Her dissertation is entitled:
“Modelling neuropathic pain in vitro: a multimodal approach using induced-pluripotent stem cell-derived sensory neurons and mechanically compressed keratinocytes”
The dissertation investigated advanced in vitro models for studying neuropathic pain mechanisms using human iPSC-derived sensory neurons and mechanically stressed keratinocytes. Patient-specific neurons carrying the potentially pathogenic genetic Nav1.9-Y66S variant were investigated for their disease-relevant changes in electrical excitability. In addition, a newly developed compression model demonstrated that keratinocytes from patients with a rare, painful skin disease exhibit enhanced pro-inflammatory responses under mechanical stress. The study thus provides valuable models for more precise mapping of neuropathic pathomechanisms and a foundation for future, more complex modeling approaches.
The Insitute for Neurophysiology would like to congratulate Dr. Fiona Roll on her achievement !
