Publikationen
2021
- Shari Wiegreffe, Daniel Löhrer, Monika Wirtz, Dominik Wiemuth. "The bile acid-sensitive ion channel (BASIC) mediates bile acid-dependent currents in bile duct epithelial cells" Pflügers Archiv - European Journal of Physiology volume 473, pages1841–1850 (2021)
- Leisle L, Margreiter M, Ortega-Ramírez A, Cleuvers E, Bachmann M, Rossetti G, Gründer S. „Dynorphin Neuropeptides Decrease Apparent Proton Affinity of ASIC1a by Occluding the Acidic Pocket“ J Med Chem. 2021;64(18):13299-13311
- Bachmann M, Ortega-Ramírez A, Leisle L, Gründer S. “Efficient expression of a cnidarian peptide-gated ion channel in mammalian cells.” Channels (Austin) 2021 Dec;15(1):273-283. doi: 10.1080/19336950.2021.1882762.
- Heinrichs* B, B Liu*, J Zhang, JE Meents, KT Le, A Erickson, P Hautvast, X Zhu, N Li, Y Liu, M Spehr, U Habel, M Rothermel, B Namer, X Zhang, A Lampert#, G Duan#. “The Potential Effect of Nav1.8 in Autism Spectrum Disorder: Evidence From a Congenital Case With Compound Heterozygous SCN10A Mutations” Frontiers in Molecular Neuroscience, accepted.
- Kuspiel S, Wiemuth D, Gründer S. “The Neuropeptide Nocistatin Is Not a Direct Agonist of Acid-Sensing Ion Channel 1a (ASIC1a).” Biomolecules 2021 Apr 13;11(4):571. doi: 10.3390/biom11040571.
- Le Cann K, A Foerster, C Rösseler, A Erickson, P Hautvast, S Giesselmann, D Pensold, I Kurth, M Rothermel, VB Mattis, G Zimmer, S von Hörsten, B Denecke, T Clarner, J Meents, A Lampert. “The difficulty to model Huntington’s Disease in vitro using striatal Medium Spiny Neurons differentiated from human induced pluripotent stem cells.” Scientific Reports, 2021; 11: 6934
- Le Cann K., Meents JE, Eswaran VSB, Dohrn MF, Bott R, Maier A, Bialer M, Hautvast P, Erickson A, Rolke R, Rothermel M, Körner J, Kurth I, Lampert A. “Assessing the impact of pain-linked Nav1.7 variants: An example of two variants with no biophysical effect.” Channels (Austin). 2021 Jan;15(1):208-228
- Neuhof A, Tian Y, Reska A, Falkenburger B, Gründer S. “Large Acid-Evoked Currents, Mediated by ASIC1a, Accompany Differentiation in Human Dopaminergic Neurons.” Front Cell Neurosci 2021 Apr 27;15:668008. doi: 10.3389/fncel.2021.668008. eCollection 2021.
2020
- Cypris O, Eipel M, Franzen J, Rösseler C, Tharmapalan V, Kuo CC, Vieri M, Nikolić M, Kirschner M, Brümmendorf TH, Zenke M, Lampert A, Beier F, Wagner W.
PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation.
Clin Epigenetics. 2020 Aug 20;12(1):125. - Kühn FJP.
Structure-Function Relationship of TRPM2: Recent Advances, Contradictions, and Open Questions.
Int J Mol Sci. 2020 Sep 4;21(18):E6481. doi: 10.3390/ijms21186481.
https://pubmed.ncbi.nlm.nih.gov/32899872/ - Israel MR, TS Dash, SN Bothe, SD Robinson, JR Deuis, DJ Craik, A Lampert, I Vetter, T Durek.
Characterization of Synthetic Tf2 as a NaV1.3 Selective Pharmacological Probe.
Biomedicines 2020, 8(6), 155 - Jo HG, O. Wudarczyk, M. Leclerc, C. Regenbogen, A. Lampert, M. Rothermel, U. Habel.
