Unsere Forschungsschwerpunkte

Vorrangiges Thema in der Forschung der Arbeitsgruppe ist die Erstellung von Evidenzsynthesen, die sich inhaltlich vorrangig mit Fragestellungen aus der Anästhesie oder Intensivmedizin beschäftigen. 
Zusätzlich wird das Thema Nachhaltigkeit in der Intensivmedizin erforscht.

  • Evidenzsynthesen
    • Frau Prof. Benstöm besitzt jahrelange Erfahrung in der Erstellung von Evidenzsynthesen. Unterstützt wird sie hierbei von ihrem Team, bei der Suche und Auswertung der Literatur.
  • Nachhaltigkeit
    • Das Thema der Nachhaltigkeit bildet einen weiteren Forschungsschwerpunkt in der AG Evidenzbasierte Gesundheitsforschung in Anästhesie und Intensivmedizin. Dieser Schwerpunkt befindet sich derzeit noch im Aufbau. Sobald erste Ergebnisse vorliegen, werden wir hier darüber informieren.
  • Nakatake R, Schulz M, Kalvelage C, Benstoem C, Tolba RH. Effects of iNOS in Hepatic Warm Ischaemia and Reperfusion Models in Mice and Rats: A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences. 2022; 23(19):11916. doi.org/10.3390/ijms231911916
  • Berg T, Benstoem C, Moza AK. VAD Patients’ Perception of Potential Telemedicine Support. International Journal of Environmental Research and Public Health. 2022; 19(7):3768. doi.org/10.3390/ijerph19073768
  • Dohmen S, Wahl A, Benstoem C. Digital gestützte intensivmedizinische Versorgungsnetzwerke [Digital Based Intensive Care Networks]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2022;57(3):211-220. doi:10.1055/a-1423-7982
  • Marx G, Greiner W, Juhra C, Elkenkamp S, Gensorowsky D, Lemmen S, Englbrecht J, Dohmen S, Gottschalk A, Haverkamp M, Hempen A, Flügel-Bleienheuft C, Bause D, Schulze-Steinen H, Rademacher S, Kistermann J, Hoch S, Beckmann HJ, Lanckohr C, Lowitsch V, Peine A, Juzek-Kuepper F, Benstoem C, Sperling K, Deisz R. An Innovative Telemedical Network to Improve Infectious Disease Management in Critically Ill Patients and Outpatients (TELnet@NRW): Stepped-Wedge Cluster Randomized Controlled Trial. J Med Internet Res. 2022;24(3):e34098. Published 2022 Mar 2. doi:10.2196/34098
  • Laaf E, Benstoem C, Rossaint R, Wendt S, Fitzner C, Moza A, Zayat R, Hill A, Heyland DK, Schomburg L, Goetzenich A, Stoppe C. High-dose supplementation of selenium in left ventricular assist device implant surgery: A double-blinded, randomized controlled pilot trial. JPEN J Parenter Enteral Nutr. 2022 Aug;46(6):1412-1419. doi: 10.1002/jpen.2309
  • Ansems K, Grundeis F, Dahms K, Mikolajewska A, Thieme V, Piechotta V, Metzendorf MI, Stegemann M, Benstoem C, Fichtner F. Remdesivir for the treatment of COVID-19. Cochrane Database Syst Rev. 2021 Aug 5;8(8):CD014962. doi: 10.1002/14651858.CD014962
  • Stroehlein JK, Wallqvist J, Iannizzi C, Mikolajewska A, Metzendorf MI, Benstoem C, Meybohm P, Becker M, Skoetz N, Stegemann M, Piechotta V. Vitamin D supplementation for the treatment of COVID-19: a living systematic review. Cochrane Database Syst Rev. 2021 May 24;5(5):CD015043. doi: 10.1002/14651858.CD015043
  • Kalvelage C, Rademacher S, Dohmen S, Marx G, Benstoem C. Decision-Making Authority During Tele-ICU Care Reduces Mortality and Length of Stay-A Systematic Review and Meta-Analysis. Crit Care Med. 2021 Jul 1;49(7):1169-1181. doi: 10.1097/CCM.0000000000004943
