We were the first to show that mechanical ventilation can release pro-inflammatory Mediators. This work was followed by papers of the Art Slutsky‘s group in 1997 (JCI 99: 944) and our own group in 1998 (AJRCCM 157:263). Subsequently, we have described several of the mechanisms of ventilation-induced inflammation, such as the role of NF-ĸ or PI3-kinase. We have recently reviewed the mechanisms of ventilation-induced lung injury.
At present we are continuing to examine the molecular and mechanical aspects of ventiulation induced lung injury.