Inhalt

Publikationen

2017

Epidemiology and distribution of 10 superantigens among invasive Streptococcus pyogenes disease in Germany from 2009 to 2014.
Imöhl M, Fitzner C, Perniciaro S, van der Linden M. PLoS One. 2017 Jul 18;12(7):e0180757.

Fluoroquinolone resistance in Streptococcus pneumoniae isolates in Germany from 2004-2005 to 2014-2015.
Schmitz J, van der Linden M, Al-Lahham A, Levina N, Pletz MW, Imöhl M.
Int J Med Microbiol. 2017 Jun;307(4-5):216-222. doi: 10.1016/j.ijmm.2017.04.003. Epub 2017 Apr 19.

Streptococcus tigurinus is frequent among gtfR-negative Streptococcus oralis isolates and in the human oral cavity, but highly virulent strains are uncommon.
Conrads G, Barth S, Möckel M, Lenz L, van der Linden M, Henne K.
J Oral Microbiol. 2017 Apr 20;9(1):1307079. doi: 10.1080/20002297.2017.1307079. eCollection 2017.

The virulence factors of group A streptococcus strains isolated from invasive and non-invasive infections in Polish and German centres, 2009-2011. 
Strus M, Heczko PB, Golińska E, Tomusiak A, Chmielarczyk A, Dorycka M, van der Linden M, Samet A, Piórkowska A.
Eur J Clin Microbiol Infect Dis. 2017 Apr 11.

Corynebacterium species nasopharyngeal carriage in asymptomatic individuals aged ≥ 65 years in Germany. 
Teutsch B, Berger A, Marosevic D, Schönberger K, Lâm TT, Hubert K, Beer S, Wienert P, Ackermann N, Claus H, Drayß M, Thiel K, van der Linden M, Vogel U, Sing A.
Infection. 2017 Apr 20.

Insight into the Diversity of Penicillin-Binding Protein 2x Alleles and Mutations in Viridans Streptococci. 
van der Linden M, Otten J, Bergmann C, Latorre C, Liñares J, Hakenbeck R.
Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02646-16.

Whole Genome Sequencing of 39 Invasive Streptococcus pneumoniae Sequence Type 199 Isolates Revealed Switches from Serotype 19A to 15B.
Makarewicz O, Lucas M, Brandt C, Herrmann L, Albersmeier A, Rückert C, Blom J, Goesmann A, van der Linden M, Kalinowski J, Pletz MW.
PLoS One. 2017 Jan 3;12(1):e0169370. doi: 10.1371/journal.pone.0169370.

2016

Therapy of 645 children with parapneumonic effusion and empyema-A german nationwide surveillance study. 
Segerer FJ, Seeger K, Maier A, Hagemann C, Schoen C, van der Linden M, Streng A, Rose MA, Liese JG.
Pediatr Pulmonol. 2016 Sep 20.

Effectiveness of Pneumococcal Conjugate Vaccines (PCV7 and PCV13) against Invasive Pneumococcal Disease among Children under Two Years of Age in Germany.
van der Linden M, Falkenhorst G, Perniciaro S, Fitzner C, Imöhl M.
PLoS One. 2016 Aug 15;11(8):e0161257. doi: 10.1371/journal.pone.0161257. eCollection 2016.

Streptococcus pneumoniae as an agent of urinary tract infections - a laboratory experience from 2010 to 2014 and further characterization of strains.
Burckhardt I, Panitz J, van der Linden M, Zimmermann S.
Diagn Microbiol Infect Dis. 2016 Jun 15. pii: S0732-8893(16)30169-9. doi: 10.1016/j.diagmicrobio.2016.06.009. [Epub ahead of print]

Identification of Streptococcus suis Meningitis through Population-Based Surveillance, Togo, 2010-2014.
Tall H, Njanpop-Lafourcade BM, Mounkoro D, Tidjani L, Agbenoko K, Alassani I, Amidou M, Tamekloe S, Laing KG, Witney AA, Hinds J, van der Linden MP, Gessner BD, Moïsi JC.
Emerg Infect Dis. 2016 Jul;22(7):1262-4. doi: 10.3201/eid2207.151511.

A cohort study of the impact and acquisition of naspharyngeal carriage of Streptococcus pneumoniae during the Hajj.
Memish ZA, Al-Tawfiq JA, Almasri M, Akkad N, Yezli S, Turkestani A, van der Linden M, Assiri A.
Travel Med Infect Dis. 2016 May-Jun;14(3):242-7. doi: 10.1016/j.tmaid.2016.05.001. Epub 2016 May 14.

The Relevance of a Novel Quantitative Assay to Detect up to 40 Major Streptococcus pneumoniae Serotypes Directly in Clinical Nasopharyngeal and Blood Specimens.
Messaoudi M, Milenkov M, Albrich WC, van der Linden MP, Bénet T, Chou M, Sylla M, Barreto Costa P, Richard N, Klugman KP, Endtz HP, Paranhos-Baccalà G, Telles JN.
PLoS One. 2016 Mar 17;11(3):e0151428. doi: 10.1371/journal.pone.0151428. eCollection 2016.

Vaccine effectiveness of PCV13 in a 3+1 vaccination schedule.
Weinberger R, van der Linden M, Imöhl M, von Kries R.
Vaccine. 2016 Apr 19;34(18):2062-5. doi: 10.1016/j.vaccine.2016.02.043. Epub 2016 Feb 23.

Epidemiological analysis of pneumococcal serotype 19A in healthy children following PCV7 vaccination.
Tóthpál A, Laub K, Kardos S, Tirczka T, Kocsis A, VAN DER Linden M, Dobay O.
Epidemiol Infect. 2016 May;144(7):1563-73. doi: 10.1017/S0950268815002757. Epub 2015 Nov 9.

Fulminant Pneumococcal Meningoencephalitis and Widespread Cerebritis with Multiple Infarctions Caused by Non–PCV13-Serotype 23A in a 12-Month-Old Girl with Down Syndrome.
Lukas Schröder, Gunnar T. R. Hischebeth, Mark van der Linden, Mark Born, Heiko Reutter, Till Dresbach, Andreas Müller
J Pediatr Infect Dis, 2016

Virulence factors of Streptococcus pyogenes strains from women in peri-labor with invasive infections. 
Golińska E, van der Linden M, Więcek G, Mikołajczyk D, Machul A, Samet A, Piórkowska A, Dorycka M, Heczko PB, Strus M.
Eur J Clin Microbiol Infect Dis. 2016 Feb 12. [Epub ahead of print]
PMID: 26873375

Antibiotic resistance patterns and risk factors of Streptococcus pneumoniae carriage among healthy Jordanian children.
Rawaa Al-Kayali, Hala Khyami-Horani, Mark van der Linden and Adnan Al-Lahham.
European International Journal of Science and Technology. January, 2016, Vol. 5 No. 1

2015

Antimicrobial Susceptibility of Invasive Streptococcus pyogenes Isolates in Germany during 2003-2013. 
Imöhl M, van der Linden M.
PLoS One. 2015 Sep 4;10(9):e0137313.

Antibiotic susceptibility rates of invasive pneumococci before and after the introduction of pneumococcal conjugate vaccination in Germany.
Imöhl M, Reinert RR, van der Linden M.
Int J Med Microbiol. 2015 Aug 22. pii: S1438-4221(15)00094-6. doi: 10.1016/j.ijmm.2015.08.031.

Effects of Infant Pneumococcal Conjugate Vaccination on Serotype Distribution in Invasive Pneumococcal Disease among Children and Adults in Germany.
van der Linden M, Falkenhorst G, Perniciaro S, Imöhl M.
PLoS One. 2015 Jul 1;10(7)

Incidence of invasive pneumococcal disease in 5-15 year old children with and without comorbidities in Germany after the introduction of PCV13: Implications for vaccinating children with comorbidities.

Weinberger R, Falkenhorst G, Bogdan C, van der Linden M, Imöhl M, von Kries R.
Vaccine. 2015 Nov 1. pii: S0264-410X(15)01558-3. doi: 10.1016/j.vaccine.2015.10.102.

Increase of serotypes 15A and 23B in IPD in Germany in the PCV13 vaccination era. 
van der Linden M, Perniciaro S, Imöhl M.
BMC Infect Dis. 2015 May 5;15(1):207. doi: 10.1186/s12879-015-0941-9.

Pneumococcal meningitis and vaccine effects in the era of conjugate vaccination: results of 20 years of nationwide surveillance in Germany. 
Imöhl M, Möller J, Reinert RR, Perniciaro S, van der Linden M, Aktas O.
BMC Infect Dis. 2015 Feb 14;15(1):61. doi: 10.1186/s12879-015-0787-1.

