Ongoing projects

  • hiPSC-derived 3D assembloids to investigate the neurodegenerative propagation along the corticospinal tract in ALS (funded by the DFG – Prof. Catanese)
  • Investigation of novel JNK inhibitors on motor neuron survival in MND (funded by the My Name´5 Doddie Foundation – Prof. Catanese; collaboration project led by Dr. Laszlo and Dr. Henstridge, Sheffield University)
  • Uncovering the role of Synaptotagmin13 in determining motor neuron vulnerability (funded by the DFG – Prof. Catanese)
  • Preclinical Validation of a Repurposed Drug Identified Through Multiomic Analysis for ALS Treatment (funded by LifeArc – Prof. Catanese; collaboration project with Prof. Lingor and Dr. Bonetto)
  • Pathomechanisms linked to rare PFN1 variants in ALS (funded by the DGM – Dr. Steffke)