Molecular mechanisms of epileptogenesis
Epilepsy is a severe chronic brain disease characterized by recurrent seizure activity due to abnormal neuronal network activity. Despite many years of research, the underlying mechanisms that trigger seizure activity are still not fully understood. Over the past decades, tremendous progress has been made in the discovery of epilepsy genes. Our research focuses on understanding the pathophysiological role of such epilepsy genes. By combining molecular, biochemical and electrophysiological experiments, we hope to improve our understanding of the pathogenesis of epilepsy. A better understanding of the (mis)functionality of such proteins could open up new possibilities for pharmacological interventions, including the development of genetic engineering methods and the development of preventive strategies.
Dr. Karen M.J. van Loo
kvanlooukaachende
Address
Dept. of Neurology, Section Epileptology
RWTH Aachen University Hospital
Pauwelsstrasse 30
52074 Aachen, Germany
Tel. +49-(0)241- 80-38610
Team
Dr. Karen M.J. van Loo
kvanlooukaachende
Address
Dept. of Neurology, Section Epileptology
RWTH Aachen University Hospital
Pauwelsstrasse 30
52074 Aachen, Germany
Tel. +49-(0)241- 80-38610
Birgit Gittel (lead technician)
bgittelukaachende
Address
Dept. of Neurology, Section Epileptology
University of Aachen
Pauwelsstrasse 30
52074 Aachen, Germany
Tel. +49-(0)241-80-38611
Kim Charlotte Niecke
knieckeukaachende
Address
Dept. of Neurology, Section Epileptology
University of Aachen
Pauwelsstrasse 30
52074 Aachen, Germany
Research projects and techniques
Genetic studies have revealed that many susceptibility genes for the epilepsies encode ion channels, including voltage-gated sodium, potassium and calcium channels. Such so-called ion channelopathies might be caused by 1) mutations (genetic epilepsies) or by 2) expression changes (acquired epilepsies). In our group, we analyze how expression changes in ion channel genes are induced and how we can modulate/antagonize such channelopathies.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971179/pdf/fncel-13-00587.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788814/pdf/zns3175.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846312/pdf/ncomms9688.pdf
Viral delivery systems, including Adeno-Associated Viruses and Lentiviruses, are valuable tools for neuroscience research, including epilepsy research. In this project, we design, produce and test viral systems to learn how we can use such approaches for the diagnosis and treatment of epilepsy. By applying such viral systems to organotypic brain slice cultures, we can analyze the molecular and electrophysiological properties at the single cell and at the small network level in mouse and human brain tissue.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770422/pdf/fnmol-14-667143.pdf
Publications
10 Selected publications
- Van Loo KMJ, Carvill GL, Becker AJ, Conboy K, Goldman AM, Kobow K, Lopes-Cendes I, Reid CA, van Vliet EA, Henshall DC : 'Epigenetic genes and epilepsy - emerging mechanisms and clinical applications.' firstNature reviews. Neurology, 2022 Sep doi: doi: 10.1038/s41582-022-00693-y