  • Petran J, Ansems K, Rossaint R, Marx G, Kalvelage C, Kopp R, Benstoem C, Brülls C. Effects of hypercapnia versus normocapnia during general anesthesia on outcomes: a systematic review and meta-analysis. Braz J Anesthesiol. 2022 May-Jun;72(3):398-406. doi: 10.1016/j.bjane.2020.11.010
  • Dohmen S, Benstoem C, Wahl A, Offermann A, Marx G. Qualitätssteigerung in der Intensivmedizin durch Telemedizin: Beispiel TELnet@NRW [Quality Improvement in Intensive Care Through Telemedicine: the TELnet@NRW Example]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2021 Jan;56(1):52-59. German. doi: 10.1055/a-1288-4587
  • Reintam Blaser A, Preiser JC, Fruhwald S, Wilmer A, Wernerman J, Benstoem C, Casaer MP, Starkopf J, van Zanten A, Rooyackers O, Jakob SM, Loudet CI, Bear DE, Elke G, Kott M, Lautenschläger I, Schäper J, Gunst J, Stoppe C, Nobile L, Fuhrmann V, Berger MM, Oudemans-van Straaten HM, Arabi YM, Deane AM; Working Group on Gastrointestinal Function within the Section of Metabolism, Endocrinology and Nutrition (MEN Section) of ESICM. Gastrointestinal dysfunction in the critically ill: a systematic scoping review and research agenda proposed by the Section of Metabolism, Endocrinology and Nutrition of the European Society of Intensive Care Medicine. Crit Care. 2020 May 15;24(1):224. doi: 10.1186/s13054-020-02889-4
  • Benstoem C, Kalvelage C, Breuer T, Heussen N, Marx G, Stoppe C, Brandenburg V. Ivabradine as adjuvant treatment for chronic heart failure. Cochrane Database Syst Rev. 2020 Nov 4;11(11):CD013004. doi: 10.1002/14651858.CD013004.pub2
  • Reintam Blaser A, Gunst J, Ichai C, Casaer MP, Benstoem C, Besch G, Dauger S, Fruhwald SM, Hiesmayr M, Joannes-Boyau O, Malbrain MLNG, Perez MH, Schaller SJ, de Man A, Starkopf J, Tamme K, Wernerman J, Berger MM. Hypophosphatemia in critically ill adults and children - A systematic review. Clin Nutr. 2021 Apr;40(4):1744-1754. doi: 10.1016/j.clnu.2020.09.045
  • Kalvelage C, Stoppe C, Marx N, Marx G, Benstoem C. Ivabradine for the Therapy of Chronic Stable Angina Pectoris: a Systematic Review and Meta-Analysis. Korean Circ J. 2020 Sep;50(9):773-786. doi: 10.4070/kcj.2020.0031
  • Hill A, Clasen KC, Wendt S, Majoros ÁG, Stoppe C, Adhikari NKJ, Heyland DK, Benstoem C. Effects of Vitamin C on Organ Function in Cardiac Surgery Patients: A Systematic Review and Meta-Analysis. Nutrients. 2019 Sep 4;11(9):2103. doi: 10.3390/nu11092103. Erratum in: Nutrients. 2020 Dec 21;12(12)
  • Stoppe C, Ney J, Lomivorotov VV, Efremov SM, Benstoem C, Hill A, Nesterova E, Laaf E, Goetzenich A, McDonald B, Peine A, Marx G, Fehnle K, Heyland DK. Prediction of Prolonged ICU Stay in Cardiac Surgery Patients as a Useful Method to Identify Nutrition Risk in Cardiac Surgery Patients: A Post Hoc Analysis of a Prospective Observational Study. JPEN J Parenter Enteral Nutr. 2019 Aug;43(6):768-779. doi: 10.1002/jpen.1486
  • Ney J, Heyland DK, Amrein K, Marx G, Grottke O, Choudrakis M, Autschbach T, Hill A, Meybohm P, Benstoem C, Goetzenich A, Fitzner C, Stoppe C. The relevance of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D concentration for postoperative infections and postoperative organ dysfunctions in cardiac surgery patients: The eVIDenCe study. Clin Nutr. 2019 Dec;38(6):2756-2762. doi: 10.1016/j.clnu.2018.11.033
