Publications

Meijer, EM,van Dijk, CGM,Kramann, R,Verhaar, MC,Cheng, C. Implementation of Pericytes in Vascular Regeneration Strategies. Tissue Eng Part B Rev. 2021

Dugourd, A,Kuppe, C,Sciacovelli, M,Gjerga, E,Gabor, A,Emdal, KB,Vieira, V,Bekker-Jensen, DB,Kranz, J,Bindels, EMJ,Costa, ASH,Sousa, A,Beltrao, P,Rocha, M,Olsen, JV,Frezza, C,Kramann, R,Saez-Rodriguez, J. Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses. Mol Syst Biol 2021
PMID: 33502086

Kuppe, C.,Ibrahim, M. M.,Kranz, J.,Zhang, X.,Ziegler, S.,Perales-Paton, J.,Jansen, J.,Reimer, K. C.,Smith, J. R.,Dobie, R.,Wilson-Kanamari, J. R.,Halder, M.,Xu, Y.,Kabgani, N.,Kaesler, N.,Klaus, M.,Gernhold, L.,Puelles, V. G.,Huber, T. B.,Boor, P.,Menzel, S.,Hoogenboezem, R. M.,Bindels, E. M. J.,Steffens, J.,Floege, J.,Schneider, R. K.,Saez-Rodriguez, J.,Henderson, N. C.,Kramann, R. Decoding myofibroblast origins in human kidney fibrosis. Nature 2021, 589, 281-286

Kuppe, C.,Perales-Paton, J.,Saez-Rodriguez, J.,Kramann, R. Experimental and computational technologies to dissect the kidney at the single-cell level. Nephrol Dial Transplant 2021

Bouteldja, N.,Klinkhammer, B.M.,Bülow, R.D. Droste, P.,Otten, S.W.,Freifrau von Stillfried, S.,Moellmann, J.,Sheehan, S.M.,Korstanje, R.,Menzel, S.,Bankhead, P.,Mietsch, M.,Drummer, C.,Lehrke, M.,Kramann, R.,Floege, J.,Boor, P.,Merhof, D. Deep Learning-Based Segmentation and Quantification in experimental Kidney Histopathology. J Am Soc Nephrol. 2021, 32, 52-68

Zewinger, S.,Reiser, J.,Jankowski, V.,Alansary, D.,Hahm, E.,Triem, S.,Klug, M.,Schunk, S. J.,Schmit, D.,Kramann, R.,Körbel, C.,Ampofo, E.,Laschke, M. W.,Selejan, S. R.,Paschen, A.,Herter, T.,Schuster, S.,Silbernagel, G.,Sester, M.,Sester, U.,Aßmann, G.,Bals, R.,Kostner, G.,Jahnen-Dechent, W.,Menger, M. D.,Rohrer, L.,März, W.,Böhm, M.,Jankowski, J.,Kopf, M.,Latz, E.,Niemeyer, B. A.,Fliser, D.,Laufs, U.,Speer, T. Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation. Nat Immunol 2020, 21, 30-41.

Tajti, F.,Kuppe, C.,Antoranz, A.,Ibrahim, M. M.,Kim, H.,Ceccarelli, F.,Holland, C. H.,Olauson, H.,Floege, J.,Alexopoulos, L. G.,Kramann, R.,Saez-Rodriguez, J. A Functional Landscape of CKD Entities From Public Transcriptomic Data. Kidney Int Rep 2020, 5, 211-224.

Sellmayr, M.,Hernandez Petzsche, M. R.,Ma, Q.,Krüger, N.,Liapis, H.,Brink, A.,Lenz, B.,Angelotti, M. L.,Gnemmi, V.,Kuppe, C.,Kim, H.,Bindels, E. M. J.,Tajti, F.,Saez-Rodriguez, J.,Lech, M.,Kramann, R.,Romagnani, P.,Anders, H. J.,Steiger, S. Only Hyperuricemia with Crystalluria, but not Asymptomatic Hyperuricemia, Drives Progression of Chronic Kidney Disease. J Am Soc Nephrol 2020.

Lanzer, J. D.,Leuschner, F.,Kramann, R.,Levinson, R. T.,Saez-Rodriguez, J. Big Data Approaches in Heart Failure Research. Curr Heart Fail Rep 2020, 17, 213-224.

