Juliane Bremer

Jun.-Prof. Dr. med. Dr. sc. nat. Juliane Bremer
Attending physician and group leader

Tel.: 0241 80-89418
jbremerukaachende

 

Research aims

We use zebrafish to model neuromuscular diseases. Using zebrafish allows us to combine genetic tools (CRISPR/Cas9, transgenesis), modern imaging tools, histological and ultrastructural analysis as well as compound library screens to determine the pathophysiology of neuromuscular diseases like Amyotrophic lateral sclerosis, hereditary peripheral neuropathies and muscle diseases. We focus on determining whether genes that are mutated in neuromuscular diseases control development, maintenance and regeneration of nerves and skeletal muscle. Findings in zebrafish are correlated with clinicopathological observations in affected patients.

Zebrafish, CRISPR/Cas9, neuromuscular diseases, spinning disc confocal microscope, compound library screen

Martin Groß, BSc, MSc
PhD student

Kamil Zajt, BSc
Master student

Xinwen Dou, BSc
Master student

Miriam Langener
Medical doctoral student

Tayfun Palaz, BTA
Technician

Klimentina Popzhelyazkova, BSc 
Student

2022: DFG funding for a spinning disk confocal microscope with ablation and FRAP laser

Postdoctoral training:
Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, USA, supervisor: Prof. Michael Granato

PhD training:
Institute of Neuropathology, University Hospital Zürich, Switzerland, supervisor: Prof. Adriano Aguzzi

Medical training:
Institute of Neuropathology, Pathology and Department of Neurology of the University Hospital Zürich, Switzerland

O'Connor T, Zhou X, Kosla J, Adili A, Garcia Beccaria M, Kotsiliti E, Pfister D, Johlke AL, Sinha A, Sankowski R, Schick M, Lewis R, Dokalis N, Seubert B, Höchst B, Inverso D, Heide D, Zhang W, Weihrich P, Manske K, Wohlleber D, Anton M, Hoellein A, Seleznik G, Bremer J, Bleul S, Augustin HG, Scherer F, Koedel U, Weber A, Protzer U, Förster R, Wirth T, Aguzzi A, Meissner F, Prinz M, Baumann B, Höpken UE, Knolle PA, von Baumgarten L, Keller U, Heikenwalder M. (2019): Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention. Cancer Cell. 36 (3): 250-267.

Bremer J, Marsden KC, Miller A, Granato M. (2019): The ubiquitin ligase PHR promotes directional regrowth of spinal zebrafish axons. Commun Biol. 2: 195

Ducommun Priest M, Navarro MF, Bremer J, Granato M (2019): Dynein promotes sustained axonal growth and Schwann cell remodeling early during peripheral nerve regeneration. PLoS Genet. 15(2): e1007982

Bremer J, Skinner J, Granato M (2017): A small molecule screen identifies in vivo modulators of peripheral nerve regeneration in zebrafish. PLoS One. 12 (6): e0178854.

Bremer J, Granato M (2016): Myosin phosphatase fine-tunes zebrafish motoneuron position during axonogenesis. PLoS Genetics. 12 (11): e1006440.

Bremer J, O’Connor T, Tiberi C, Rehrauer H, Weis J, Aguzzi A (2010): Ablation of Dicer from murine Schwann cells increases their proliferation while blocking myelination. PLoS One. 5 (8): e12450.

Bremer J, Baumann F, Tiberi C, Wessig C, Fischer H, Schwarz P, Steele AD, Toyka KV, Nave KA, Weis J, Aguzzi A (2010): Axonal prion protein is required for peripheral myelin maintenance. Nature Neurosci. 13 (3): 310-318.

Bremer J, Heikenwalder M, Haybaeck J, Tiberi C, Krautler NJ, Kurrer MO, Aguzzi A (2009): Repetitive immunization enhances the susceptibility of mice to peripherally administered prions. PLoS One. 4 (9): e7160.

Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Graf R, Clavien PA, Thimme R, Blum H, Nedospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL, Aguzzi A, Heikenwalder M (2009): A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell. 16 (4): 295-308.

Aguzzi A, Baumann F, Bremer J (2008): The prion's elusive reason for being. Annu Rev Neurosci. 31: 439-77. Review.