The main interest in our Institute is to understand the role of distinct signaling and transcriptional processes during inflammatory processes and tumor development.
• The group of Dr. Vervoorts studies the cell cycle, in particular the role of the tumor suppressor p27. In addition to inhibiting cyclin-dependent kinases, p27 also controls cell migration and autophagy, aspects that are addressed using the purification of protein complexes and cell biological approaches.
• Dr. Lüscher-Firzlaff studies the trithorax protein ASH2L that functions in a chromatin-modifying complex. The function of ASH2L in the control of cell proliferation is determined using chromatin immunoprecipitations and conditional knock-out mice.
• The laboratory of Prof. Müller-Newen studies cytokine signaling through the JAK/STAT pathway which is often deregulated in inflammation and cancer. The temporal and spatial organization of JAK/STAT signaling is analyzed in living cells using advanced microscopy techniques.
• The group of Prof. Lüscher wants to understand how mono-ADP-ribosylation controls cellular processes. In particular the role of the mono-ADP-ribosyltransferase ARTD10 and the antagonizing ADP-ribosylhydrolases are analyzed in NF-kB signaling using gene expression.
• The group of Dr. Verheugd is interested in the function and molecular characterization of ADP-ribosylhydrolases.
• In a second project Prof. Lüscher, in close collaboration with Prof. Baron (Dermatology), studies the role of cytokines in the regulation of keratinocyte differentiation using 3-dimensional skin models and gene expression arrays.
• Dr Feijs, Dr Žaja and their team are studying the function of mono(ADP-ribosyl)ation in diverse (patho)physiological processes, such as metabolism, immunity and cancer. Employed methods range from molecular biology, biochemistry, tumor and primary cell culture to animal models.
For more information please see the individual links of all the group leaders (team).
Here all the names of the group leaders: