Publications

Nintedanib targets KIT D816V neoplastic cells derived from induced pluripotent stem cells of systemic mastocytosis.
Toledo, M. A. S., Gatz, M., Sontag, S., Gleixner, K. V., Eisenwort, G., Feldberg, K., Hamouda, A. E. I., Kluge, F., Guareschi, R., Rossetti, G., Sechi, A. S., Dufva, O. M. J., Mustjoki, S. M., Maurer, A., Schüler, H. M., Goetzke, R., Braunschweig, T., Simonowski, A., Panse, J., Jawhar, M., Reiter, A., Hilberg, F., Ettmayer, P., Wagner, W., Koschmieder, S., Brümmendorf, T. H., Valent, P., Chatain, N., and Zenke, M. (2020).
Blood, in press.
Abstract | Full

Human sensory neurons derived from pluripotent stem cells for disease modelling and personalized medicine.
Lampert, A., Bennett, D. L., McDermott, L. A., Neureiter, A., Eberhardt, E., Winner, B., and Zenke, M. (2020).
Neurobiology of Pain, in press.
Abstract | Full

Human ES cell-derived dendritic cells: meeting the challenge of immune rejection in allogeneic cell therapy.
Zenke, M. (2020).
EBioMedicine, in press.
Abstract | Full

Epigenetic aspects of DC development and differentiation.
Chauvistré, H., and Seré, K. (2020).
Mol. Immunol. 128,116-124.
 Abstract | Full

The StemCellFactory: a modular system integration for automated generation and expansion of human induced pluripotent stem cells.
Elanzew, A., Nießing, B., Langendoerfer, D., Rippel, O., Piotrowski, T., Schenk, F., Kulik, M., Peitz, M., Breitkreuz, Y., Jung, S., Wanek, P., Stappert, L., Schmitt, R. H., Haupt, S., Zenke, M., König, N., and Brüstle, O. (2020).
Frontiers Bioeng. Biotech. 8, 580352.
Full

The role of Nav1.7 in human nociceptors: insights from human iPS cell-derived sensory neurons of erythromelalgia patients.
Meents, J. E., Bressan, E., Sontag, S., Foerster, A., Hautvast, P., Rösseler, C., Hampl, M., Schüler, H., Goetzke, R., Chi Le, T. K., Kleggetveit, I. P., Le Cann, K., Kerth, C., Rush, A. M., Rogers, M., Kohl, Z., Schmelz, M., Wagner, W., Jørum, E., Namer, B., Winner, B., Zenke, M., and Lampert, A. (2019).
Pain 160, 1327-1341.
Abstract | Full

Identification of transcription factor binding sites using ATAC-seq.
Li, Z., Schulz, M. H., Look, T., Begemann, M., Zenke, M., and Ivan G. Costa, I. G. (2019).
Genome Biol. 20, 45.
Abstract | Full

Stem cell research – Current scientific and societal developments.
Zenke, M., Marx-Stölting and Schickl, H., Editors (2018).
Berlin-Brandenburg Academy of Sciences and Humanities, Nomos Publisher, Baden-Baden, Germany.
Abstract | Full

Differentiation of human induced pluripotent stem cells (iPS cells) and embryonic stem cells (ES cells) into dendritic cell (DC) subsets.
Sontag, S., Förster, M., Seré, K. and Zenke, M. (2017).
Bio-protocol 7, e2419.
Abstract | Full

Modelling IRF8 deficient human hematopoiesis and dendritic cell development with engineered induced pluripotent stem cells.
Sontag, S., Förster, M., Qin, J., Wanek, P., Mitzka, S., Schüler, H. M., Koschmieder, S., Rose-John, S., Seré, K. and Zenke, M. (2017).
Stem Cells 35, 898-908.
Abstract | Full

Surface-grafted nanogel arrays direct cell adhesion and motility.
Sechi, A, Freitas, J, Wünnemann, P, Töpel, A, Paschoalin, RT, Ullmann, S, Schröder, R, Aydin, G, Rütten, S, Böker, A, Zenke, M and Pich, A. (2016).
Adv Mater Int, 1600455, doi: 10.1002/admi.201600455.
Abstract

PubMed Link (to last publications)

Analysis of computational footprinting methods for DNase sequencing experiments.
Gusmao, E. G., Allhoff, M., Zenke, M., and Costa, I. G. (2016).Nature Methods 13, 303-309 (see also Editorial Nature Methods 13, 185).
Abstract | Full

