Die aktuelle Corona-Krise ist für unsere Patientinnen und Patienten und deren Angehörige mit vielen Fragen verbunden. Daher haben wir hilfreiche Informationen auf unserer Sonderseite zusammengestellt. Wichtiger Hinweis: Bitte rufen Sie bei Schlaganfall- oder Herzinfarkt-Symptomen sowie bei allen anderen Notfällen unbedingt die 112 an – die Versorgung im Notfall ist in der Uniklinik RWTH Aachen uneingeschränkt rund um die Uhr gewährleistet. Skip navigation Publications of Prof. Joachim Jankowski over the last 5 years:
- Zewinger, S., Reiser, J., Jankowski, V., Alansary, D., Hahm, E., Triem, S., Klug, M., Schunk, S. J., Schmit, D., Kramann, R., Korbel, C., Ampofo, E., Laschke, M. W., Selejan, S. R., Paschen, A., Herter, T., Schuster, S., Silbernagel, G., Sester, M., Sester, U., Assmann, G., Bals, R., Kostner, G., Jahnen-Dechent, W., Menger, M. D., Rohrer, L., Marz, W., Bohm, M., Jankowski, J., Kopf, M., Latz, E., Niemeyer, B. A., Fliser, D., Laufs, U. & Speer, T. Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation. Nat Immunol 21, 30-41, doi:10.1038/s41590-019-0548-1 (2020).
- Tilstam, P. V., Soppert, J., Hemmers, C., Harlacher, E., Doring, Y., van der Vorst, E. P. C., Schulte, C., Alampour-Rajabi, S., Theelen, W., Asare, Y., de Winther, M. P. J., Lawrence, T., Bernhagen, J., Schober, A., Zernecke, A., Jankowski, J., Weber, C. & Noels, H. Non-activatable mutant of inhibitor of kappa B kinase alpha (IKKalpha) exerts vascular site-specific effects on atherosclerosis in Apoe-deficient mice. Atherosclerosis 292, 23-30, doi:10.1016/j.atherosclerosis.2019.10.023 (2020).
- Sternkopf, M., Nagy, M., Baaten, C., Kuijpers, M. J. E., Tullemans, B. M. E., Wirth, J., Theelen, W., Mastenbroek, T. G., Lehrke, M., Winnerling, B., Baerts, L., Marx, N., De Meester, I., Doring, Y., Cosemans, J., Daiber, A., Steven, S., Jankowski, J., Heemskerk, J. W. M. & Noels, H. Native, Intact Glucagon-Like Peptide-1 Is a Natural Suppressor of Thrombus Growth Under Physiological Flow Conditions. Arterioscler Thromb Vasc Biol, ATVBAHA119313645, doi:10.1161/ATVBAHA.119.313645 (2020).
- Hermann, J., Noels, H., Theelen, W., Lellig, M., Orth-Alampour, S., Boor, P., Jankowski, V. & Jankowski, J. Sample preparation of formalin-fixed paraffin-embedded tissue sections for MALDI-mass spectrometry imaging. Anal Bioanal Chem 412, 1263-1275, doi:10.1007/s00216-019-02296-x (2020).
- Vollmer, T., Ljungberg, B., Jankowski, V., Jankowski, J., Glorieux, G. & Stegmayr, B. G. An in-vitro assay using human spermatozoa to detect toxicity of biologically active substances. Sci Rep 9, 14525, doi:10.1038/s41598-019-50929-z (2019).
- van der Made, T. K., Fedecostante, M., Scotcher, D., Rostami-Hodjegan, A., Sastre Torano, J., Middel, I., Koster, A. S., Gerritsen, K. G., Jankowski, V., Jankowski, J., Hoenderop, J. G. J., Masereeuw, R. & Galetin, A. Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease. Mol Pharm 16, 4551-4562, doi:10.1021/acs.molpharmaceut.9b00681 (2019).