Effect of odor pleasantness on heat-induced pain: An fMRI study.
Brain Imaging and Behavior, 2020 Aug 8. - Kerth CM, Hautvast P, Körner J, Lampert A, Meents JE. “Phosphorylation of a chronic pain mutation in the voltage-gated sodium channel Nav1.7 increases voltage sensitivity.” J Biol Chem. 2020 Dec 22
- Lampert, A, DL Bennett, LA McDermott, A Neureiter, E Eberhardt, B Winner, M Zenke. „Human sensory neurons derived from pluripotent stem cells for disease modelling and personalized medicine.” Neurobiology of pain, 2020 Nov 18;8:100055.
- Liu BW, Zhang J, Hong YS, Li NB, Liu Y, Zhang M, Wu WY, Zheng H, Lampert A, Zhang XW.
NGF-Induced Nav1.7 Upregulation Contributes to Chronic Post-surgical Pain by Activating SGK1-Dependent Nedd4-2 Phosphorylation.
Mol Neurobiol. 2020 Oct 16. - Mehrjardi NZ, Molcanyi M, Hatay FF, Timmer M, Shahbazi E, Ackermann JP, Herms S, Heilmann-Heimbach S, Wunderlich TF, Prochnow N, Haghikia A, Lampert A, Hescheler J, Neugebauer EAM, Baharvand H, Šarić T.
Acquisition of chromosome 1q duplication in parental and genome edited human induced pluripotent stem cell-derived neural stem cells results in their higher proliferation rate in vitro and in vivo.
Cell Prolif. 2020 Oct;53(10):e12892. - Rühlmann, AH, J Körner, R Hausmann, N Bebrivenski, C Neuhof, S Detro-Dassen, P Hautvast, CA Benasolo, J Meents, JP Machtens, G Schmalzing, A Lampert.
Uncoupling sodium channel dimers rescues the phenotype of a pain-linked Nav1.7 mutation.
British Journal of Pharmacology, 2020 Jul 14. doi: 10.1111/bph.15196. - Thull S, Neacsu C, O'Reilly AO, Bothe S, Hausmann R, Huth T, Meents J, Lampert A.
Dataset of electrophysiological patch-clamp recordings of the effect of the compounds deltamethrin, ATx-II and β4-peptide on human cardiac Nav1.5 sodium channel gating properties.
Data in Brief, 8 June 2020, 105844 - Thull S, Neacsu C, O'Reilly AO, Bothe S, Hausmann R, Huth T, Meents J, Lampert A.
Mechanism underlying hooked resurgent-like tail currents induced by an insecticide in human cardiac Nav1.5.
Toxicol Appl Pharmacol. 2020 Apr 14:115010. doi: 10.1016/j.taap.2020.115010 Weber S, Lampert A, Stingl J, Peuckmann-Post V, Hiddemann S, Elsner F, Neuner I, Rolke R. “Basic Knowledge of Drug Pain Therapy in the Palliative Situation” [Article in German] Dtsch Med Wochenschr. 2020 Jul;145(13):917-925. doi: 10.1055/a-1016-9941. Epub 2020 Jul 2
2019
- Schmidt A, Joussen S, Hausmann R, Gründer S, Wiemuth D
Bile acids are potent inhibitors of rat P2X2 receptors
Purinergic Signal 2019, 15(2): 213-221
https://pubmed.ncbi.nlm.nih.gov/31098843/ - Effraim, P.R., J. Huang, A. Lampert, S. Stamboulian, P. Zhao, J. A. Black, S. G. Waxman, S. D. Dib-Hajj.
- Fibroblast Growth Factor Homologous Factor 2 (FGF-13) associates with Nav1.7 in DRG neurons and alters its current properties in an isoform-dependent manner.
Neurobiology of Pain, 6, 2019, 1000029 - Maroni M, Körner J, Schüttler J, Winner B, Lampert A, Eberhardt E.