Kuppe, C.,Ramirez Flores, R. O.,Li, Z.,Hannani, M. T.,Tanevski, J.,Halder, M.,Cheng, M.,Ziegler, S.,Zhang, X.,Priester, F.,Kaesler, N.,Xu, Y.,Hoogenboezem, R.,Bindels, E.,Schneider-Kramann, R.,Milting, H.,Gesteira Costa Filho, I.,Saez Rodriguez, J.,Kramann, R. Spatial multi-omic map of human myocardial infarction. bioRxiv 2020, 2020.2012.2008.411686.

Kaesler, N.,Goettsch, C.,Weis, D.,Schurgers, L.,Hellmann, B.,Floege, J.,Kramann, R. Magnesium but not nicotinamide prevents vascular calcification in experimental uraemia. Nephrol Dial Transplant 2020, 35, 65-73.

Kaesler, N.,Babler, A.,Floege, J.,Kramann, R. Cardiac Remodeling in Chronic Kidney Disease. Toxins (Basel) 2020, 12.

Herrmann, M.,Babler, A.,Moshkova, I.,Gremse, F.,Kiessling, F.,Kusebauch, U.,Nelea, V.,Kramann, R.,Moritz, R. L.,McKee, M. D.,Jahnen-Dechent, W. Lumenal calcification and microvasculopathy in fetuin-A-deficient mice lead to multiple organ morbidity. PLoS One 2020, 15, e0228503.

Gleitz, H.,Dugourd, A. J. F.,Leimkühler, N. B.,Snoeren, I. A. M.,Fuchs, S. N. R.,Menzel, S.,Ziegler, S.,Kroeger, N.,Triviai, I.,Büsche, G.,Kreipe, H.,Banjanin, B.,Pritchard, J.,Hoogenboezem, R.,Bindels, E.,Schumacher, N.,Rose-John, S.,Elf, S.,Saez-Rodriguez, J.,Kramann, R.,Schneider, R. K. Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN. Blood 2020.

Broeker, K. A. E.,Fuchs, M. A. A.,Schrankl, J.,Kurt, B.,Nolan, K. A.,Wenger, R. H.,Kramann, R.,Wagner, C.,Kurtz, A. Different subpopulations of kidney interstitial cells produce erythropoietin and factors supporting tissue oxygenation in response to hypoxia in vivo. Kidney Int 2020.

Brandt, S.,Ballhause, T. M.,Bernhardt, A.,Becker, A.,Salaru, D.,Le-Deffge, H. M.,Fehr, A.,Fu, Y.,Philipsen, L.,Djudjaj, S.,Müller, A. J.,Kramann, R.,Ibrahim, M.,Geffers, R.,Siebel, C.,Isermann, B.,Heidel, F. H.,Lindquist, J. A.,Mertens, P. R. Fibrosis and Immune Cell Infiltration Are Separate Events Regulated by Cell-Specific Receptor Notch3 Expression. J Am Soc Nephrol 2020.

Akbulut, A. C.,Pavlic, A.,Petsophonsakul, P.,Halder, M.,Maresz, K.,Kramann, R.,Schurgers, L. Vitamin K2 Needs an RDI Separate from Vitamin K1. Nutrients 2020, 12.

Leimkühler, N.B.,Gleitz, H.F.E.,Ronghui, L.,Snoeren, I.A.M.,Fuchs, S.N.R.,Nagai, J.S.,Banjanin, B.,Lam, K.H.,Vogl, T.,Kuppe, C.,Stalmann, U.S.A.,Büsche, G.,Kreipe, H.,Gütgemann, I.,Krebs, P.,Banz, Y.,Boor, P.,Tai, E.W.,Brümmendorf, T.H.,Koschmieder, S.,Crysandt, M.,Bindels, E.,Kramann, R.,Costa, I.G.,Schneider, R.K. Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis. Cell Stem Cell 2020, S1934-5909, 30542-30547

Meijer, E.M.,van Dijk, C.G.M.,Kramann, R.,Verhaar, M.C.,Cheng, C. Implementation of pericytes in vascular regeneration strategies. Tissue Eng Part B Rev. 2020

van Kuijk, K.,Kuppe, C.,Betsholtz, C.,Vanlandewijck, M.,Kramann, R.,Sluimer, J. C. Heterogeneity and plasticity in healthy and atherosclerotic vasculature explored by single-cell sequencing. Cardiovasc Res 2019, 115, 1705-1715.

