Publikationen
- Nagel, M., Niestroj M., Bansal R., Fleck D., Lampert A., Stopkova R., Ben-Shaul Y., Spehr M. “The rules of sex and strain: deciphering the chemical language of inbred and wild mouse conspecific scents.” eLife. 2023.
- Anna Maxion, Ekaterina Kutafina, Maike Dohrn, Pierre Sacré, Angelika Lampert, Jenny Tigerholm, Barbara Namer. “A modelling study to dissect the potential role of voltage-gated ion channels in activity-dependent conduction velocity changes as identified in small fiber neuropathy patients.” Front. Comput. Neurosci. 2023.
- Annette Lischka, Katja Eggermann, Christopher J Record, Maike F Dohrn, Petra Laššuthová, Florian Kraft, Matthias Begemann, Daniela Dey, Thomas Eggermann, Jana Šoukalová, Matilde Laura, Alexander M Rossor, Radim Mazanec, Jonas Van Lent, Pedro J Tomaselli, Martin Ungelenk, Karlien Debus, Shawna M E Feely, Dieter Gläser, Sujatha Jagadeesh, Madelena Martin, Geeta M Govindaraj, Pratibha Singhi, Revanth Baineni, Marisol Ibarra-Ramírez, Maryse Bonduelle, Burkhard Gess, Juan Romero Sánchez, Renu Suthar, Vrajesh Udani, Atchayaram Nalini, Gopikrishnan Unnikrishnan, Wilson Marques Junior, Sandra Mercier, Vincent Procaccio, Céline Bris, Sheela Nampoothiri, Wolfgang Müller-Felber, Katharina Vill, Tobias B Haack, Behiye S Bolgül, Michael Abele, Yesim Parman, Pavel Seeman, Angelika Lampert, Jörg B Schulz, John N Wood, James J Cox, Michaela Auer-Grumbach, Jonathan Baets, Jonathan de Winter, Andreas Themistocleous, Michael Shy, David L Bennett, Vincent Timmerman, Christian A Hübner, Enrico Leipold, Stefan Züchner, Jan Senderek, Miriam Elbracht, Arman Çakar, Thorsten Hornemann, C Geoffrey Woods, Mary M Reilly, Ingo Kurth. “Genetic landscape of congenital insensitivity to pain and hereditary sensory and autonomic neuropathies.” Brain. 2023.
- Schwarzenauer, M., R. M. Rukwied, A. Lampert, R. Rolke, B. Namer. “Electrical matrix stimulation suppresses acute itch independently of activation of sleeping nociceptors.” Eur J Pain. 2024 Epub 2023.
- Sophia Kriegeskorte, Raya Bott, Martin Hampl, Alon Korngreen, Ralf Hausmann*, Angelika Lampert* “Cold and warmth intensify pain-linked sodium channel gating effects and persistent currents” J Gen Physiol 2023.
- Grohs L, Cheng L, Cönen S, Haddad BG, Bülow A, Toklucu I, Ernst L, Körner J, Schmalzing G, Lampert A, Machtens JP, Hausmann R. “Diclofenac and other non-steroidal anti-inflammatory drugs (NSAIDs) are competitive antagonists of the human P2X3 receptor”. Front Pharmacol. 2023.
Sierra-Marquez J, J Gehlen, M Schöneck, S Bungert-Plümke, A Willuweit, C Balduin, F Müller, A Lampert, C Fahlke, RM Guzman. „ ClC-3 regulates the excitability of nociceptive neurons and is involved in inflammatory processes within the spinal sensory pathway” Frontiers in Cellular Neuroscience, Research Topic: Insights in Cellular Neurophysiology.Front. Cell. Neurosci., 24 August 2023.
- Neureiter A., Eberhardt E., Lampert A.“Differentiation of iPS-cells into peripheral sensory neurons” Methods in Molecular Biology “Stem Cell Assays”, Springer Nature, Methods and Protocols.1st ed. 2022.