Radical serotype rearrangement of carried pneumococci in the first 3 years after intensive vaccination started in Hungary.
Tóthpál A, Kardos S, Laub K, Nagy K, Tirczka T, van der Linden M, Dobay O.
Eur J Pediatr. 2015 Mar;174(3):373-81. doi: 10.1007/s00431-014-2408-1. Epub 2014 Sep 2.

Impact of 10- and 13-valent pneumococcal conjugate vaccines on incidence of invasive pneumococcal disease in children aged under 16 years in Germany, 2009 to 2012. 
Weiss S, Falkenhorst G, van der Linden M, Imohl M, von Kries R.
Euro Surveill. 2015 Mar 12;20(10):21057.

Impact of the hajj on pneumococcal transmission.
Memish ZA, Assiri A, Almasri M, Alhakeem RF, Turkestani A, Al Rabeeah AA, Akkad N, Yezli S, Klugman KP, O'Brien KL, van der Linden M, Gessner BD.
Clin Microbiol Infect. 2015 Jan;21(1):77.e11-8. doi: 10.1016/j.cmi.2014.07.005. Epub 2014 Oct 12.

2014

Trends in antimicrobial non-susceptibility in methicillin-resistant Staphylococcus aureus from Germany (2004-2011).
Schaumburg F, Idelevich EA, Peters G, Mellmann A, von Eiff C, Becker K; Study Group.
Clin Microbiol Infect. 2014 Sep;20(9):O554-7. doi: 10.1111/1469-0691.12519. Epub 2014 Jan 23.

Recent trends in epidemiology of invasive pneumococcal disease in Poland.
Skoczyńska A, Kuch A, Sadowy E, Waśko I, Markowska M, Ronkiewicz P, Matynia B, Bojarska A, Wasiak K, Gołębiewska A, van der Linden M, Hryniewicz W; Participants of a laboratory-based surveillance of community acquired invasive bacterial infections (BINet).
Eur J Clin Microbiol Infect Dis. 2014 Dec 5. [Epub ahead of print] 

Bacterial spectrum of spontaneously ruptured otitis media in the era of pneumococcal conjugate vaccination in Germany. 
van der Linden M, Imöhl M, Busse A, Rose M, Adam D.
Eur J Pediatr. 2014 Aug 30. [Epub ahead of print]

Radical serotype rearrangement of carried pneumococci in the first 3 years after intensive vaccination started in Hungary. 
Tóthpál A, Kardos S, Laub K, Nagy K, Tirczka T, van der Linden M, Dobay O.
Eur J Pediatr. 2014 Sep 2. [Epub ahead of print]

Variable recombination dynamics during the emergence, transmission and `disarming` of a multidrug-resistant pneumococcal clone. 
Croucher NJ, Hanage WP, Harris SR, McGee L, van der Linden M, de Lencastre H, Sá-Leão R, Song JH, Ko KS, Beall B, Klugman KP, Parkhill J, Tomasz A, Kristinsson KG, Bentley SD.
BMC Biol. 2014 Jun 23;12(1):49. doi: 10.1186/1741-7007-12-49.

Penicillin susceptibility breakpoints for Streptococcus pneumoniae and their effect on susceptibility categorisation in Germany (1997-2013). 
Imöhl M, Reinert RR, Tulkens PM, van der Linden M.
Eur J Clin Microbiol Infect Dis. 2014 Jun 15. [Epub ahead of print] 

Evidence for soft selective sweeps in the evolution of pneumococcal multidrug resistance and vaccine escape. 
Croucher NJ, Chewapreecha C, Hanage WP, Harris SR, McGee L, van der Linden M, Song JH, Ko KS, de Lencastre H, Turner C, Yang F, Sá-Leão R, Beall B, Klugman KP, Parkhill J, Turner P, Bentley SD.
Genome Biol Evol. 2014 Jun 10;6(7):1589-602. doi: 10.1093/gbe/evu120.

[Invasive pneumococcal disease in Germany in the era of pneumococcal conjugate vaccination] 
Imöhl M, van der Linden M.
Dtsch Med Wochenschr. 2014 Jun;139(25-26):1346-51. doi: 10.1055/s-0034-1370126. Epub 2014 Jun 10. German.

[Prevention in the elderly: position paper on pneumococcal vaccinations : Results of an expert workshop on 15 November 2013 in Cologne, Germany.] 
Fätkenheuer G, Kwetkat A, Pletz MW, Schelling J, Schulz RJ, van der Linden M, Welte T.
Z Gerontol Geriatr. 2014 May 22. [Epub ahead of print] German.

A Systematic and Functional Classification of Streptococcus pyogenes That Serves as a New Tool for Molecular Typing and Vaccine Development. 
Sanderson-Smith M, De Oliveira DM, Guglielmini J, McMillan DJ, Vu T, Holien JK, Henningham A, Steer AC, Bessen DE, Dale JB, Curtis N, Beall BW, Walker MJ, Parker MW, Carapetis JR, Van Melderen L, Sriprakash KS, Smeesters PR; The M Protein Study Group.
J Infect Dis. 2014 May 5. pii: jiu260. [Epub ahead of print]

Neonatal group B streptococcal septicemia transmitted by contaminated breast milk, proven by pulsed field gel electrophoresis in 2 cases. 
Salamat S, Fischer D, van der Linden M, Buxmann H, Schlösser R.
Pediatr Infect Dis J. 2014 Apr;33(4):428.

Factors that cause trimethoprim resistance in Streptococcus pyogenes. 
Bergmann R, van der Linden M, Chhatwal GS, Nitsche-Schmitz DP.
Antimicrob Agents Chemother. 2014 Apr;58(4):2281-8. doi: 10.1128/AAC.02282-13. Epub 2014 Feb 3.

Purulent pericarditis and pneumonia caused by Streptococcus equi subsp. zooepidemicus. 
Held J, Schmitz R, van der Linden M, Nührenberg T, Häcker G, Neumann FJ.
J Med Microbiol. 2014 Feb;63(Pt 2):313-6.

2013

Viridans and bovis group streptococci that cause infective endocarditis in two regions with contrasting epidemiology. 
Naveen Kumar V, van der Linden M, Menon T, Nitsche-Schmitz DP.
Int J Med Microbiol. 2013 Oct 20. pii: S1438-4221(13)00154-9. 

Serotype-specific changes in invasive pneumococcal disease after pneumococcal conjugate vaccine introduction: a pooled analysis of multiple surveillance sites. 
Feikin DR, Kagucia EW, Loo JD, Link-Gelles R, Puhan MA, Cherian T, Levine OS, Whitney CG, O`Brien KL, Moore MR; Serotype Replacement Study Group.
PLoS Med. 2013;10(9):e1001517.

Seven-Year Surveillance of emm Types of Pediatric Group A Streptococcal Pharyngitis Isolates in Western Greece. 
Syrogiannopoulos GA, Grivea IN, Al-Lahham A, Panagiotou M, Tsantouli AG, Michoula Ralf René Reinert AN, van der Linden M.
PLoS One. 2013 Aug 19;8(8):e71558. doi: 10.1371/journal.pone.0071558.

Discovery of Streptococcus pneumoniae serotype 6 variants with glycosyltransferases synthesizing two differing repeating units. 
Oliver MB, van der Linden MP, Küntzel SA, Saad JS, Nahm MH.
J Biol Chem. 2013 Sep 6;288(36):25976-85. doi: 10.1074/jbc.M113.480152. Epub 2013 Jul 29.

Epidemiology of Streptococcus pneumoniae serogroup 6 isolates from IPD in children and adults in Germany. 
van der Linden M, Winkel N, Küntzel S, Farkas A, Perniciaro SR, Reinert RR, Imöhl M.
PLoS One. 2013 Apr 9;8(4):e60848. doi: 10.1371/journal.pone.0060848. Print 2013.

Epidemiology of serotype 19A isolates from invasive pneumococcal disease in German children. 
van der Linden M, Reinert RR, Kern WV, Imöhl M.
BMC Infect Dis. 2013 Feb 5;13:70. doi: 10.1186/1471-2334-13-70.

A single amino acid substitution in the MurF UDP-MurNAc-pentapeptide synthetase renders Streptococcus pneumoniae dependent on CO2 and temperature. 
Burghout P, Quintero B, Bos L, Beilharz K, Veening JW, de Jonge MI, van der Linden M, van der Ende A, Hermans PW.
Mol Microbiol. 2013 Aug;89(3):494-506. doi: 10.1111/mmi.12292. Epub 2013 Jun 28.

