Publications of Prof. Joachim Jankowski over the last 5 years:

  1. Zewinger, S., Reiser, J., Jankowski, V., Alansary, D., Hahm, E., Triem, S., Klug, M., Schunk, S. J., Schmit, D., Kramann, R., Korbel, C., Ampofo, E., Laschke, M. W., Selejan, S. R., Paschen, A., Herter, T., Schuster, S., Silbernagel, G., Sester, M., Sester, U., Assmann, G., Bals, R., Kostner, G., Jahnen-Dechent, W., Menger, M. D., Rohrer, L., Marz, W., Bohm, M., Jankowski, J., Kopf, M., Latz, E., Niemeyer, B. A., Fliser, D., Laufs, U. & Speer, T. Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation. Nat Immunol 21, 30-41, doi:10.1038/s41590-019-0548-1 (2020).
     
  2. Tilstam, P. V., Soppert, J., Hemmers, C., Harlacher, E., Doring, Y., van der Vorst, E. P. C., Schulte, C., Alampour-Rajabi, S., Theelen, W., Asare, Y., de Winther, M. P. J., Lawrence, T., Bernhagen, J., Schober, A., Zernecke, A., Jankowski, J., Weber, C. & Noels, H. Non-activatable mutant of inhibitor of kappa B kinase alpha (IKKalpha) exerts vascular site-specific effects on atherosclerosis in Apoe-deficient mice. Atherosclerosis 292, 23-30, doi:10.1016/j.atherosclerosis.2019.10.023 (2020).
     
  3. Sternkopf, M., Nagy, M., Baaten, C., Kuijpers, M. J. E., Tullemans, B. M. E., Wirth, J., Theelen, W., Mastenbroek, T. G., Lehrke, M., Winnerling, B., Baerts, L., Marx, N., De Meester, I., Doring, Y., Cosemans, J., Daiber, A., Steven, S., Jankowski, J., Heemskerk, J. W. M. & Noels, H. Native, Intact Glucagon-Like Peptide-1 Is a Natural Suppressor of Thrombus Growth Under Physiological Flow Conditions. Arterioscler Thromb Vasc Biol, ATVBAHA119313645, doi:10.1161/ATVBAHA.119.313645 (2020).
     
  4. Hermann, J., Noels, H., Theelen, W., Lellig, M., Orth-Alampour, S., Boor, P., Jankowski, V. & Jankowski, J. Sample preparation of formalin-fixed paraffin-embedded tissue sections for MALDI-mass spectrometry imaging. Anal Bioanal Chem 412, 1263-1275, doi:10.1007/s00216-019-02296-x (2020).
     
  5. Vollmer, T., Ljungberg, B., Jankowski, V., Jankowski, J., Glorieux, G. & Stegmayr, B. G. An in-vitro assay using human spermatozoa to detect toxicity of biologically active substances. Sci Rep 9, 14525, doi:10.1038/s41598-019-50929-z (2019).
     
  6. van der Made, T. K., Fedecostante, M., Scotcher, D., Rostami-Hodjegan, A., Sastre Torano, J., Middel, I., Koster, A. S., Gerritsen, K. G., Jankowski, V., Jankowski, J., Hoenderop, J. G. J., Masereeuw, R. & Galetin, A. Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease. Mol Pharm 16, 4551-4562, doi:10.1021/acs.molpharmaceut.9b00681 (2019).
     
  7. Sternkopf, M., Thoroe-Boveleth, S., Beck, T., Oleschko, K., Erlenkotter, A., Tschulena, U., Steppan, S., Speer, T., Goettsch, C., Jankowski, V., Jankowski, J., Noels, H. & European Uremic Toxin Work Group, E. A Bifunctional Adsorber Particle for the Removal of Hydrophobic Uremic Toxins from Whole Blood of Renal Failure Patients. Toxins (Basel) 11, doi:10.3390/toxins11070389 (2019).
     