- van Loo KM, Schaub C, Pitsch J, Kulbida R, Opitz T, Ekstein D, Dalal A, Urbach H, Beck H, Yaari Y, Schoch S, Becker AJ : 'Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1.' firstNature communications, 2015 Oct 26 doi: doi: 10.1038/ncomms9688
- van Loo KMJ, Rummel CK, Pitsch J, Müller JA, Bikbaev AF, Martinez-Chavez E, Blaess S, Dietrich D, Heine M, Becker AJ, Schoch S : 'Calcium Channel Subunit α2δ4 Is Regulated by Early Growth Response 1 and Facilitates Epileptogenesis.' firstThe Journal of neuroscience : the official journal of the Society for Neuroscience, 2019 Apr 24 doi: doi: 10.1523/JNEUROSCI.1731-18.2019
- van Loo KM, Schaub C, Pernhorst K, Yaari Y, Beck H, Schoch S, Becker AJ : 'Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST).' firstThe Journal of biological chemistry, 2012 May 4 doi: doi: 10.1074/jbc.M111.310763
- van Loo KM, Martens GJ : 'Genetic and environmental factors in complex neurodevelopmental disorders.' firstCurrent genomics, 2007 Nov doi: doi: 10.2174/138920207783591717
- van Loo KMJ, Becker AJ : 'Transcriptional Regulation of Channelopathies in Genetic and Acquired Epilepsies.' firstFrontiers in cellular neuroscience, 2019 doi: doi: 10.3389/fncel.2019.00587
- van Loo KMJ, Bak A, Hodge R, Bedogni F, Ramirez JSB, Emerson SN, Höllig A, Mansvelder HD, Goriounova NA, Ramirez JM, Koch H : 'What makes the human brain special: from cellular function to clinical translation.' firstJournal of neurophysiology, 2025 Oct 1 doi: doi: 10.1152/jn.00120.2025
- Tsortouktzidis D, Schulz H, Hamed M, Vatter H, Surges R, Schoch S, Sander T, Becker AJ, van Loo KMJ : 'Gene expression analysis in epileptic hippocampi reveals a promoter haplotype conferring reduced aldehyde dehydrogenase 5a1 expression and responsiveness.' last (senior)Epilepsia, 2021 Jan doi: doi: 10.1111/epi.16789
- Kostoula C, Pascente R, Ravizza T, McCown T, Schoch S, Vezzani A, Becker AJ, van Loo KMJ : 'Development of In Vivo Imaging Tools for Investigating Astrocyte Activation in Epileptogenesis.' last (senior)Molecular neurobiology, 2018 May doi: doi: 10.1007/s12035-017-0660-x
- Tsortouktzidis D, Tröscher AR, Schulz H, Opitz T, Schoch S, Becker AJ, van Loo KMJ : 'A Versatile Clustered Regularly Interspaced Palindromic Repeats Toolbox to Study Neurological Ca(V)3.2 Channelopathies by Promoter-Mediated Transcription Control.' last (senior)Frontiers in molecular neuroscience, 2021 doi: doi: 10.3389/fnmol.2021.667143
Further publications
2026
- van Loo KMJ, Galvis-Montes DS, Breuer A, Berns JL, Hummel CA, Baumgartner T, Freyberg M, Mair KM, Bauer J, Rüber T, van Waardenberg AJ, Hamed M, Borger V, Vatter H, Surges R, Schoch S, Becker AJ, Pitsch J : 'Forkhead box versus NF-κB hippocampal snRNA-seq profiles distinguish anti-Drebrin- and anti-GAD65-positive encephalitis.' Journal of neuroinflammation, 2026 Jul 7 doi: pii: 232. doi: 10.1186/s12974-026-03951-8
