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Open positions at MOCA

Im Institut für Molekulare und Zelluläre Anatomie der Uniklinik RWTH Aachen sind zum frühestmöglichen Zeitpunkt folgende Stellen zu besetzen: 

PhD Student:
Keratin intermediate filament network dynamics

Keratin intermediate filaments are major constituents of the epithelial cytoskeleton. Their organizing function of cellular space is important for diverse epithelial functions requiring a high degree of keratin network plasticity. We have recently proposed that a continuous cycle of keratin filament assembly and disassembly facilitates rapid and precise adaptation to the different functional requirements.

The successful candidate will (i) further refine methods and tools for monitoring and manipulating the keratin cycle and its modulators, (ii) focus on identifying and characterizing the molecular motors involved in keratin movement and tension generation within the keratin network, and (iii) examine modulators of the keratin cycle that are identified in genetic screens.

We are looking for a candidate with experience in molecular biology, microscopical techniques and image analysis. The candidate should have a strong background in cell biology. It is expected that the successful candidate is highly motivated to independently pursue the DFG-funded project as a basis for a PhD thesis.

Further information

Please send your written application as soon as possible to:

Prof. Dr. Rudolf E. Leube
Institute of Molecular and Cellular Anatomy
RWTH Aachen
UniversityWendlingweg 2
52074 Aachen
rleube@remove-this.ukaachen.de

 

PhD Student:
Compromised distribution of desmosomal proteins with pathogenic mutation amics

Arrhythmogenic cardiomyopathy (AC) is an inherited heart disease for which no pathomechanism-based therapy exists. AC may lead to sudden cardiac death and chronic heart failure. The desmoglein 2 gene (DSG2) is one of the most frequently mutated genes in AC. DSG2 codes for a calcium dependent transmebrane prtoein that localizes to desmosomal cell-cell adhesions. In the heart, desmoglein 2 proteins (Dsg2) are part of a complex electromechanic coupling structure known as the intercalated disc. Even though DSG2 point mutations were identified in patient pedigrees and have been shown to give rise to an AC-like phenotype in mice, only little is known about the compromised properties of mutated Dsg2.

The successful PhD candidate will establish and refine biochemical and microscopical methods to investigate the biosynthesis, transport and degradation of mutated Dsg2. Functional characterization of the mutated proteins will be performed in cell culture systems and will be validated in existing AC model mice.

We are looking for a candidate with experience in molecular biology, microscopical techniques and protein trafficking. The candidate should have a strong background in cell biology. It is expected that the successful candidate is highly motivated to independently pursue the project as part of a PhD thesis.

Further information

Please send your written application as soon as possible to:
Dr. Sebastian Kant
Institute of Molecular and Cellular Anatomy
RWTH Aachen University
Wendlingweg 2
52074 Aachen
skant@remove-this.ukaachen.de

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