- Sternkopf, M., Thoroe-Boveleth, S., Beck, T., Oleschko, K., Erlenkotter, A., Tschulena, U., Steppan, S., Speer, T., Goettsch, C., Jankowski, V., Jankowski, J., Noels, H. & European Uremic Toxin Work Group, E. A Bifunctional Adsorber Particle for the Removal of Hydrophobic Uremic Toxins from Whole Blood of Renal Failure Patients. Toxins (Basel) 11, doi:10.3390/toxins11070389 (2019).
- Schumacher, D., Alampour-Rajabi, S., Ponomariov, V., Curaj, A., Wu, Z., Staudt, M., Rusu, M., Jankowski, V., Marx, N., Jankowski, J., Brandenburg, V., Liehn, E. A. & Schuh, A. Cardiac FGF23: new insights into the role and function of FGF23 after acute myocardial infarction. Cardiovasc Pathol 40, 47-54, doi:10.1016/j.carpath.2019.02.001 (2019).
- Mossanen, J. C., Kohlhepp, M., Wehr, A., Krenkel, O., Liepelt, A., Roeth, A. A., Mockel, D., Heymann, F., Lammers, T., Gassler, N., Hermann, J., Jankowski, J., Neumann, U. P., Luedde, T., Trautwein, C. & Tacke, F. CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T- and CD4(+) T-Cell-Dependent Control of Senescence. Gastroenterology 156, 1877-1889 e1874, doi:10.1053/j.gastro.2019.01.247 (2019).
- Gajjala, P. R., Bruck, H., Noels, H., Heinze, G., Ceccarelli, F., Kribben, A., Saez-Rodriguez, J., Marx, N., Zidek, W., Jankowski, J. & Jankowski, V. Novel plasma peptide markers involved in the pathology of CKD identified using mass spectrometric approach. J Mol Med (Berl) 97, 1451-1463, doi:10.1007/s00109-019-01823-8 (2019).
- Seibert, F. S., Bernhard, F., Stervbo, U., Vairavanathan, S., Bauer, F., Rohn, B., Pagonas, N., Babel, N., Jankowski, J. & Westhoff, T. H. The Effect of Microgravity on Central Aortic Blood Pressure. Am J Hypertens 31, 1183-1189, doi:10.1093/ajh/hpy119 (2018).
- Schmitz, C., Noels, H., El Bounkari, O., Straussfeld, E., Megens, R. T. A., Sternkopf, M., Alampour-Rajabi, S., Krammer, C., Tilstam, P. V., Gerdes, N., Burger, C., Kapurniotu, A., Bucala, R., Jankowski, J., Weber, C. & Bernhagen, J. Mif-deficiency favors an atheroprotective autoantibody phenotype in atherosclerosis. FASEB J 32, 4428-4443, doi:10.1096/fj.201800058R (2018).
- Sawant, M., Schwarz, N., Windoffer, R., Magin, T. M., Krieger, J., Mucke, N., Obara, B., Jankowski, V., Jankowski, J., Wally, V., Lettner, T. & Leube, R. E. Threonine 150 Phosphorylation of Keratin 5 Is Linked to Epidermolysis Bullosa Simplex and Regulates Filament Assembly and Cell Viability. J Invest Dermatol 138, 627-636, doi:10.1016/j.jid.2017.10.011 (2018).
- Noels, H., Theelen, W., Sternkopf, M., Jankowski, V., Moellmann, J., Kraemer, S., Lehrke, M., Marx, N., Martin, L., Marx, G., Jankowski, J., Goetzenich, A. & Stoppe, C. Reduced post-operative DPP4 activity associated with worse patient outcome after cardiac surgery. Sci Rep 8, 11820, doi:10.1038/s41598-018-30235-w (2018).
- Noels, H., Boor, P., Goettsch, C., Hohl, M., Jahnen-Dechent, W., Jankowski, V., Kindermann, I., Kramann, R., Lehrke, M., Linz, D., Maack, C., Niemeyer, B., Roma, L. P., Schuett, K., Speer, T., Wagenpfeil, S., Werner, C., Zewinger, S., Bohm, M., Marx, N., Floege, J., Fliser, D. & Jankowski, J. The new SFB/TRR219 Research Centre. Eur Heart J 39, 975-977, doi:10.1093/eurheartj/ehy083 (2018).