- Tröscher AR, Tsortouktzidis D, Ammer-Pickhardt F, Penzenleitner M, Aichholzer M, Rauch PR, Rossmann T, Stroh-Holly N, Atli B, Gruber A, Helbok R, Haubold J, Thome C, Engelhardt M, von Oertzen TJ, Schoch S, Becker AJ, van Loo KMJ : 'HIF1α activation is associated with increased CaV3.2 expression and hypoxia-induced neuronal hyperexcitability.' Neurobiology of disease, 2026 Jun 11 doi: doi: 10.1016/j.nbd.2026.107482
- Oudart M, van Loo KMJ, Kronenberg-Versteeg D : 'Live-cell physiology in human brain tissue culture-the potential, the challenges, and the lessons learned.' Frontiers in cellular neuroscience, 2026 doi: doi: 10.3389/fncel.2026.1777650
- Bak AV, van Loo KMJ, Kronenberg-Versteeg D, Koch H : 'From mice to clinical relevance: humanizing neuroscience with human-based model systems.' Frontiers in cellular neuroscience, 2026 doi: doi: 10.3389/fncel.2026.1776439
2025
- Meconi A, Schmied K, Bak A, Pitsch J, Koch H, Schoch S, Becker AJ, van Loo KMJ : 'A New Toolbox to Label Zinc-MTF1 Responsive Neuronal Populations Unravels Cellular Congruence between MTF1 Responses and T-type Calcium Channelopathies in an Experimental Model of Epilepsy.' Molecular neurobiology, 2025 Dec 13 doi: doi: 10.1007/s12035-025-05433-z
- Karge RA, Fischer FP, Schüth H, Wechner A, Peter S, Kilo LA, Dichter M, Voigt A, Tavosanis G, van Loo KMJ, Koch H, Weber YG, Wolking S : 'Modeling AP2M1 developmental and epileptic encephalopathy in Drosophila.' Disease models & mechanisms, 2025 Nov 1 doi: doi: 10.1242/dmm.052419
- Cases-Cunillera S, Müller P, van Waardenberg AJ, Schoch S, Huberfeld G, Höllig A, Delev D, Hamed M, Becker AJ, van Loo KMJ : 'Single-nucleus RNA sequencing: immature excitatory neurons and transformed glia build human BRAF(V600E)-negative gangliogliomas.' Brain communications, 2025 doi: doi: 10.1093/braincomms/fcaf372
- van Loo KMJ, Bak A, Hodge R, Bedogni F, Ramirez JSB, Emerson SN, Höllig A, Mansvelder HD, Goriounova NA, Ramirez JM, Koch H : 'What makes the human brain special: from cellular function to clinical translation.' Journal of neurophysiology, 2025 Oct 1 doi: doi: 10.1152/jn.00120.2025
- Schünemann KD, Hattingh RM, Verhoog MB, Yang D, Bak AV, Peter S, van Loo KMJ, Wolking S, Kronenberg-Versteeg D, Weber Y, Schwarz N, Raimondo JV, Melvill R, Tromp SA, Butler JT, Höllig A, Delev D, Wuttke TV, Kampa BM, Koch H : 'Comprehensive analysis of human dendritic spine morphology and density.' Journal of neurophysiology, 2025 Apr 1 doi: doi: 10.1152/jn.00622.2024
2024
- Bak A, Schmied K, Jakob ML, Bedogni F, Squire OA, Gittel B, Jesinghausen M, Schünemann KD, Weber Y, Kampa B, van Loo KMJ, Koch H : 'Temporal dynamics of neocortical development in organotypic mouse brain cultures: a comprehensive analysis.' Journal of neurophysiology, 2024 Sep 1 doi: doi: 10.1152/jn.00178.2024
- Bak A, Koch H, van Loo KMJ, Schmied K, Gittel B, Weber Y, Ort J, Schwarz N, Tauber SC, Wuttke TV, Delev D : 'Human organotypic brain slice cultures: a detailed and improved protocol for preparation and long-term maintenance.' Journal of neuroscience methods, 2024 Apr doi: doi: 10.1016/j.jneumeth.2023.110055
- Noebels JL, Avoli M, Rogawski MA, Vezzani A, Delgado-Escueta AV, Brennan GP, van Loo KMJ : 'Transcriptomic Alterations in Epileptogenesis: Transcription Factors in the Spotlight.' , 2024
