As a tertiary and quaternary level provider of medical care, the University Hospital of RWTH Aachen combines patient-oriented medicine and care, teaching and research at an international level. The entire spectrum of medical care is provided through 36 specialist departments, 33 institutes and six interdisciplinary units. The co-location of patient care, research and teaching in a central building offers the best conditions for intensive interdisciplinary exchange and close clinical and scientific networking. Highly qualified teams of doctors, nurses and scientists work collaboratively to optimise the healthcare provision of our local, regional, national and international patients. Around 9,000 employees ensure that our care delivery is patient-oriented medicine and surpasses the highest quality standards. With 1,400 beds, the university hospital treats around 50,000 inpatient and 200,000 outpatient cases per year.
The Institute of Biochemistry and Molecular Cell Biology is looking for a
PhD student (f/m/d) biology / biotechnology / human biology / molecular medicine / biochemistry or equivalent
The part-time position 65% (25,03 hours/week) starts as soon as possible. The position is initially funded for one year, with an option of a prolongation to three years.
Nuclear pore complexes (NPCs) are the gatekeepers of the nuclear envelope that mediate the transport of proteins and RNA between the cell nucleus and the cytoplasm. To do this, they deform the two membranes of the nuclear envelope into a pore. Amphipathic helices in a large number of NPC proteins are crucial for this process. This DFG-funded project is investigating how a newly identified amphipathic helix in the NPC transmembrane protein NDC1 (https://rupress.org/jcb/article/222/6/e202210059/214094/Distinct-domains-in-Ndc1-mediate-its-interaction) contributes to this process. Cell-free and cell-based assays will be used to test whether this motif is required for the assembly and function of NPCs in vertebrates. In minimal membrane systems (liposomes, giant unilamellar vesicles) membrane binding of the helix, e.g. preference for certain lipids, will be characterized and tested whether the helix can bend membranes by inserting into the lipid leaflet. Since NDC1 interacts with other NPC proteins that also possess amphipathic helices, the potential synergistic function of these helices for membrane curvature and NPC assembly and function in minimal membrane systems and cellular assays will be analyzed.
- The applicant must hold an above-average master/diploma degree in biology / biotechnology / human biology / molecular medicine / biochemistry
- Strong interest in basic research in biochemistry and cell biology
- Basic knowledge of protein purification, cell culture as well as cell biology and molecular biology is helpful
- Team-oriented work, enthusiasm for establishing new experimental models and above-average commitment are expected
Why should you choose us?
- 300 professions under one roof - more variety is not possible.
- We offer performance-based remuneration in accordance with the provisions of TV-L (EG 13), including attractive public service benefits.
- In addition to a wide range of further education and training opportunities we offer a wide range of health promotion options as well as the extensive university sports program
- Monthly employee discounts through our corporate benefits program to save on private shopping.
- Flexible working hours so that you can better combine work and private life, because your work-life balance is important to us.
- Attractive conditions for public transport or discounted employee parking so that you have a relaxed commute.
- A company kindergarten so that your children are always close by
This position is not gender specific.
The RWTH Aachen University Hospital promotes equal opportunities and diversity. Applications from women are expressly encouraged and if the applicant is suitable qualified, they will be given priority in accordance with the LGG. If suitably qualified, people with a registered disability will also receive priority.
Weekly hours are negotiable.
You should preferably use our digital application portal at www.karriere.ukaachen.de for your application. There you have the option of securing your documents in the electronic application folder to prevent unauthorized access. Applications that reach us by email to: firstname.lastname@example.org (this transmission path cannot be as effectively secured) will be transferred to the aforementioned portal and any accompanying documents will be disposed of in accordance with data protection regulations immediately after transfer. After the retention period has expired, the data in the portal will also be deleted. If you do not agree to a transfer to the Application portal your application cannot be considered.
The application deadline for the advertised position GB-P 46400 is 27th of February 2024.
Uniklinik RWTH Aachen, Institute of Biochemistry and Molecular Cell Biology, Univ.-Prof. Dr. rer. nat. Wolfram Antonin, Pauwelsstr.30, 52074 Aachen.
For more detailed information please contact Patricia Hans, Tel.: +49 241/ 80-88841, E-Mail: phansukaachende .