- Moellmann, J., Klinkhammer, B. M., Onstein, J., Stohr, R., Jankowski, V., Jankowski, J., Lebherz, C., Tacke, F., Marx, N., Boor, P. & Lehrke, M. Glucagon-Like Peptide 1 and Its Cleavage Products Are Renoprotective in Murine Diabetic Nephropathy. Diabetes 67, 2410-2419, doi:10.2337/db17-1212 (2018).
- Marx, N., Noels, H., Jankowski, J., Floege, J., Fliser, D. & Bohm, M. Mechanisms of cardiovascular complications in chronic kidney disease: research focus of the Transregional Research Consortium SFB TRR219 of the University Hospital Aachen (RWTH) and the Saarland University. Clin Res Cardiol 107, 120-126, doi:10.1007/s00392-018-1260-0 (2018).
- Magalhaes, P., Pontillo, C., Pejchinovski, M., Siwy, J., Krochmal, M., Makridakis, M., Carrick, E., Klein, J., Mullen, W., Jankowski, J., Vlahou, A., Mischak, H., Schanstra, J. P., Zurbig, P. & Pape, L. Comparison of Urine and Plasma Peptidome Indicates Selectivity in Renal Peptide Handling. Proteomics Clin Appl 12, e1700163, doi:10.1002/prca.201700163 (2018).
- Kumar, R. K., Heuchel, M., Kratz, K., Lendlein, A., Jankowski, J. & Tetali, S. D. Effects of extracts prepared from modified porous poly(ether imide) microparticulate absorbers on cytotoxicity, macrophage differentiation and proinflammatory behavior of human monocytic (THP-1) cells. Clin Hemorheol Microcirc 69, 175-185, doi:10.3233/CH-189112 (2018).
- Kork, F., Jankowski, J., Goswami, A., Weis, J., Brook, G., Yamoah, A., Anink, J., Aronica, E., Fritz, S., Huck, C., Schipke, C., Peters, O., Tepel, M., Noels, H. & Jankowski, V. Golgin A4 in CSF and granulovacuolar degenerations of patients with Alzheimer disease. Neurology 91, e1799-e1808, doi:10.1212/WNL.0000000000006457 (2018).
- Hegner, B., Schaub, T., Janke, D., Zickler, D., Lange, C., Girndt, M., Jankowski, J., Schindler, R. & Dragun, D. Targeting proinflammatory cytokines ameliorates calcifying phenotype conversion of vascular progenitors under uremic conditions in vitro. Sci Rep 8, 12087, doi:10.1038/s41598-018-30626-z (2018).
- Siwy, J., Zurbig, P., Argiles, A., Beige, J., Haubitz, M., Jankowski, J., Julian, B. A., Linde, P. G., Marx, D., Mischak, H., Mullen, W., Novak, J., Ortiz, A., Persson, F., Pontillo, C., Rossing, P., Rupprecht, H., Schanstra, J. P., Vlahou, A. & Vanholder, R. Noninvasive diagnosis of chronic kidney diseases using urinary proteome analysis. Nephrol Dial Transplant 32, 2079-2089, doi:10.1093/ndt/gfw337 (2017).
- Rowinska, Z., Koeppel, T. A., Sanati, M., Schelzig, H., Jankowski, J., Weber, C., Zernecke, A. & Liehn, E. A. Role of the CX3C chemokine receptor CX3CR1 in the pathogenesis of atherosclerosis after aortic transplantation. PLoS One 12, e0170644, doi:10.1371/journal.pone.0170644 (2017).
- Pontillo, C., Zhang, Z. Y., Schanstra, J. P., Jacobs, L., Zurbig, P., Thijs, L., Ramirez-Torres, A., Heerspink, H. J. L., Lindhardt, M., Klein, R., Orchard, T., Porta, M., Bilous, R. W., Charturvedi, N., Rossing, P., Vlahou, A., Schepers, E., Glorieux, G., Mullen, W., Delles, C., Verhamme, P., Vanholder, R., Staessen, J. A., Mischak, H. & Jankowski, J. Prediction of Chronic Kidney Disease Stage 3 by CKD273, a Urinary Proteomic Biomarker. Kidney Int Rep 2, 1066-1075, doi:10.1016/j.ekir.2017.06.004 (2017).