β1 and β3 subunits amplify mechanosensitivity of the cardiac voltage-gated sodium channel Nav1.5.
Pflugers Arch. 2019 Dec;471(11-12):1481-1492. - Ciotu CI, Tsantoulas C, Meents J, Lampert A, McMahon SB, Ludwig A, Fischer MJM.
Noncanonical Ion Channel Behaviour in Pain.
Int J Mol Sci. 2019 Sep 15;20(18). - Obrecht AS, Urban N, Schaefer M, Röse A, Kless A, Meents JE, Lampert A, Abdelrahman A, Müller CE, Schmalzing G, Hausmann R.
Identification of aurintricarboxylic acid as a potent allosteric antagonist of P2X1 and P2X3 receptors.
Neuropharmacology. 2019 Nov 1;158:107749. - Kühn, F.J.P. Ehrlich, W. Barth, D. Kühn, C. Lückhoff, A.
Functional importance of NUDT9H domain and N-terminal ADPR-binding pocket in two species variants of vertebrate TRPM2 channels.
Sci Rep 9, 19224 (2019) - Meents, J.E.*, E. Bressan*, S. Sontag*, A. Foerster*, P. Hautvast, C. Rösseler, M. Hampl, H. Schüler, R. Goetzke, T. K. Chi Le, I. P. Kleggetveit, K.Le Cann, C. Kerth, A. M. Rush, M. Rogers, Z. Kohl, M. Schmelz, W. Wagner, E. Jørum, B. Namer, B. Winner, M. Zenke, A. Lampert.
The role of Nav1.7 in human nociceptors: insights from human iPS cell-derived sensory neurons of erythromelalgia patients
Pain, 2019 March 22. - Dohrn MF, Lampert A, Üçeyler N, Kurth I.
Neuropathic pain syndromes and channelopathies
[Article in German] Internist (Berl). 2019 Jan; 60(1):90-97. Frank J.P. Kühn*, Joanna M. Watt Barry V.L. Potter, Andreas Lückhoff (2019)
Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR
Sci Rep. 2019 Mar 21: 9(1):4985. doi:10.1038/s41598-019-41531-4. PMD: 308
2018
- Anna Vyvers, Axel Schmidt, Dominik Wiemuth, Stefan Gründer
Screening of 109 neuropeptides on ASICs reveals no direct agonists and dynorphin A, YFMRFamide and endomorphin-1 as modulators
2018, Scientific Reports - Article - Reiners M, Margreiter MA, Oslender-Bujotzek A, Rossetti G, Gründer S, Schmidt A.
The ConorRFamide RPRFa Stabilizes the Open Conformation of Acid-Sensing Ion Channel 3 via the Nonproton Ligand-Sensing Domain.
Mol Pharmacol. 2018 Oct;94(4):1114-1124. doi: 10.1124/mol.118.112375. Epub 2018 Jul 16 - Schmidt A, Bauknecht P, Williams EA, Augustinowski K, Gründer S, Jékely G.
Dual signaling of Wamide myoinhibitory peptides through a peptide-gated channel and a GPCR in Platynereis.
FASEB J. 2018 Oct;32(10):5338-5349. doi: 10.1096/fj.201800274R. Epub 2018 Apr 24.
PMID: 29688813 - Lehmke L, Coburn M, Möller M, Blaumeiser-Debarry R, Lenzig P, Wiemuth D, Gründer S.
Inhalational anesthetics accelerate desensitization of acid-sensing ion channels.
Neuropharmacology. 2018 Jun;135:496-505. doi: 10.1016/j.neuropharm.2018.04.004. Epub 2018 Apr 5.
PMID: 29627444 - Schmidt A, Alsop RJ, Rimal R, Lenzig P, Joussen S, Gervasi NN, Khondker A, Gründer S, Rheinstädter MC, Wiemuth D.
Modulation of DEG/ENaCs by Amphiphiles Suggests Sensitivity to Membrane Alterations.
