Prof. Dr. rer. nat. Stefan Gründer

Room: 5th Floor, Corridor D, Room 20

Tel: +49 241 80-88800
Fax: +49 241 80-82434
sgruenderukaachende

Curriculum Vitae

1983 - 1989
Studies of Biology at the University of Cologne

1989 - 1990
Community service at the University of Cologne, Department of Otolaryngology, Head and Neck Surgery (Division of Audiology)

1990 - 1993
Doctoral work with Thomas J. Jentsch at the centre for Molecular Neurobiology Hamburg /ZMNH)

1993
PhD in Biology, University of Hamburg

1993 - 1997
Postdoctoral work with Bernard C. Rossier at the Institute of Pharmacology, Lausanne, Switzerland

1998 - 1999
Labhead at the Department of Otolaryngology, University of Tübingen; Group of J. Peter Ruppersberg

2000 - 2002
Head of a Research Group at the Medical School of the University of Tübingen

2003 - 2004
Research Group Leader at the Department of Physiology, University Tübingen

2004 - 2007
Associate Professor of Physiology, University Würzburg

2007
Acting Chairman of the Physiological Institute II, University Würzburg

since 2008
Full Professor of Physiology (Director), RWTH-Aachen

Honors and Awards

Faculty Work 

  • 2012 - 2016: Dean of Studies

Work as a Referee

Referee for scientific organisations:

  • French National Research Agency (ANR)
  • Deutsche Forschungsgemeinschaft (DFG)
  • Research Foundation - Flanders (FWO), Belgium
  • Austrian Science Fund (FWF)
  • German Israeli Foundation (GIF)
  • National Science Foundation (NSF), USA
  • Netherlands Organisation for Scientific Research (NWO)
  • Swiss National Science Foundation (SNF)

Referee for Scientific Journals (selection):

  • Nature
  • Nature Chemical Biology
  • Nature Communications
  • Nature Structural and Molecular Biology
  • Proceedings of the National Academy of Sciences (USA)
  • Journal of Clinical Investigation
  • Journal of Neuroscience
  • Journal of Biological Chemistry
  • Journal of General Physiology
  • Journal of Physiology, London

Member of the Editorial Board of the „International Journal of Physiology, Pathophysiology and Pharmacology

Selected Publications

  • Gründer S, Thiemann A, Pusch M und Jentsch TJ.
    Regions involved in the opening of ClC-2 chloride channel by voltage and cell-volume.
    Nature 360: 759 – 762, (1992)
    [demonstration that the ubiquitoulsy expressed chloride channel ClC-2 is sensitive to changes in cell volume]
  • Gründer S, Firsov D, Chang SS, Fowler Jaeger N, Gautschi I, Schild S, Lifton RP und Rossier BC.
    A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel.
    EMBO J. 16: 899 – 907, (1997)
    [demonstration that a mutation leading to the salt-wasting syndrome pseudohypoaldosteronism type I reduces the open probability of the epithelial Na+ channel, explaining disease pathophysiology]
  • Babini E, Paukert M, Geisler H-S und Gründer S
    Alternative splicing and interaction with di- and polyvalent cations control the dynamic range of acid-sensing ion channel (ASIC) 1.
    J. Biol. Chem. 277, 41597-41603 (2002)
    [thorough characterization of gating of acid-sensing ion channels; demonstration that extracellular Ca2+ has a strong influence on gating]
  • Chen X, Kalbacher H und Gründer S
    The tarantula toxin Psalmotoxin 1 inhibits Acid Sensing Ion Channel (ASIC) 1a by increasing ist apparent H+ affinity.
    J. Gen. Physiol. 126 (1), 71-79 (2005)
    [demonstration that the spider toxin PcTx1 is a gating-modifier of acid-sensing ion channels]
  • Golubovic A, Kuhn A, Williamson M, Kalbacher H, Holstein TW, Grimmelikhuijzen CJ und Gründer S
    A peptide-gated ion channel from the freshwater polyp Hydra.
    J. Biol. Chem., 282, 35098-35103 (2007)
    [first cloning of a ligand-gated ion channel from Hydra, directly gated by a peptide of the Hydra nervous system]
  • Bartoi T, Augustinowski K, Polleichtner G, Gründer S & Ulbrich MH
    Acid-sensing ion channel (ASIC) 1a/2a heteromers have a flexible 2:1/1:2 stoichiometry.
    Proc. Natl. Acad. Sci. USA, 111(2), 8281-8286 (2014)

All Publications