Sun, Q.,Baues, M.,Klinkhammer, B. M.,Ehling, J.,Djudjaj, S.,Drude, N. I.,Daniel, C.,Amann, K.,Kramann, R.,Kim, H.,Saez-Rodriguez, J.,Weiskirchen, R.,Onthank, D. C.,Botnar, R. M.,Kiessling, F.,Floege, J.,Lammers, T.,Boor, P. Elastin imaging enables noninvasive staging and treatment monitoring of kidney fibrosis. Sci Transl Med 2019, 11.

Saritas, T.,Puelles, V. G.,Su, X. T.,Ellison, D. H.,Kramann, R. Optical Clearing and Imaging of Immunolabeled Kidney Tissue. J Vis Exp 2019.

Saritas, T.,Cuevas, C. A.,Ferdaus, M. Z.,Kuppe, C.,Kramann, R.,Moeller, M. J.,Floege, J.,Singer, J. D.,McCormick, J. A. Disruption of CUL3-mediated ubiquitination causes proximal tubule injury and kidney fibrosis. Sci Rep 2019, 9, 4596.

Saez-Rodriguez, J.,Rinschen, M. M.,Floege, J.,Kramann, R. The authors reply. Kidney Int 2019, 96, 1422-1423.

Saez-Rodriguez, J.,Rinschen, M. M.,Floege, J.,Kramann, R. Big science and big data in nephrology. Kidney Int 2019, 95, 1326-1337.

Rohwer, N.,Jumpertz, S.,Erdem, M.,Egners, A.,Warzecha, K. T.,Fragoulis, A.,Kühl, A. A.,Kramann, R.,Neuss, S.,Rudolph, I.,Endermann, T.,Zasada, C.,Apostolova, I.,Gerling, M.,Kempa, S.,Hughes, R.,Lewis, C. E.,Brenner, W.,Malinowski, M. B.,Stockmann, M.,Schomburg, L.,Faller, W.,Sansom, O. J.,Tacke, F.,Morkel, M.,Cramer, T. Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis. Oncogene 2019, 38, 5670-5685.

Ribezzo, F.,Snoeren, I. A. M.,Ziegler, S.,Stoelben, J.,Olofsen, P. A.,Henic, A.,Ferreira, M. V.,Chen, S.,Stalmann, U. S. A.,Buesche, G.,Hoogenboezem, R. M.,Kramann, R.,Platzbecker, U.,Raaijmakers, M.,Ebert, B. L.,Schneider, R. K. Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome. Leukemia 2019, 33, 1759-1772.

Puelles, V. G.,van der Wolde, J. W.,Wanner, N.,Scheppach, M. W.,Cullen-McEwen, L. A.,Bork, T.,Lindenmeyer, M. T.,Gernhold, L.,Wong, M. N.,Braun, F.,Cohen, C. D.,Kett, M. M.,Kuppe, C.,Kramann, R.,Saritas, T.,van Roeyen, C. R.,Moeller, M. J.,Tribolet, L.,Rebello, R.,Sun, Y. B.,Li, J.,Müller-Newen, G.,Hughson, M. D.,Hoy, W. E.,Person, F.,Wiech, T.,Ricardo, S. D.,Kerr, P. G.,Denton, K. M.,Furic, L.,Huber, T. B.,Nikolic-Paterson, D. J.,Bertram, J. F. mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans. JCI Insight 2019, 4.

Puelles, V. G.,Fleck, D.,Ortz, L.,Papadouri, S.,Strieder, T.,Böhner, A. M. C.,van der Wolde, J. W.,Vogt, M.,Saritas, T.,Kuppe, C.,Fuss, A.,Menzel, S.,Klinkhammer, B. M.,Müller-Newen, G.,Heymann, F.,Decker, L.,Braun, F.,Kretz, O.,Huber, T. B.,Susaki, E. A.,Ueda, H. R.,Boor, P.,Floege, J.,Kramann, R.,Kurts, C.,Bertram, J. F.,Spehr, M.,Nikolic-Paterson, D. J.,Moeller, M. J. Novel 3D analysis using optical tissue clearing documents the evolution of murine rapidly progressive glomerulonephritis. Kidney Int 2019, 96, 505-516.