- Körner J., Haag N., Kurth I., Lampert A. “Genetics meets function in sodium channel-related pain disorders” Neuroforum 2022.
- Scheliga, S., Kellermann T., Lampert A., Rolke R., Spehr M. and Habel U. „Neural correlates of multisensory integration in the human brain: An ALE meta-analysis.” Reviews in the Neurosciences 2022.
- Lampert A., Bennett D. L., Üceyler N., Dib-Hajj S. D. “Human Cells and Tissue in Pre-clinical Studies: Induced Pluripotent Stem Cells.” IASP Fact Sheets 2022.Lischka, A., P. Lassuthova, A. Çakar, C.J. Record, J. Van Lent, J. Baets, M. F. Dohrn, J. Senderek, A. Lampert, D. L. Bennett, J.N. Wood, V. Timmerman, T. Hornemann, M. Auer-Grumbach, Y. Parman, C. A. Hübner, M. Elbracht, K. Eggermann, C. G. Woods, J.J. Cox, M. M. Reill and I. Kurth “Genetic pain loss disorders.” Nature Reviews Disease Primers 2022.
- Dohrn* MF, C Dumke*, T Hornemann, S Nikolin, A Lampert, V Espenkott, J Vollert, A Ouwenbroek, M Zanella, JB Schulz, B Gess, Roman Rolke. Deoxy-sphingolipids, oxidative stress, and vitamin C correlate with qualitative and quantitative patterns of small fiber dysfunction and degeneration. Pain. 2022.Deoxy-sphingolipids, oxidative stress, and vitamin C correlate with qualitative and quantitative patterns of small fiber dysfunction and degeneration. Pain. 2022.
- Körner, J, S Albani, V Sudha Bhagavath Eswaran, AB Roehl, G Rossetti, A Lampert. „Sodium Channels and Local Anesthetics—Old Friends With New Perspectives.” Front Pharmacol. 2022.
- Körner J. and Lampert A. “Functional subgroups of rat and human sensory neurons: a systematic review of electrophysiological properties.” Special issue on “Electrophysiology of Nociception” in European Journal of Physiology, 2022.
- Haag, N. and Lampert A. “Nociception, Transcriptomics ET CETERA: NOCICEPTRA” European Journal of Physiology, 2022.
- Heinrichs* B, B Liu*, J Zhang, JE Meents, KT Le, A Erickson, P Hautvast, X Zhu, N Li, Y Liu, M Spehr, U Habel, M Rothermel, B Namer, X Zhang, A Lampert#, G Duan#. “The Potential Effect of Nav1.8 in Autism Spectrum Disorder: Evidence From a Congenital Case With Compound Heterozygous SCN10A Mutations” Frontiers in Molecular Neuroscience, accepted.
- Le Cann K, A Foerster, C Rösseler, A Erickson, P Hautvast, S Giesselmann, D Pensold, I Kurth, M Rothermel, VB Mattis, G Zimmer, S von Hörsten, B Denecke, T Clarner, J Meents, A Lampert. “The difficulty to model Huntington’s Disease in vitro using striatal Medium Spiny Neurons differentiated from human induced pluripotent stem cells.” Scientific Reports, 2021; 11: 6934
- Le Cann K., Meents JE, Eswaran VSB, Dohrn MF, Bott R, Maier A, Bialer M, Hautvast P, Erickson A, Rolke R, Rothermel M, Körner J, Kurth I, Lampert A. “Assessing the impact of pain-linked Nav1.7 variants: An example of two variants with no biophysical effect.” Channels (Austin). 2021 Jan;15(1):208-228
- Cypris O, Eipel M, Franzen J, Rösseler C, Tharmapalan V, Kuo CC, Vieri M, Nikolić M, Kirschner M, Brümmendorf TH, Zenke M, Lampert A, Beier F, Wagner W.
PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation.