- Ramos-Moreno T, Cifra A, Litsa NL, Melin E, Ahl M, Christiansen SH, Gøtzsche CR, Cescon M, Bonaldo P, van Loo K, Borger V, Jasper JA, Becker A, van Vliet EA, Aronica E, Woldbye DP, Kokaia M. Collagen VI: Role in synaptic transmission and seizure-related excitability., Exp Neurol. 2024 Oct;380:114911. doi: 10.1016/j.expneurol.2024.114911. Epub 2024 Jul 31. PMID: 39094767
2023
- Galvis-Montes DS, van Loo KMJ, van Waardenberg AJ, Surges R, Schoch S, Becker AJ, Pitsch J : 'Highly dynamic inflammatory and excitability transcriptional profiles in hippocampal CA1 following status epilepticus.' Scientific reports, 2023 Dec 14 doi: doi: 10.1038/s41598-023-49310-y
- Vana NS, van Loo KMJ, van Waardenberg AJ, Tießen M, Cases-Cunillera S, Sun W, Quatraccioni A, Schoch S, Dietrich D : 'Early cortical oligodendrocyte precursor cells are transcriptionally distinct and lack synaptic connections.' Glia, 2023 Sep doi: doi: 10.1002/glia.24388
- Gallus M, Roll W, Dik A, Barca C, Zinnhardt B, Hicking G, Mueller C, Naik VN, Anstötz M, Krämer J, Rolfes L, Wachsmuth L, Pitsch J, van Loo KMJ, Räuber S, Okada H, Wimberley C, Strippel C, Golombeck KS, Johnen A, Kovac S, Groß CC, Backhaus P, Seifert R, Lewerenz J, Surges R, Elger CE, Wiendl H, Ruck T, Becker AJ, Faber C, Jacobs AH, Bauer J, Meuth SG, Schäfers M, Melzer N : 'Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell-mediated limbic encephalitis.' Science advances, 2023 Jun 9 doi: doi: 10.1126/sciadv.abq7595
- Kyriazi M, Müller P, Pitsch J, van Loo KMJ, Quatraccioni A, Opitz T, Schoch S, Becker AJ, Cases-Cunillera S : 'Neurochemical Profile of BRAFV600E/AktT308D/S473D Mouse Gangliogliomas Reveals Impaired GABAergic System Inhibition.' Developmental neuroscience, 2023 doi: doi: 10.1159/000528587
2022
- Van Loo KMJ, Carvill GL, Becker AJ, Conboy K, Goldman AM, Kobow K, Lopes-Cendes I, Reid CA, van Vliet EA, Henshall DC : 'Epigenetic genes and epilepsy - emerging mechanisms and clinical applications.' Nature reviews. Neurology, 2022 Sep doi: doi: 10.1038/s41582-022-00693-y
- Silvennoinen K, Gawel K, Tsortouktzidis D, Pitsch J, Alhusaini S, van Loo KMJ, Picardo R, Michalak Z, Pagni S, Martins Custodio H, Mills J, Whelan CD, de Zubicaray GI, McMahon KL, van der Ent W, Kirstein-Smardzewska KJ, Tiraboschi E, Mudge JM, Frankish A, Thom M, Wright MJ, Thompson PM, Schoch S, Becker AJ, Esguerra CV, Sisodiya SM : 'SCN1A overexpression, associated with a genomic region marked by a risk variant for a common epilepsy, raises seizure susceptibility.' Acta neuropathologica, 2022 Jul doi: doi: 10.1007/s00401-022-02429-0
- Cases-Cunillera S, van Loo KMJ, Pitsch J, Quatraccioni A, Sivalingam S, Salomoni P, Borger V, Dietrich D, Schoch S, Becker AJ : 'Heterogeneity and excitability of BRAFV600E-induced tumors is determined by Akt/mTOR-signaling state and Trp53-loss.' Neuro-oncology, 2022 May 4 doi: doi: 10.1093/neuonc/noab268
2021