Biophys J. 2018 Mar 27;114(6):1321-1335. doi: 10.1016/j.bpj.2018.01.028.
PMID: 29590590 - Namer B., D. Schmidt, E. Eberhardt, M. Maroni, E. Dorfmeister, I. P. Kleggetveit, L. Kaluza, J. Meents, A. Gerlach, Z. Lin, A. Winterpacht, E. Dragicevic, Z. Kohl, J. Schüttler, I. Kurth, T. Warncke, E. Jorum, B. Winner*, A. Lampert*. “Pain relief in a neuropathy patient by lacosamide: proof of principle of clinical translation from patient-specific iPS cell-derived nociceptors.” EbioMedicine, 2018.
- Legradi J.B., C. Di Paolo, M. H. S. Kraak, H. G. van der Geest, E. L. Schymanski, A. J. Williams, M. M. L. Dingemans, R. Massei, W. Brack, X. Cousin, M.‑L. Begout, R. van der Oost, A. Carion, V. Suarez‑Ulloa, F. Silvestre, B. I. Escher, M. Engwall, G. Nilén, S. H. Keiter, D. Pollet, P. Waldmann, C. Kienle, I. Werner, A.‑C. Haigis, D. Knapen, L. Vergauwen, M. Spehr, W. Schulz, W. Busch, D. Leuthold, S. Scholz, C. M. vom Berg, N. Basu, C. A. Murphy, A. Lampert, J. Kuckelkorn, T. Grummt and H. Hollert. “An ecotoxicological view on neurotoxicity Assessment.” Environmental Science Europe, 2018, 30:46.
- Meents J.E., Ciotu C., Fischer M.J.M. “TRPA1 - a molecular view.” Journal of Neurophysiology, 2018, Nov 28. doi: 10.1152/jn.00524.2018.
- Schrenk-Siemens, K., C. Rösseler, A. Lampert. Translational Model Systems for Complex Sodium Channel Pathophysiology in Pain. Handbook of Experimental Pharmacology, 2018, doi: 10.1007/164_2017_91
- DeLaney K, Buchberger AR, Atkinson L, Gründer S, Mousley A, Li L. New techniques, applications and perspectives in neuropeptide research.
J Exp Biol. 2018 Feb 8;221(Pt 3). pii: jeb151167. doi: 10.1242/jeb.151167. - Körner J, Meents JE, Machtens JP, Lampert A. β1 subunit stabilises sodium channel Nav1.7 against mechanical stress. Journal of Phyisology, 2018 https://doi.org/10.1113/JP27590
- Meents JE, Juhasz K, Stölzle-Feix S, Peuckmann-Post V, Rolke R, Lampert A. The opioid oxycodone use-dependently inhibits the cardiac sodium channel Nav1.5. Brit J Pharmacol, 2018. https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.14348
- Almog, M., T. Barkai, A. Lampert, A. Korngreen. “Voltage-gated sodium channels in neocortical pyramidal neurons display Cole-Moore activation kinetics”. Frontiers in Cellular Neuroscience, 2018.
2017
- Schmidt A, Rossetti G, Joussen S, Gründer S
Diminazene Is a Slow Pore Blocker of Acid-Sensing Ion Channel 1a (ASIC1a).
Mol Pharmacol. 2017 Dec;92(6):665-675. doi: 10.1124/mol.117.110064. Epub 2017 Oct 12. - Frank J.P. Kühn, Mathis Winking, Cornelia Kühn, Daniel C. Hoffmann and Andreas Lückhoff (2017).
Modulation of activation and inactivation by Ca2+ and 2-APB in the pore of an archetypal TRPM channel from Nematostella vectensis.
Sci Rep. 7:7245. - Frank J.P. Kühn
New insights into the interaction between ADP-ribose and human TRPM2 channel.