Antihypertensives suppress the emergence of fluoroquinolone-resistant mutants in pneumococci: an in vitro study. 
Pletz MW, Michaylov N, Schumacher U, van der Linden M, Duesberg CB, Fuehner T, Klugman KP, Welte T, Makarewicz O.
Int J Med Microbiol. 2013 May;303(4):176-81. doi: 10.1016/j.ijmm.2013.02.014. Epub 2013 Mar 14. 

Severe soft tissue infection caused by a non-beta-hemolytic Streptococcus pyogenes strain harboring a premature stop mutation in the sagC gene. 
Jantsch J, Gerlach RG, Ensser A, Dahesh S, Popp I, Heeg C, Bleiziffer O, Merz T, Schulz T, Horch RE, Bogdan C, Nizet V, van der Linden M.
J Clin Microbiol. 2013 Jun;51(6):1962-5. doi: 10.1128/JCM.00175-13. Epub 2013 Mar 20.

[Pneumococcal vaccination in adults: background of the current discussion]. 
Pletz MW, van der Linden M, Fobiwe JP, Theilacker C.
Dtsch Med Wochenschr. 2013 Feb;138(5):185-7. doi: 10.1055/s-0032-1327411. Epub 2013 Jan 22. German.

Streptococcus pneumoniae colonization in remote African Pygmies. 
Schaumburg F, Alabi A, von Eiff C, Flamen A, Traore H, Grobusch MP, Peters G, Kremsner PG, van der Linden M.
Trans R Soc Trop Med Hyg. 2013 Feb;107(2):105-9. doi: 10.1093/trstmh/trs018. Epub 2012 Nov 14.

Carriage of encapsulated bacteria in Gabonese children with sickle cell anaemia. 
Schaumburg F, Biallas B, Ngoune Feugap E, Alabi AS, Mordmüller B, Kremsner PG, Grobusch MP, Lell B, van der Linden M, Peters G, Adegnika AA.
Clin Microbiol Infect. 2013 Mar;19(3):235-41. doi: 10.1111/j.1469-0691.2012.03771.x. Epub 2012 Feb 13.

2012

Pneumococci in the African meningitis belt: meningitis incidence and carriage prevalence in children and adults.t 
Mueller JE, Yaro S, Ouédraogo MS, Levina N, Njanpop-Lafourcade BM, Tall H, Idohou RS, Sanou O, Kroman SS, Drabo A, Nacro B, Millogo A, van der Linden M, Gessner BD.
PLoS One. 2012;7(12):e52464. doi: 10.1371/journal.pone.0052464. Epub 2012 Dec 20.

Cost-effectiveness of vaccinating adults with the 23-valent pneumococcal polysaccharide vaccine (PPV23) in Germany. 
Jiang Y, Gauthier A, Annemans L, van der Linden M, Nicolas-Spony L, Bresse X.
Expert Rev Pharmacoecon Outcomes Res. 2012 Oct;12(5):645-60. doi: 10.1586/erp.12.54. Epub 2012 Oct 1. 

A public health and budget impact analysis of vaccinating at-risk adults and the elderly against pneumococcal diseases in Germany. 
Jiang Y, Gauthier A, Annemans L, van der Linden M, Nicolas-Spony L, Bresse X.
Expert Rev Pharmacoecon Outcomes Res. 2012 Oct;12(5):631-43. doi: 10.1586/erp.12.55. Epub 2012 Oct 1.

Opportunity for healthy ageing: lessening the burden of adult pneumococcal disease in Central and Eastern Europe, and Israel. 
Ludwig E, Unal S, Bogdan M, Chlibek R, Ivanov Y, Kozlov R, van der Linden M, Lode H, Mészner Z, Prymula R, Rahav G, Skoczynska A, Solovic I, Uzaslan E.
Cent Eur J Public Health. 2012 Jun;20(2):121-5.

Prevention of pneumococcal diseases in the post-seven valent vaccine era: a European perspective.
Weil-Olivier C, van der Linden M, de Schutter I, Dagan R, Mantovani L.
BMC Infect Dis. 2012 Sep 7;12:207. doi: 10.1186/1471-2334-12-207. Review.

The burden of pneumococcal pneumonia - experience of the German competence network CAPNETZ.
Pletz MW, von Baum H, van der Linden M, Rohde G, Schütte H, Suttorp N, Welte T.
Pneumologie. 2012 Aug;66(8):470-5. Epub 2012 Aug 8.

Population dynamics among methicillin-resistant Staphylococcus aureus isolates in Germany during a 6-year period.
Schaumburg F, Köck R, Mellmann A, Richter L, Hasenberg F, Kriegeskorte A, Friedrich AW, Gatermann S, Peters G, von Eiff C, Becker K; study group.
J Clin Microbiol. 2012 Oct;50(10):3186-92. doi: 10.1128/JCM.01174-12. Epub 2012 Jul 18.

Four years of universal pneumococcal conjugate infant vaccination in Germany: impact on incidence of invasive pneumococcal disease and serotype distribution in children. 
van der Linden M, Weiß S, Falkenhorst G, Siedler A, Imöhl M, von Kries R.
Vaccine. 2012 Aug 31;30(40):5880-5. doi: 10.1016/j.vaccine.2012.06.068. Epub 2012 Jul 4.

[Infections with pneumococci, menigococci, H. influenzae and diphtheria in Germany: the RKI Reference Network for Invasive Bacterial Infections (IBI) at the 5th Würzburg Workshop on Epidemiology, Prevention and Therapy for Invasive Meningococcal Diseases 2010 (meeting report)]. 
Lâm TT, Claus H, Elias J, Hellenbrand W, Imöhl M, Prelog M, Sing A, van der Linden M, Vogel U.
Gesundheitswesen. 2012 Nov;74(11):747-53. doi: 10.1055/s-0031-1286269. Epub 2011 Dec 27. German.

2011

International pneumococcal clones match or exceed the fitness of other strains despite the accumulation of antibiotic resistance. 
Rudolf D, Michaylov N, van der Linden M, Hoy L, Klugman KP, Welte T, Pletz MW; CAPNETZ Study Group.
Antimicrob Agents Chemother. 2011 Oct;55(10):4915-7. doi: 10.1128/AAC.00250-11. Epub 2011 Aug 8.

Pneumococcal polysaccharide vaccination for adults: new perspectives for Europe. 
Fedson DS, Nicolas-Spony L, Klemets P, van der Linden M, Marques A, Salleras L, Samson SI.
Expert Rev Vaccines. 2011 Aug;10(8):1143-67. doi: 10.1586/erv.11.99. Epub 2011 Aug 3. Review.

The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia. 
Witzenrath M, Pache F, Lorenz D, Koppe U, Gutbier B, Tabeling C, Reppe K, Meixenberger K, Dorhoi A, Ma J, Holmes A, Trendelenburg G, Heimesaat MM, Bereswill S, van der Linden M, Tschopp J, Mitchell TJ, Suttorp N, Opitz B.
J Immunol. 2011 Jul 1;187(1):434-40. doi: 10.4049/jimmunol.1003143. Epub 2011 Jun 6.

Travel-related Streptococcal toxic shock syndrome caused by emm type 78 Streptococcus pyogenes. 
Tappe D, Schulze MH, van der Linden M, Ziegler U, Müller A, Stich A.
J Clin Microbiol. 2011 Aug;49(8):3094-5. doi: 10.1128/JCM.02623-10. Epub 2011 Jun 1.

Group A streptococcal vertebral osteomyelitis presenting with acute quadriplegia 
Furitsch M, Träger K, van der Linden M, Spellerberg B.
Infection. 2011 Aug;39(4):389-91. doi: 10.1007/s15010-011-0113-9. Epub 2011 Apr 22. No abstract available.

mef(A) is the predominant macrolide resistance determinant in Streptococcus pneumoniae and Streptococcus pyogenes in Germany. 
Bley C, van der Linden M, Reinert RR.
Int J Antimicrob Agents. 2011 May;37(5):425-31. doi: 10.1016/j.ijantimicag.2011.01.019. Epub 2011 Mar 21.

Invasive group A streptococcal disease and association with varicella in Germany, 1996-2009. 
Imöhl M, van der Linden M, Reinert RR, Ritter K.
FEMS Immunol Med Microbiol. 2011 Jun;62(1):101-9. doi: 10.1111/j.1574-695X.2011.00788.x. Epub 2011 Mar 2.

