Clinical pharmacogenetic research

In our clinical research projects, we focus on variability in drug effects between patients. Differences in drug response and safety depend on individual parameters and life circumstances such as age, pharmacogenetic profiles, disease characteristics, and comedication. By assessing individual differences in therapy outcomes, we intend to better understand vulnerability and therapy risk factors but also get insights into off-target effects of drugs and substances thereby enabling studies on new molecular pathways of drug action. Our current clinical research projects focus on implementation of pharmacogenetic testing into clinical practice (U-PGx), and on age-related susceptibility to drug side effects and the association with pharmacogenetic risk profiles and frailty (ADRED, ActiFE Ulm).