In order to understand the effect of a drug on the body, it is important to understand how it is metabolized and which factors can influence drug metabolism. The individual genetic make-up often plays an important role in determining how effective a particular drug is and whether undesirable side effects occur. However, other aspects such as the tissue compartment in which the drug is localized, interactions with other drugs or enzymes and the presence of other exo- or endogenous chemical substances can also alter the functionality of drug metabolizing enzymes. For a better understanding of human drug metabolism, we conduct multidisciplinary research at the interfaces of pharmacology, biochemistry, enzymology and medicinal chemistry. Our enzymatic research projects aim to provide deeper insights into metabolic profiles and the factors that influence them. The knowledge gained in this way should contribute to safe and effective drug therapy.