Prof. Dr. Angelika Lampert

Etage 5, Gang D, Raum 23
Tel: 0241 80-88811
Fax: 0241 80-82434
alampertukaachende

 

Lebenslauf

Seit 2013
W2 Professur für Physiologie, Schwerpunkt Neurophysiologie, Uniklinik RWTH Aachen

2008 - 2013
Wiss. MA und Gruppenleiterin, Physiologie und Pathophysiologie, FAU Erlangen-Nürnberg

2007 - 2008
Akademische Rätin, Physiologie, LMU München

2004 - 2007
Post-Doc, Yale University, New Haven, USA; Labor Stephen G. Waxman

2002 - 2004
ÄiP/Wiss. MA, Physiologie, EKU Tübingen

1998 - 2003
Dissertation (Dr. med., MPI für molekulare und zelluläre Biophysik Jena)

1995 - 2001
Studium der Humanmedizin FSU Jena und ULP Strasbourg, France

Gutachtertätigkeiten

Mitgliedschaft im Editorial Board

  • Journal of Neurophysiology
  • Frontiers in Molecular Neuroscience
  • Journal of Pediatric Neurology

Gutachten für wissenschaftliche Organisationen (Auswahl):

  • Deutsche Forschungsgemeinschaft (DFG)
  • National Institute For Academic Anaesthesia (NIAA)

Mitgliedschaft in Gremien der Medizinischen Fakultät der RWTH Aachen

  • Mitglied der Strukturkommission
  • Mitglied der Tenure-Kommission
  • Mitglied der MD PhD Kommission
  • Mitglied in mehreren laufenden Berufungskommissionen

Preise, Auszeichnungen, Weiteres 

  • Vertrauensdozentin der Studienstiftung des deutschen Volkes
  • 1. Preis, Förderpreis für Schmerzforschung 2012 in der Kategorie Grundlagenforschung der Deutschen Schmerzgesellschaft
  • „Fast Track" Stipendiatin der Robert Bosch Stiftung "Exzellenz und Führungskompetenz für Wissenschaftlerinnen auf der Überholspur", 2007-2009

Publikationen bis 2013

Nadrowitz, F., C. Stoetzer, N. Foadi, J. Ahrens, F. Wegner, A. Lampert, W. Koppert, J. de la Roche, A. Leffler. "Distinct effects of lipid emulsions employed for "lipid resuscitation" on gating and bupivacaine-induced inhibition of the cardiac sodium channel Nav1.5". Anesthesia & Analgesia, 2013 Nov;117(5):1101-8.

de la Roche, J., M. J. Eberhardt, A. B. Klinger, N. Stanslowsky, F. Wegner, W. Koppert, P. W. Reeh, A. Lampert, M. J. M. Fischer, A. Leffler. „The molecular basis for species-specific activation of human TRPA1 by protons involves poorly conserved residues within transmembrane domains 5 and 6". Journal of Biological Chemistry. 2013 Jul 12;288(28):20280-92.

Freisinger, W., J. Schatz, T. Ditting, A. Lampert, S. Heinlein, N. Lale, R. E. Schmieder, R. Veelken. " Sensory renal innervation: a kidney-specific firing activity due to a unique expression pattern of voltage gated sodium channels?" American Journal of Physiology - Renal Physiology, 2013 Mar 1;304(5):F491-7.

Klinger, A. B., M. Eberhardt, A. S. Link, B. Namer, L. K. Kutsche, E. T. Schuy, R. Sittl, T. Hoffmann, C. Alzheimer, T. Huth, R. W. Carr, A. Lampert. "Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons". Molecular Pain, 2012, 8(1): 69.

Vetter, I., F. Touska, A. Hess, R. Hinsbey, S. Sattler, A. Lampert, M. Sergejeva, B. Namer, A. Sharov, L. S. Collins, M. Eberhardt, M. Engel, P. J. Cabot, J. N. Wood, V. Vlachová, P. W. Reeh, R. J. Lewis and K. Zimmermann. "Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling". The EMBO Journal, 2012 Oct 3;31(19):3795-808.

O'Reilly, A. O., E. Eberhardt, C. Weidner, C. Alzheimer, B. A. Wallace and A. Lampert. "Bisphenol A binds to the local anesthetic receptor site to block the cardiac sodium channel". PLoS One 2012, 7(7): e41667.

Sittl*, R., Lampert*, A., Huth, T., Schuy, E. T., Link, A. S., Fleckenstein, J., Alzheimer, C., Grafe P. and Carr, R.W., Anti-cancer drug oxaliplatin induces acute cooling-aggravated neuropathy via Nav1.6-mediated resurgent and persistent current. Proceedings of the National Academy of Sciences (PNAS), 2012, 109 (17): 6704-6709. *contributed equally

Gurkiewicz, M., Korngreen, A., Waxman, S. G. and Lampert, A., "Kinetic Modeling of Nav1.7 Provides Insight Into Erythromelalgia-associated F1449V Mutation." Journal of Neurophysiolgy 2011, 105 (4): 1546-1557.

Lampert, A. "Resurgent currents turn painfully exciting." The Journal of Physiology 2011, 589(4): 773-774, comment.