Epigenetic program and transcription factor circuitry of dendritic cell development.
Lin, Q., Chauvistré, H., Costa, I. G., Gusmão, E. G., Mitzka, S., Haenzelmann, S., Baying, B., Klisch, T., Moriggl, R., Hennuy, B., Smeets, H., Hoffmann, K., Benes, V., Seré, K., and Zenke, M. (2015). Nucl. Acid Res. 43, 9680-9693.
Abstract | Full

Crucial role for the LSP1-Myosin 1e bi-molecular complex in the regulation of Fcγ receptor-driven phagocytosis.
Maxeiner, S., Shi, N., Schalla, C., Aydin, G., Hoss, M., Vogel, S., Zenke, M., and Sechi, A. S. (2014).Mol. Biol. Cell, in press.

The clash of Langerhans cell homeostasis in skin: Should I stay or should I go?
Hieronymus T, Zenke M, Baek JH, Seré K. (2014).
Semin Cell Dev Biol., Epub ahead of print.
Abstract | Full

Reduced immunogenicity of induced pluripotent stem cells derived from Sertoli cells.
Wang, X., Qin, J., Zhao, R.C., and Zenke, M. (2014).
PLoS One 9, e106110. 
Abstract | Full

Cell fusion enhances mesendodermal differentiation of human induced pluripotent stem cells.
Qin, J., Sontag, S., Lin, Q., Mitzka, S., Leisten, I., Schneider, R.K., Wang, X., Jauch, A., Peitz, M., Brüstle, O., Wagner, W., Zhao, R.C., and Zenke, M. (2014)
Stem Cells Dev., 2014 Aug 19. [Epub ahead of print]. 
Abstract | Full

Dendritic cell development requires histone deacetylase activity.
Chauvistré, H., Küstermann, C., Rehage, N., Klisch, T., Mitzka, S., Felker, P., Rose-John, S., Zenke, M., and Seré, K. (2014).
Eur J Immunol. 44, 2478-2488.
Abstract | Full

The polycomb protein Ezh2 impacts on induced pluripotent stem cell generation.
Ding, X., Wang, X., Sontag, S., Qin, J., Wanek, P., Lin, Q., and Zenke, M. (2014). Stem Cells Dev. 23, 931-940.
Abstract | Full

Two distinct types of Langerhans cells populate the skin during steady state and inflammation.
Seré, K., Baek, J.H., Ober-Blöbaum, J., Müller-Newen, G., Tacke, F., Yokota, Y., Zenke, M., and Hieronymus, T. (2012).
Immunity 37, 905-916.
Abstract | Full

The HGF receptor/met tyrosine kinase is a key regulator of dendritic cell migration in skin immunity.
Baek, J.H., Birchmeier, C., Zenke, M., and Hieronymus, T. (2012).
J Immunol. 189, 1699-1707.
Abstract | Full

Polycomb group protein Bmi1 promotes hematopoietic cell development from ES cells.
Ding, X., Lin, Q., Ensenat-Waser, R., Rose-John, S., and Zenke, M. (2012).
Stem Cells Dev. 21, 121-132.
Abstract | Full

TGF-ß1 accelerates dendritic cell differentiation from common dendritic cell progenitors and directs subset specification toward conventional dendritic cells.
Felker, P., Seré, K., Lin, Q., Becker, C., Hristov, M., Hieronymus, T., and Zenke, M. (2010).
J Immunol. 185, 5326-5335.
Abstract | Full

Human adult germline stem cells in question.
Ko, K., Araúzo-Bravo, M. J., Tapia, N., Kim, J., Lin, Q., Bernemann, C., Han, D. W., Gentile, L., Reinhardt, P., Greber, B., Schneider, R. K., Kliesch, S., Zenke, M., and Schöler, H. R. (2010).
Nature 465, E1-E3.
Abstract | Full

Induction of pluripotency in adult unipotent germline stem cells.
Ko, K., Tapia, N., Wu, G., Kim, J. B., Araúzo Bravo, M. J., Sasse, P., Glaser, T., Ruau, D., Han. D. W., Greber, B., Hausdörfer, K., Sebastiano, V., Stehling, M., Fleischmann, B. K., Brüstle, O., Zenke, M., and Schöler, H. R. (2009).
Cell Stem Cell 5, 87-96.
Abstract | Full

Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors.
Kim, J. B., Zaehres, H., Wu, G., Gentile, L., Ko, K., Sebastiano, V., Arauzo-Bravo J. M., Ruau, D., Han, D. W., Zenke, M., and Schöler H. R. (2008).
Nature 54, 646-650.
Abstract | Full

