Publikationen

• Bachmann M, Ortega-Ramírez A, Leisle L, Gründer S. “Efficient expression of a cnidarian peptide-gated ion channel in mammalian cells.” Channels (Austin) 2021 Dec;15(1):273-283. doi: 10.1080/19336950.2021.1882762.
• Heinrichs* B, B Liu*, J Zhang, JE Meents, KT Le, A Erickson, P Hautvast, X Zhu, N Li, Y Liu, M Spehr, U Habel, M Rothermel, B Namer, X Zhang, A Lampert#, G Duan#. “The Potential Effect of Nav1.8 in Autism Spectrum Disorder: Evidence From a Congenital Case With Compound Heterozygous SCN10A Mutations” Frontiers in Molecular Neuroscience, accepted.
• Kuspiel S, Wiemuth D, Gründer S. “The Neuropeptide Nocistatin Is Not a Direct Agonist of Acid-Sensing Ion Channel 1a (ASIC1a).” Biomolecules 2021 Apr 13;11(4):571. doi: 10.3390/biom11040571.
• Le Cann K, A Foerster, C Rösseler, A Erickson, P Hautvast, S Giesselmann, D Pensold, I Kurth, M Rothermel, VB Mattis, G Zimmer, S von Hörsten, B Denecke, T Clarner, J Meents, A Lampert. “The difficulty to model Huntington’s Disease in vitro using striatal Medium Spiny Neurons differentiated from human induced pluripotent stem cells.” Scientific Reports, 2021; 11: 6934
• Le Cann K., Meents JE, Eswaran VSB, Dohrn MF, Bott R, Maier A, Bialer M, Hautvast P, Erickson A, Rolke R, Rothermel M, Körner J, Kurth I, Lampert A. “Assessing the impact of pain-linked Nav1.7 variants: An example of two variants with no biophysical effect.” Channels (Austin). 2021 Jan;15(1):208-228
• Neuhof A, Tian Y, Reska A, Falkenburger B, Gründer S. “Large Acid-Evoked Currents, Mediated by ASIC1a, Accompany Differentiation in Human Dopaminergic Neurons.” Front Cell Neurosci 2021 Apr 27;15:668008. doi: 10.3389/fncel.2021.668008. eCollection 2021.

• Cypris O, Eipel M, Franzen J, Rösseler C, Tharmapalan V, Kuo CC, Vieri M, Nikolić M, Kirschner M, Brümmendorf TH, Zenke M, Lampert A, Beier F, Wagner W.
  PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation.
  Clin Epigenetics. 2020 Aug 20;12(1):125.
• Kühn FJP.
  Structure-Function Relationship of TRPM2: Recent Advances, Contradictions, and Open Questions.
  Int J Mol Sci. 2020 Sep 4;21(18):E6481. doi: 10.3390/ijms21186481.
  https://pubmed.ncbi.nlm.nih.gov/32899872/
• Israel MR, TS Dash, SN Bothe, SD Robinson, JR Deuis, DJ Craik, A Lampert, I Vetter, T Durek.
  Characterization of Synthetic Tf2 as a NaV1.3 Selective Pharmacological Probe.
  Biomedicines 2020, 8(6), 155
• Jo HG, O. Wudarczyk, M. Leclerc, C. Regenbogen, A. Lampert, M. Rothermel, U. Habel.
  Effect of odor pleasantness on heat-induced pain: An fMRI study.
  Brain Imaging and Behavior, 2020 Aug 8.
• Kerth CM, Hautvast P, Körner J, Lampert A, Meents JE. “Phosphorylation of a chronic pain mutation in the voltage-gated sodium channel Nav1.7 increases voltage sensitivity.” J Biol Chem. 2020 Dec 22
• Lampert, A, DL Bennett, LA McDermott, A Neureiter, E Eberhardt, B Winner, M Zenke. „Human sensory neurons derived from pluripotent stem cells for disease modelling and personalized medicine.” Neurobiology of pain, 2020 Nov 18;8:100055.
• Liu BW, Zhang J, Hong YS, Li NB, Liu Y, Zhang M, Wu WY, Zheng H, Lampert A, Zhang XW.
  NGF-Induced Nav1.7 Upregulation Contributes to Chronic Post-surgical Pain by Activating SGK1-Dependent Nedd4-2 Phosphorylation.
  Mol Neurobiol. 2020 Oct 16.
• Mehrjardi NZ, Molcanyi M, Hatay FF, Timmer M, Shahbazi E, Ackermann JP, Herms S, Heilmann-Heimbach S, Wunderlich TF, Prochnow N, Haghikia A, Lampert A, Hescheler J, Neugebauer EAM, Baharvand H, Šarić T.
  Acquisition of chromosome 1q duplication in parental and genome edited human induced pluripotent stem cell-derived neural stem cells results in their higher proliferation rate in vitro and in vivo.
  Cell Prolif. 2020 Oct;53(10):e12892.
• Rühlmann, AH, J Körner, R Hausmann, N Bebrivenski, C Neuhof, S Detro-Dassen, P Hautvast, CA Benasolo, J Meents, JP Machtens, G Schmalzing, A Lampert.
  Uncoupling sodium channel dimers rescues the phenotype of a pain-linked Nav1.7 mutation.
  British Journal of Pharmacology, 2020 Jul 14. doi: 10.1111/bph.15196.
• Thull S, Neacsu C, O'Reilly AO, Bothe S, Hausmann R, Huth T, Meents J, Lampert A.
  Dataset of electrophysiological patch-clamp recordings of the effect of the compounds deltamethrin, ATx-II and β4-peptide on human cardiac Nav1.5 sodium channel gating properties.
  Data in Brief, 8 June 2020, 105844
• Thull S, Neacsu C, O'Reilly AO, Bothe S, Hausmann R, Huth T, Meents J, Lampert A.
  Mechanism underlying hooked resurgent-like tail currents induced by an insecticide in human cardiac Nav1.5.
  Toxicol Appl Pharmacol. 2020 Apr 14:115010. doi: 10.1016/j.taap.2020.115010

