With his colleagues Kit Roes and Nigel Stellard, Prof. Ralf-Dieter Hilgers published a precedent-setting paper on methodology for small population group trials. The paper “Directions for new developments on statistical design and analysis of small population group trials” addresses the challenges presented by the EMA/CHMP guideline and discusses recent developments in extrapolation. It was issued in the Orphanet Journal of Rare Diseases, and can be accessed here.
Prof. Ralf-Dieter Hilgers publishes paper on new developments for small population group trials
Uniklinik RWTH Aachen
Dr. Mathias Brandstädter
Tel. 0241 80-89893