- Tsortouktzidis D, Tröscher AR, Schulz H, Opitz T, Schoch S, Becker AJ, van Loo KMJ : 'A Versatile Clustered Regularly Interspaced Palindromic Repeats Toolbox to Study Neurological Ca(V)3.2 Channelopathies by Promoter-Mediated Transcription Control.' Frontiers in molecular neuroscience, 2021 doi: doi: 10.3389/fnmol.2021.667143
- Schoch S, Quatraccioni A, Robens BK, Maresch R, van Loo KMJ, Cases-Cunillera S, Kelly T, Opitz T, Borger V, Dietrich D, Pitsch J, Beck H, Becker AJ : 'Ste20-like Kinase Is Critical for Inhibitory Synapse Maintenance and Its Deficiency Confers a Developmental Dendritopathy.' The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021 Sep 29 doi: doi: 10.1523/JNEUROSCI.0352-21.2021
- Tolve M, Ulusoy A, Patikas N, Islam KUS, Bodea GO, Öztürk E, Broske B, Mentani A, Wagener A, van Loo KMJ, Britsch S, Liu P, Khaled WT, Metzakopian E, Baader SL, Di Monte DA, Blaess S : 'The transcription factor BCL11A defines distinct subsets of midbrain dopaminergic neurons.' Cell reports, 2021 Sep 14 doi: doi: 10.1016/j.celrep.2021.109697
- Pitsch J, van Loo KMJ, Gallus M, Dik A, Kamalizade D, Baumgart AK, Gnatkovsky V, Müller JA, Opitz T, Hicking G, Naik VN, Wachsmuth L, Faber C, Surges R, Kurts C, Schoch S, Melzer N, Becker AJ : 'CD8(+) T-Lymphocyte-Driven Limbic Encephalitis Results in Temporal Lobe Epilepsy.' Annals of neurology, 2021 Apr doi: doi: 10.1002/ana.26000
- Tsortouktzidis D, Schulz H, Hamed M, Vatter H, Surges R, Schoch S, Sander T, Becker AJ, van Loo KMJ : 'Gene expression analysis in epileptic hippocampi reveals a promoter haplotype conferring reduced aldehyde dehydrogenase 5a1 expression and responsiveness.' Epilepsia, 2021 Jan doi: doi: 10.1111/epi.16789
2020
- Pensold D, Reichard J, Van Loo KMJ, Ciganok N, Hahn A, Bayer C, Liebmann L, Groß J, Tittelmeier J, Lingner T, Salinas-Riester G, Symmank J, Halfmann C, González-Bermúdez L, Urbach A, Gehrmann J, Costa I, Pieler T, Hübner CA, Vatter H, Kampa B, Becker AJ, Zimmer-Bensch G : 'DNA Methylation-Mediated Modulation of Endocytosis as Potential Mechanism for Synaptic Function Regulation in Murine Inhibitory Cortical Interneurons.' Cerebral cortex (New York, N.Y. : 1991), 2020 Jun 1 doi: doi: 10.1093/cercor/bhaa009
2019
- van Loo KMJ, Becker AJ : 'Transcriptional Regulation of Channelopathies in Genetic and Acquired Epilepsies.' Frontiers in cellular neuroscience, 2019 doi: doi: 10.3389/fncel.2019.00587
- van Loo KMJ, Rummel CK, Pitsch J, Müller JA, Bikbaev AF, Martinez-Chavez E, Blaess S, Dietrich D, Heine M, Becker AJ, Schoch S : 'Calcium Channel Subunit α2δ4 Is Regulated by Early Growth Response 1 and Facilitates Epileptogenesis.' The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019 Apr 24 doi: doi: 10.1523/JNEUROSCI.1731-18.2019
- Pitsch J, Kuehn JC, Gnatkovsky V, Müller JA, van Loo KMJ, de Curtis M, Vatter H, Schoch S, Elger CE, Becker AJ : 'Anti-epileptogenic and Anti-convulsive Effects of Fingolimod in Experimental Temporal Lobe Epilepsy.' Molecular neurobiology, 2019 Mar doi: doi: 10.1007/s12035-018-1181-y
2018
- Kostoula C, Pascente R, Ravizza T, McCown T, Schoch S, Vezzani A, Becker AJ, van Loo KMJ : 'Development of In Vivo Imaging Tools for Investigating Astrocyte Activation in Epileptogenesis.' Molecular neurobiology, 2018 May doi: doi: 10.1007/s12035-017-0660-x