- Pontillo, C., Jacobs, L., Staessen, J. A., Schanstra, J. P., Rossing, P., Heerspink, H. J. L., Siwy, J., Mullen, W., Vlahou, A., Mischak, H., Vanholder, R., Zurbig, P. & Jankowski, J. A urinary proteome-based classifier for the early detection of decline in glomerular filtration. Nephrol Dial Transplant 32, 1510-1516, doi:10.1093/ndt/gfw239 (2017).
- Krochmal, M., Cisek, K., Filip, S., Markoska, K., Orange, C., Zoidakis, J., Gakiopoulou, C., Spasovski, G., Mischak, H., Delles, C., Vlahou, A. & Jankowski, J. Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis. Sci Rep 7, 9091, doi:10.1038/s41598-017-09393-w (2017).
- Krieter, D. H., Devine, E., Korner, T., Ruth, M., Wanner, C., Raine, M., Jankowski, J. & Lemke, H. D. Haemodiafiltration at increased plasma ionic strength for improved protein-bound toxin removal. Acta Physiol (Oxf) 219, 510-520, doi:10.1111/apha.12730 (2017).
- Kork, F., Balzer, F., Krannich, A., Bernardi, M. H., Eltzschig, H. K., Jankowski, J. & Spies, C. Back-calculating baseline creatinine overestimates prevalence of acute kidney injury with poor sensitivity. Acta Physiol (Oxf) 219, 613-624, doi:10.1111/apha.12763 (2017).
- Jansen, J., Jankowski, J., Gajjala, P. R., Wetzels, J. F. M. & Masereeuw, R. Disposition and clinical implications of protein-bound uremic toxins. Clin Sci (Lond) 131, 1631-1647, doi:10.1042/CS20160191 (2017).
- Gajjala, P. R., Jankowski, V., Heinze, G., Bilo, G., Zanchetti, A., Noels, H., Liehn, E., Perco, P., Schulz, A., Delles, C., Kork, F., Biessen, E., Narkiewicz, K., Kawecka-Jaszcz, K., Floege, J., Soranna, D., Zidek, W. & Jankowski, J. Proteomic-Biostatistic Integrated Approach for Finding the Underlying Molecular Determinants of Hypertension in Human Plasma. Hypertension 70, 412-419, doi:10.1161/HYPERTENSIONAHA.116.08906 (2017).
- Asare, Y., Ommer, M., Azombo, F. A., Alampour-Rajabi, S., Sternkopf, M., Sanati, M., Gijbels, M. J., Schmitz, C., Sinitski, D., Tilstam, P. V., Lue, H., Gessner, A., Lange, D., Schmid, J. A., Weber, C., Dichgans, M., Jankowski, J., Pardi, R., de Winther, M. P., Noels, H. & Bernhagen, J. Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo. Proc Natl Acad Sci U S A 114, E2766-E2775, doi:10.1073/pnas.1618411114 (2017).
- Tetali, S. D., Jankowski, V., Luetzow, K., Kratz, K., Lendlein, A. & Jankowski, J. Adsorption capacity of poly(ether imide) microparticles to uremic toxins. Clin Hemorheol Microcirc 61, 657-665, doi:10.3233/CH-152026 (2016).
- Smith, A., L'Imperio, V., De Sio, G., Ferrario, F., Scalia, C., Dell'Antonio, G., Pieruzzi, F., Pontillo, C., Filip, S., Markoska, K., Granata, A., Spasovski, G., Jankowski, J., Capasso, G., Pagni, F. & Magni, F. alpha-1-Antitrypsin detected by MALDI imaging in the study of glomerulonephritis: Its relevance in chronic kidney disease progression. Proteomics 16, 1759-1766, doi:10.1002/pmic.201500411 (2016).
- Scholze, A., Jankowski, J., Pedraza-Chaverri, J. & Evenepoel, P. Oxidative Stress in Chronic Kidney Disease. Oxid Med Cell Longev 2016, 8375186, doi:10.1155/2016/8375186 (2016).