  • Wendt S, Goetzenich A, Goettsch C, Stoppe C, Bleilevens C, Kraemer S, Benstoem C. Evaluation of the cardioprotective potential of extracellular vesicles - a systematic review and meta-analysis. Sci Rep. 2018 Oct 24;8(1):15702. doi: 10.1038/s41598-018-33862-5
  • Hill A, Wendt S, Benstoem C, Neubauer C, Meybohm P, Langlois P, Adhikari NK, Heyland DK, Stoppe C. Vitamin C to Improve Organ Dysfunction in Cardiac Surgery Patients-Review and Pragmatic Approach. Nutrients. 2018 Jul 27;10(8):974. doi: 10.3390/nu10080974
  • Benstoem C, Bleilevens C, Borchard R, Stoppe C, Goetzenich A, Autschbach R, Breuer T. Retrospective Analysis of Air Handling by Contemporary Oxygenators in the Setting of Cardiac Surgery. Ann Thorac Cardiovasc Surg. 2018 Oct 19;24(5):230-237. doi: 10.5761/atcs.oa.18-00019. Epub 2018 Jul 11. Erratum in: Ann Thorac Cardiovasc Surg. 2018;24(6):328
  • Bleilevens C, Hill A, Grzanna T, Fechter T, Bohnen M, Weber HJ, Beckers C, Borosch S, Zayat R, Benstoem C, Rossaint R, Goetzenich A. In vitro head-to-head comparison of anticoagulation properties of two heparin brands in a human blood miniature mock loop. Interact Cardiovasc Thorac Surg. 2019 Jan 1;28(1):120-127. doi: 10.1093/icvts/ivy206
  • Benstoem C, Goetzenich A, Autschbach R, Marx G, Stoppe C, Breuer T. Volatile anesthetics versus propofol in the cardiac surgical setting of remote ischemic preconditioning: a secondary analysis of a Cochrane Systematic Review. Minerva Anestesiol. 2018 Nov;84(11):1298-1306. doi: 10.23736/S0375-9393.18.12465-5
  • Benstoem C, Wübker R, Lüngen M, Breuer T, Marx G, Autschbach R, Goetzenich A, Schnoering H. „Sense-of-coherence“-Skala nach Antonovsky als möglicher Prädiktor für den Wiedereinstieg in das Berufsleben für herzchirurgische Intensivpatienten [Sense of Coherence Scale according to Antonovsky as a possible predictor for return to work for cardiac surgery intensive care patients]. Anaesthesist. 2018 Jul;67(7):512-518. German. doi: 10.1007/s00101-018-0448-z
  • Hill A, Nesterova E, Lomivorotov V, Efremov S, Goetzenich A, Benstoem C, Zamyatin M, Chourdakis M, Heyland D, Stoppe C. Current Evidence about Nutrition Support in Cardiac Surgery Patients-What Do We Know? Nutrients. 2018 May 11;10(5):597. doi: 10.3390/nu10050597
  • Ney J, Hoffmann K, Meybohm P, Goetzenich A, Kraemer S, Benstöm C, Weber NC, Bickenbach J, Rossaint R, Marx G, Zacharowski K, Bernhagen J, Stoppe C. Remote Ischemic Preconditioning Does Not Affect the Release of Humoral Factors in Propofol-Anesthetized Cardiac Surgery Patients: A Secondary Analysis of the RIPHeart Study. Int J Mol Sci. 2018 Apr 5;19(4):1094. doi: 10.3390/ijms19041094
  • Benstoem C, Goetzenich A, Stoppe C. The role of propofol for remote ischaemic preconditioning in the setting of cardiac surgery - a Cochrane systematic review. Br J Anaesth. 2017 Dec 1;119(6):1234-1235. doi: 10.1093/bja/aex357
  • Benstoem C, Moza A, Meybohm P, Stoppe C, Autschbach R, Devane D, Goetzenich A. A core outcome set for adult cardiac surgery trials: A consensus study. PLoS One. 2017 Nov 2;12(11):e0186772. doi: 10.1371/journal.pone.0186772