Rapid pneumococcal evolution in response to clinical interventions. 
Croucher NJ, Harris SR, Fraser C, Quail MA, Burton J, van der Linden M, McGee L, von Gottberg A, Song JH, Ko KS, Pichon B, Baker S, Parry CM, Lambertsen LM, Shahinas D, Pillai DR, Mitchell TJ, Dougan G, Tomasz A, Klugman KP, Parkhill J, Hanage WP, Bentley SD.
Science. 2011 Jan 28;331(6016):430-4. doi: 10.1126/science.1198545. 

Potential benefits from currently available three pneumococcal vaccines for children--population-based Evaluation.
Rückinger S, van der Linden M, Siedler A, von Kries R.
Klin Padiatr. 2011 Mar;223(2):61-4. doi: 10.1055/s-0030-1268465. Epub 2011 Jan 26.

The current status of invasive pneumococcal disease in Poland.
Skoczyńska A, Sadowy E, Bojarska K, Strzelecki J, Kuch A, Gołębiewska A, Waśko I, Foryś M, van der Linden M, Hryniewicz W; Participants of laboratory-based surveillance of community acquired invasive bacterial infections (BINet).
Vaccine. 2011 Mar 3;29(11):2199-205. doi: 10.1016/j.vaccine.2010.09.100. Epub 2010 Oct 27.

Low prevalence of fluoroquinolone resistant strains and resistance precursor strains in Streptococcus pneumoniae from patients with community-acquired pneumonia despite high fluoroquinolone usage. 
Pletz MW, van der Linden M, von Baum H, Duesberg CB, Klugman KP, Welte T; CAPNETZ study group.
Int J Med Microbiol. 2011 Jan;301(1):53-7. doi: 10.1016/j.ijmm.2010.05.004. Epub 2010 Aug 7.

2010

Meningitis durch Streptococcus pneumoniae Serotyp 19F. Kleinkind nach zweimaliger, nicht termingerechter Pneumokokkenimpfung. 
Kunze, W., M. van der Linden, T.Klemm, K.Gröger
prädiat. prax. 75, 249-254 (2010) Hans Marseille Verlag GmbH München 

Macrolide susceptibility and serotype specific macrolide resistance of invasive isolates of Streptococcus pneumoniae in Germany from 1992 to 2008.
Imöhl M, Reinert RR, Mutscher C, van der Linden M.
BMC Microbiol. 2010 Nov 25;10:299. doi: 10.1186/1471-2180-10-299.

Influence of antiretroviral therapy on immunogenicity of simultaneous vaccinations against influenza, pneumococcal disease and hepatitis A and B in human immunodeficiency virus positive individuals. 
Horster S, Laubender RP, Lehmeyer L, Ankerst DP, Eberle J, Reinert R, Imöhl M, van der Linden M, Schweiger B, Bogner JR.
J Infect. 2010 Dec;61(6):484-91. doi: 10.1016/j.jinf.2010.09.030. Epub 2010 Sep 25.

Temporal Variations among Invasive Pneumococcal Disease Serotypes in Children and Adults in Germany (1992-2008). 
Imöhl M, Reinert RR, van der Linden M.
Int J Microbiol. 2010;2010:874189. doi: 10.1155/2010/874189. Epub 2010 Jun 30.

Efficacy of 7-valent pneumococcal conjugate vaccination in Germany: An analysis using the indirect cohort method.
Rückinger S, van der Linden M, Reinert RR, von Kries R.
Vaccine. 2010 Jul 12;28(31):5012-6. doi: 10.1016/j.vaccine.2010.05.021. Epub 2010 May 21

Detection of large numbers of pneumococcal virulence genes in streptococci of the mitis group.
Johnston C, Hinds J, Smith A, van der Linden M, Van Eldere J, Mitchell TJ.
J Clin Microbiol. 2010 Aug;48(8):2762-9. doi: 10.1128/JCM.01746-09. Epub 2010 Jun 2.

Superantigen genes are more important than the emm type for the invasiveness of group A Streptococcus infection.
Lintges M, van der Linden M, Hilgers RD, Arlt S, Al-Lahham A, Reinert RR, Plücken S, Rink L.
J Infect Dis. 2010 Jul 1;202(1):20-8. doi: 10.1086/653082.

Serotype distribution of invasive pneumococcal disease during the first 60 days of life. 
Imöhl M, van der Linden M, Mutscher C, Reinert RR.
Vaccine. 2010 Jul 5;28(30):4758-62. doi: 10.1016/j.vaccine.2010.04.097. Epub 2010 May 14

Serotype distribution in pneumococcal acute otitis media with ruptured tympanic membrane or sepsis in Germany. 
van der Linden M, Reinert RR.
Eur J Clin Microbiol Infect Dis. 2010 Jul;29(7):749-54. doi: 10.1007/s10096-010-0945-8.
Epub 2010 Apr 30. Review. Erratum in: Eur J Clin Microbiol Infect Dis. 2010
Aug;29(8):1047.

Epidemiology of invasive Streptococcus pyogenes disease in Germany during 2003-2007. 
Imöhl M, Reinert RR, Ocklenburg C, van der Linden M.
FEMS Immunol Med Microbiol. 2010 Apr;58(3):389-96. doi: 10.1111/j.1574-695X.2010.00652.x. Epub 2010 Jan 19.

Association of serotypes of Streptococcus pneumoniae with age in invasive pneumococcal disease.
Imöhl M, Reinert RR, Ocklenburg C, van der Linden M.
J Clin Microbiol. 2010 Apr;48(4):1291-6. doi: 10.1128/JCM.01937-09. Epub 2010 Jan 27.

Risk factor analysis for pneumococcal meningitis in adults with invasive pneumococcal infection.
Burckhardt I, Burckhardt F, van der Linden M, Heeg C, Reinert RR.
Epidemiol Infect. 2010 Sep;138(9):1353-8. doi: 10.1017/S0950268809991683. Epub 2010 Jan 22.

Effect of heptavalent pneumococcal conjugate vaccination on invasive pneumococcal disease in preterm born infants. 
Rückinger S, van der Linden M, von Kries R.
BMC Infect Dis. 2010 Jan 19;10:12. doi: 10.1186/1471-2334-10-12.

Serotype-specific penicillin resistance of Streptococcus pneumoniae in Germany from 1992 to 2008.
Imöhl M, Reinert RR, van der Linden M.
Int J Med Microbiol. 2010 Jun;300(5):324-30. doi: 10.1016/j.ijmm.2009.11.004. Epub 2010 Jan 13.

Microbiological investigation of a hospital outbreak of invasive group A streptococcal disease in Krakow, Poland. 
Strus M, Drzewiecki A, Chmielarczyk A, Tomusiak A, Romanek P, Kosowski K, Kochan P, van der Linden M, Lütticken R, Heczko PB.
Clin Microbiol Infect. 2010 Sep;16(9):1442-7. doi: 10.1111/j.1469-0691.2009.03139.x.

Serotyping pneumococcal meningitis cases in the African meningitis belt by use of multiplex PCR with cerebrospinal fluid. 
Njanpop Lafourcade BM, Sanou O, van der Linden M, Levina N, Karanfil M, Yaro S, Tamekloe TA, Mueller JE.
J Clin Microbiol. 2010 Feb;48(2):612-4. doi: 10.1128/JCM.01402-09. Epub 2009 Dec 9.

Regional differences in serotype distribution, pneumococcal vaccine coverage, and antimicrobial resistance of invasive pneumococcal disease among German federal states. 
Imöhl M, Reinert RR, van der Linden M.
Int J Med Microbiol. 2010 Apr;300(4):237-47. doi: 10.1016/j.ijmm.2009.05.005. Epub 2009 Jul 14.

Multi-organ failure in a previously healthy 10-year-old boy: streptococcal toxic shock syndrome (STSS) - a rare differential diagnosis. 
Meedt B, Gharavi B, Imöhl M, Becker JC.
Klin Padiatr. 2010 Sep;222(5):310-1. doi: 10.1055/s-0030-1254112. Epub 2010 Jun 16.

Distribution of emm types among group A streptococcal isolates from Serbia. 
Mijac V, Ranin L, Marković M, Heeg C, Reinert RR, Opavski N.
Clin Microbiol Infect. 2010 Mar;16(3):295-8. doi: 10.1111/j.1469-0691.2009.02823.x. Epub 2009 Jun 6.

2009

Molecular characterization of pneumococcal isolates from pets and laboratory animals. 
van der Linden M, Al-Lahham A, Nicklas W, Reinert RR.
PLoS One. 2009 Dec 14;4(12):e8286. doi: 10.1371/journal.pone.0008286.