  8. Schumacher, D., Alampour-Rajabi, S., Ponomariov, V., Curaj, A., Wu, Z., Staudt, M., Rusu, M., Jankowski, V., Marx, N., Jankowski, J., Brandenburg, V., Liehn, E. A. & Schuh, A. Cardiac FGF23: new insights into the role and function of FGF23 after acute myocardial infarction. Cardiovasc Pathol 40, 47-54, doi:10.1016/j.carpath.2019.02.001 (2019).
     
  9. Mossanen, J. C., Kohlhepp, M., Wehr, A., Krenkel, O., Liepelt, A., Roeth, A. A., Mockel, D., Heymann, F., Lammers, T., Gassler, N., Hermann, J., Jankowski, J., Neumann, U. P., Luedde, T., Trautwein, C. & Tacke, F. CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T- and CD4(+) T-Cell-Dependent Control of Senescence. Gastroenterology 156, 1877-1889 e1874, doi:10.1053/j.gastro.2019.01.247 (2019).
     
  10. Gajjala, P. R., Bruck, H., Noels, H., Heinze, G., Ceccarelli, F., Kribben, A., Saez-Rodriguez, J., Marx, N., Zidek, W., Jankowski, J. & Jankowski, V. Novel plasma peptide markers involved in the pathology of CKD identified using mass spectrometric approach. J Mol Med (Berl) 97, 1451-1463, doi:10.1007/s00109-019-01823-8 (2019).
     
  11. Seibert, F. S., Bernhard, F., Stervbo, U., Vairavanathan, S., Bauer, F., Rohn, B., Pagonas, N., Babel, N., Jankowski, J. & Westhoff, T. H. The Effect of Microgravity on Central Aortic Blood Pressure. Am J Hypertens 31, 1183-1189, doi:10.1093/ajh/hpy119 (2018).
     
  12. Schmitz, C., Noels, H., El Bounkari, O., Straussfeld, E., Megens, R. T. A., Sternkopf, M., Alampour-Rajabi, S., Krammer, C., Tilstam, P. V., Gerdes, N., Burger, C., Kapurniotu, A., Bucala, R., Jankowski, J., Weber, C. & Bernhagen, J. Mif-deficiency favors an atheroprotective autoantibody phenotype in atherosclerosis. FASEB J 32, 4428-4443, doi:10.1096/fj.201800058R (2018).
     
  13. Sawant, M., Schwarz, N., Windoffer, R., Magin, T. M., Krieger, J., Mucke, N., Obara, B., Jankowski, V., Jankowski, J., Wally, V., Lettner, T. & Leube, R. E. Threonine 150 Phosphorylation of Keratin 5 Is Linked to Epidermolysis Bullosa Simplex and Regulates Filament Assembly and Cell Viability. J Invest Dermatol 138, 627-636, doi:10.1016/j.jid.2017.10.011 (2018).
     
  14. Noels, H., Theelen, W., Sternkopf, M., Jankowski, V., Moellmann, J., Kraemer, S., Lehrke, M., Marx, N., Martin, L., Marx, G., Jankowski, J., Goetzenich, A. & Stoppe, C. Reduced post-operative DPP4 activity associated with worse patient outcome after cardiac surgery. Sci Rep 8, 11820, doi:10.1038/s41598-018-30235-w (2018).
     
  15. Noels, H., Boor, P., Goettsch, C., Hohl, M., Jahnen-Dechent, W., Jankowski, V., Kindermann, I., Kramann, R., Lehrke, M., Linz, D., Maack, C., Niemeyer, B., Roma, L. P., Schuett, K., Speer, T., Wagenpfeil, S., Werner, C., Zewinger, S., Bohm, M., Marx, N., Floege, J., Fliser, D. & Jankowski, J. The new SFB/TRR219 Research Centre. Eur Heart J 39, 975-977, doi:10.1093/eurheartj/ehy083 (2018).
     
  16. Moellmann, J., Klinkhammer, B. M., Onstein, J., Stohr, R., Jankowski, V., Jankowski, J., Lebherz, C., Tacke, F., Marx, N., Boor, P. & Lehrke, M. Glucagon-Like Peptide 1 and Its Cleavage Products Are Renoprotective in Murine Diabetic Nephropathy. Diabetes 67, 2410-2419, doi:10.2337/db17-1212 (2018).
     