Clin Epigenetics. 2020 Aug 20;12(1):125. - Israel MR, TS Dash, SN Bothe, SD Robinson, JR Deuis, DJ Craik, A Lampert, I Vetter, T Durek.
Characterization of Synthetic Tf2 as a NaV1.3 Selective Pharmacological Probe.
Biomedicines 2020, 8(6), 155 - Jo HG, O. Wudarczyk, M. Leclerc, C. Regenbogen, A. Lampert, M. Rothermel, U. Habel.
Effect of odor pleasantness on heat-induced pain: An fMRI study.
Brain Imaging and Behavior, 2020 Aug 8. - Kerth CM, Hautvast P, Körner J, Lampert A, Meents JE. “Phosphorylation of a chronic pain mutation in the voltage-gated sodium channel Nav1.7 increases voltage sensitivity.” J Biol Chem. 2020 Dec 22
- Lampert, A, DL Bennett, LA McDermott, A Neureiter, E Eberhardt, B Winner, M Zenke. „Human sensory neurons derived from pluripotent stem cells for disease modelling and personalized medicine.” Neurobiology of pain, 2020 Nov 18;8:100055.
- Liu BW, Zhang J, Hong YS, Li NB, Liu Y, Zhang M, Wu WY, Zheng H, Lampert A, Zhang XW.
NGF-Induced Nav1.7 Upregulation Contributes to Chronic Post-surgical Pain by Activating SGK1-Dependent Nedd4-2 Phosphorylation.
Mol Neurobiol. 2020 Oct 16. - Mehrjardi NZ, Molcanyi M, Hatay FF, Timmer M, Shahbazi E, Ackermann JP, Herms S, Heilmann-Heimbach S, Wunderlich TF, Prochnow N, Haghikia A, Lampert A, Hescheler J, Neugebauer EAM, Baharvand H, Šarić T.
Acquisition of chromosome 1q duplication in parental and genome edited human induced pluripotent stem cell-derived neural stem cells results in their higher proliferation rate in vitro and in vivo.
Cell Prolif. 2020 Oct;53(10):e12892. - Rühlmann, AH, J Körner, R Hausmann, N Bebrivenski, C Neuhof, S Detro-Dassen, P Hautvast, CA Benasolo, J Meents, JP Machtens, G Schmalzing, A Lampert.
Uncoupling sodium channel dimers rescues the phenotype of a pain-linked Nav1.7 mutation.
British Journal of Pharmacology, 2020 Jul 14. doi: 10.1111/bph.15196. - Thull S, Neacsu C, O'Reilly AO, Bothe S, Hausmann R, Huth T, Meents J, Lampert A.
Dataset of electrophysiological patch-clamp recordings of the effect of the compounds deltamethrin, ATx-II and β4-peptide on human cardiac Nav1.5 sodium channel gating properties.
Data in Brief, 8 June 2020, 105844 - Thull S, Neacsu C, O'Reilly AO, Bothe S, Hausmann R, Huth T, Meents J, Lampert A.
Mechanism underlying hooked resurgent-like tail currents induced by an insecticide in human cardiac Nav1.5.
Toxicol Appl Pharmacol. 2020 Apr 14:115010. doi: 10.1016/j.taap.2020.115010 - Weber S, Lampert A, Stingl J, Peuckmann-Post V, Hiddemann S, Elsner F, Neuner I, Rolke R. “Basic Knowledge of Drug Pain Therapy in the Palliative Situation” [Article in German] Dtsch Med Wochenschr. 2020 Jul;145(13):917-925. doi: 10.1055/a-1016-9941. Epub 2020 Jul 2
- Effraim, P.R., J. Huang, A. Lampert, S. Stamboulian, P. Zhao, J. A. Black, S. G. Waxman, S. D. Dib-Hajj. Fibroblast Growth Factor Homologous Factor 2 (FGF-13) associates with Nav1.7 in DRG neurons and alters its current properties in an isoform-dependent manner. Neurobiology of Pain, 6, 2019, 1000029
- Maroni M, Körner J, Schüttler J, Winner B, Lampert A, Eberhardt E.
