Molekulare Pharmakologie

Main scientific interest: Structure and function of ligand-gated ion channels

A channel' s a hole With a physiological role A peptide chain In a lipid domain With its helical coil Twisted through oil And its aqueous pore An open pore A path for glow Where ions may go If not too large With a electrostatic charge Examined kinetically Determined frenetically With equipment deluxe Measuring currents and flux Just a spike on the screen In fluorescent green Does it really exist? Does the channel persist? Or is it invention To bemuse the convention?
Rothstein, 1980

Topics under study

  • Identification of assembly domains of P2X receptors
  • Intracellular trafficking of ligand-gated ion channels
  • Identification of P2X selective antagonists
  • Identification of proteins interacting with P2X7 receptors
  • Regulation of ligand-gated ion channels by ubiquitination