Lampert, A., O'Reilly, A. O., Reeh, P. W. and Leffler A., "Sodium channelopathies and pain." European Journal of Physiology 2010, Jul;460(2):249-63

Lampert, A., Dib-Hajj, S. D., Eastman, E. M., Tyrrell, L., Lin, Z., Yang, Y., Waxman, S. G., "Erythromelalgia mutation L823R shifts activation and inactivation of threshold sodium channel Nav1.7 to hyperpolarized potentials." Biochemical and Biophysical Research Communications 2009, Dec 11;390(2):319-24

Laezza, F., Lampert, A., Kozel, M. A., Gerber, B. R., Rush, A. M., Nerbonne, J. M., Waxman, S. G., Dib-Hajj, S. D., Ornitz, D. M., "FGF14 N-Terminal Splice Variants Differentially Modulate Nav1.2 and Nav1.6 Sodium Channels." Molecular and Cellular Neuroscience 2009, Oct 42(2): 90-101.

Blumenfeld, H., A. Lampert, J. P. Klein, J. Mission, M. C. Chen, M. Rivera, S. D. Dib-Hajj, A. Brennan, B. C. Hains, S. G. Waxman, "Role of hippocampal sodium channel Nav1.6 in kindling epileptogenesis." Epilepsia 2009, Jan 50(1):44-55.

Zolles G., E. Wagner, A. Lampert, B. Sutor, "Functional Expression of Nicotinic Acetylcholine Receptors in Rat Neocortical Layer 5 Pyramidal Cells." Cerebral Cortex 2009, May 19(5):1079-91.

Lampert,A.*, A.O. O'Reilly*, S.D. Dib-Hajj, L. Tyrrell, B.A. Wallace, and S.G. Waxman, "A pore-blocking hydrophobic motif at the cytoplasmic aperture of the closed-state Nav1.7 channel is disrupted by the erythromelalgia-associated F1449V mutation." Journal of Biological Chemistry 2008, 283(35):24118-27

Han, C.*, A. Lampert*, A. M. Rush, S. D. Dib-Hajj, X. Wang, Y. Yang, S. G. Waxman, Temperature dependence of erythromelalgia mutation L858F in sodium channel Nav1.7. Molecular Pain 2007, 3(1):3.

Frey, A., A. Lampert, K. Dietz, S. Striebich, C. Locher, O.Fedorenko, R. Möhle, J. Gallinat, F. Lang, U. Lang, Thyrotropin serum concentrations in healthy volunteers are associated with depression-related personality traits. Neuropsychobiology 2007, 56(2-3):123-6.

Frey A.*, A. Lampert*, S. Waldegger, N. Jeck, P. Waldegger, F. Artunc, G. Seebohm, U. Lang, S. Kupka, M. Pfister, J. Hoppe, C. Gerloff, E. Schaeffeler, M. Schwab, F. Lang, Influence of gain of function epithelial chloride channel ClC-Kb mutation on hearing thresholds. Hearing Research 2006, 214 (1-2):68-75.

Lampert, A., B. C. Hains, S. G. Waxman, Upregulation of ramp and persistent sodium current in dorsal horn neurons after spinal cord injury. Experimental Brain Research 2006, 174 (4):660-6.

Lampert, A., S. D. Dib-Hajj, L. Tyrrell, S. G. Waxman, Size matters: erythromelalgia mutation S241T in domain I S4-S5 linker of Nav1.7 alters channel gating. Journal of Biological Chemistry 2006, 281(47):36029-35.

Strutz-Seebohm, N., G. Seebohm, E. Shumilina, A. F. Mack, H.-J. Wagner, A. Lampert, F. Grahammer, G. Henke, L. Just, T. Skutella, M. Hollmann, F. Lang, Glucocorticoid adrenal steroids and glucocorticoid inducible kinase isoforms in the regulation of GluR6 expression. Journal of Physiology 2005, 565(2):391-401.

Seebohm, G., N. Strutz-Seebohm, O. Ureche, R. Baltaev, A. Lampert, G. Kornichuk, K. Kamiya, T. Wuttke, H. Lerche, M. C. Sanguinetti and F. Lang, Differential roles of S6 domain hinges in the gating of KCNQ potassium channels. Biophysical Journal 2005, 90(6):2235-44.

Jeck, N.*, S. Waldegger*, A. Lampert, C. Boehmer, P. Waldegger, P. A. Lang, B. Wissinger, B. Friedrich, T. Risler, R. Moehle, U. E. Lang, P. Zill, B. Bondy, E. Schaeffeler, S. Asante-Poku, H. Seyberth, M. Schwab§, F. Lang, Activating mutation of the renal epithelial chloride channel ClC-Kb predisposing to hypertension. Hypertension 2004, 43:1175-1181

Shumilina, E., A. Lampert, A. Lupescu, S. Myssina, N. Strutz-Seebohm, G. Henke, F. Grahammer, P. Wulff, D. Kuhl, F. Lang, Deranged Kv channel regulation in fibroblasts from mice lacking the serum and glucocorticoid inducible kinase SGK1. Journal of Cellular Physiology 2004, 204(1):87-98.

Lampert, A., M. M. Müller, S. Berchtold, K. S. Lang, O. Dobrovinskaya, F. Lang, Effect of dexamethasone on Kv1.3 potassium channel in a human T lymphocyte cell line. European Journal of Physiology 2003, 447:168-174.