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Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy
The integrated stress response (ISR) converges on eIF2α phosphorylation to regulate protein synthesis. ISR is activated by several stress conditions, including endoplasmic reticulum (ER) stress,…
Stimulus strength determines the BTK-dependence of the SHIP1- deficient phenotype in IgE/antigen-triggered mast cells
Antigen-mediated crosslinking of IgE-loaded high-affinity receptors for IgE (FcεRI) on mast cells triggers activation of proinflammatory effector functions relevant for IgE-associated allergic…
Unexpected IgG-independent tyrosine phosphorylation of the inhibitory IgG receptor FcγRIIB in antigen/allergen-activated mast cells
The high-affinity receptor for IgE (FcγRI) is crucial for the IgE/antigen-triggered allergic activation of mast cells. This activation follows a so-called bell-shaped dose-response curve with weak…
Finally a role of CD13/aminopeptidase N in myeloid cells: Negative regulation of mast cell activation in vitro and in vivo
CD13 (aminopeptidase N) is a type-II membrane protein with an extracellular zinc-dependent metalloprotease domain. CD13 was originally identified as a surface protein in myeloid cells, however, its…
"Caspase-3 revisited" – New functions for an old acquaintance
Caspase-3 is a central execution caspase contributing to and finalizing the process of induced cell death, also know as apoptosis. Caspase-3 is localized in the cytoplasm and proteolytically activated…
Forschungsbericht 2012
Forschungsbericht 2012 als PDF-Download