• Weber S, Lampert A, Stingl J, Peuckmann-Post V, Hiddemann S, Elsner F, Neuner I, Rolke R. “Basic Knowledge of Drug Pain Therapy in the Palliative Situation” [Article in German] Dtsch Med Wochenschr. 2020 Jul;145(13):917-925. doi: 10.1055/a-1016-9941. Epub 2020 Jul 2

2019

• Schmidt A, Joussen S, Hausmann R, Gründer S, Wiemuth D
  Bile acids are potent inhibitors of rat P2X2 receptors
  Purinergic Signal 2019, 15(2): 213-221
  https://pubmed.ncbi.nlm.nih.gov/31098843/
• Effraim, P.R., J. Huang, A. Lampert, S. Stamboulian, P. Zhao, J. A. Black, S. G. Waxman, S. D. Dib-Hajj.
• Fibroblast Growth Factor Homologous Factor 2 (FGF-13) associates with Nav1.7 in DRG neurons and alters its current properties in an isoform-dependent manner.
  Neurobiology of Pain, 6, 2019, 1000029
• Maroni M, Körner J, Schüttler J, Winner B, Lampert A, Eberhardt E.
  β1 and β3 subunits amplify mechanosensitivity of the cardiac voltage-gated sodium channel Nav1.5.
  Pflugers Arch. 2019 Dec;471(11-12):1481-1492.
• Ciotu CI, Tsantoulas C, Meents J, Lampert A, McMahon SB, Ludwig A, Fischer MJM.
  Noncanonical Ion Channel Behaviour in Pain.
  Int J Mol Sci. 2019 Sep 15;20(18).
• Obrecht AS, Urban N, Schaefer M, Röse A, Kless A, Meents JE, Lampert A, Abdelrahman A, Müller CE, Schmalzing G, Hausmann R.
  Identification of aurintricarboxylic acid as a potent allosteric antagonist of P2X1 and P2X3 receptors.
  Neuropharmacology. 2019 Nov 1;158:107749.
• Kühn, F.J.P. Ehrlich, W. Barth, D. Kühn, C. Lückhoff, A.
  Functional importance of NUDT9H domain and N-terminal ADPR-binding pocket in two species variants of vertebrate TRPM2 channels.
  Sci Rep 9, 19224 (2019)
• Meents, J.E.*, E. Bressan*, S. Sontag*, A. Foerster*, P. Hautvast, C. Rösseler, M. Hampl, H. Schüler, R. Goetzke, T. K. Chi Le, I. P. Kleggetveit, K.Le Cann, C. Kerth, A. M. Rush, M. Rogers, Z. Kohl, M. Schmelz, W. Wagner, E. Jørum, B. Namer, B. Winner, M. Zenke, A. Lampert.
  The role of Nav1.7 in human nociceptors: insights from human iPS cell-derived sensory neurons of erythromelalgia patients
  Pain, 2019 March 22.
• Dohrn MF, Lampert A, Üçeyler N, Kurth I.
  Neuropathic pain syndromes and channelopathies
  [Article in German] Internist (Berl). 2019 Jan; 60(1):90-97.