Adult invasive pneumococcal disease between 2003 and 2006 in North-Rhine Westphalia, Germany: serotype distribution before recommendation for general pneumococcal conjugate vaccination for children <2 years of age. 
Imöhl M, Reinert RR, van der Linden M.
Clin Microbiol Infect. 2009 Nov;15(11):1008-12. doi: 10.1111/j.1469-0691.2009.02895.x. Epub 2009 Jul 20.

Outbreak of Streptococcus equi subsp. zooepidemicus infection in a group of rhesus monkeys (Macaca mulatta). 
Mätz-Rensing K, Winkelmann J, Becker T, Burckhardt I, van der Linden M, Köndgen S, Leendertz F, Kaup FJ.
J Med Primatol. 2009 Oct;38(5):328-34. doi: 10.1111/j.1600-0684.2009.00359.x. Epub 2009 Jun 7.

New penicillin susceptibility breakpoints for Streptococcus pneumoniae and their effects on susceptibility categorisation in Germany (1992-2008). 
Imöhl M, Reinert RR, van der Linden M.
Int J Antimicrob Agents. 2009 Sep;34(3):271-3. doi: 10.1016/j.ijantimicag.2009.03.022. Epub 2009 May 5.

Reduction in the incidence of invasive pneumococcal disease after general vaccination with 7-valent pneumococcal conjugate vaccine in Germany. 
Rückinger S, van der Linden M, Reinert RR, von Kries R, Burckhardt F, Siedler A.
Vaccine. 2009 Jun 24;27(31):4136-41. doi: 10.1016/j.vaccine.2009.04.057. Epub 2009 May 9.
Clinical and microbiological characteristics of severe Streptococcus pyogenes disease in Europe.
Luca-Harari B, Darenberg J, Neal S, Siljander T, Strakova L, Tanna A, Creti R, Ekelund K, Koliou M, Tassios PT, van der Linden M, Straut M, Vuopio-Varkila J, Bouvet A, Efstratiou A, Schalén C, Henriques-Normark B; Strep-EURO Study Group, Jasir A.
J Clin Microbiol. 2009 Apr;47(4):1155-65. doi: 10.1128/JCM.02155-08. Epub 2009 Jan 21.

Association of serotype of Streptococcus pneumoniae with risk of severe and fatal outcome.
Rückinger S, von Kries R, Siedler A, van der Linden M.
Pediatr Infect Dis J. 2009 Feb;28(2):118-22. doi: 10.1097/INF.0b013e318187e215. 

Cost effectiveness analysis of heptavalent pneumococcal conjugate vaccine in Germany considering herd immunity effects.
Claes C, Reinert RR, von der Schulenburg JM.
Eur J Health Econ. 2009 Feb;10(1):25-38. doi: 10.1007/s10198-008-0098-1. Epub 2008 Apr 1.

2008

Molecular characterization of invasive and non-invasive Streptococcus pyogenes isolates from Romania. 
Luca-Harari B, Straut M, Cretoiu S, Surdeanu M, Ungureanu V, van der Linden M, Jasir A.
J Med Microbiol. 2008 Nov;57(Pt 11):1354-63. doi: 10.1099/jmm.0.2008/001875-0.

Childhood invasive pneumococcal disease in Germany between 1997 and 2003: variability in incidence and serotype distribution in absence of general pneumococcal conjugate vaccination. 
Rückinger S, von Kries R, Reinert RR, van der Linden M, Siedler A.
Vaccine. 2008 Jul 29;26(32):3984-6. doi: 10.1016/j.vaccine.2008.04.031. Epub 2008 May 5.

Polyclonal population structure of Streptococcus pneumoniae isolates in Spain carrying mef and mef plus erm (B). 
de la Pedrosa EG, Morosini MI, van der Linden M, Ruiz-Garbajosa P, Galán JC, Baquero F, Reinert RR, Cantón R.
Antimicrob Agents Chemother. 2008 Jun;52(6):1964-9. doi: 10.1128/AAC.01487-07. Epub 2008 Mar 24.

Clinical and epidemiological aspects of invasive Streptococcus pyogenes infections in Denmark during 2003 and 2004.
Luca-Harari B, Ekelund K, van der Linden M, Staum-Kaltoft M, Hammerum AM, Jasir A.
J Clin Microbiol. 2008 Jan;46(1):79-86. Epub 2007 Oct 24.

Epidemiology of severe Streptococcus pyogenes disease in Europe.
Lamagni TL, Darenberg J, Luca-Harari B, Siljander T, Efstratiou A, Henriques-Normark B, Vuopio-Varkila J, Bouvet A, Creti R, Ekelund K, Koliou M, Reinert RR, Stathi A, Strakova L, Ungureanu V, Schalén C; Strep-EURO Study Group, Jasir A.
J Clin Microbiol. 2008 Jul;46(7):2359-67. doi: 10.1128/JCM.00422-08. Epub 2008 May 7

Mechanisms of macrolide resistance among Streptococcus pneumoniae isolates from Russia.
Reinert RR, Filimonova OY, Al-Lahham A, Grudinina SA, Ilina EN, Weigel LM, Sidorenko SV.
Antimicrob Agents Chemother. 2008 Jun;52(6):2260-2. doi: 10.1128/AAC.01270-07. Epub 2008 Mar 31.

2007

Epidemiology of invasive Streptococcus pyogenes infections in Germany, 1996-2002: results from a voluntary laboratory surveillance system. 
Wahl RU, Lütticken R, Stanzel S, van der Linden M, Reinert RR.
Clin Microbiol Infect. 2007 Dec;13(12):1173-8. Epub 2007 Sep 10.

Molecular epidemiology of penicillin-non-susceptible Streptococcus pneumoniae isolates from children with invasive pneumococcal disease in Germany.
Reinert RR, van der Linden M, Seegmüller I, Al-Lahham A, Siedler A, Weissmann B, Toschke AM, von Kries R.
Clin Microbiol Infect. 2007 Apr;13(4):363-8.

Clonal spread of mef-positive macrolide-resistant Streptococcus pneumoniae isolates causing invasive disease in adults in Germany. 
van der Linden M, Al-Lahham A, Haupts S, Reinert RR.
Antimicrob Agents Chemother. 2007 May;51(5):1830-4. Epub 2007 Feb 26.

Globicatella sanguinis is an etiological agent of ventriculoperitoneal shunt-associated meningitis.
Seegmüller I, van der Linden M, Heeg C, Reinert RR.
J Clin Microbiol. 2007 Feb;45(2):666-7. Epub 2006 Nov 22. 

Genetic diversity of pneumococcal surface protein A of Streptococcus pneumoniae meningitis in German children.
Heeg C, Franken C, van der Linden M, Al-Lahham A, Reinert RR.
Vaccine. 2007 Jan 22;25(6):1030-5. Epub 2006 Oct 2.

Multidrug-resistant Streptococcus pneumoniae infections: current and future therapeutic options.
Van Bambeke F, Reinert RR, Appelbaum PC, Tulkens PM, Peetermans WE.
Drugs. 2007;67(16):2355-82. Review.

Antimicrobial susceptibility among organisms from the Asia/Pacific Rim, Europe and Latin and North America collected as part of TEST and the in vitro activity of tigecycline.
Reinert RR, Low DE, Rossi F, Zhang X, Wattal C, Dowzicky MJ.
J Antimicrob Chemother. 2007 Nov;60(5):1018-29. Epub 2007 Sep 13.

Cost-effectiveness of pneumococcal vaccination for prevention of invasive pneumococcal disease in the elderly: an update for 10 Western European countries. 
Evers SM, Ament AJ, Colombo GL, Konradsen HB, Reinert RR, Sauerland D, Wittrup-Jensen K, Loiseau C, Fedson DS.
Eur J Clin Microbiol Infect Dis. 2007 Aug;26(8):531-40.

Sepsis severity predicts outcome in community-acquired pneumococcal pneumonia.
Schaaf B, Kruse J, Rupp J, Reinert RR, Droemann D, Zabel P, Ewig S, Dalhoff K.
Eur Respir J. 2007 Sep;30(3):517-24. Epub 2007 May 30.

A new closed-tube multiplex real-time PCR to detect eleven superantigens of Streptococcus pyogenes identifies a strain without superantigen activity.
Lintges M, Arlt S, Uciechowski P, Plümäkers B, Reinert RR, Al-Lahham A, Lütticken R, Rink L.
Int J Med Microbiol. 2007 Oct;297(6):471-8. Epub 2007 May 3.

