High-resolution 3D Imaging
Molecular Signaling Pathways
Clinical Research
Read more Educational Research
A central research focus at Department of Orthodontics is the investigation of organ crosstalk, specifically the molecular and functional communication between oral tissues and other organ systems. The aim is to enhance understanding of inflammatory and degenerative processes and to develop preventive strategies for stabilizing periodontal hard and soft tissue.
With its strong focus and comprehensive expertise in organ crosstalk, the Department of Orthodontics is a leading contributor to the interdisciplinary SFB consortium “Periodontal Remodelling” (SFB1739, currently in preparation). This consortium builds on the IZKF “Organ-Crosstalk” project (2019–2023), initiated and coordinated within the Department of Orthodontics, which provided an essential scientific basis by characterizing key regulatory networks governing periodontal remodelling.
The Department of Orthodontics possesses particular expertise in high-resolution three-dimensional tissue analysis using high-resolution micro-computed tomography (µCT), which enables detailed visualization of periodontal remodeling processes. Established methods, including cell culture models, molecular biological analyses (e.g., qRT-PCR, Western Blot, ELISA), as well as histological and immunofluorescence-based techniques, are also employed. This integrative combination of methods allows for systematic capture and evaluation of complex mechanobiological and inflammatory signaling networks. Educational research and clinical studies are closely integrated into this thematic complex, contributing to the translational application of scientific findings in patiet care.
