Prof. Dr. rer. nat.



1987 - 1991  PhD student, Max-Planck-Institute for Brain Research, Frankfurt, Germany, Prof. H. Wässle
1991 – 1996 Post-Doc, Institute of Biological Information Processing, Molecular and Cellular Physiology (IBI-1), Forschungszentrum Jülich, Jülich, Germany
1996 – present   Group leader “Signal processing in the retina”, Institute of Biological Information Processing, Molecular and Cellular Physiology (IBI-1), Forschungszentrum Jülich, Jülich, Germany
2006 – present                              Prof. for Molecular Sensory Biology and Neurobiology, RWTH Aachen, Germany


Academic Qualification and Education

1987         Diploma in Biology, Johannes-Gutenberg-University, Mainz, Germany
1991 Doctor of natural sciences, Johannes-Gutenberg-University, Mainz, Germany
2006  Professor at RWTH Aachen University


Teaching Experience

  • Molecular Neurobiology (Winter Semesters since 2006), M.Sc. Level.
  • Molecular Sensory Biology (Summer Semesters, since 2006), M.Sc. Level.
  • Cell Biology (International Helmholtz Research School Biosoft, since 2008).
  • Signaling (International Helmholtz Research School Biosoft, since 2012)


Honors, Awards, Scholarships and Other Appointments (Selection)

  • Reviewer for different international scientific journals


Research Topics

Information and signal processing in the healthy and diseased retina. Modulation of signal processing. Development of new therapeutic approaches and retinal implants.


Key Publications

  1. Müller, F., Scholten, A., Ivanova, E., Haverkamp, S., Kremmer, E., und Kaupp, U.B. (2003): HCN channels are differentially expressed in retinal bipolar cells and concentrated at synaptic terminals. European Journal of Neuroscience 17: 2084-2096.
  2. Mataruga, A., Kremmer, E. und Müller, F. (2007): Type 3a and 3b OFF-cone bipolar cells provide for the alternative rod pathway in the mouse retina. Journal of Comparative Neurology 502: 1123-1137.
  3. Knop, G., Seeliger, M.W., Thiel, F., Mataruga, A., Kaupp, U.B., Friedburg, C., Tanimoto, N, und Müller, F. (2008): Light responses in the mouse retina are prolonged upon targeted deletion of the HCN1 channel gene. European Journal of Neurosience 28:2221-2230
  4. Wässle, H., Puller, C., Müller, F. und Haverkamp, S.  (2009): Cone contacts, mosaics, and territories of bipolar cells in the mouse retina. Journal of Neuroscience 29: 106-117.
  5. Seeliger, M.W., Brombas, A., Weiler, R., Humphries, P., Knop, G., Tanimoto, N., and Müller, F. (2012): Modulation of rod photoreceptor output by HCN1 channels is essential for regular mesopic cone vision. Nature Communications 2:532/DOI:10.1038/ncomms1540
  6. Biswas S, Haselier C, Mataruga A, Thumann G, Walter P, Müller F. Pharmacological analysis of intrinsic neuronal oscillations in rd10 retina. PloS one. 2014;9(6):e99075. doi: 10.1371/journal.pone.0099075. PubMed PMID: 24918437; PubMed Central PMCID: PMC4053359.
  7. Rösch S, Johnen S, Mataruga A, Müller F, Pfarrer C, Walter P. Selective photoreceptor degeneration by intravitreal injection of N-methyl-N-nitrosourea. Investigative ophthalmology & visual science. 2014;55(3):1711-23. doi: 10.1167/iovs.13-13242. PubMed PMID: 24550357.
  8. Rösch S, Johnen S, Mazinani B, Müller F, Pfarrer C, Walter P. (2015) The effects of iodoacetic acid on the mouse retina. Graefes Arch Clin Exp Ophthalmol; 253(1):25-35.
  9. Rösch S, Werner C, Müller F, Walter P. Photoreceptor degeneration by intravitreal injection of N-methyl-N-nitrosourea (MNU) in rabbits: a pilot study. Graefes Arch Clin Exp Ophthalmol. 2017 Feb;255(2):317-331. doi: 10.1007/s00417-016-3531-7.
  10. Haselier, C, Biswas, S, Rösch S, Thumann G, Müller F, Walter P. Correlations between specific patterns of spontaneous activity and stimulation efficiency in degenerated retina. PLoS ONE 12(12):e0190048. doi.org/10.1371/journal.pone.0190048