Message archive
Phentolamine Helps End Local Anesthesia but Also Blocks Sodium Channels
Phentolamine is a commonly used drug in clinical practice, above all to lower blood pressure through vasodilation. This vasodilatory effect leads to a faster local elimination of injected substances.…
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The Central Ethics Commission for Stem Cell Research (ZES) of the Federal Republic of Germany appoints Univ.-Prof. Dr. Lampert as a member
At the beginning of December, Prof. Dr. Lampert was appointed by the Federal Government of the Federal Republic of Germany to the ZES, which reviews research proposals from scientists in Germany who…
Congratulations to Dr. med. Björn Heinrichs!
We congratulate Dr. Björn Heinrichs on his successfully completed medical doctorate with the title "Contribution of the voltage-gated sodium channels Nav1.7 and Nav1.8 to the pathophysiology of pain…
Cholesterol depletion increases sodium currents mediated by Nav1.7
Cholesterol is a crucial component of cellular membranes. In our latest study in cooperation with Giulia Rossetti, we explored the impact of cholesterol depletion on Nav1.7, a key ion channel found…
Congratulations to Dr Claudia Trinler
We are very happy to congratulate Dr. Claudia Trinler on her successfully completed medical doctorate with the title "Characterization of a co-culture system of human induced pluripotent stem…
Botulinum toxin alleviates pain independently of sodium channels
Botulinum toxin is not only a very dangerous neurotoxin, but also a frequently used drug in various medical fields. Apart from its muscle relaxant effect, the toxin has recently been used more and…
New spokesperson for translational neurosciences
Prof. Angelika Lampert is the new spokesperson for the Translational Neurosciences research focus at the Faculty of Medicine at RWTH Aachen University. The head of the Institute of Neurophysiology…
Patient derived neurons express Nav1.7
We use induced pluripotent stem cells to produce nerve cells from chronic pain patients. Thereby, we focus on the voltage-gated sodium channel Nav1.7, as it has been associated with pain. In order to…
Validation of stem cell-derived sensory neurons for modelling genetic pain disorders
Stem cells, such as induced pluripotent stem cells (iPSC), can be used to generate human sensory neurons. They offer an attractive humanized model system to study pathophysiological mechanisms of…
Worldwide Sodium Channel Conference 2024
At the end of January, a unique conference took place in Grindelwald in Switzerland. For three days, over one hundred scientists from 19 countries gathered to discuss and present novel insights within…
Night of the Profs: Angelika Lampert DJs at the Apollo
On Friday, October 13, 2023, the guests at the Apollo experienced a unique night when professors from Aachen's RWTH university took over the DJ booth. Among them was Prof. Dr. med. Angelika Lampert…
Temperature can trigger pain and alters sodium channel function
Sodium channels are essential for the function of peripheral sensory nerve fibers and mutations in these channels can result in chronic pain syndromes. Pain attacks are often triggered by temperature…