Welcome to the Website of the Institute of Physiology!

The Institute of Physiology is one of three Physiological Institutes. Our research has a focus on ion channels. Ion channels are the basis of neuronal excitability and of communication between neurons. Mutations in ion channels can lead to diseases and malregulation of ion channels determines the clinical picture of many diseases. The analysis of ion channels in molecular detail contributes to a better understanding of their pathophysiological role and is the basis for an educated pharmacotherapy. In addition, the group of Khosrow Mottaghy works on artificial organs, in particular on extracorporeal circulation.

On our website you can find the most relevant information on us and on our research. We strive for a high quality in teaching. More information on our teaching and on the history of the Institute can be found here (in German only).

Yours sincerely
Stefan Gründer

News from the Institute of Physiology

08/09/2023

Functional characterisation of Acid-Sensing Ion Channels in Glioblastoma stem cell lines

Typically, the micro-environment of a tumour has a slightly acidic pH. It it therefore important to characterize acid sensors, like Acid-sensing ion channels (ASICs), in tumor cells. In our most…

08/08/2023

Functional characterisation of an important heteromeric Acid-Sensing Ion Channels of the PNS

Acid-sensing ion channels (ASICs) are proton-gated ion channels that are also expressed in the peripheral nervous system where they detect painful acidosis. ASICs assemble as homo- or heterotrimers.…

06/28/2023

Modulation of Acid-Sensing Ion Channels by tannic acid and green tea

Phytochemicals represent a large pool of substances with the potential to modulate diverse proteins, for example ion channels. In our recent study, which has been published in the journal ACS Chemical…

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Welcome to the Website of the Institute of Physiology!

News from the Institute of Physiology

Functional characterisation of Acid-Sensing Ion Channels in Glioblastoma stem cell lines

Functional characterisation of an important heteromeric Acid-Sensing Ion Channels of the PNS

Modulation of Acid-Sensing Ion Channels by tannic acid and green tea

Calendar of events

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Stiftung Universitätsmedizin Aachen

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