Jahn, L.,Kramann, R.,Marx, N.,Floege, J.,Becker, M.,Schlieper, G. Speckle Tracking Echocardiography and All-Cause and Cardiovascular Mortality Risk in Chronic Kidney Disease Patients. Kidney Blood Press Res 2019, 44, 690-703.

Halder, M.,Petsophonsakul, P.,Akbulut, A. C.,Pavlic, A.,Bohan, F.,Anderson, E.,Maresz, K.,Kramann, R.,Schurgers, L. Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease. Int J Mol Sci 2019, 20.

Brandt, M. M.,van Dijk, C. G. M.,Maringanti, R.,Chrifi, I.,Kramann, R.,Verhaar, M. C.,Duncker, D. J.,Mokry, M.,Cheng, C. Transcriptome analysis reveals microvascular endothelial cell-dependent pericyte differentiation. Sci Rep 2019, 9, 15586.

Brandenburg, V. M.,Schuh, A.,Kramann, R. Valvular Calcification in Chronic Kidney Disease. Adv Chronic Kidney Dis 2019, 26, 464-471.

Schurgers, L. J.,Akbulut, A. C.,Kaczor, D. M.,Halder, M.,Koenen, R. R.,Kramann, R. Initiation and Propagation of Vascular Calcification Is Regulated by a Concert of Platelet- and Smooth Muscle Cell-Derived Extracellular Vesicles. Front Cardiovasc Med 2018, 5, 36.

Schneider, R. K.,Mullally, A.,Dugourd, A.,Peisker, F.,Hoogenboezem, R.,Van Strien, P. M. H.,Bindels, E. M.,Heckl, D.,Büsche, G.,Fleck, D.,Müller-Newen, G.,Wongboonsin, J.,Ventura Ferreira, M.,Puelles, V. G.,Saez-Rodriguez, J.,Ebert, B. L.,Humphreys, B. D.,Kramann, R. Gli1(+) Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target. Cell Stem Cell 2018, 23, 308-309.

Noels, H.,Boor, P.,Goettsch, C.,Hohl, M.,Jahnen-Dechent, W.,Jankowski, V.,Kindermann, I.,Kramann, R.,Lehrke, M.,Linz, D.,Maack, C.,Niemeyer, B.,Roma, L. P.,Schuett, K.,Speer, T.,Wagenpfeil, S.,Werner, C.,Zewinger, S.,Böhm, M.,Marx, N.,Floege, J.,Fliser, D.,Jankowski, J. The new SFB/TRR219 Research Centre. Eur Heart J 2018, 39, 975-977.

Kramann, R.,Schneider, R. K. The identification of fibrosis-driving myofibroblast precursors reveals new therapeutic avenues in myelofibrosis. Blood 2018, 131, 2111-2119.

Kramann, R.,Machado, F.,Wu, H.,Kusaba, T.,Hoeft, K.,Schneider, R. K.,Humphreys, B. D. Parabiosis and single-cell RNA sequencing reveal a limited contribution of monocytes to myofibroblasts in kidney fibrosis. JCI Insight 2018, 3.

Kaesler, N.,Verhulst, A.,De Maré, A.,Deck, A.,Behets, G. J.,Hyusein, A.,Evenepoel, P.,Floege, J.,Marx, N.,Babler, A.,Kramer, I.,Kneissel, M.,Kramann, R.,Weis, D.,D'Haese, P. C.,Brandenburg, V. M. Sclerostin deficiency modifies the development of CKD-MBD in mice. Bone 2018, 107, 115-123.

Höhne, M.,Frese, C. K.,Grahammer, F.,Dafinger, C.,Ciarimboli, G.,Butt, L.,Binz, J.,Hackl, M. J.,Rahmatollahi, M.,Kann, M.,Schneider, S.,Altintas, M. M.,Schermer, B.,Reinheckel, T.,Göbel, H.,Reiser, J.,Huber, T. B.,Kramann, R.,Seeger-Nukpezah, T.,Liebau, M. C.,Beck, B. B.,Benzing, T.,Beyer, A.,Rinschen, M. M. Single-nephron proteomes connect morphology and function in proteinuric kidney disease. Kidney Int 2018, 93, 1308-1319.