• Frank J.P. Kühn*, Joanna M. Watt Barry V.L. Potter, Andreas Lückhoff (2019)
  Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR
  Sci Rep. 2019 Mar 21: 9(1):4985. doi:10.1038/s41598-019-41531-4. PMD: 308

2018

• Anna Vyvers, Axel Schmidt, Dominik Wiemuth, Stefan Gründer
  Screening of 109 neuropeptides on ASICs reveals no direct agonists and dynorphin A, YFMRFamide and endomorphin-1 as modulators 
  2018, Scientific Reports - Article
• Reiners M, Margreiter MA, Oslender-Bujotzek A, Rossetti G, Gründer S, Schmidt A.
  The ConorRFamide RPRFa Stabilizes the Open Conformation of Acid-Sensing Ion Channel 3 via the Nonproton Ligand-Sensing Domain. 
  Mol Pharmacol. 2018 Oct;94(4):1114-1124. doi: 10.1124/mol.118.112375. Epub 2018 Jul 16
• Schmidt A, Bauknecht P, Williams EA, Augustinowski K, Gründer S, Jékely G.
  Dual signaling of Wamide myoinhibitory peptides through a peptide-gated channel and a GPCR in Platynereis. 
  FASEB J. 2018 Oct;32(10):5338-5349. doi: 10.1096/fj.201800274R. Epub 2018 Apr 24.
  PMID: 29688813
• Lehmke L, Coburn M, Möller M, Blaumeiser-Debarry R, Lenzig P, Wiemuth D, Gründer S.
  Inhalational anesthetics accelerate desensitization of acid-sensing ion channels.
  Neuropharmacology. 2018 Jun;135:496-505. doi: 10.1016/j.neuropharm.2018.04.004. Epub 2018 Apr 5.
  PMID: 29627444
• Schmidt A, Alsop RJ, Rimal R, Lenzig P, Joussen S, Gervasi NN, Khondker A, Gründer S, Rheinstädter MC, Wiemuth D.
  Modulation of DEG/ENaCs by Amphiphiles Suggests Sensitivity to Membrane Alterations. 
  Biophys J. 2018 Mar 27;114(6):1321-1335. doi: 10.1016/j.bpj.2018.01.028.
  PMID: 29590590
• Namer B., D. Schmidt, E. Eberhardt, M. Maroni, E. Dorfmeister, I. P. Kleggetveit, L. Kaluza, J. Meents, A. Gerlach, Z. Lin, A. Winterpacht, E. Dragicevic, Z. Kohl, J. Schüttler, I. Kurth, T. Warncke, E. Jorum, B. Winner*, A. Lampert*. “Pain relief in a neuropathy patient by lacosamide: proof of principle of clinical translation from patient-specific iPS cell-derived nociceptors.” EbioMedicine, 2018.
• Legradi J.B., C. Di Paolo, M. H. S. Kraak, H. G. van der Geest, E. L. Schymanski, A. J. Williams, M. M. L. Dingemans, R. Massei, W. Brack, X. Cousin, M.‑L. Begout, R. van der Oost, A. Carion, V. Suarez‑Ulloa, F. Silvestre, B. I. Escher, M. Engwall, G. Nilén, S. H. Keiter, D. Pollet, P. Waldmann, C. Kienle, I. Werner, A.‑C. Haigis, D. Knapen, L. Vergauwen, M. Spehr, W. Schulz, W. Busch, D. Leuthold, S. Scholz, C. M. vom Berg, N. Basu, C. A. Murphy, A. Lampert, J. Kuckelkorn, T. Grummt and H. Hollert. “An ecotoxicological view on neurotoxicity Assessment.” Environmental Science Europe, 2018, 30:46.
• Meents J.E., Ciotu C., Fischer M.J.M. “TRPA1 - a molecular view.” Journal of Neurophysiology, 2018, Nov 28. doi: 10.1152/jn.00524.2018.
• Schrenk-Siemens, K., C. Rösseler, A. Lampert. Translational Model Systems for Complex Sodium Channel Pathophysiology in Pain. Handbook of Experimental Pharmacology, 2018, doi: 10.1007/164_2017_91
• DeLaney K, Buchberger AR, Atkinson L, Gründer S, Mousley A, Li L. New techniques, applications and perspectives in neuropeptide research.
  J Exp Biol. 2018 Feb 8;221(Pt 3). pii: jeb151167. doi: 10.1242/jeb.151167.
• Körner J, Meents JE, Machtens JP, Lampert A. β1 subunit stabilises sodium channel Nav1.7 against mechanical stress. Journal of Phyisology, 2018 https://doi.org/10.1113/JP27590
• Meents JE, Juhasz K, Stölzle-Feix S, Peuckmann-Post V, Rolke R, Lampert A. The opioid oxycodone use-dependently inhibits the cardiac sodium channel Nav1.5. Brit J Pharmacol, 2018. https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.14348
• Almog, M., T. Barkai, A. Lampert, A. Korngreen. “Voltage-gated sodium channels in neocortical pyramidal neurons display Cole-Moore activation kinetics”. Frontiers in Cellular Neuroscience, 2018.