  17. Marx, N., Noels, H., Jankowski, J., Floege, J., Fliser, D. & Bohm, M. Mechanisms of cardiovascular complications in chronic kidney disease: research focus of the Transregional Research Consortium SFB TRR219 of the University Hospital Aachen (RWTH) and the Saarland University. Clin Res Cardiol 107, 120-126, doi:10.1007/s00392-018-1260-0 (2018).
     
  18. Magalhaes, P., Pontillo, C., Pejchinovski, M., Siwy, J., Krochmal, M., Makridakis, M., Carrick, E., Klein, J., Mullen, W., Jankowski, J., Vlahou, A., Mischak, H., Schanstra, J. P., Zurbig, P. & Pape, L. Comparison of Urine and Plasma Peptidome Indicates Selectivity in Renal Peptide Handling. Proteomics Clin Appl 12, e1700163, doi:10.1002/prca.201700163 (2018).
     
  19. Kumar, R. K., Heuchel, M., Kratz, K., Lendlein, A., Jankowski, J. & Tetali, S. D. Effects of extracts prepared from modified porous poly(ether imide) microparticulate absorbers on cytotoxicity, macrophage differentiation and proinflammatory behavior of human monocytic (THP-1) cells. Clin Hemorheol Microcirc 69, 175-185, doi:10.3233/CH-189112 (2018).
     
  20. Kork, F., Jankowski, J., Goswami, A., Weis, J., Brook, G., Yamoah, A., Anink, J., Aronica, E., Fritz, S., Huck, C., Schipke, C., Peters, O., Tepel, M., Noels, H. & Jankowski, V. Golgin A4 in CSF and granulovacuolar degenerations of patients with Alzheimer disease. Neurology 91, e1799-e1808, doi:10.1212/WNL.0000000000006457 (2018).
     
  21. Hegner, B., Schaub, T., Janke, D., Zickler, D., Lange, C., Girndt, M., Jankowski, J., Schindler, R. & Dragun, D. Targeting proinflammatory cytokines ameliorates calcifying phenotype conversion of vascular progenitors under uremic conditions in vitro. Sci Rep 8, 12087, doi:10.1038/s41598-018-30626-z (2018).
     
  22. Siwy, J., Zurbig, P., Argiles, A., Beige, J., Haubitz, M., Jankowski, J., Julian, B. A., Linde, P. G., Marx, D., Mischak, H., Mullen, W., Novak, J., Ortiz, A., Persson, F., Pontillo, C., Rossing, P., Rupprecht, H., Schanstra, J. P., Vlahou, A. & Vanholder, R. Noninvasive diagnosis of chronic kidney diseases using urinary proteome analysis. Nephrol Dial Transplant 32, 2079-2089, doi:10.1093/ndt/gfw337 (2017).
     
  23. Rowinska, Z., Koeppel, T. A., Sanati, M., Schelzig, H., Jankowski, J., Weber, C., Zernecke, A. & Liehn, E. A. Role of the CX3C chemokine receptor CX3CR1 in the pathogenesis of atherosclerosis after aortic transplantation. PLoS One 12, e0170644, doi:10.1371/journal.pone.0170644 (2017).
     
  24. Pontillo, C., Zhang, Z. Y., Schanstra, J. P., Jacobs, L., Zurbig, P., Thijs, L., Ramirez-Torres, A., Heerspink, H. J. L., Lindhardt, M., Klein, R., Orchard, T., Porta, M., Bilous, R. W., Charturvedi, N., Rossing, P., Vlahou, A., Schepers, E., Glorieux, G., Mullen, W., Delles, C., Verhamme, P., Vanholder, R., Staessen, J. A., Mischak, H. & Jankowski, J. Prediction of Chronic Kidney Disease Stage 3 by CKD273, a Urinary Proteomic Biomarker. Kidney Int Rep 2, 1066-1075, doi:10.1016/j.ekir.2017.06.004 (2017).
     