Gleitz, H. F.,Kramann, R.,Schneider, R. K. Understanding deregulated cellular and molecular dynamics in the haematopoietic stem cell niche to develop novel therapeutics for bone marrow fibrosis. J Pathol 2018, 245, 138-146.

Schneider, R. K.,Mullally, A.,Dugourd, A.,Peisker, F.,Hoogenboezem, R.,Van Strien, P. M. H.,Bindels, E. M.,Heckl, D.,Büsche, G.,Fleck, D.,Müller-Newen, G.,Wongboonsin, J.,Ventura Ferreira, M.,Puelles, V. G.,Saez-Rodriguez, J.,Ebert, B. L.,Humphreys, B. D.,Kramann, R. Gli1(+) Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target. Cell Stem Cell 2017, 20, 785-800.e788.

Mukherjee, E.,Maringer, K.,Papke, E.,Bushnell, D.,Schaefer, C.,Kramann, R.,Ho, J.,Humphreys, B. D.,Bates, C.,Sims-Lucas, S. Endothelial marker-expressing stromal cells are critical for kidney formation. Am J Physiol Renal Physiol 2017, 313, F611-f620.

Kramann, R.,Wongboonsin, J.,Chang-Panesso, M.,Machado, F. G.,Humphreys, B. D. Gli1(+) Pericyte Loss Induces Capillary Rarefaction and Proximal Tubular Injury. J Am Soc Nephrol 2017, 28, 776-784.

El Agha, E.,Kramann, R.,Schneider, R. K.,Li, X.,Seeger, W.,Humphreys, B. D.,Bellusci, S. Mesenchymal Stem Cells in Fibrotic Disease. Cell Stem Cell 2017, 21, 166-177.

Brandenburg, V. M.,Reinartz, S.,Kaesler, N.,Krüger, T.,Dirrichs, T.,Kramann, R.,Peeters, F.,Floege, J.,Keszei, A.,Marx, N.,Schurgers, L. J.,Koos, R. Slower Progress of Aortic Valve Calcification With Vitamin K Supplementation: Results From a Prospective Interventional Proof-of-Concept Study. Circulation 2017, 135, 2081-2083.

Brandenburg, V. M.,Kramann, R.,Rothe, H.,Kaesler, N.,Korbiel, J.,Specht, P.,Schmitz, S.,Krüger, T.,Floege, J.,Ketteler, M. Calcific uraemic arteriolopathy (calciphylaxis): data from a large nationwide registry. Nephrol Dial Transplant 2017, 32, 126-132.

Ventura Ferreira, M. S.,Bergmann, C.,Bodensiek, I.,Peukert, K.,Abert, J.,Kramann, R.,Kachel, P.,Rath, B.,Rütten, S.,Knuchel, R.,Ebert, B. L.,Fischer, H.,Brümmendorf, T. H.,Schneider, R. K. An engineered multicomponent bone marrow niche for the recapitulation of hematopoiesis at ectopic transplantation sites. J Hematol Oncol 2016, 9, 4.

Schneider, R. K.,Schenone, M.,Ferreira, M. V.,Kramann, R.,Joyce, C. E.,Hartigan, C.,Beier, F.,Brümmendorf, T. H.,Germing, U.,Platzbecker, U.,Büsche, G.,Knüchel, R.,Chen, M. C.,Waters, C. S.,Chen, E.,Chu, L. P.,Novina, C. D.,Lindsley, R. C.,Carr, S. A.,Ebert, B. L. Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9. Nat Med 2016, 22, 288-297.

Maarouf, O. H.,Aravamudhan, A.,Rangarajan, D.,Kusaba, T.,Zhang, V.,Welborn, J.,Gauvin, D.,Hou, X.,Kramann, R.,Humphreys, B. D. Paracrine Wnt1 Drives Interstitial Fibrosis without Inflammation by Tubulointerstitial Cross-Talk. J Am Soc Nephrol 2016, 27, 781-790.

Kuppe, C.,Kramann, R. Role of mesenchymal stem cells in kidney injury and fibrosis. Curr Opin Nephrol Hypertens 2016, 25, 372-377.

