Message archive

Functional characterisation of Acid-Sensing Ion Channels in Glioblastoma stem cell lines

Typically, the micro-environment of a tumour has a slightly acidic pH. It it therefore important to characterize acid sensors, like Acid-sensing ion channels (ASICs), in tumor cells. In our most…

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Functional characterisation of an important heteromeric Acid-Sensing Ion Channels of the PNS

Acid-sensing ion channels (ASICs) are proton-gated ion channels that are also expressed in the peripheral nervous system where they detect painful acidosis. ASICs assemble as homo- or heterotrimers.…

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Modulation of Acid-Sensing Ion Channels by tannic acid and green tea

Phytochemicals represent a large pool of substances with the potential to modulate diverse proteins, for example ion channels. In our recent study, which has been published in the journal ACS Chemical…

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Our former scientist Elinor Cleuvers successfully finished her MD thesis

Today our MD student Elinor Cleuvers successfully passed the oral examination at the end of her thesis. Part of the results of her doctoral thesis entitled „Interaction of the opioid neuropeptid Big…

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Das Institut für Physiologie trauert um Helmut Kammermeier

Am 21.02.2023 verstarb Helmut Kammermeier, von 1971-1997 Professor am Institut für Physiologie. Bereits 1966 kam H. Kammermeier mit dem Gründungsdirektor des Instituts, Eckehard Gerlach, aus Freiburg…

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Jan Clusmann successfully finished his MD thesis with highest honors.

Today our MD student Jan Clusmann successfully passed the oral examination at the end of his thesis with summa cum laude. The results of his doctoral thesis entitled „Acid-sensing ion channel 1a…

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Katharina Foreman successfully finished her PhD thesis

Today our PhD student Katharina Foreman successfully defended her dissertation entitled „Functional Ion Channel Characterization in the Cnidarian Nematostella vectensis”. We sincerely congratulate her…

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The complexity of the DEG/ENaC ion channel family revealed

DEG/ENaC ion channels share a common structure but serve many different functions. What was the ancestral function of these channels? How did their diversity develop during evolution? These are the…

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Why do tumor cells grow more aggressively in an acidic microenvironment?

Glioblastoma stem cells grow more aggressively in an acidic microenvironment.  In our most recent publication, which was published in Pflügers Archiv – European Journal of Physiology, we show that…

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Interaction of an ion channel family with neuropeptides in diverse animals

DEG/ENaC ion channels serve different functions: in some animals they detect mechanical stimuli, in others they detect pheromones, and in humans they are sensitive for acid and are important for…

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Catharina Maiers receives the Friedrich Wilhelm Award of RWTH Aachen University

Today, our former MD student, Catharina Maiers (née Reimers), received the Friedrich Wilhelm Award of RWTH Aachen University. The Friedrich Wilhelm Award is awarded by the foundation of the same name…

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Annual Retreat of the Institute of Physiology

Today more than 30 members of the Institute of Physiology assembled at Youth Hostel Aachen for our annual retreat. Big thanks to everyone  for the great presentations and lively discussions. And for…

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