  25. Pontillo, C., Jacobs, L., Staessen, J. A., Schanstra, J. P., Rossing, P., Heerspink, H. J. L., Siwy, J., Mullen, W., Vlahou, A., Mischak, H., Vanholder, R., Zurbig, P. & Jankowski, J. A urinary proteome-based classifier for the early detection of decline in glomerular filtration. Nephrol Dial Transplant 32, 1510-1516, doi:10.1093/ndt/gfw239 (2017).
     
  26. Krochmal, M., Cisek, K., Filip, S., Markoska, K., Orange, C., Zoidakis, J., Gakiopoulou, C., Spasovski, G., Mischak, H., Delles, C., Vlahou, A. & Jankowski, J. Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis. Sci Rep 7, 9091, doi:10.1038/s41598-017-09393-w (2017).
     
  27. Krieter, D. H., Devine, E., Korner, T., Ruth, M., Wanner, C., Raine, M., Jankowski, J. & Lemke, H. D. Haemodiafiltration at increased plasma ionic strength for improved protein-bound toxin removal. Acta Physiol (Oxf) 219, 510-520, doi:10.1111/apha.12730 (2017).
     
  28. Kork, F., Balzer, F., Krannich, A., Bernardi, M. H., Eltzschig, H. K., Jankowski, J. & Spies, C. Back-calculating baseline creatinine overestimates prevalence of acute kidney injury with poor sensitivity. Acta Physiol (Oxf) 219, 613-624, doi:10.1111/apha.12763 (2017).
     
  29. Jansen, J., Jankowski, J., Gajjala, P. R., Wetzels, J. F. M. & Masereeuw, R. Disposition and clinical implications of protein-bound uremic toxins. Clin Sci (Lond) 131, 1631-1647, doi:10.1042/CS20160191 (2017).
     
  30. Gajjala, P. R., Jankowski, V., Heinze, G., Bilo, G., Zanchetti, A., Noels, H., Liehn, E., Perco, P., Schulz, A., Delles, C., Kork, F., Biessen, E., Narkiewicz, K., Kawecka-Jaszcz, K., Floege, J., Soranna, D., Zidek, W. & Jankowski, J. Proteomic-Biostatistic Integrated Approach for Finding the Underlying Molecular Determinants of Hypertension in Human Plasma. Hypertension 70, 412-419, doi:10.1161/HYPERTENSIONAHA.116.08906 (2017).
     
  31. Asare, Y., Ommer, M., Azombo, F. A., Alampour-Rajabi, S., Sternkopf, M., Sanati, M., Gijbels, M. J., Schmitz, C., Sinitski, D., Tilstam, P. V., Lue, H., Gessner, A., Lange, D., Schmid, J. A., Weber, C., Dichgans, M., Jankowski, J., Pardi, R., de Winther, M. P., Noels, H. & Bernhagen, J. Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo. Proc Natl Acad Sci U S A 114, E2766-E2775, doi:10.1073/pnas.1618411114 (2017).
     
  32. Tetali, S. D., Jankowski, V., Luetzow, K., Kratz, K., Lendlein, A. & Jankowski, J. Adsorption capacity of poly(ether imide) microparticles to uremic toxins. Clin Hemorheol Microcirc 61, 657-665, doi:10.3233/CH-152026 (2016).
     
  33. Smith, A., L'Imperio, V., De Sio, G., Ferrario, F., Scalia, C., Dell'Antonio, G., Pieruzzi, F., Pontillo, C., Filip, S., Markoska, K., Granata, A., Spasovski, G., Jankowski, J., Capasso, G., Pagni, F. & Magni, F. alpha-1-Antitrypsin detected by MALDI imaging in the study of glomerulonephritis: Its relevance in chronic kidney disease progression. Proteomics 16, 1759-1766, doi:10.1002/pmic.201500411 (2016).
     
  34. Scholze, A., Jankowski, J., Pedraza-Chaverri, J. & Evenepoel, P. Oxidative Stress in Chronic Kidney Disease. Oxid Med Cell Longev 2016, 8375186, doi:10.1155/2016/8375186 (2016).
     
  35. Kumar, R. K., Basu, S., Lemke, H. D., Jankowski, J., Kratz, K., Lendlein, A. & Tetali, S. D. Effect of extracts of poly(ether imide) microparticles on cytotoxicity, ROS generation and proinflammatory effects on human monocytic (THP-1) cells. Clin Hemorheol Microcirc 61, 667-680, doi:10.3233/CH-152027 (2016).
     