Kramann, R.,Goettsch, C.,Wongboonsin, J.,Iwata, H.,Schneider, R. K.,Kuppe, C.,Kaesler, N.,Chang-Panesso, M.,Machado, F. G.,Gratwohl, S.,Madhurima, K.,Hutcheson, J. D.,Jain, S.,Aikawa, E.,Humphreys, B. D. Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease. Cell Stem Cell 2016, 19, 628-642.

Kramann, R. Hedgehog Gli signalling in kidney fibrosis. Nephrol Dial Transplant 2016, 31, 1989-1995.

Goettsch, C.,Hutcheson, J. D.,Aikawa, M.,Iwata, H.,Pham, T.,Nykjaer, A.,Kjolby, M.,Rogers, M.,Michel, T.,Shibasaki, M.,Hagita, S.,Kramann, R.,Rader, D. J.,Libby, P.,Singh, S. A.,Aikawa, E. Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. J Clin Invest 2016, 126, 1323-1336.

Brandenburg, V. M.,Kaesler, N.,Kramann, R.,Floege, J.,Marx, N. [Magnesium: a kardio-renal viewpoint]. Dtsch Med Wochenschr 2016, 141, 1537-1542.

Brandenburg, V. M.,Evenepoel, P.,Floege, J.,Goldsmith, D.,Kramann, R.,Massy, Z.,Mazzaferro, S.,Schurgers, L. J.,Sinha, S.,Torregrosa, V.,Ureña-Torres, P.,Vervloet, M.,Cozzolino, M. Lack of evidence does not justify neglect: how can we address unmet medical needs in calciphylaxis? Nephrol Dial Transplant 2016, 31, 1211-1219.

Barros, X.,Dirrichs, T.,Koos, R.,Reinartz, S.,Kaesler, N.,Kramann, R.,Gladziwa, U.,Ketteler, M.,Floege, J.,Marx, N.,Torregrosa, J. V.,Keszei, A.,Brandenburg, V. M. Epicardial adipose tissue in long-term hemodialysis patients: its association with vascular calcification and long-term development. J Nephrol 2016, 29, 241-250.

Kramann, R.,Schneider, R. K.,DiRocco, D. P.,Machado, F.,Fleig, S.,Bondzie, P. A.,Henderson, J. M.,Ebert, B. L.,Humphreys, B. D. Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis. Cell Stem Cell 2015, 16, 51-66.

Kramann, R.,Kusaba, T.,Humphreys, B. D. Who regenerates the kidney tubule? Nephrol Dial Transplant 2015, 30, 903-910.

Kramann, R.,Fleig, S. V.,Schneider, R. K.,Fabian, S. L.,DiRocco, D. P.,Maarouf, O.,Wongboonsin, J.,Ikeda, Y.,Heckl, D.,Chang, S. L.,Rennke, H. G.,Waikar, S. S.,Humphreys, B. D. Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis. J Clin Invest 2015, 125, 2935-2951.

Schneider, R. K.,Ademà, V.,Heckl, D.,Järås, M.,Mallo, M.,Lord, A. M.,Chu, L. P.,McConkey, M. E.,Kramann, R.,Mullally, A.,Bejar, R.,Solé, F.,Ebert, B. L. Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS. Cancer Cell 2014, 26, 509-520.

Kusaba, T.,Lalli, M.,Kramann, R.,Kobayashi, A.,Humphreys, B. D. Differentiated kidney epithelial cells repair injured proximal tubule. Proc Natl Acad Sci U S A 2014, 111, 1527-1532.

Kramann, R.,Tanaka, M.,Humphreys, B. D. Fluorescence microangiography for quantitative assessment of peritubular capillary changes after AKI in mice. J Am Soc Nephrol 2014, 25, 1924-1931.

Kramann, R.,Humphreys, B. D. Kidney pericytes: roles in regeneration and fibrosis. Semin Nephrol 2014, 34, 374-383.

Kramann, R.,Erpenbeck, J.,Schneider, R. K.,Röhl, A. B.,Hein, M.,Brandenburg, V. M.,van Diepen, M.,Dekker, F.,Marx, N.,Floege, J.,Becker, M.,Schlieper, G. Speckle tracking echocardiography detects uremic cardiomyopathy early and predicts cardiovascular mortality in ESRD. J Am Soc Nephrol 2014, 25, 2351-2365.

