panse, Stefan Wilop, Stefan Balabanov, Klaus Schwarz, Uwe M Martens, Tim H Brümmendorf: Telomere elongation and clinical response to androgen treatment in a patient with aplastic anemia and a heterozygous hTERT gene mutation. Annals of Hematology 04/2012; 91(7):1115-20. DOI:10.1007/s00277-012-1454-x

Patrick Ziegler, Tuhama Chahoud, Thomas Wilhelm, Nora Pällman, Melanie Braig, Valeska Wiehle, Susanne Ziegler, Marcus Schröder, Chris Meier, Adrian Kolodzik, Matthias Rarey, Jens Panse, Joachim Hauber, Stefan Balabanov, Tim H Brümmendorf: Evaluation of deoxyhypusine synthase inhibitors targeting BCR-ABL positive leukemias. Investigational New Drugs 03/2012; 30(6). DOI:10.1007/s10637-012-9810-1

M.B. Stope, C. Rönnau, T. Schubert, D. Staar, J. Bradl, P. Ziegler, A. Streitbörger, N. Kroeger, U. Zimmermann, R. Walther, M. Burchardt, C. Börgermann: „Transforming growth factor β“ im Prostatakarzinom. Der Urologe 03/2012; 52(3). DOI:10.1007/s00120-012-3049-5

Isabelle Leisten, Rafael Kramann, Mónica S Ventura Ferreira, Manfred Bovi, Sabine Neuss, Patrick Ziegler, Wolfgang Wagner, Ruth Knüchel, Rebekka K Schneider: 3D co-culture of hematopoietic stem and progenitor cells and mesenchymal stem cells in collagen scaffolds as a model of hematopoietic niche. Biomaterials 11/2011; 33(6):1736-47. DOI:10.1016/j.biomaterials.2011.11.034

P Ziegler, S Teller, N H Ha, B Giese, M Fraunholz, R Walther: Phosphoproteomic Identification of a PDX-1/14-3-3 epsilon Interaction in Pancreatic Beta Cells. Hormone and Metabolic Research 02/2011; 43(3):165-70. DOI:10.1055/s-0030-1270526

Martha R Neagu, Patrick Ziegler, Thomas Pertel, Caterina Strambio-De-Castillia, Christian Grütter, Gladys Martinetti, Luca Mazzucchelli, Markus Grütter, Markus G Manz, Jeremy Luban: Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components. The Journal of clinical investigation 10/2009; 119(10):3035-47. DOI:10.1172/JCI39354

Nicolas Legrand, Alexander Ploss, Rudi Balling, Pablo D Becker, Chiara Borsotti, Nicolas Brezillon, Jennifer Debarry, Ype de Jong, Hongkui Deng, James P Di Santo, Stephanie Eisenbarth, Elizabeth Eynon, Richard A Flavell, Carlos A Guzman, Nicholas D Huntington, Dina Kremsdorf, Michael P Manns, Markus G Manz, Jean-Jacques Mention, Michael Ott, Chozhavendan Rathinam, Charles M Rice, Anthony Rongvaux, Sean Stevens, Hergen Spits, Hélène Strick-Marchand, Hitoshi Takizawa, Anja U van Lent, Chengyan Wang, Kees Weijer, Tim Willinger, Patrick Ziegler: Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook. Cell host & microbe 08/2009; 6(1):5-9. DOI:10.1016/j.chom.2009.06.006

N Martinez Soria, R Tussiwand, P Ziegler, M.G. Manz, O Heidenreich: Transient depletion of RUNX1/RUNX1T1 by RNA interference delays tumour formation in vivo. Leukemia: official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 07/2008; 23(1):188-90. DOI:10.1038/leu.2008.157

S Baenziger, P Ziegler, L Mazzucchelli, L Bronz, R F Speck, M G Manz: Human T Cell Development and HIV Infection in Human Hemato-Lymphoid System Mice. Current topics in microbiology and immunology 02/2008; 324:125-31. DOI:10.1007/978-3-540-75647-7_8

Stefan Balabanov, Artur Gontarewicz, Patrick Ziegler, Ulrike Hartmann, Winfried Kammer, Mhairi Copland, Ute Brassat, Martin Priemer, Ilona Hauber, Thomas Wilhelm, Gerold Schwarz, Lothar Kanz, Carsten Bokemeyer, Joachim Hauber, Tessa L Holyoake, Alfred Nordheim, Tim H Brümmendorf: Balabanov, S. et al. Hypusination of eukaryotic initiation factor 5A (eIF5A): a novel therapeutic target in BCR-ABL-positive leukemias identified by a proteomics approach. Blood 109, 1701-1711. Blood 03/2007; 109(4):1701-11. DOI:10.1182/blood-2005-03-037648

Patrick Ziegler, Markus G Manz: Mouse Models for Human Hemato-Lymphopoiesis. Current protocols in toxicology 02/2007; Chapter 2:Unit2.13. DOI:10.1002/0471140856.tx0213s31

Ulrike Hartmann, Stefan Balabanov, Patrick Ziegler, Jörg Fellenberg, Heiko van der Kuip, Justus Duyster, Hans-Peter Lipp, Carsten Bokemeyer, Lothar Kanz, Tim H Brümmendorf: Telomere length and telomerase activity in the BCR-ABL-transformed murine Pro-B cell line BaF3 is unaffected by treatment with imatinib. Experimental Hematology 06/2005; 33(5):542-9. DOI:10.1016/j.exphem.2005.02.002

Behnam Hessabi, Patrick Ziegler, Ines Schmidt, Claudia Hessabi, Reinhard Walther: The nuclear localization signal (NLS) of PDX-1 is part of the homeodomain and represents a novel type of NLS. European Journal of Biochemistry 08/1999; 263(1):170-7. DOI:10.1046/j.1432-1327.1999.00481.x

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