β1 and β3 subunits amplify mechanosensitivity of the cardiac voltage-gated sodium channel Nav1.5. Pflugers Arch. 2019 Dec;471(11-12):1481-1492. - Ciotu CI, Tsantoulas C, Meents J, Lampert A, McMahon SB, Ludwig A, Fischer MJM.
Noncanonical Ion Channel Behaviour in Pain.
Int J Mol Sci. 2019 Sep 15;20(18). - Obrecht AS, Urban N, Schaefer M, Röse A, Kless A, Meents JE, Lampert A, Abdelrahman A, Müller CE, Schmalzing G, Hausmann R.
Identification of aurintricarboxylic acid as a potent allosteric antagonist of P2X1 and P2X3 receptors.
Neuropharmacology. 2019 Nov 1;158:107749. - Meents, J.E.*, E. Bressan*, S. Sontag*, A. Foerster*, P. Hautvast, C. Rösseler, M. Hampl, H. Schüler, R. Goetzke, T. K. Chi Le, I. P. Kleggetveit, K.Le Cann, C. Kerth, A. M. Rush, M. Rogers, Z. Kohl, M. Schmelz, W. Wagner, E. Jørum, B. Namer, B. Winner, M. Zenke, A. Lampert.
The role of Nav1.7 in human nociceptors: insights from human iPS cell-derived sensory neurons of erythromelalgia patients
Pain, 2019 March 22. - Dohrn MF, Lampert A, Üçeyler N, Kurth I.
Neuropathic pain syndromes and channelopathies
[Article in German] Internist (Berl). 2019 Jan; 60(1):90-97.
- Namer B., D. Schmidt, E. Eberhardt, M. Maroni, E. Dorfmeister, I. P. Kleggetveit, L. Kaluza, J. Meents, A. Gerlach, Z. Lin, A. Winterpacht, E. Dragicevic, Z. Kohl, J. Schüttler, I. Kurth, T. Warncke, E. Jorum, B. Winner*, A. Lampert*. “Pain relief in a neuropathy patient by lacosamide: proof of principle of clinical translation from patient-specific iPS cell-derived nociceptors.” EbioMedicine, 2018.
- Legradi J.B., C. Di Paolo, M. H. S. Kraak, H. G. van der Geest, E. L. Schymanski, A. J. Williams, M. M. L. Dingemans, R. Massei, W. Brack, X. Cousin, M.‑L. Begout, R. van der Oost, A. Carion, V. Suarez‑Ulloa, F. Silvestre, B. I. Escher, M. Engwall, G. Nilén, S. H. Keiter, D. Pollet, P. Waldmann, C. Kienle, I. Werner, A.‑C. Haigis, D. Knapen, L. Vergauwen, M. Spehr, W. Schulz, W. Busch, D. Leuthold, S. Scholz, C. M. vom Berg, N. Basu, C. A. Murphy, A. Lampert, J. Kuckelkorn, T. Grummt and H. Hollert. “An ecotoxicological view on neurotoxicity Assessment.” Environmental Science Europe, 2018, 30:46.
- Schrenk-Siemens, K., C. Rösseler, A. Lampert. Translational Model Systems for Complex Sodium Channel Pathophysiology in Pain. Handbook of Experimental Pharmacology, 2018, doi: 10.1007/164_2017_91
- Körner J, Meents JE, Machtens JP, Lampert A. β1 subunit stabilises sodium channel Nav1.7 against mechanical stress. Journal of Phyisology, 2018 https://doi.org/10.1113/JP27590
- Meents JE, Juhasz K, Stölzle-Feix S, Peuckmann-Post V, Rolke R, Lampert A. The opioid oxycodone use-dependently inhibits the cardiac sodium channel Nav1.5. Brit J Pharmacol, 2018. https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.14348
- Almog, M., T. Barkai, A. Lampert, A. Korngreen. “Voltage-gated sodium channels in neocortical pyramidal neurons display Cole-Moore activation kinetics”. Frontiers in Cellular Neuroscience, 2018.
