Message archive
Annual Retreat of the Institute of Physiology
Today more than 40 members of the Institute of Physiology assembled at Youth Hostel Aachen for our annual retreat. Exciting presentations and lively discussions – but also the table tennis tournament…
Newly discovered effects of bile acids on P2X receptors
In addition to their classical role in digestion, bile acids have been shown in recent years to have additional functions, particularly in various cellular signaling cascades. Recently we were able to…
First functional characterization of a novel ADPR-interaction site in TRPM2 channels
Recent cryo-electron microscopic analyzes of a species variant of the human TRPM2 channel confirm the existence of a novel interaction site for ADP-ribose (ADPR) as already postulated by our group in…
Two prizes at the 7th Symposium of the Young Physiologists in Nuremberg
At the 7th Symposium of the Young Physiologists, which took place on 14 and 15 March 2019 in Nuremberg, Germany, Sarah Thull won the prize for the best talk. The title of her talk was “Resurgent-like…
Gelungenes Forschungsprojekt
Forschungsprojekt des Instituts für Physiologie wird vom Bundesministerium für Wirtschaft und Energie als Erfolgsbeispiel hervorgehoben
Annual Retreat of the Institute of Physiology
Today the Institute of Physiology had for the fourth time its annual retreat – for the third time at Youth Hostel Aachen. Even if the location does not seem to be very fancy (it is better than it…
Stefan Gründer was elected to Vice-President of the German Physiological Society
At the general meeting of the German Physiological Society (DPG) at the Europhysiology meeting in London, Stefan Gründer was elected to Vice-President of the DPG. His term starts on 1st of January…
Dr. Lilia Leisle comes from Cornell University to work at the Institute of Physiology
On August 1 2018, Dr. Lilia Leisle starts at the Institute of Physiology in the Gründer group. After finishing her thesis at the Max-Delbrück-Center for Molecular Medicine in Berlin, she moved for six…
Putative binding site of RFamide-neuropeptides on ASIC3 identified
RFamid-neuropeptides are important modulators of Acid-sensing ion channels (ASICs), in particular of ASIC3. By slowing desensitization of ASIC3, they strongly increase the excitatory current, which…
The sodium channel Nav1.7 is mechanically stabilized by its β-subunit
Voltage-gated sodium channels (Navs) not only respond to changes in membrane potential, but are also modified by mechanical stress in the cell membrane. In a living organism, mechanical influences are…
The opioid oxycodone inhibits the sodium channel of cardiomyocytes
Opioids are often the last resort for pain relief in patients that suffer from severe acute or chronic pain. Unfortunately, opioids can cause addiction and they have recently become notorious for…
Characterisation of a Wamid-activated ion channel in a marine annelid
Neuropeptides are structurally diverse and broadly distributed in the animal kingdom. Typically, they activate G protein-coupled receptors. But we also know a few ion channels that are directly…