Biotarget 1:14 (invited Editorial). - Reimers C, Lee CH, Kalbacher H, Tian Y, Hung CH, Schmidt A, Prokop L, Kauferstein S, Mebs D, Chen CC, Gründer S
Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain
PNAS April 25, 2017 vol. 114 no. 17 E3507-E3515 - Tian Y, Bresenitz P, Reska A, El Moussaoui L, Beier CP, Gründer S
Glioblastoma cancer stem cell lines express functional acid sensing ion channels ASIC1a and ASIC3
Scientific Reports 7, Article number: 13674 (2017) doi:10.1038/s41598-017-13666-9 - Kühn Frank JP, Kühn Cornelia, Lückhoff Andreas
Different Principles of ADP-Ribose-Mediated Activation and Opposite Roles of the NUDT9 Homology Domain in the TRPM2 Orthologs of Man and Sea Anemone
Frontiers in Physiology / 8: 879 / DOI:10.3389/fphys.2017.00879 - Kist AM, Lampert A, O'Reilly AO.
DIsulfide Mapping PLanner Software Tool.
J Comput Biol. 2017 Aug 17. doi: 10.1089/cmb.2017.0129. [Epub ahead of print] - O'Reilly AO, Lattrell A, Miles AJ, Klinger AB, Nau C, Wallace BA, Lampert A.
Mutagenesis of the NaChBac sodium channel discloses a functional role for a conserved S6 asparagine.
Eur Biophys J. 2017 Aug 20. doi: 10.1007/s00249-017-1246-2. [Epub ahead of print] - Dreser A, Vollrath JT, Sechi A, Johann S, Roos A, Yamoah A, Katona I, Bohlega S, Wiemuth D, Tian Y, Schmidt A, Vervoorts J, Dohmen M, Beyer C3, Anink J, Aronica E, Troost D, Weis J, Goswami A.
The ALS-linked E102Q mutation in Sigma receptor-1 leads to ER stress-mediated defects in protein homeostasis and dysregulation of RNA-binding proteins.
Cell Death Differ. 2017 Jun 16. doi: 10.1038/cdd.2017.88. [Epub ahead of print] - Bosch TC, Klimovich A, Domazet-Lošo T, Gründer S, Holstein TW, Jékely G, Miller DJ, Murillo-Rincon AP, Rentzsch F, Richards GS, Schröder K, Technau U, Yuste R
Back to the Basics: Cnidarians Start to Fire.
Trends Neurosci. 2017 Feb;40(2):92-105. doi: 10.1016/j.tins.2016.11.005. Epub 2016 Dec 30. - Meents JE, Fischer MJ, McNaughton PA.
Sensitization of TRPA1 by Protein Kinase A.
PLoS ONE. 2017 Jan 11; 12(1): e0170097
2016
- Schmidt A, Löhrer D, Alsop RJ, Lenzig P, Oslender-Bujotzek A, Wirtz M, Rheinstädter MC, Gründer S, Wiemuth D.
A Cytosolic Amphiphilic α-Helix Controls the Activity of the Bile Acid-sensitive Ion Channel (BASIC).
J Biol Chem. 2016 Nov 18;291(47):24551-24565. - Hendriks CM, Penning TM, Zang T, Wiemuth D, Gründer S, Sanhueza IA, Schoenebeck F, Bolm C.
Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities.
Bioorg Med Chem Lett. 2015 Oct 15;25(20):4437-40. doi: 10.1016/j.bmcl.2015.09.012. - Daniel Komnig, Silke Imgrund, Arno Reich, Stefan Gründer, Björn H. Falkenburger
ASIC1a Deficient Mice Show Unaltered Neurodegeneration in the Subacute MPTP Model of Parkinson Disease.