  36. Kumar, R. K., Basu, S., Lemke, H. D., Jankowski, J., Kratz, K., Lendlein, A. & Tetali, S. D. Influence of nanoporous poly(ether imide) particle extracts on human aortic endothelial cells (HAECs). Clin Hemorheol Microcirc 64, 931-940, doi:10.3233/CH-168046 (2016).
     
  37. Krochmal, M., Fernandes, M., Filip, S., Pontillo, C., Husi, H., Zoidakis, J., Mischak, H., Vlahou, A. & Jankowski, J. PeptiCKDdb-peptide- and protein-centric database for the investigation of genesis and progression of chronic kidney disease. Database (Oxford) 2016, doi:10.1093/database/baw128 (2016).
     
  38. Selle, J., Asare, Y., Kohncke, J., Alampour-Rajabi, S., Shagdarsuren, G., Klos, A., Weber, C., Jankowski, J. & Shagdarsuren, E. Atheroprotective role of C5ar2 deficiency in apolipoprotein E-deficient mice. Thromb Haemost 114, 848-858, doi:10.1160/TH14-12-1075 (2015).
     
  39. Schanstra, J. P., Zurbig, P., Alkhalaf, A., Argiles, A., Bakker, S. J., Beige, J., Bilo, H. J., Chatzikyrkou, C., Dakna, M., Dawson, J., Delles, C., Haller, H., Haubitz, M., Husi, H., Jankowski, J., Jerums, G., Kleefstra, N., Kuznetsova, T., Maahs, D. M., Menne, J., Mullen, W., Ortiz, A., Persson, F., Rossing, P., Ruggenenti, P., Rychlik, I., Serra, A. L., Siwy, J., Snell-Bergeon, J., Spasovski, G., Staessen, J. A., Vlahou, A., Mischak, H. & Vanholder, R. Diagnosis and Prediction of CKD Progression by Assessment of Urinary Peptides. J Am Soc Nephrol 26, 1999-2010, doi:10.1681/ASN.2014050423 (2015).
     
  40. Salem, S., Jankowski, V., Asare, Y., Liehn, E., Welker, P., Raya-Bermudez, A., Pineda-Martos, C., Rodriguez, M., Munoz-Castaneda, J. R., Bruck, H., Marx, N., Machado, F. B., Staudt, M., Heinze, G., Zidek, W. & Jankowski, J. Identification of the Vasoconstriction-Inhibiting Factor (VIF), a Potent Endogenous Cofactor of Angiotensin II Acting on the Angiotensin II Type 2 Receptor. Circulation 131, 1426-1434, doi:10.1161/CIRCULATIONAHA.114.013168 (2015).
     
  41. Rueth, M., Lemke, H. D., Preisinger, C., Krieter, D., Theelen, W., Gajjala, P., Devine, E., Zidek, W., Jankowski, J. & Jankowski, V. Guanidinylations of albumin decreased binding capacity of hydrophobic metabolites. Acta Physiol (Oxf) 215, 13-23, doi:10.1111/apha.12518 (2015).
     
  42. Pena, M. J., Jankowski, J., Heinze, G., Kohl, M., Heinzel, A., Bakker, S. J., Gansevoort, R. T., Rossing, P., de Zeeuw, D., Heerspink, H. J. & Jankowski, V. Plasma proteomics classifiers improve risk prediction for renal disease in patients with hypertension or type 2 diabetes. J Hypertens 33, 2123-2132, doi:10.1097/HJH.0000000000000685 (2015).
     
  43. Pena, M. J., de Zeeuw, D., Mischak, H., Jankowski, J., Oberbauer, R., Woloszczuk, W., Benner, J., Dallmann, G., Mayer, B., Mayer, G., Rossing, P. & Lambers Heerspink, H. J. Prognostic clinical and molecular biomarkers of renal disease in type 2 diabetes. Nephrol Dial Transplant 30 Suppl 4, iv86-95, doi:10.1093/ndt/gfv252 (2015).
     
