PD Dr. Dominik Wiemuth

Room: 6th Floor, Corridor D, Room 20
Room: 5th Floor, Corridor 43, Room 17

Tel: +49 241 80-88802
Fax: +49 241 80-82434

Curriculum Vitae

1997 - 2002
Study of Biology with focus on molecularbiology and biochemistry, University of Mainz

2003 - 2006
PhD thesis at the Department of Physiology, with Fiona J. McDonnald, University of Otago, New Zealand

PhD in Physiology, topic: Regulation of the Epithelial Sodium Channel (ENaC) by Ubiquitination

07/2006 - 03/2008
Postdoc at the Institute of Physiology, University Würzburg

since 04/2008
Postdoc at the Institute of Physiology, University Hospital Aachen


Research Interests

  • Proton-activated channnels (Acid-sensing ion channels)
  • TRP Channels
  • Bile Acid-Sensitive Ion Channel (BASIC)


  1. Schmidt A, Löhrer D, Alsop RJ, Lenzig P, Oslender-Bujotzek A, Wirtz M, Rheinstädter MC, Gründer S, Wiemuth D.
    A Cytosolic Amphiphilic α-Helix Controls the Activity of the Bile Acid-sensitive Ion Channel (BASIC).
    J Biol Chem. 2016 Nov 18;291(47):24551-24565.
  2. Hendriks CM, Penning TM, Zang T, Wiemuth D, Gründer S, Sanhueza IA, Schoenebeck F, Bolm C.
    Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities.
    Bioorg Med Chem Lett. 2015 Oct 15;25(20):4437-40. doi: 10.1016/j.bmcl.2015.09.012.
  3. Schmidt, A., Lenzig, P., Oslender-Bujotzek, A., Kusch, J., Dias Lucas, S., Gründer, S., and Wiemuth, D. (2014)
    The bile acid-sensitive ion channel (BASIC) is activated by alterations of its membrane Environment.
    PLoS One 9, e111549.
  4. Wiemuth, D., Assmann, M., and Gründer, S. (2014)
    The bile acid-sensitive ion channel (BASIC), the neglected cousin of ASICs and ENaC. Channels (Austin) 8, 29-34.
  5. Wiemuth, D., Lefevre, C. M., Heidtmann, H., and Gründer, S. (2014)
    Bile acids increase the activity of the epithelial Na+ hannel.
    Pflugers Arch 466, 1725-1733
  6. Vollrath, J. T., Sechi, A., Dreser, A., Katona, I., Wiemuth, D., Vervoorts, J., Dohmen, M., Chandrasekar, A., Prause, J., Brauers, E., Jesse, C. M., Weis, J., and Goswami, A. (2014)
    Loss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbances.
    Cell death & disease 5, e1290.
  7. Lefevre, C. M., Diakov, A., Haerteis, S., Korbmacher, C., Gründer, S., and Wiemuth, D. (2014) Pharmacological and electrophysiological characterization of the human bile acid-sensitive ion channel (hBASIC).
    Pflugers Arch 466, 253-263.
  8. Wiemuth D, Sahin H, Lefèvre CM, Wasmuth H, Gründer S.
    Strong activation of bile acid-sensitive ion channel (BASIC) by ursodeoxycholic acid.
    Channels (Austin). 2012 Oct 12;7(1). [Epub ahead of print]
  9. Wiemuth D, van de Sandt L, Herr R, Gründer S. (2012)
    Transient receptor potential N (TRPN1) from Xenopus interacts with the penta-EF-hand protein peflin
    FEBS Letters 586 (2012) 4276–4281
  10. Wiemuth D, Sahin H, Falkenburger BH, Lefèvre CM, Wasmuth HE, Gründer S (2012)
    BASIC-a bile acid-sensitive ion channel highly expressed in bile ducts.
    FASEB J. 26(10), 4122-30
  11. Wiemuth D, Gründer S (2011) 
    The pharmacological profile of brain liver intestine Na+ channel (BLINaC): inhibition by diarylamidines and activation by fenamates.  
    Mol Pharmacol, 80(5), 911–919
  12. Wiemuth D, Lott JS, Ly K, Ke Y, Teesdale-Spittle P, Snyder PM, McDonald FJ. (2010)
    Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation. 
    PLoS One, 5(8):e12163.
  13. Wiemuth D, Gründer S. (2010)
    A single amino acid tunes Ca2+ inhibition of brain liver intestine Na+ channel(BLINaC). 
    J Biol Chem, 285(40), 30404-10
  14. Wiemuth D, Ke Y, Rohlfs M und McDonald FJ (2007)
    Epithelialsodiumchannel (ENaC) is multiubiquitinated at the cell surface. 
    Biochem J, 405 (1):147:55