Pluripotency associated genes are reactivated by chromatin modifying agents in neurosphere cells.
Ruau, D., Ensenat-Waser, R., Dinger, T. C., Vallabhapurapu, D. S., Rolletschek, A., Hacker, C., Hieronymus, T., Wobus, A. M., Müller, A. M., and Zenke, M. (2008). Stem Cells 26, 920-926.
Abstract | Full

Assessment of stem cell/biomaterial combinations for stem cell-based tissue engineering.
Neuss, S., Apel, C., Buttler, P., Denecke, B., Dhanasingh, A., Ding, X., Grafahrend, D., Groger, A., Hemmrich, K., Herr, A., Jahnen-Dechent, W., Mastitskaya, S., Perez-Bouza, A., Rosewick, S., Salber, J., Wöltje, M., and Zenke, M. (2008).
Biomaterials 29, 302-313.
Abstract | Full

Transforming growth factor beta1 up-regulates interferon regulatory factor 8 during dendritic cell development.
Ju, X,-S, Ruau, D., Jantti, P., Sere, K., Becker, C., Wiercinska, E., Bartz, C., Erdmann, B., Dooley, S., and Zenke, M. (2007).
Eur. J. Immunol. 37, 1174-1183.
Abstract | Full

Towards an understanding of the transcription factor network of dendritic cell development.
Zenke, M., and Hieronymus, T. (2006).
Trends Immunol. 27, 140-145.
Abstract | Full

Progressive and controlled development of mouse dendritic cells from Flt3+CD11b+ progenitors in vitro.
Hieronymus, T., Gust T. C., Kirsch, R. D., Jorgas, T., Blendinger, G., Goncharenko, M., Supplitt, K., Rose-John, S., Muller, A. M., and Zenke, M. (2005).
J. Immunol. 174, 2552-2562.
Abstract | Full

In vivo haematopoietic activity is induced in neurosphere cells by chromatin-modifying agents.
Schmittwolf, C., Kirchhof, N., Jauch, A., Durr, M., Harder, F., Zenke, M., and Muller, A. M. (2005).
EMBO J. 24, 554-566.
Abstract | Full

RNA-containing adenovirus/polyethylenimine transfer complexes effectively transduce dendritic cells and induce antigen-specific T cell responses.
Gust, T. C., Diebold, S. S., Cotten, M., and Zenke, M. (2004).
J. Gene Med. 6, 464-470.
Abstract | Full

Transcriptional profiling identifies Id2 function in dendritic cell development.
Hacker. C., Kirsch, R. D., Ju, X.-S., Hieronymus, T., Gust, T. C., Kuhl, C., Jorgas, T., Kurz, S. M., Rose-John, S., Yokota, Y., and Zenke, M. (2003).
Nat. Immunol. 4, 380-386.
Abstract | Full

Towards determining the differentation program of antigen presenting dendritic cells by transcriptional profiling.
Ju, X.-S., Hacker, C., Madruga, J., Kurz, S. M., Knespel, S., Blendinger, G., Rose-John, S., and Zenke M. (2003).
Eur. J. Cell Biol. 82, 75-86.
Abstract | Full

bFGF signaling and v-Myb cooperate in sustained growth of primitive erythroid progenitors.
Bartunek, P., Pajer, P., Karafiát, V., Blendinger, G., Dvorák, M., and Zenke, M. (2002).
Oncogene 21, 400-410.
Abstract | Full

The impact of c-met/scatter factor receptor on dendritic cell migration.
Kurz S. M., Diebold S. S., Hieronymus T., Gust T. C., Bartunek P., Sachs M., Birchmeier W. and Zenke M. (2002).
Eur. J. Immunol. 32, 1832-1838.
Abstract | Full

MHC class II presentation of endogenously expressed antigens by transfected dendritic cells.
Diebold, S. S., Cotten, M., Koch, N. and Zenke, M. (2001).
Gene Ther. 8, 487-493.
Abstract | Full

Thyroid hormone regulates the obesity gene tub.
Koritschoner, N. P., Alvarez-Dolado, M., Kurz, S. M., Heikenwälder, C. Hacker, M. F., Vogel, F., Munoz, A. and Zenke, M. (2001).
EMBO Rep. 2, 499-504.
Abstract | Full

Mannose polyethylenimine conjugates for targeted DNA delivery into dendritic cells.
Diebold, S. S., Kursa, M., Wagner, E., Cotten, M., and Zenke, M. (1999).
J. Biol. Chem. 274, 19087-19094.
Abstract | Full

