Acid-sensing ion channels (ASICs) are proton-gated Na+-channels, which are normally expressed in neurons. However, also many tumour cells express ASICs. Because tumour cells thrive in an acidic…

Melatonin is well known as “sleeping hormone”. In the USA and Canada, it is also sold as an over-the-counter dietary supplement and strong antioxidative effects and positive effects on diverse…

Typically, the micro-environment of a tumour has a slightly acidic pH. It it therefore important to characterize acid sensors, like Acid-sensing ion channels (ASICs), in tumor cells. In our most…