PLos Published: November 7, 2016 - Kist, A.M., D. Sagafos, A. M. Rush, C. Neacsu, E. Eberhardt, R. Schmidt, L. K. Lunden, K. Ørstavik, L. Kaluza, J. Meents, Z. Zhang, T. H. Carr, H. Salter, D. Malinowsky, P. Wollberg, J. Krupp, I. P. Kleggetveit, M. Schmelz, E. Jørum*, A. Lampert*, B. Namer*
SCN10A Mutation in a patient with Erythromelalgia enhances C-fiber activity dependent slowing.
PLoS One. 2016 Sep 6;11(9) - Mishra HK, Prots I, Havlicek S, Kohl Z, Perez-Branguli F, Boerstler T, Anneser L, Minakaki G, Wend H, Hampl M, Leone M, Brückner M, Klucken J, Reis A, Boyer L, Schuierer G, Behrens J, Lampert A, Engel FB, Gage FH, Winkler J, Winner B.
GSK3ß-dependent dysregulation of neurodevelopment in SPG11-patient iPSC model.
Ann Neurol. 2016 Mar 11. - Fischer TM.
Creep and stress relaxation of human red cell membrane.
Biomech Model Mechanobiol. 2016 Aug 11. [Epub ahead of print] - Joeres N, Augustinowski K, Neuhof A, Assmann M, Gründer S.
Functional and pharmacological characterization of two different ASIC1a/2a heteromers reveals their sensitivity to the spider toxin PcTx1.
Sci Rep. 2016 Jun 9;6:27647. doi: 10.1038/srep27647. - Schmidt A, Löhrer D, Alsop RJ, Lenzig P, Oslender-Bujotzek A, Wirtz M, Rheinstädter MC, Gründer S, Wiemuth D.
A cytosolic amphiphilic alpha helix controls the activity of the bile acid-sensitive ion channel BASIC.
J Biol Chem. 2016 Sep 27. pii: jbc.M116.756437. [Epub ahead of print] - Bressan E, Touska F, Vetter I, Kistner K, Kichko TI, Teixeira NB, Picolo G, Cury Y, Lewis RJ, Fischer MJ, Zimmermann K, Reeh PW.
Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia.
Pain. 2016 Jul 18. [Epub ahead of print] - Kühn FJP, Kühn C, Winking M, Hoffmann DC, Lückhoff A.
ADP-Ribose activates the TRPM2 channel from the sea anemone Nematostella vectensis independently of the NUDT9H Domain.
PLoS ONE 11(6): e0158060. doi:10.1371 (2016) - Meents, JE, Fischer MJ, McNaughton PA.
Agonist-induced sensitisation of the irritant receptor ion channel TRPA1.
J Physiol. 2016 Nov 15;594(22):6643-6660 - Hampl* M., Eberhardt* E., O'Reilly AO, Lampert A.
Sodium channel slow inactivation interferes with open channel block.
Sci Rep. 2016, May 13;6:25974 - E. Shahbazi, S. Moradi, S. Nemati, L. Satarian, M. Basiri, H. Gourabi, N. Z. Mehrjardi, P. Günther, A. Lampert, K. Händler, M. Molcanyi, D. Schmidt, F. Hatay, J. Hescheler, J. L. Schultze, T. Šarić, H. Baharvand.
Generation of Stably Self-Renewing Neural Stem Cells by Conversion of Human Fibroblasts with a Single Zinc-Finger Transcription Factor.
Stem Cell Reports, 2016 Apr 12;6(4):539-51. - Meents, J. E. und A. Lampert.
Studying sodium channel gating in heterologous expression systems.
Patch-Clamp Analysis: Advanced Techniques, Third Edition, Volume 113 of the series Neuromethods, pp 37-65
2015
- Salehi-Nik, N., Amoabediny, G., Shokrgozar, M. A., Mottaghy, K., Klein-Nulend, J., & Zandieh-Doulabi, B.
Surface modification of silicone tubes by functional carboxyl and amine.
Biomed Mater. 2015 Mar 2;10(1):015024. doi: 10.1088/1748-6041/10/1/015024. - Schwartz V, Friedrich K, Polleichtner G, Gründer S.
