Interaction of opioid neuropeptides with ASIC1a resolved
The opioid neuropeptide big dynorphin increases the activity of Acid-Sensing Ion Channel 1a (ASIC1a) during sustained acidosis, as it occurs, for example, during stroke. Because sustained activation…
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Characterization of proton-sensitive ion channels in human dopaminergic neurons
Proton-sensitive ion channels, so called ASICs, have already been characterized in many neurons of rodents – mice and rats. Their characterization in human neurons, however, is more difficult and…
Indirect regulation of the voltage-gated K+ channel Kv1.1 by the mono-ADP-ribosyltransferase ARTD10 identified
The voltage-gated K+ channel Kv1.1 is one of the dominant K+ channels in the central nervous system. Kv1.1 activity is tightly regulated by different mechanisms. For example, protein kinase C (PKC)…