- Kist AM, Lampert A, O'Reilly AO.
DIsulfide Mapping PLanner Software Tool.
J Comput Biol. 2017 Aug 17. doi: 10.1089/cmb.2017.0129. [Epub ahead of print] - O'Reilly AO, Lattrell A, Miles AJ, Klinger AB, Nau C, Wallace BA, Lampert A.
Mutagenesis of the NaChBac sodium channel discloses a functional role for a conserved S6 asparagine.
Eur Biophys J. 2017 Aug 20. doi: 10.1007/s00249-017-1246-2. [Epub ahead of print]
- Kist, A.M., D. Sagafos, A. M. Rush, C. Neacsu, E. Eberhardt, R. Schmidt, L. K. Lunden, K. Ørstavik, L. Kaluza, J. Meents, Z. Zhang, T. H. Carr, H. Salter, D. Malinowsky, P. Wollberg, J. Krupp, I. P. Kleggetveit, M. Schmelz, E. Jørum*, A. Lampert*, B. Namer*
SCN10A Mutation in a patient with Erythromelalgia enhances C-fiber activity dependent slowing.
PLoS One. 2016 Sep 6;11(9) - Mishra HK, Prots I, Havlicek S, Kohl Z, Perez-Branguli F, Boerstler T, Anneser L, Minakaki G, Wend H, Hampl M, Leone M, Brückner M, Klucken J, Reis A, Boyer L, Schuierer G, Behrens J, Lampert A, Engel FB, Gage FH, Winkler J, Winner B.
GSK3ß-dependent dysregulation of neurodevelopment in SPG11-patient iPSC model.
Ann Neurol. 2016 Mar 11. - Hampl* M., Eberhardt* E., O'Reilly AO, Lampert A.
Sodium channel slow inactivation interferes with open channel block.
Sci Rep. 2016, May 13;6:25974 - E. Shahbazi, S. Moradi, S. Nemati, L. Satarian, M. Basiri, H. Gourabi, N. Z. Mehrjardi, P. Günther, A. Lampert, K. Händler, M. Molcanyi, D. Schmidt, F. Hatay, J. Hescheler, J. L. Schultze, T. Šarić, H. Baharvand.
Generation of Stably Self-Renewing Neural Stem Cells by Conversion of Human Fibroblasts with a Single Zinc-Finger Transcription Factor.
Stem Cell Reports, 2016 Apr 12;6(4):539-51. - Meents, J. E. und A. Lampert.
Studying sodium channel gating in heterologous expression systems.
Patch-Clamp Analysis: Advanced Techniques, Third Edition, Volume 113 of the series Neuromethods, pp 37-65
- Lampert, A., W. Stühmer, S. G. Waxman.
Sodium channels.
eLS (encyclopedia of Life Sciences) – Wiley Online Library, 2015
(DOI: 10.1002/9780470015902.a0000127.pub2) - Tigerholm J., M.E. Petersson, O. Obreja, E. Eberhardt, B. Namer, C. Weidner, A. Lampert, R. W. Carr, M. Schmelz, E. Fransén.
C-fiber recovery cycle supernormality depends on ion concentration and ion channel permeability.
Biophysical Journal, 2015 Mar 10;108(5):1057-71. - Esther Eberhardt*, Steven Havlicek*, Diana Schmidt*, Andrea S. Link, Cristian Neacsu, Zacharias Kohl, Martin Hampl, Andreas M. Kist, Alexandra Klinger, Carla Nau, Jürgen Schüttler, Christian Alzheimer, Jürgen Winkler, Barbara Namer, Beate Winner, Angelika Lampert.
Pattern of functional TTX-resistant sodium channels reveals developmental stage of human iPS- and ES cell-derived nociceptors.