Acid-sensing ion channel (ASIC) 4 predominantly localizes to an early endosome-related organelle upon heterologous expression.
Sci Rep. 2015 Dec 15;5:18242. - Hendriks CM, Penning TM, Zang T, Wiemuth D, Gründer S, Sanhueza IA, Schoenebeck F, Bolm C. Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities.
Bioorg Med Chem Lett. 2015 Oct 15;25(20):4437-40. - Lampert, A., W. Stühmer, S. G. Waxman.
Sodium channels.
eLS (encyclopedia of Life Sciences) – Wiley Online Library, 2015
(DOI: 10.1002/9780470015902.a0000127.pub2) - Tigerholm J., M.E. Petersson, O. Obreja, E. Eberhardt, B. Namer, C. Weidner, A. Lampert, R. W. Carr, M. Schmelz, E. Fransén.
C-fiber recovery cycle supernormality depends on ion concentration and ion channel permeability.
Biophysical Journal, 2015 Mar 10;108(5):1057-71. - Esther Eberhardt*, Steven Havlicek*, Diana Schmidt*, Andrea S. Link, Cristian Neacsu, Zacharias Kohl, Martin Hampl, Andreas M. Kist, Alexandra Klinger, Carla Nau, Jürgen Schüttler, Christian Alzheimer, Jürgen Winkler, Barbara Namer, Beate Winner, Angelika Lampert.
Pattern of functional TTX-resistant sodium channels reveals developmental stage of human iPS- and ES cell-derived nociceptors.
Stem Cell Reports, 2015 Sep 8;5(3):305-13.
Weitere Informationen finden Sie hier. - Gründer S, Assmann M.
Peptide-gated ion channels and the simple nervous system of Hydra.
J Exp Biol. 2015 Feb 15;218(Pt 4):551-561. - Gründer S & Pusch M.
Biophysical properties of acid-sensing ion channels (ASICs).
Neuropharmacol. 2015 Jan 10. pii: S0028-3908(14)00467-5 (in press). - Stadler T.S., A.O. O’Reilly, A. Lampert.
Erythromelalgia Mutation Q875E Stabilizes The Activated State Of Sodium Channel Nav1.7.
Journal of Biological Chemistry; 2015 Mar 6;290(10):6316-25. - Frank J.P. Kühn, Cornelia Kühn and Andreas Lückhoff.
Functional Characterisation of a TRPM2 orthologue from the sea anemone Nematostella vectensis in human cells.
Sci Rep. 2015 Jan 26;5:8032
2014
- Assmann M, Kuhn A, Dürrnagel S, Holstein TW und Gründer S.
The comprehensive analysis of DEG/ENaC subunits in Hydra reveals a large variety of peptide-gated channels, potentially involved in neuromuscular transmission.
BMC Biology 2014 Oct 14;12(1):84. - Schmidt A, Lenzig P, Oslender-Bujotzek A, Gründer S und Wiemuth D.
The bile acid-sensitive ion channel (BASIC) is activated by alterations of its membrane environment.
PLOS ONE 2014 Oct 31;9(10):e111549 - Mirjam Eberhardt, Maria Dux, Barbara Namer, Jan Miljkovic, Nada Cordasic, Christine Will, Tatjana I. Kichko, Jeanne de la Roche, Michael Fischer, Sebastián A. Suárez, Damian Bikiel, Karola Dorsch, Andreas Leffler, Alexandru Babes, Angelika Lampert, Jochen K. Lennerz, Johannes Jacob5, Marcelo A. Martí, Fabio Doctorovich, Edward D. Högestätt, Peter M. Zygmunt, Ivana Ivanovic-Burmazovic, Karl Messlinger, Peter Reeh, Milos R Filipovic.
H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway.
Nature Communications 2014 Jun 12; 5:4381. - Eberhardt M, Nakajima J, Klinger AB, Neacsu C, Hühne K, O'Reilly AO, Kist AM, Lampe AK, Fischer K, Gibson J, Nau C, Winterpacht A, Lampert A.