2016
- Golombeck KS, Bönte K, Mönig C, van Loo KM, Hartwig M, Schwindt W, Widman G, Lindenau M, Becker AJ, Glatzel M, Elger CE, Wiendl H, Meuth SG, Lohmann H, Gross CC, Melzer N : 'Evidence of a pathogenic role for CD8(+) T cells in anti-GABAB receptor limbic encephalitis.' Neurology(R) neuroimmunology & neuroinflammation, 2016 Jun doi: doi: 10.1212/NXI.0000000000000232
- Woitecki AM, Müller JA, van Loo KM, Sowade RF, Becker AJ, Schoch S : 'Identification of Synaptotagmin 10 as Effector of NPAS4-Mediated Protection from Excitotoxic Neurodegeneration.' The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016 Mar 2 doi: doi: 10.1523/JNEUROSCI.2027-15.2016
- Pabst M, Braganza O, Dannenberg H, Hu W, Pothmann L, Rosen J, Mody I, van Loo K, Deisseroth K, Becker AJ, Schoch S, Beck H. Neuron. Astrocyte Intermediaries of Septal Cholinergic Modulation in the Hippocampus., 2016 May 18;90(4):853-65. doi: 10.1016/j.neuron.2016.04.003. Epub 2016 May 5. PMID: 27161528
2015
- van Loo KM, Schaub C, Pitsch J, Kulbida R, Opitz T, Ekstein D, Dalal A, Urbach H, Beck H, Yaari Y, Schoch S, Becker AJ : 'Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1.' Nature communications, 2015 Oct 26 doi: doi: 10.1038/ncomms9688
- Kulbida R, Wang Y, Mandelkow EM, Schoch S, Becker AJ, van Loo KM : 'Molecular imaging reveals epileptogenic Ca2+-channel promoter activation in hippocampi of living mice.' Brain structure & function, 2015 Sep doi: doi: 10.1007/s00429-014-0801-1
2013
- Pernhorst K, van Loo KM, von Lehe M, Priebe L, Cichon S, Herms S, Hoffmann P, Helmstaedter C, Sander T, Schoch S, Becker AJ : 'Rs6295 promoter variants of the serotonin type 1A receptor are differentially activated by c-Jun in vitro and correlate to transcript levels in human epileptic brain tissue.' Brain research, 2013 Mar 7 doi: doi: 10.1016/j.brainres.2012.12.045
2012
- Ekstein D, Benninger F, Daninos M, Pitsch J, van Loo KM, Becker AJ, Yaari Y : 'Zinc induces long-term upregulation of T-type calcium current in hippocampal neurons in vivo.' The Journal of physiology, 2012 Nov 15 doi: doi: 10.1113/jphysiol.2012.242537
- van Loo KM, Schaub C, Pernhorst K, Yaari Y, Beck H, Schoch S, Becker AJ : 'Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST).' The Journal of biological chemistry, 2012 May 4 doi: doi: 10.1074/jbc.M111.310763
2011
- Pernhorst K, Raabe A, Niehusmann P, van Loo KM, Grote A, Hoffmann P, Cichon S, Sander T, Schoch S, Becker AJ : 'Promoter variants determine γ-aminobutyric acid homeostasis-related gene transcription in human epileptic hippocampi.' Journal of neuropathology and experimental neurology, 2011 Dec doi: doi: 10.1097/NEN.0b013e318238b9af
- Van Schijndel JE, Van Zweeden M, Van Loo KM, Djurovic S, Andreassen OA, Hansen T, Werge T, Nyegaard M, Sørensen KM, Nordentoft M, Mortensen PB, Mors O, Børglum AD, Del-Favero J, Norrback KF, Adolfsson R, De Hert M, Claes S, Cichon S, Rietschel M, Nöthen MM, Kallunki P, Pedersen JT, Martens GJ : 'Dual association of a TRKA polymorphism with schizophrenia.' Psychiatric genetics, 2011 Jun doi: doi: 10.1097/YPG.0b013e3283437194