Stem Cell Reports, 2015 Sep 8;5(3):305-13.
Weitere Informationen finden Sie hier. - Stadler T.S., A.O. O’Reilly, A. Lampert.
Erythromelalgia Mutation Q875E Stabilizes The Activated State Of Sodium Channel Nav1.7.
Journal of Biological Chemistry; 2015 Mar 6;290(10):6316-25.
- Mirjam Eberhardt, Maria Dux, Barbara Namer, Jan Miljkovic, Nada Cordasic, Christine Will, Tatjana I. Kichko, Jeanne de la Roche, Michael Fischer, Sebastián A. Suárez, Damian Bikiel, Karola Dorsch, Andreas Leffler, Alexandru Babes, Angelika Lampert, Jochen K. Lennerz, Johannes Jacob5, Marcelo A. Martí, Fabio Doctorovich, Edward D. Högestätt, Peter M. Zygmunt, Ivana Ivanovic-Burmazovic, Karl Messlinger, Peter Reeh, Milos R Filipovic.
H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway.
Nature Communications 2014 Jun 12; 5:4381. - Eberhardt M, Nakajima J, Klinger AB, Neacsu C, Hühne K, O'Reilly AO, Kist AM, Lampe AK, Fischer K, Gibson J, Nau C, Winterpacht A, Lampert A.
Inherited Pain: Sodium Channel Nav1.7 A1632T Mutation Causes Erythromelalgia Due to a Shift of Fast Inactivation.
J Biol Chem. 2014 Jan 24;289(4):1971-80.
Dr. Mirjam Eberhardt hat aufgrund dieser Publikation den “EFIC- IBSA Foundation Publication Award“ gewonnen. - Havlicek S., Z. Kohl, H.K. Mishra, I. Prots, E. Eberhardt, N. Denguir, H. Wend, S. Plötz, L. Boyer, M.C. Marchetto, S. Aigner, H. Sticht, T.W. Groemer, U. Hehr, A. Lampert, U. Schlötzer-Schrehardt, J. Winkler, F.H. Gage, B. Winner.
Gene dosage dependent rescue of HSP neurite defects in SPG4 patients’ neurons.
Hum Mol Genet. 2014 May 15;23(10):2527-41. - Lampert A, Eberhardt M, Waxman SG.
Altered sodium channel gating as molecular basis for pain: contribution of activation, inactivation, and resurgent currents.
Handb Exp Pharmacol. 2014;221:91-110. - Lampert A, Korngreen A.
Markov modeling of ion channels: implications for understanding disease.
Prog Mol Biol Transl Sci. 2014;123:1-21. - O’Reilly, A. O., A. R. Cole, J. L. Lopes, A. Lampert, B. A. Wallace.
Chaperone-mediated Native Folding of a β-scorpion Toxin in the Periplasm of E.coli.
Biochim Biophys Acta. 2014 Jan;1840(1):10-5. - Petersson M.E., O. Obreja, A. Lampert, R.W. Carr, M. Schmelz, E. Fransén.
Differential axonal conduction patterns of mechano-sensitive and mechano-insensitive nociceptors--a combined experimental and modelling study.
PLoS ONE, 2014 Aug; 9(8): e103556. - Schulze, V., C.Stoetzer, A.O. O´Reilly, E. Eberhardt, N. Foadi, J. Ahrens, F. Wegner, A. Lampert, J. de la Roche, A. Leffler.
The opioid methadone induces a local anesthetic like inhibition of the cardiac Na+ channel Nav1.5.
British Journal of Pharmacology, 2014 Jan;171(2):427-37. - Tigerholm, J. M. Petersson, O. Obreja, A. Lampert, R. Carr, M. Schmelz, and E. Fransen.
Modelling activity-dependent changes of axonal spike conduction in primary afferent C-nociceptors.
Journal of Neurophysiology, 2014 May;111(9):1721-35.
