Group Leader
Univ.-Prof. Dr. med. Michael Gramlich
Facharzt für Innere Medizin – Kardiologie, Spezielle Rhythmologie/invasive Elektrophysiologie
Tel.: 0241 80-80186
Fax: 0241 80 82142
mgramlichukaachende
Genetic Mechanisms of Heart Failure and Arrhythmias
One focus of our working group is the identification of genetic alterations that lead to cardiomyopathies and arrhythmias. If we can demonstrate a disease-causing mutation in a patient, it can be introduced into a mouse or cell culture model (hiSPC) using CRISPR/Cas9 technology. We use these models to better understand disease mechanisms and to develop personalized therapy concepts.
Mechanisms of Atrial Fibrosis
Another focus of the working group is the identification of disease mechanisms that lead to atrial remodeling processes and the development of atrial fibrillation. Additionally, we investigate blood biomarkers that reflect the extent of atrial cardiomyopathy.
Clinical Studies
The Rhythmology department at UK Aachen participates in numerous studies related to the treatment of atrial fibrillation.
Examples:
- OCEANIC-AF: Global multicenter study on the effectiveness of a new anticoagulant (so-called Factor XI inhibitor Asundexian)
- MANIFEST-17K: Evaluation of the safety profile of a pulsed-field ablation system
- POLAR: Comparison of two cryoablation systems for the treatment of atrial fibrillation
- MISTRAL: Identification of miRNA biomarkers that predict treatment success in atrial fibrillation ablation
If you are interested in participating as a patient in a clinical study, please contact us. We would be happy to check if inclusion in a study is possible.