Efficient gene delivery into human dendritic cells by adenovirus polyethylenimine and mannose polyethylenimine transfection.
Diebold, S. S., Lehrmann, H., Kursa, M., Wagner, E., Cotten, M., and Zenke, M. (1999).
Hum. Gene Ther. 10, 775-786.
Abstract | Full

Polarised expression pattern of focal contact proteins in highly motile antigen presenting dendritic cells.
Madruga, J., Koritschoner, N. P., Diebold, S. S., Kurz, S. M., and Zenke, M. (1999).
J. Cell Sci. 112, 1685-1696.
Abstract | Full

Growth and differentiation of human stem cell factor/erythropoietin-dependent erythroid progenitor cells in vitro.
Panzenböck, B., Bartunek, P., Mapara, M. Y., and Zenke, M. (1998).
Blood 92, 3658-3668.
Abstract | Full

Retinoid X receptor and c-cerbA/thyroid hormone receptor regulate erythroid cell growth and differentiation.
Bartunek, P., and Zenke, M. (1998).
Mol. Endocrinol. 12, 1269-1279.
Abstract | Full

Regulation and function of transcription factor GATA-1 during red blood cell differentiation.
Briegel, K., Bartunek, P., Stengl, G., Lim, K. C., Beug, H., Engel, J. D., and Zenke, M. (1996).
Development 122, 3839-3850.
Abstract | Full

Dendritic cell progenitor is transformed by a conditional v-Rel estrogen receptor fusion protein v-RelER.
Boehmelt, G., Madruga, J., Dorfler, P., Briegel, K., Schwarz, H., Enrietto, P. J., and Zenke, M. (1995).
Cell 80, 341-352.
Abstract | Full

Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner.
Briegel, K., Lim, K. C., Plank, C., Beug, H., Engel, J. D., and Zenke, M. (1993).
Genes Dev. 7, 1097-1109.
Abstract | Full

Hormone-regulated v-rel estrogen receptor fusion protein: reversible induction of cell transformation and cellular gene expression.
Boehmelt, G., Walker, A., Kabrun, N., Mellitzer, G., Beug, H., Zenke, M., and Enrietto, P. J. (1992).
EMBO J. 11, 4641-4652.
Abstract | Full

v-erbA overexpression is required to extinguish c-erbA function in erythroid cell differentiation and regulation of the erbA target gene CAII.
Disela, C., Glineur, C., Bugge, T., Sap, J., Stegl, G., Dodgson, J., Stunnenberg, H., Beug, H. and Zenke, M. (1991).
Genes Dev. 5, 2033-2047.
Abstract | Full

Receptor-mediated endocytosis of transferrin-polycation conjugates: An efficient way to introduce DNA into hematopoietic cells.
Zenke M, Steinlein P, Wagner E, Cotten M, Beug H, Birnstiel ML. (1990).
Proc. Natl. Acad. Sci. USA 87, 3655-3659.
Abstract | Full

v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA.
Zenke M, Munoz A, Sap J, Vennström B, Beug H. (1990).
Cell 61, 1035-1049.
Abstract | Full

v-erbA specifically suppresses transcription of the avian erythrocyte anion transporter (band 3) gene.
Zenke M, Kahn P, Disela C, Vennstrom B, Leutz A, Keegan K, Hayman MJ, Choi HR, Yew N, Engel JD, et al. (1988).
Cell 52, 107-19.
Abstract | Full

Cell-type specific protein binding to the enhancer of simian virus 40 in nuclear extracts.
Davidson I, Fromental C, Augereau P, Wildeman A, Zenke M, Chambon P. (1986).
Nature 323, 544-8.
Abstract | Full

Specific protein binding to the simian virus 40 enhancer in vitro.
Wildeman AG, Zenke M, Schatz C, Wintzerith M, Grundstrom T, Matthes H, Takahashi K, Chambon P. (1986).
Mol. Cell Biol. 6, 2098-105.
Abstract | Full

Requirement of stereospecific alignments for initiation from the simian virus 40 early promoter.
Takahashi K, Vigneron M, Matthes H, Wildeman A, Zenke M, Chambon P. (1986).
Nature 319, 121-6.
Abstract | Full

Multiple sequence motifs are involved in SV40 enhancer function.
Zenke M, Grundstrom T, Matthes H, Wintzerith M, Schatz C, Wildeman A, Chambon P. (1986).
EMBO J. 5, 387-97.
Abstract | Full