Streptococcus pneumoniae incidence in western Europe.
Vergison A, Reinert RR.
Lancet Infect Dis. 2007 Apr;7(4):240-2. No abstract available. 

Time-kill kinetics of Streptococcus pneumoniae with reduced susceptibility to telithromycin.
Al-Lahham A, Reinert RR.
Chemotherapy. 2007;53(3):190-3. Epub 2007 Mar 7.

International quality assurance study for characterization of Streptococcus pyogenes.
Neal S, Beall B, Ekelund K, Henriques-Normark B, Jasir A, Johnson D, Kaplan E, Lovgren M, Reinert RR; Strep-EURO Study Group; International Streptococcus Reference Laboratories, Efstratiou A.
J Clin Microbiol. 2007 Apr;45(4):1175-9. Epub 2007 Jan 31.

2006

Telithromycin-nonsusceptible clinical isolates of Streptococcus pneumoniae from Europe.
Al-Lahham A, Appelbaum PC, van der Linden M, Reinert RR.
Antimicrob Agents Chemother. 2006 Nov;50(11):3897-900.

Emergence of a unique multiply-antibiotic-resistant Streptococcus pneumoniae serotype 7B clone in Dhaka, Bangladesh.
Rahman M, Hossain S, Shoma S, Rashid H, Hel Baqui A, van der Linden M, Al-Lahham A, Reinert RR.
J Clin Microbiol. 2006 Dec;44(12):4625-7. Epub 2006 Sep 27. No abstract available.

[Medical indications and effectiveness of the pneumococcal conjugate vaccine].
Reinert RR.
Laryngorhinootologie. 2006 Apr;85(4):291-8; quiz 299-300. German. 

Distribution of four capsular serotypes of Enterococcus faecalis among clinical isolates from different geographical origins and infection sites.
Hufnagel M, Carey VJ, Baldassarri L, Reinert RR, Huebner J.
Infection. 2006 Feb;34(1):22-5. 

Comparative evaluation of a new Vitek 2 system for identification and antimicrobial susceptibility testing of Streptococcus pneumoniae.
Abele-Horn M, Stoy K, Frosch M, Reinert RR.
Eur J Clin Microbiol Infect Dis. 2006 Jan;25(1):55-7. No abstract available. 

Resistance to erythromycin and telithromycin in Streptococcus pyogenes isolates obtained between 1999 and 2002 from Greek children with tonsillopharyngitis: phenotypic and genotypic analysis.
Grivea IN, Al-Lahham A, Katopodis GD, Syrogiannopoulos GA, Reinert RR.
Antimicrob Agents Chemother. 2006 Jan;50(1):256-61.

Regional differences in the epidemiology of invasive pneumococcal disease in toddlers in Germany.
Siedler A, Reinert RR, Toschke M, Al-Lahham A, von Kries R; ESPED Clinic and Laboratory Study Group.
Pediatr Infect Dis J. 2005 Dec;24(12):1114-5. 

Epidemiology of Streptococcus agalactiae colonization in Germany.
Brimil N, Barthell E, Heindrichs U, Kuhn M, Lütticken R, Spellerberg B.
Int J Med Microbiol. 2006 Feb;296(1):39-44. Epub 2005 Dec 19.

2005

Relationship between the original multiply resistant South African isolates of Streptococcus pneumoniae from 1977 to 1978 and contemporary international resistant clones
Reinert RR, Jacobs MR, Appelbaum PC, Bajaksouzian S, Cordeiro S, van der Linden M, Al-Lahham A.
J Clin Microbiol. 2005 Dec;43(12):6035-41.

Invasive pneumococcal disease in adults in North-Rhine Westphalia, Germany, 2001-2003.
Reinert RR, Haupts S, van der Linden M, Heeg C, Cil MY, Al-Lahham A, Fedson DS.
Clin Microbiol Infect. 2005 Dec;11(12):985-91.

Molecular characterization of the first telithromycin-resistant Streptococcus pneumoniae isolate in Germany.
Reinert RR, van der Linden M, Al-Lahham A.
Antimicrob Agents Chemother. 2005 Aug;49(8):3520-2. 

Antimicrobial susceptibility of Streptococcus pneumoniae in eight European countries from 2001 to 2003.
Reinert RR, Reinert S, van der Linden M, Cil MY, Al-Lahham A, Appelbaum P.
Antimicrob Agents Chemother. 2005 Jul;49(7):2903-13.

Molecular epidemiology of macrolide-resistant Streptococcus pneumoniae isolates in Europe.
Reinert RR, Ringelstein A, van der Linden M, Cil MY, Al-Lahham A, Schmitz FJ.
J Clin Microbiol. 2005 Mar;43(3):1294-300.

Enterococcus raffinosus infection in an immunosuppressed patient: case report and review of the literature.
Freyaldenhoven BS, Schlieper G, Lütticken R, Reinert RR.
J Infect. 2005 Oct;51(3):e121-4. Epub 2004 Nov 21. Review. 

Time-kill study of the activity of telithromycin against macrolide-resistant Streptococcus pneumoniae Isolates with 23S rRNA mutations and changes in ribosomal proteins L4 and L22.
Reinert RR, Al-Lahham A.
Antimicrob Agents Chemother. 2005 Jul;49(7):3011-3. 

Lack of mitogenic activity of speG- and speG(dys)-positive Streptococcus dysgalactiae subspecies equisimilis isolates from patients with invasive infections.
Brandt CM, Schweizer KG, Holland R, Lütticken R, Freyaldenhoven BS.
Int J Med Microbiol. 2005 Dec;295(8):539-46. Epub 2005 Oct 20.

2004

Molecular characterisation of macrolide resistance mechanisms of Streptococcus pneumoniae and Streptococcus pyogenes isolated in Germany, 2002-2003.
Reinert RR, Franken C, van der Linden M, Lütticken R, Cil M, Al-Lahham A.
Int J Antimicrob Agents. 2004 Jul;24(1):43-7.

Resistance phenotypes and multi-drug resistance in Streptococcus pneumoniae (PROTEKT years 1-3 [1999-20021).
Reinert RR.
J Chemother. 2004 Dec;16 Suppl 6:35-48. No abstract available.

Pneumococcal conjugate vaccines--a European perspective.
Reinert RR.
Int J Med Microbiol. 2004 Oct;294(5):277-94. Review. 

Global distribution of Streptococcus pneumoniae serotypes isolated from paediatric patients during 1999-2000 and the in vitro efficacy of telithromycin and comparators.
Farrell DJ, Jenkins SG, Reinert RR.
J Med Microbiol. 2004 Nov;53(Pt 11):1109-17.

Antimicrobial resistance of Streptococcus pneumoniae isolates of outpatients in Germany, 1999-2000.
Reinert RR, Lütticken R, Reinert S, Al-Lahham A, Lemmen S.
Chemotherapy. 2004 Oct;50(4):184-9. Epub 2004 Sep 3. 

Antibacterial resistance of community-acquired respiratory tract pathogens recovered from patients in Germany and activity of the Ketolide Telithromycin: results from the PROTEKT surveillance study (1999-2000).
Reinert RR, Rodloff AC, Halle E, Baer W, Beyreiss B, Seifert H, Wichelhaus TA, Maass M, Mehl M.
Chemotherapy. 2004 Jun;50(3):143-51. 

Differences in clinical manifestation of Streptococcus pneumoniae infection are not correlated with in vitro production and release of the virulence factors pneumolysin and lipoteichoic and teichoic acids.
Spreer A, Lis A, Gerber J, Reinert RR, Eiffert H, Nau R.
J Clin Microbiol. 2004 Jul;42(7):3342-5.

High-level fluoroquinolone resistance in a clinical Streptoccoccus pyogenes isolate in Germany.
Reinert RR, Lütticken R, Al-Lahham A.
Clin Microbiol Infect. 2004 Jul;10(7):659-62.

Clinical efficacy of ketolides in the treatment of respiratory tract infections.
Reinert RR.
J Antimicrob Chemother. 2004 Jun;53(6):918-27. Epub 2004 Apr 29. Review.

Blood culture sampling rates at a German pediatric university hospital and incidence of invasive pneumococcal disease.
Rüggeberg JU, Ketteler K, MacKenzie CR, Von Kries R, Reinert RR, Schroten H.
Infection. 2004 Apr;32(2):78-81.

Clonal relatedness of erythromycin-resistant Streptococcus pyogenes isolates in Germany.
Reinert RR, Lütticken R, Sutcliffe JA, Tait-Kamradt A, Cil MY, Schorn HM, Bryskier A, Al-Lahham A.
Antimicrob Agents Chemother. 2004 Apr;48(4):1369-73. 