Inherited Pain: Sodium Channel Nav1.7 A1632T Mutation Causes Erythromelalgia Due to a Shift of Fast Inactivation.
J Biol Chem. 2014 Jan 24;289(4):1971-80.
Dr. Mirjam Eberhardt hat aufgrund dieser Publikation den “EFIC- IBSA Foundation Publication Award“ gewonnen. - Bartoi T, Augustinowski K, Polleichtner G, Gründer S, Ulbrich MH.
Acid-sensing ion channel (ASIC) 1a/2a heteromers have a flexible 2:1/1:2 stoichiometry.
Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8281-6. - Havlicek S., Z. Kohl, H.K. Mishra, I. Prots, E. Eberhardt, N. Denguir, H. Wend, S. Plötz, L. Boyer, M.C. Marchetto, S. Aigner, H. Sticht, T.W. Groemer, U. Hehr, A. Lampert, U. Schlötzer-Schrehardt, J. Winkler, F.H. Gage, B. Winner.
Gene dosage dependent rescue of HSP neurite defects in SPG4 patients’ neurons.
Hum Mol Genet. 2014 May 15;23(10):2527-41. - Lampert A, Eberhardt M, Waxman SG.
Altered sodium channel gating as molecular basis for pain: contribution of activation, inactivation, and resurgent currents.
Handb Exp Pharmacol. 2014;221:91-110. - Lampert A, Korngreen A.
Markov modeling of ion channels: implications for understanding disease.
Prog Mol Biol Transl Sci. 2014;123:1-21. - Lefèvre CM, Diakov A, Haerteis S, Korbmacher C, Gründer S, Wiemuth D.
Pharmacological and electrophysiological characterization of the human bile acid-sensitive ion channel (hBASIC).
Pflugers Arch. 2014 Feb;466(2):253-63. - O’Reilly, A. O., A. R. Cole, J. L. Lopes, A. Lampert, B. A. Wallace.
Chaperone-mediated Native Folding of a β-scorpion Toxin in the Periplasm of E.coli.
Biochim Biophys Acta. 2014 Jan;1840(1):10-5. - Petersson M.E., O. Obreja, A. Lampert, R.W. Carr, M. Schmelz, E. Fransén.
Differential axonal conduction patterns of mechano-sensitive and mechano-insensitive nociceptors--a combined experimental and modelling study.
PLoS ONE, 2014 Aug; 9(8): e103556. - Schulze, V., C.Stoetzer, A.O. O´Reilly, E. Eberhardt, N. Foadi, J. Ahrens, F. Wegner, A. Lampert, J. de la Roche, A. Leffler.
The opioid methadone induces a local anesthetic like inhibition of the cardiac Na+ channel Nav1.5.
British Journal of Pharmacology, 2014 Jan;171(2):427-37. - Tigerholm, J. M. Petersson, O. Obreja, A. Lampert, R. Carr, M. Schmelz, and E. Fransen.
Modelling activity-dependent changes of axonal spike conduction in primary afferent C-nociceptors.
Journal of Neurophysiology, 2014 May;111(9):1721-35. - Vollrath JT, Sechi A, Dreser A, Katona I, Wiemuth D, Vervoorts J, Dohmen M, Chandrasekar A, Prause J, Brauers E, Jesse CM, Weis J, Goswami A.
Loss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbances.
Cell Death Dis. 2014 Jun 12;5:e1290. - Wiemuth D, Assmann M, Gründer S.
The bile acid-sensitive ion channel (BASIC), the ignored cousin of ASICs and ENaC.
Channels 2014 Jan 1; 8(1): 29–34. - Wiemuth D, Lefèvre CM, Heidtmann H, Gründer S.
Bile acid increase the activity of the epithelial Na+ channel.
Pflügers Archive 2014 Sep;466(9):1725-33.
