The DEAD-box helicase eIF4A1/2 acts as RNA chaperone during mitotic exit enabling chromatin decondensation

• Our new work on how DEAD-box helicase eIF4A1/2 regulates the composition and fluidity of the mitotic perichromatin layer has just been published.For more info, look the paper at Nature Communications and do not hesitate to contact us.
• This moonlighting activity of eIF4A1/2 is independent of its primary function as a transcription factor and is crucial for the dynamic reorganization of chromatin as cells exit mitosis.
• We are very happy to share our research that has been only possible thanks to the dedication of Ramona Jühlen, Sabine Wiesmann, Wolfram Antonin and the great team at the Institute of Biochemistry and Molecular Cell Biology, Medical School, Uniklinik RWTH Aachen University