  44. Pasqualon, T., Pruessmeyer, J., Jankowski, V., Babendreyer, A., Groth, E., Schumacher, J., Koenen, A., Weidenfeld, S., Schwarz, N., Denecke, B., Jahr, H., Dreymueller, D., Jankowski, J. & Ludwig, A. A cytoplasmic C-terminal fragment of Syndecan-1 is generated by sequential proteolysis and antagonizes Syndecan-1 dependent lung tumor cell migration. Oncotarget 6, 31295-31312, doi:10.18632/oncotarget.5174 (2015).
     
  45. Lanza, D., Perna, A. F., Oliva, A., Vanholder, R., Pletinck, A., Guastafierro, S., Di Nunzio, A., Vigorito, C., Capasso, G., Jankowski, V., Jankowski, J. & Ingrosso, D. Impact of the uremic milieu on the osteogenic potential of mesenchymal stem cells. PLoS One 10, e0116468, doi:10.1371/journal.pone.0116468 (2015).
     
  46. Kork, F., Balzer, F., Spies, C. D., Wernecke, K. D., Ginde, A. A., Jankowski, J. & Eltzschig, H. K. Minor Postoperative Increases of Creatinine Are Associated with Higher Mortality and Longer Hospital Length of Stay in Surgical Patients. Anesthesiology 123, 1301-1311, doi:10.1097/ALN.0000000000000891 (2015).
     
  47. Jankowski, J., Schanstra, J. P. & Mischak, H. Body fluid peptide and protein signatures in diabetic kidney diseases. Nephrol Dial Transplant 30 Suppl 4, iv43-53, doi:10.1093/ndt/gfv091 (2015).
     
  48. Holzweber, M., Lippitz, A., Krueger, K., Jankowski, J. & Unger, W. E. Surface characterization of dialyzer polymer membranes by imaging ToF-SIMS and quantitative XPS line scans. Biointerphases 10, 019011, doi:10.1116/1.4907937 (2015).
     
  49. Holmar, J., Uhlin, F., Fernstrom, A., Luman, M., Jankowski, J. & Fridolin, I. An optical method for serum calcium and phosphorus level assessment during hemodialysis. Toxins (Basel) 7, 719-727, doi:10.3390/toxins7030719 (2015).
     
  50. Glorieux, G., Mullen, W., Duranton, F., Filip, S., Gayrard, N., Husi, H., Schepers, E., Neirynck, N., Schanstra, J. P., Jankowski, J., Mischak, H., Argiles, A., Vanholder, R., Vlahou, A. & Klein, J. New insights in molecular mechanisms involved in chronic kidney disease using high-resolution plasma proteome analysis. Nephrol Dial Transplant 30, 1842-1852, doi:10.1093/ndt/gfv254 (2015).
     
  51. Gajjala, P. R., Sanati, M. & Jankowski, J. Cellular and Molecular Mechanisms of Chronic Kidney Disease with Diabetes Mellitus and Cardiovascular Diseases as Its Comorbidities. Front Immunol 6, 340, doi:10.3389/fimmu.2015.00340 (2015).
     
  52. Gajjala, P. R., Fliser, D., Speer, T., Jankowski, V. & Jankowski, J. Emerging role of post-translational modifications in chronic kidney disease and cardiovascular disease. Nephrol Dial Transplant 30, 1814-1824, doi:10.1093/ndt/gfv048 (2015).
     
  53. Filip, S., Vougas, K., Zoidakis, J., Latosinska, A., Mullen, W., Spasovski, G., Mischak, H., Vlahou, A. & Jankowski, J. Comparison of Depletion Strategies for the Enrichment of Low-Abundance Proteins in Urine. PLoS One 10, e0133773, doi:10.1371/journal.pone.0133773 (2015).
     
  54. Bohringer, F., Jankowski, V., Gajjala, P. R., Zidek, W. & Jankowski, J. Release of uremic retention solutes from protein binding by hypertonic predilution hemodiafiltration. ASAIO J 61, 55-60, doi:10.1097/MAT.0000000000000166 (2015).