Evaluation of recombinant antigens for the measurement of antibodies to streptolysin O and streptococcal DNase B on the Beckman Coulter IMMAGE system and comparison with a method employing conventional antigens. 
Freyaldenhoven BS, Moos G, Hinzmann RD, Lütticken R.
Clin Lab. 2004;50(11-12):667-73.

2003

Meningitis due to multiple-resistant penicillin- and cefotaxime-intermediate Streptococcus pneumoniae in a German child after bone marrow transplantation.
Buxmann H, Soerensen J, Koehl U, Schwabe D, Klingebiel T, Reinert RR, Schaefer V.
Infection. 2003 Dec;31(6):425-7.

Antibacterial resistance among children with community-acquired respiratory tract infections (PROTEKT 1999-2000).
Felmingham D, Farrell DJ, Reinert RR, Morrissey I.
J Infect. 2004 Jan;48(1):39-55.

Characterization of German penicillin non-susceptible serotype 23F pneumococci using multilocus sequence typing.
Reinert RR, Muckel S, Al-Lahham A, Spratt BG, Brueggemann AB, Hakenbeck R, Lütticken R.
J Med Microbiol. 2003 Nov;52(Pt 11):981-7.

Ribosomal mutations conferring resistance to macrolides in Streptococcus pneumoniae clinical strains isolated in Germany.
Reinert RR, Wild A, Appelbaum P, Lütticken R, Cil MY, Al-Lahham A.
Antimicrob Agents Chemother. 2003 Jul;47(7):2319-22.

Immune response to capsular polysaccharide and surface proteins of Streptococcus pneumoniae in patients with invasive pneumococcal disease.
Zysk G, Bethe G, Nau R, Koch D, Gräfin Von Bassewitz VC, Heinz HP, Reinert RR.
J Infect Dis. 2003 Jan 15;187(2):330-3. Epub 2002 Dec 19. 

Macrolide-resistant Streptococcus pneumoniae and Streptococcus pyogenes in the pediatric population in Germany during 2000-2001.
Reinert RR, Lütticken R, Bryskier A, Al-Lahham A.
Antimicrob Agents Chemother. 2003 Feb;47(2):489-93.

drs (Distantly related sic) gene polymorphisms among emm12-type Streptococcus pyogenes isolates.
Brandt CM, Haase G, Spellerberg B, Holland R, Lütticken R.
J Clin Microbiol. 2003 Apr;41(4):1794-7.

2002

Will the 7-valent pneumococcal vaccine have a similar impact on all invasive pneumococcal infections in children in Germany as in the Kaiser Permanente Trial?
von Kries R, Hermann M, Al-Lahham A, Siedler A, Reinert RR.
Eur J Pediatr. 2002 Dec;161 Suppl 2:S140-3. Epub 2002 Oct 2.

Prediction of the potential benefit of different pneumococcal conjugate vaccines on invasive pneumococcal disease in German children.
von Kries R, Hermann M, Hachmeister A, Siedler A, Schmitt HJ, Al-Lahham A, Reinert RR.
Pediatr Infect Dis J. 2002 Nov;21(11):1017-23.

Increasing prevalence of antimicrobial resistance among isolates of Streptococcus pneumoniae from the PROTEKT surveillance study, and compatative in vitro activity of the ketolide, telithromycin.
Felmingham D, Reinert RR, Hirakata Y, Rodloff A.
J Antimicrob Chemother. 2002 Sep;50 Suppl S1:25-37. 

Characterization of clinical Streptococcus pneumoniae strains from Germany with decreased susceptibility to fluoroquinolones.
Reinert RR, Al-Lahham A, Lütticken R, Boos M, Schmitz FJ.
J Antimicrob Chemother. 2002 Jun;49(6):1015-8. 

Emergence of macrolide and penicillin resistance among invasive pneumococcal isolates in Germany.
Reinert RR, Al-Lahham A, Lemperle M, Tenholte C, Briefs C, Haupts S, Gerards HH, Lütticken R.
J Antimicrob Chemother. 2002 Jan;49(1):61-8. 

rgf encodes a novel two-component signal transduction system of Streptococcus agalactiae.
Spellerberg B, Rozdzinski E, Martin S, Weber-Heynemann J, Lütticken R.
Infect Immun. 2002 May;70(5):2434-40.

2001

The cell wall-associated serine protease PrtA: a highly conserved virulence factor of Streptococcus pneumoniae.
Bethe G, Nau R, Wellmer A, Hakenbeck R, Reinert RR, Heinz HP, Zysk G.
FEMS Microbiol Lett. 2001 Nov 27;205(1):99-104. 

In vitro activity of cefditoren against clinical isolates of penicillin-susceptible and penicillin-intermediate strains of Streptococcus pneumoniae isolated in Germany, 1992-1998.´
Reinert RR, Al-Lahham A, Lütticken R.
J Antimicrob Chemother. 2001 Aug;48(2):279-81. 

Macrolide resistance in Streptococcus pyogenes isolates from throat infections in the region of Aachen, Germany.
Brandt CM, Honscha M, Truong ND, Holland R, Hövener B, Bryskier A, Lütticken R, Reinert RR.
Microb Drug Resist. 2001 Summer;7(2):165-70.

Nationwide German multicenter study on the prevalence of antibiotic resistance in streptococcal blood isolates from neutropenic patients and comparative in vitro activities of quinupristin-dalfopristin and eight other antimicrobials.
Reinert RR, von Eiff C, Kresken M, Brauers J, Hafner D, Al-Lahham A, Schorn H, Lütticken R, Peters G; Multicenter Study on Antibiotic Resistance in Staphylococci and other Gram-positive Cocci (MARS) Study Group.
J Clin Microbiol. 2001 May;39(5):1928-31.

Increased titers of antibodies against streptococcal M12 and M19 proteins in patients with Tourette´s syndrome.
Müller N, Kroll B, Schwarz MJ, Riedel M, Straube A, Lütticken R, Reinert RR, Reineke T, Kühnemund O.
Psychiatry Res. 2001 Mar 25;101(2):187-93.

Antimicrobial resistance of Streptococcus pneumoniae recovered from outpatients with respiratory tract infections in Germany from 1998 to 1999: results of a national surveillance study.
Reinert RR, Simic S, Al-Lahham A, Reinert S, Lemperle M, Lütticken R.
J Clin Microbiol. 2001 Mar;39(3):1187-9.

In vitro activity of gemifloxacin against Streptococcus pneumoniae isolates in Germany.
Lemmen S, Al-Lahham A, Lütticken R, Reinert RR.
Chemotherapy. 2001 Mar-Apr;47(2):104-9. 

Comparison of serum bactericidal activity of ceftazidime, ciprofloxacin and meropenem against Stenotrophomonas maltophilia.
Lemmen SW, Häfner H, Reinert RR, Zolldann D, Kümmerer K, Lütticken R.
J Antimicrob Chemother. 2001 Jan;47(1):118-20. No abstract available. 

Horizontal gene transfer and host specificity of beta-haemolytic streptococci: the role of a putative composite transposon containing scpB and lmb.
Franken C, Haase G, Brandt C, Weber-Heynemann J, Martin S, Lämmler C, Podbielski A, Lütticken R, Spellerberg B.
Mol Microbiol. 2001 Aug;41(4):925-35.

Typing of Streptococcus pyogenes strains isolated from throat infections in the region of Aachen, Germany.
Brandt CM, Spellerberg B, Honscha M, Truong ND, Hoevener B, Lütticken R.
Infection. 2001 May-Jun;29(3):163-5.

Characterization of consecutive Streptococcus pyogenes isolates from patients with pharyngitis and bacteriological treatment failure: special reference to prtF1 and sic / drs.
Brandt CM, Allerberger F, Spellerberg B, Holland R, Lütticken R, Haase G.
J Infect Dis. 2001 Feb 15;183(4):670-4. Epub 2001 Jan 24.

2000

In vitro activity of gatifloxacin against Streptococcus pneumoniae isolates in Germany.
Reinert RR, Al-Lahham A, Lemmen S, Lütticken R.
J Antimicrob Chemother. 2000 Nov;46(5):854-6. No abstract available.

Proportion of invasive pneumococcal infections in German children preventable by pneumococcal conjugate vaccines.
von Kries R, Siedler A, Schmitt HJ, Reinert RR.
Clin Infect Dis. 2000 Aug;31(2):482-7. Epub 2000 Aug 30.

