WP 2.3 Animal model causality testing: Antibodies as hunger and satiety peptide carriers, brain passage and effect on dopamine release
Objective: To determine whether plasmatic antibodies may transport the hormones ghrelin and alpha-MSH to the brain across the blood-brain-barrier resulting in the activation of dopamine neurons involved in the control of appetite and whether this function of antibodies is altered in patients with AN.
Professor S. Fetissov
(PI) Inserm Neuroendocrinology Research Unit,
Rouen University, France.