2017

• Schmidt A, Rossetti G, Joussen S, Gründer S
  Diminazene Is a Slow Pore Blocker of Acid-Sensing Ion Channel 1a (ASIC1a).
  Mol Pharmacol. 2017 Dec;92(6):665-675. doi: 10.1124/mol.117.110064. Epub 2017 Oct 12.
• Frank J.P. Kühn, Mathis Winking, Cornelia Kühn, Daniel C. Hoffmann and Andreas Lückhoff (2017).
  Modulation of activation and inactivation by Ca2+ and 2-APB in the pore of an archetypal TRPM channel from Nematostella vectensis.
  Sci Rep. 7:7245.
• Frank J.P. Kühn
  New insights into the interaction between ADP-ribose and human TRPM2 channel.
  Biotarget 1:14 (invited Editorial).
• Reimers C, Lee CH, Kalbacher H, Tian Y, Hung CH, Schmidt A, Prokop L, Kauferstein S, Mebs D, Chen CC, Gründer S
  Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain
  PNAS April 25, 2017 vol. 114 no. 17 E3507-E3515
• Tian Y, Bresenitz P, Reska A, El Moussaoui L, Beier CP, Gründer S
  Glioblastoma cancer stem cell lines express functional acid sensing ion channels ASIC1a and ASIC3
  Scientific Reports 7, Article　number:　13674 (2017) doi:10.1038/s41598-017-13666-9
• Kühn Frank JP, Kühn Cornelia, Lückhoff Andreas
  Different Principles of ADP-Ribose-Mediated Activation and Opposite Roles of the NUDT9 Homology Domain in the TRPM2 Orthologs of Man and Sea Anemone
  Frontiers in Physiology / 8: 879 / DOI:10.3389/fphys.2017.00879
• Kist AM, Lampert A, O'Reilly AO.
  DIsulfide Mapping PLanner Software Tool.
  J Comput Biol. 2017 Aug 17. doi: 10.1089/cmb.2017.0129. [Epub ahead of print]
• O'Reilly AO, Lattrell A, Miles AJ, Klinger AB, Nau C, Wallace BA, Lampert A.
  Mutagenesis of the NaChBac sodium channel discloses a functional role for a conserved S6 asparagine.
  Eur Biophys J. 2017 Aug 20. doi: 10.1007/s00249-017-1246-2. [Epub ahead of print]
• Dreser A, Vollrath JT, Sechi A, Johann S, Roos A, Yamoah A, Katona I, Bohlega S, Wiemuth D, Tian Y, Schmidt A, Vervoorts J, Dohmen M, Beyer C3, Anink J, Aronica E, Troost D, Weis J, Goswami A.
  The ALS-linked E102Q mutation in Sigma receptor-1 leads to ER stress-mediated defects in protein homeostasis and dysregulation of RNA-binding proteins.
  Cell Death Differ. 2017 Jun 16. doi: 10.1038/cdd.2017.88. [Epub ahead of print]
• Bosch TC, Klimovich A, Domazet-Lošo T, Gründer S, Holstein TW, Jékely G, Miller DJ, Murillo-Rincon AP, Rentzsch F, Richards GS, Schröder K, Technau U, Yuste R
  Back to the Basics: Cnidarians Start to Fire.
  Trends Neurosci. 2017 Feb;40(2):92-105. doi: 10.1016/j.tins.2016.11.005. Epub 2016 Dec 30.
• Meents JE, Fischer MJ, McNaughton PA.
  Sensitization of TRPA1 by Protein Kinase A.
  PLoS ONE. 2017 Jan 11; 12(1): e0170097