Nationwide German multicenter study on prevalence of antibiotic resistance in staphylococcal bloodstream isolates and comparative in vitro activities of quinupristin-dalfopristin.
von Eiff C, Reinert RR, Kresken M, Brauers J, Hafner D, Peters G.
J Clin Microbiol. 2000 Aug;38(8):2819-23.

Release of teichoic and lipoteichoic acids from 30 different strains of Streptococcus pneumoniae during exposure to ceftriaxone, meropenem, quinupristin/dalfopristin, rifampicin and trovafloxacin.
Heer C, Stuertz K, Reinert RR, Mäder M, Nau R.
Infection. 2000 Jan-Feb;28(1):13-20. 

The cyl genes of Streptococcus agalactiae are involved in the production of pigment.
Spellerberg B, Martin S, Brandt C, Lütticken R.
FEMS Microbiol Lett. 2000 Jul 15;188(2):125-8.

Identification of a novel insertion sequence element in Streptococcus agalactiae.
Spellerberg B, Martin S, Franken C, Berner R, Lütticken R.
Gene. 2000 Jan 4;241(1):51-6.

Characterization of blood culture isolates of Streptococcus dysgalactiae subsp. equisimilis possessing Lancefield´s group A antigen.
Brandt CM, Haase G, Schnitzler N, Zbinden R, Lütticken R.
J Clin Microbiol. 1999 Dec;37(12):4194-7.

1999

A comparative study of the in-vitro activity of levofloxacin against Streptococcus pneumoniae.
Reinert RR, Lütticken R, Lemperle M, Bryskier A.
J Antimicrob Chemother. 1999 Jun;43 Suppl C:5-8. 

Quinupristin/dalfopristin attenuates the inflammatory response and reduces the concentration of neuron-specific enolase in the cerebrospinal fluid of rabbits with experimental Streptococcus pneumoniae meningitis.
Trostdorf F, Reinert RR, Schmidt H, Nichterlein T, Stuertz K, Schmitz-Salue M, Sadowski I, Brück W, Nau R.
J Antimicrob Chemother. 1999 Jan;43(1):87-94. 

Molecular relationships and antimicrobial susceptibilities of viridans group streptococci isolated from blood of neutropenic cancer patients.
Wisplinghoff H, Reinert RR, Cornely O, Seifert H.
J Clin Microbiol. 1999 Jun;37(6):1876-80.

Survey of antibiotic resistance among enterococci in North Rhine-Westphalia, Germany.
Reinert RR, Conrads G, Schlaeger JJ, Werner G, Witte W, Lütticken R, Klare I.
J Clin Microbiol. 1999 May;37(5):1638-41. 

Identification of genetic determinants for the hemolytic activity of Streptococcus agalactiae by ISS1 transposition.
Spellerberg B, Pohl B, Haase G, Martin S, Weber-Heynemann J, Lütticken R.
J Bacteriol. 1999 May;181(10):3212-9.

Lmb, a protein with similarities to the LraI adhesin family, mediates attachment of Streptococcus agalactiae to human laminin.
Spellerberg B, Rozdzinski E, Martin S, Weber-Heynemann J, Schnitzler N, Lütticken R, Podbielski A.
Infect Immun. 1999 Feb;67(2):871-8.

In vitro activity of gatifloxacin against Streptococcus pneumoniae isolates in Germany.
Reinert RR, Al-Lahham A, Lemmen S, Lütticken R.
J Antimicrob Chemother. 2000 Nov;46(5):854-6. No abstract available.

1998

Moxifloxacin: a comparison with other antimicrobial agents of in-vitro activity against Streptococcus pneumoniae.
Reinert RR, Schlaeger JJ, Lütticken R.
J Antimicrob Chemother. 1998 Dec;42(6):803-6.

In vitro activity of quinupristin/dalfopristin against erythromycin-susceptible and erythromycin-resistant Streptococcus pneumoniae.
Reinert RR, Kresken M, Mechery V, Lemperle M, Lütticken R.
Eur J Clin Microbiol Infect Dis. 1998 Sep;17(9):662-5.

In vitro activities of the new ketolide antibiotics HMR 3004 and HMR 3647 against Streptococcus pneumoniae in Germany.
Reinert RR, Bryskier A, Lütticken R.
Antimicrob Agents Chemother. 1998 Jun;42(6):1509-11.

Streptococcus mitis with unusually high level resistance to beta-lactam antibiotics.
König A, Reinert RR, Hakenbeck R.
Microb Drug Resist. 1998 Spring;4(1):45-9.

Estimation of type-specific anti-streptococcal M-protein antibodies with biotinylated peptides in human sera.
Kühnemund O, Schumacher F, Casaretto M, Holm SE, Lütticken R.
APMIS. 1998 Feb;106(2):288-92.

1997

Overwhelming postsplenectomy infection with vaccine-type Streptococcus pneumoniae in a 12-year-old girl despite vaccination and antibiotic prophylaxis.
Klinge J, Hammersen G, Scharf J, Lütticken R, Reinert RR.
Infection. 1997 Nov-Dec;25(6):368-71. 

Rifabutin for experimental pneumococcal meningitis
Schmidt H, Zysk G, Reinert RR, Brück W, Stringaris A, Chen V, Stuertz K, Fischer F, Bartels R, Schaper KJ, Weinig S, Nau R.
Chemotherapy. 1997 Jul-Aug;43(4):264-71.

Endophthalmitis due to Microbacterium species: case report and review of microbacterium infections.
Funke G, Haase G, Schnitzler N, Schrage N, Reinert RR.
Clin Infect Dis. 1997 Apr;24(4):713-6. Review.

Serotype distribution and antibiotic susceptibility of Streptococcus pneumoniae isolates causing systemic infections among children in Germany, 1992 to 1996.
Reinert RR, Kaufhold A, Schlaeger JJ, Mechery V, Lütticken R.
Pediatr Infect Dis J. 1997 Feb;16(2):244-5. No abstract available.

Immune response to the 23-valent pneumococcal polysaccharide vaccine in lymphoma patients and patients with chronic renal diseases.
Kühnemund O, Stütz A, Fuchshuber A, Querfeld U, Petrasch S, Reinert RR, Lütticken R.
Adv Exp Med Biol. 1997;418:837-9. No abstract available.

1995

Activity of fosfomycin in a rabbit model of experimental pneumococcal meningitis.
Nau R, Zysk G, Reinert RR, Mergeryan H, Eiffert H, Prange HW.
J Antimicrob Chemother. 1995 Dec;36(6):997-1004.

Antimicrobial resistance and type distribution of Streptococcus pneumoniae isolates causing systemic infections in Germany, 1992-1994.
Reinert RR, Queck A, Kaufhold A, Kresken M, Lütticken R.
Clin Infect Dis. 1995 Dec;21(6):1398-401.

Penicillin-resistant Streptococcus pneumoniae in Germany: genetic relationship to clones from other European countries.
Reichmann P, Varon E, Günther E, Reinert RR, Lüttiken R, Marton A, Geslin P, Wagner J, Hakenbeck R.
J Med Microbiol. 1995 Nov;43(5):377-85. 

[Nosocomial transmission of pneumococcus].
Dallügge-Tamm H, Höpken ME, Alt B, Reinert RR.
Immun Infekt. 1995 Oct;23(5):185-6. German.

1994

Serum antibody responses to vaccination with 23-valent pneumococcal vaccine in splenectomized patients.
Reinert RR, Kaufhold A, Kühnemund O, Lütticken R.
Zentralbl Bakteriol. 1994 Nov;281(4):481-90.

Recurrent systemic pneumococcal infection in an immunocompromised patient.
Reinert RR, Büssing A, Kierdorf H, Kühnemund O, Kaufhold A.
Eur J Clin Microbiol Infect Dis. 1994 Apr;13(4):304-7.

Antibiotic sensitivity of Streptococcus pneumoniae isolated from normally sterile body sites: first results of a multicenter study in Germany.
Reinert RR, Queck A, Kaufhold A, Kresken M, Lütticken R.
Infection. 1994 Mar-Apr;22(2):113-4. No abstract available.

[Current data on the antibiotic sensitivity of Streptococcus pneumoniae (Pneumococcus). The significance of penicillin resistant isolates].
Reinert RR, Lütticken R, Kaufhold A.
Med Klin (Munich). 1993 Jun 15;88(6):357-61. German.

Penicillin-resistant pneumococcus in community-acquired bacteremic pneumonia in Germany.
Reinert RR, Kaufhold A, Kierdorf H.
Infection. 1992 Jul-Aug;20(4):238-9. No abstract available.