- Kumar, R. K., Basu, S., Lemke, H. D., Jankowski, J., Kratz, K., Lendlein, A. & Tetali, S. D. Effect of extracts of poly(ether imide) microparticles on cytotoxicity, ROS generation and proinflammatory effects on human monocytic (THP-1) cells. Clin Hemorheol Microcirc 61, 667-680, doi:10.3233/CH-152027 (2016).
- Kumar, R. K., Basu, S., Lemke, H. D., Jankowski, J., Kratz, K., Lendlein, A. & Tetali, S. D. Influence of nanoporous poly(ether imide) particle extracts on human aortic endothelial cells (HAECs). Clin Hemorheol Microcirc 64, 931-940, doi:10.3233/CH-168046 (2016).
- Krochmal, M., Fernandes, M., Filip, S., Pontillo, C., Husi, H., Zoidakis, J., Mischak, H., Vlahou, A. & Jankowski, J. PeptiCKDdb-peptide- and protein-centric database for the investigation of genesis and progression of chronic kidney disease. Database (Oxford) 2016, doi:10.1093/database/baw128 (2016).
- Selle, J., Asare, Y., Kohncke, J., Alampour-Rajabi, S., Shagdarsuren, G., Klos, A., Weber, C., Jankowski, J. & Shagdarsuren, E. Atheroprotective role of C5ar2 deficiency in apolipoprotein E-deficient mice. Thromb Haemost 114, 848-858, doi:10.1160/TH14-12-1075 (2015).
- Schanstra, J. P., Zurbig, P., Alkhalaf, A., Argiles, A., Bakker, S. J., Beige, J., Bilo, H. J., Chatzikyrkou, C., Dakna, M., Dawson, J., Delles, C., Haller, H., Haubitz, M., Husi, H., Jankowski, J., Jerums, G., Kleefstra, N., Kuznetsova, T., Maahs, D. M., Menne, J., Mullen, W., Ortiz, A., Persson, F., Rossing, P., Ruggenenti, P., Rychlik, I., Serra, A. L., Siwy, J., Snell-Bergeon, J., Spasovski, G., Staessen, J. A., Vlahou, A., Mischak, H. & Vanholder, R. Diagnosis and Prediction of CKD Progression by Assessment of Urinary Peptides. J Am Soc Nephrol 26, 1999-2010, doi:10.1681/ASN.2014050423 (2015).
- Salem, S., Jankowski, V., Asare, Y., Liehn, E., Welker, P., Raya-Bermudez, A., Pineda-Martos, C., Rodriguez, M., Munoz-Castaneda, J. R., Bruck, H., Marx, N., Machado, F. B., Staudt, M., Heinze, G., Zidek, W. & Jankowski, J. Identification of the Vasoconstriction-Inhibiting Factor (VIF), a Potent Endogenous Cofactor of Angiotensin II Acting on the Angiotensin II Type 2 Receptor. Circulation 131, 1426-1434, doi:10.1161/CIRCULATIONAHA.114.013168 (2015).
- Rueth, M., Lemke, H. D., Preisinger, C., Krieter, D., Theelen, W., Gajjala, P., Devine, E., Zidek, W., Jankowski, J. & Jankowski, V. Guanidinylations of albumin decreased binding capacity of hydrophobic metabolites. Acta Physiol (Oxf) 215, 13-23, doi:10.1111/apha.12518 (2015).
- Pena, M. J., Jankowski, J., Heinze, G., Kohl, M., Heinzel, A., Bakker, S. J., Gansevoort, R. T., Rossing, P., de Zeeuw, D., Heerspink, H. J. & Jankowski, V. Plasma proteomics classifiers improve risk prediction for renal disease in patients with hypertension or type 2 diabetes. J Hypertens 33, 2123-2132, doi:10.1097/HJH.0000000000000685 (2015).
- Pena, M. J., de Zeeuw, D., Mischak, H., Jankowski, J., Oberbauer, R., Woloszczuk, W., Benner, J., Dallmann, G., Mayer, B., Mayer, G., Rossing, P. & Lambers Heerspink, H. J. Prognostic clinical and molecular biomarkers of renal disease in type 2 diabetes. Nephrol Dial Transplant 30 Suppl 4, iv86-95, doi:10.1093/ndt/gfv252 (2015).