Klinkhammer, B. M.,Kramann, R.,Mallau, M.,Makowska, A.,van Roeyen, C. R.,Rong, S.,Buecher, E. B.,Boor, P.,Kovacova, K.,Zok, S.,Denecke, B.,Stuettgen, E.,Otten, S.,Floege, J.,Kunter, U. Mesenchymal stem cells from rats with chronic kidney disease exhibit premature senescence and loss of regenerative potential. PLoS One 2014, 9, e92115.

Kramann, R.,Schneider, R. K. Parathyroid hormone-related protein and regulation of cell survival in the kidney. Kidney Int 2013, 83, 777-779.

Kramann, R.,Kunter, U.,Brandenburg, V. M.,Leisten, I.,Ehling, J.,Klinkhammer, B. M.,Knüchel, R.,Floege, J.,Schneider, R. K. Osteogenesis of heterotopically transplanted mesenchymal stromal cells in rat models of chronic kidney disease. J Bone Miner Res 2013, 28, 2523-2534.

Kramann, R.,Dirocco, D. P.,Maarouf, O. H.,Humphreys, B. D. Matrix Producing Cells in Chronic Kidney Disease: Origin, Regulation, and Activation. Curr Pathobiol Rep 2013, 1.

Kramann, R.,DiRocco, D. P.,Humphreys, B. D. Understanding the origin, activation and regulation of matrix-producing myofibroblasts for treatment of fibrotic disease. J Pathol 2013, 231, 273-289.

Kramann, R.,Brandenburg, V. M.,Schurgers, L. J.,Ketteler, M.,Westphal, S.,Leisten, I.,Bovi, M.,Jahnen-Dechent, W.,Knüchel, R.,Floege, J.,Schneider, R. K. Novel insights into osteogenesis and matrix remodelling associated with calcific uraemic arteriolopathy. Nephrol Dial Transplant 2013, 28, 856-868.

Koos, R.,Brandenburg, V.,Mahnken, A. H.,Schneider, R.,Dohmen, G.,Autschbach, R.,Marx, N.,Kramann, R. Sclerostin as a potential novel biomarker for aortic valve calcification: an in-vivo and ex-vivo study. J Heart Valve Dis 2013, 22, 317-325.

Brandenburg, V. M.,Kramann, R.,Koos, R.,Krüger, T.,Schurgers, L.,Mühlenbruch, G.,Hübner, S.,Gladziwa, U.,Drechsler, C.,Ketteler, M. Relationship between sclerostin and cardiovascular calcification in hemodialysis patients: a cross-sectional study. BMC Nephrol 2013, 14, 219.

Yagmur, E.,Koch, A.,Haumann, M.,Kramann, R.,Trautwein, C.,Tacke, F. Hyaluronan serum concentrations are elevated in critically ill patients and associated with disease severity. Clin Biochem 2012, 45, 82-87.

van de Kamp, J.,Kramann, R.,Anraths, J.,Schöler, H. R.,Ko, K.,Knüchel, R.,Zenke, M.,Neuss, S.,Schneider, R. K. Epithelial morphogenesis of germline-derived pluripotent stem cells on organotypic skin equivalents in vitro. Differentiation 2012, 83, 138-147.

Leisten, I.,Kramann, R.,Ventura Ferreira, M. S.,Bovi, M.,Neuss, S.,Ziegler, P.,Wagner, W.,Knüchel, R.,Schneider, R. K. 3D co-culture of hematopoietic stem and progenitor cells and mesenchymal stem cells in collagen scaffolds as a model of the hematopoietic niche. Biomaterials 2012, 33, 1736-1747.

Kramann, R.,Frank, D.,Brandenburg, V. M.,Heussen, N.,Takahama, J.,Krüger, T.,Riehl, J.,Floege, J. Prognostic impact of renal arterial resistance index upon renal allograft survival: the time point matters. Nephrol Dial Transplant 2012, 27, 3958-3963.

Kramann, R.,Floege, J.,Ketteler, M.,Marx, N.,Brandenburg, V. M. Medical options to fight mortality in end-stage renal disease: a review of the literature. Nephrol Dial Transplant 2012, 27, 4298-4307.