  • Berg T, Tewarie L, Moza A, Zayat R, Autschbach R, Stoppe C, Goetzenich A, Benstoem C. Anforderungen an die ambulante Versorgung nach Implantation eines ventrikulären Herzunterstützungssystems : Sichtweise von Patienten und Angehörigen [Requirements for outpatient care after implantation of a ventricular assist device : Views of patients and their relatives]. Herz. 2019 May;44(3):257-264. German. doi: 10.1007/s00059-017-4636-4
  • Stoppe C, Goetzenich A, Whitman G, Ohkuma R, Brown T, Hatzakorzian R, Kristof A, Meybohm P, Mechanick J, Evans A, Yeh D, McDonald B, Chourdakis M, Jones P, Barton R, Tripathi R, Elke G, Liakopoulos O, Agarwala R, Lomivorotov V, Nesterova E, Marx G, Benstoem C, Lemieux M, Heyland DK. Role of nutrition support in adult cardiac surgery: a consensus statement from an International Multidisciplinary Expert Group on Nutrition in Cardiac Surgery. Crit Care. 2017 Jun 5;21(1):131. doi: 10.1186/s13054-017-1690-5
  • Benstoem C, Stoppe C, Liakopoulos OJ, Ney J, Hasenclever D, Meybohm P, Goetzenich A. Remote ischaemic preconditioning for coronary artery bypass grafting (with or without valve surgery). Cochrane Database Syst Rev. 2017 May 5;5(5):CD011719. doi: 10.1002/14651858.CD011719.pub3
  • Stoppe C, Meybohm P, Benstoem C, Goetzenich A. Remote ischemic preconditioning in cardiac anesthesia: a review focusing on translation. Minerva Anestesiol. 2017 Jun;83(6):610-623. doi: 10.23736/S0375-9393.17.11756-6
  • Moza A, Benstoem C, Autschbach R, Stoppe C, Goetzenich A. A core outcome set for all types of cardiac surgery effectiveness trials: a study protocol for an international eDelphi survey to achieve consensus on what to measure and the subsequent selection of measurement instruments. Trials. 2015 Dec 2;16:545. doi: 10.1186/s13063-015-1072-8
  • Breuer T, Emontzpohl C, Coburn M, Benstoem C, Rossaint R, Marx G, Schälte G, Bernhagen J, Bruells CS, Goetzenich A, Stoppe C. Xenon triggers pro-inflammatory effects and suppresses the anti-inflammatory response compared to sevoflurane in patients undergoing cardiac surgery. Crit Care. 2015 Oct 15;19:365. doi: 10.1186/s13054-015-1082-7
  • Stoppe C, McDonald B, Benstoem C, Elke G, Meybohm P, Whitlock R, Fremes S, Fowler R, Lamarche Y, Jiang X, Day AG, Heyland DK. Evaluation of Persistent Organ Dysfunction Plus Death As a Novel Composite Outcome in Cardiac Surgical Patients. J Cardiothorac Vasc Anesth. 2016 Jan;30(1):30-8. doi: 10.1053/j.jvca.2015.07.035
  • Benstoem C, Goetzenich A, Kraemer S, Borosch S, Manzanares W, Hardy G, Stoppe C. Selenium and its supplementation in cardiovascular disease--what do we know? Nutrients. 2015 Apr 27;7(5):3094-118. doi: 10.3390/nu7053094
  • Benstoem C, Moza A, Autschbach R, Stoppe C, Goetzenich A. Evaluating outcomes used in cardiothoracic surgery interventional research: a systematic review of reviews to develop a core outcome set. PLoS One. 2015 Apr 1;10(4):e0122204. doi: 10.1371/journal.pone.0122204
  • Begley CM, Gross MM, Dencker A, Benstoem C, Berg M, Devane D. Outcome measures in studies on the use of oxytocin for the treatment of delay in labour: a systematic review. Midwifery. 2014 Sep;30(9):975-82. doi: 10.1016/j.midw.2014.06.005
  • Smith V, Daly D, Lundgren I, Eri T, Benstoem C, Devane D. Salutogenically focused outcomes in systematic reviews of intrapartum interventions: a systematic review of systematic reviews. Midwifery. 2014 Apr;30(4):e151-6. doi: 10.1016/j.midw.2013.11.002