- Pasqualon, T., Pruessmeyer, J., Jankowski, V., Babendreyer, A., Groth, E., Schumacher, J., Koenen, A., Weidenfeld, S., Schwarz, N., Denecke, B., Jahr, H., Dreymueller, D., Jankowski, J. & Ludwig, A. A cytoplasmic C-terminal fragment of Syndecan-1 is generated by sequential proteolysis and antagonizes Syndecan-1 dependent lung tumor cell migration. Oncotarget 6, 31295-31312, doi:10.18632/oncotarget.5174 (2015).
- Lanza, D., Perna, A. F., Oliva, A., Vanholder, R., Pletinck, A., Guastafierro, S., Di Nunzio, A., Vigorito, C., Capasso, G., Jankowski, V., Jankowski, J. & Ingrosso, D. Impact of the uremic milieu on the osteogenic potential of mesenchymal stem cells. PLoS One 10, e0116468, doi:10.1371/journal.pone.0116468 (2015).
- Kork, F., Balzer, F., Spies, C. D., Wernecke, K. D., Ginde, A. A., Jankowski, J. & Eltzschig, H. K. Minor Postoperative Increases of Creatinine Are Associated with Higher Mortality and Longer Hospital Length of Stay in Surgical Patients. Anesthesiology 123, 1301-1311, doi:10.1097/ALN.0000000000000891 (2015).
- Jankowski, J., Schanstra, J. P. & Mischak, H. Body fluid peptide and protein signatures in diabetic kidney diseases. Nephrol Dial Transplant 30 Suppl 4, iv43-53, doi:10.1093/ndt/gfv091 (2015).
- Holzweber, M., Lippitz, A., Krueger, K., Jankowski, J. & Unger, W. E. Surface characterization of dialyzer polymer membranes by imaging ToF-SIMS and quantitative XPS line scans. Biointerphases 10, 019011, doi:10.1116/1.4907937 (2015).
- Holmar, J., Uhlin, F., Fernstrom, A., Luman, M., Jankowski, J. & Fridolin, I. An optical method for serum calcium and phosphorus level assessment during hemodialysis. Toxins (Basel) 7, 719-727, doi:10.3390/toxins7030719 (2015).
- Glorieux, G., Mullen, W., Duranton, F., Filip, S., Gayrard, N., Husi, H., Schepers, E., Neirynck, N., Schanstra, J. P., Jankowski, J., Mischak, H., Argiles, A., Vanholder, R., Vlahou, A. & Klein, J. New insights in molecular mechanisms involved in chronic kidney disease using high-resolution plasma proteome analysis. Nephrol Dial Transplant 30, 1842-1852, doi:10.1093/ndt/gfv254 (2015).
- Gajjala, P. R., Sanati, M. & Jankowski, J. Cellular and Molecular Mechanisms of Chronic Kidney Disease with Diabetes Mellitus and Cardiovascular Diseases as Its Comorbidities. Front Immunol 6, 340, doi:10.3389/fimmu.2015.00340 (2015).
- Gajjala, P. R., Fliser, D., Speer, T., Jankowski, V. & Jankowski, J. Emerging role of post-translational modifications in chronic kidney disease and cardiovascular disease. Nephrol Dial Transplant 30, 1814-1824, doi:10.1093/ndt/gfv048 (2015).
- Filip, S., Vougas, K., Zoidakis, J., Latosinska, A., Mullen, W., Spasovski, G., Mischak, H., Vlahou, A. & Jankowski, J. Comparison of Depletion Strategies for the Enrichment of Low-Abundance Proteins in Urine. PLoS One 10, e0133773, doi:10.1371/journal.pone.0133773 (2015).
- Bohringer, F., Jankowski, V., Gajjala, P. R., Zidek, W. & Jankowski, J. Release of uremic retention solutes from protein binding by hypertonic predilution hemodiafiltration. ASAIO J 61, 55-60, doi:10.1097/MAT.0000000000000166 (2015).