- Moons T, Claes S, Martens GJ, Peuskens J, Van Loo KM, Van Schijndel JE, De Hert M, van Winkel R : 'Clock genes and body composition in patients with schizophrenia under treatment with antipsychotic drugs.' Schizophrenia research, 2011 Feb doi: doi: 10.1016/j.schres.2010.10.008
- van Schijndel JE, van Zweeden M, van Loo KM, Lubbers LJ, Pesman GJ, Sweep FC, Martens GJ : 'Dopamine susceptibility of APO-SUS rats is not per se coupled to HPA-axis activity.' Physiology & behavior, 2011 Feb 1 doi: doi: 10.1016/j.physbeh.2010.10.013
2010
- Van Schijndel JE, Van Zweeden M, Van Loo KM, Martens GJ : 'Gene expression profiling in brain regions of a rat model displaying schizophrenia-related features.' Behavioural brain research, 2010 Mar 5 doi: doi: 10.1016/j.bbr.2009.10.042
2009
- van Loo KM, van Schijndel JE, van Zweeden M, van Manen D, Trip MD, Petersen DC, Schuitemaker H, Hayes VM, Martens GJ : 'Correlation between HIV-1 seropositivity and prevalence of a gamma-secretase polymorphism in two distinct ethnic populations.' Journal of medical virology, 2009 Nov doi: doi: 10.1002/jmv.21601
- van Schijndel JE, van Loo KM, van Zweeden M, Djurovic S, Andreassen OA, Hansen T, Werge T, Kallunki P, Pedersen JT, Martens GJ : 'Three-cohort targeted gene screening reveals a non-synonymous TRKA polymorphism associated with schizophrenia.' Journal of psychiatric research, 2009 Oct doi: doi: 10.1016/j.jpsychires.2009.04.006
2008
- Verheij MM, de Mulder EL, De Leonibus E, van Loo KM, Cools AR : 'Rats that differentially respond to cocaine differ in their dopaminergic storage capacity of the nucleus accumbens.' Journal of neurochemistry, 2008 Jun 1 doi: doi: 10.1111/j.1471-4159.2008.05323.x
- van Loo KM, Dejaegere T, van Zweeden M, van Schijndel JE, Wijmenga C, Trip MD, Martens GJ : 'Male-specific association between a gamma-secretase polymorphism and premature coronary atherosclerosis.' PloS one, 2008 doi: doi: 10.1371/journal.pone.0003662
2007
- van Loo KM, Martens GJ : 'Genetic and environmental factors in complex neurodevelopmental disorders.' Current genomics, 2007 Nov doi: doi: 10.2174/138920207783591717
- van Loo KM, Martens GJ : 'Identification of genetic and epigenetic variations in a rat model for neurodevelopmental disorders.' Behavior genetics, 2007 Sep
2006
- Coolen MW, van Loo KM, Ellenbroek BA, Cools AR, Martens GJ : 'Ontogenic reduction of Aph-1b mRNA and gamma-secretase activity in rats with a complex neurodevelopmental phenotype.' Molecular psychiatry, 2006 Aug
- Coolen MW, van Loo KM, van Bakel NN, Ellenbroek BA, Cools AR, Martens GJ : 'Reduced Aph-1b expression causes tissue- and substrate-specific changes in gamma-secretase activity in rats with a complex phenotype.' FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006 Jan
2005
- Coolen MW, Van Loo KM, Van Bakel NN, Pulford DJ, Serneels L, De Strooper B, Ellenbroek BA, Cools AR, Martens GJ : 'Gene dosage effect on gamma-secretase component Aph-1b in a rat model for neurodevelopmental disorders.' Neuron, 2005 Feb 17
