SART1 uniquely localizes to spindle poles forming a SART1 cap and promotes spindle pole assembly
- In our latest collaboration led by Hideki Yokoyama, we reveal an unexpected, moonlighting role for this pre-mRNA splicing protein at the mitotic centrosome which is essential for spindle function-a novel feature not previously described for SART1.
- Discover at JBC how SART1 forms a unique cap at the distal surface of mitotic centrosomes, facilitating spindle pole assembly and ensuring accurate chromosome segregation during mitosis.

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