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Stimulus strength determines the BTK-dependence of the SHIP1- deficient phenotype in IgE/antigen-triggered mast cells

Antigen-mediated crosslinking of IgE-loaded high-affinity receptors for IgE (FcεRI) on mast cells triggers activation of proinflammatory effector functions relevant for IgE-associated allergic...

Unexpected IgG-independent tyrosine phosphorylation of the inhibitory IgG receptor FcγRIIB in antigen/allergen-activated mast cells

The high-affinity receptor for IgE (FcγRI) is crucial for the IgE/antigen-triggered allergic activation of mast cells. This activation follows a so-called bell-shaped dose-response curve with weak...

Finally a role of CD13/aminopeptidase N in myeloid cells: Negative regulation of mast cell activation in vitro and in vivo

CD13 (aminopeptidase N) is a type-II membrane protein with an extracellular zinc-dependent metalloprotease domain. CD13 was originally identified as a surface protein in myeloid cells, however, its...

"Caspase-3 revisited" – New functions for an old acquaintance

Caspase-3 is a central execution caspase contributing to and finalizing the process of induced cell death, also know as apoptosis. Caspase-3 is localized in the cytoplasm and proteolytically activated...

Forschungsbericht 2012

Forschungsbericht 2012 als PDF-Download