Kramann, R.,Couson, S. K.,Neuss, S.,Floege, J.,Knüchel, R.,Schneider, R. K. Uraemia disrupts the vascular niche in a 3D co-culture system of human mesenchymal stem cells and endothelial cells. Nephrol Dial Transplant 2012, 27, 2693-2702.

Brandenburg, V. M.,Kramann, R.,Specht, P.,Ketteler, M. Calciphylaxis in CKD and beyond. Nephrol Dial Transplant 2012, 27, 1314-1318.

Kramann, R.,Moeller, M. J. The next level of complexity: post-transcriptional regulation by microRNAs. Kidney Int 2011, 80, 692-693.

Kramann, R.,Couson, S. K.,Neuss, S.,Kunter, U.,Bovi, M.,Bornemann, J.,Knüchel, R.,Jahnen-Dechent, W.,Floege, J.,Schneider, R. K. Exposure to uremic serum induces a procalcific phenotype in human mesenchymal stem cells. Arterioscler Thromb Vasc Biol 2011, 31, e45-54.

Schneider, R. K.,Püllen, A.,Kramann, R.,Bornemann, J.,Knüchel, R.,Neuss, S.,Perez-Bouza, A. Long-term survival and characterisation of human umbilical cord-derived mesenchymal stem cells on dermal equivalents. Differentiation 2010, 79, 182-193.

Schneider, R. K.,Puellen, A.,Kramann, R.,Raupach, K.,Bornemann, J.,Knuechel, R.,Pérez-Bouza, A.,Neuss, S. The osteogenic differentiation of adult bone marrow and perinatal umbilical mesenchymal stem cells and matrix remodelling in three-dimensional collagen scaffolds. Biomaterials 2010, 31, 467-480.

Schneider, R. K.,Anraths, J.,Kramann, R.,Bornemann, J.,Bovi, M.,Knüchel, R.,Neuss, S. The role of biomaterials in the direction of mesenchymal stem cell properties and extracellular matrix remodelling in dermal tissue engineering. Biomaterials 2010, 31, 7948-7959.

Becker, M.,Lenzen, A.,Ocklenburg, C.,Stempel, K.,Kühl, H.,Neizel, M.,Katoh, M.,Kramann, R.,Wildberger, J.,Kelm, M.,Hoffmann, R. Myocardial deformation imaging based on ultrasonic pixel tracking to identify reversible myocardial dysfunction. J Am Coll Cardiol 2008, 51, 1473-1481.

Becker, M.,Kramann, R.,Franke, A.,Breithardt, O. A.,Heussen, N.,Knackstedt, C.,Stellbrink, C.,Schauerte, P.,Kelm, M.,Hoffmann, R. Impact of left ventricular lead position in cardiac resynchronization therapy on left ventricular remodelling. A circumferential strain analysis based on 2D echocardiography. Eur Heart J 2007, 28, 1211-1220.

Becker, M.,Kramann, R.,Dohmen, G.,Lückhoff, A.,Autschbach, R.,Kelm, M.,Hoffmann, R. Impact of left ventricular loading conditions on myocardial deformation parameters: analysis of early and late changes of myocardial deformation parameters after aortic valve replacement. J Am Soc Echocardiogr 2007, 20, 681-689.

Becker, M.,Franke, A.,Breithardt, O. A.,Ocklenburg, C.,Kaminski, T.,Kramann, R.,Knackstedt, C.,Stellbrink, C.,Hanrath, P.,Schauerte, P.,Hoffmann, R. Impact of left ventricular lead position on the efficacy of cardiac resynchronisation therapy: a two-dimensional strain echocardiography study. Heart 2007, 93, 1197-1203.

Becker, M.,Hoffmann, R.,Kühl, H. P.,Grawe, H.,Katoh, M.,Kramann, R.,Bücker, A.,Hanrath, P.,Heussen, N. Analysis of myocardial deformation based on ultrasonic pixel tracking to determine transmurality in chronic myocardial infarction. Eur Heart J 2006, 27, 2560-2566.

Becker, M.,Bilke, E.,Kühl, H.,Katoh, M.,Kramann, R.,Franke, A.,Bücker, A.,Hanrath, P.,Hoffmann, R. Analysis of myocardial deformation based on pixel tracking in two dimensional echocardiographic images enables quantitative assessment of regional left ventricular function. Heart 2006, 92, 1102-1108.