Message archive

Diagram of a foot with the superficial peroneal nerve highlighted. Electrical stimulation is applied to the nerve while the response is recorded on a monitor. Labels in the image include “N. peroneus superficialis”, ‘recording’ and “electrical stimulation”.
Functional signatures of human somatosensory C-fibers described by microneurography

How can we better understand and treat pain? An important question that many people ask when they suffer from chronic pain. An answer could lie in the characterization of different types of pain…

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Representation of a molecular structure with labeled helices and amino acid residues. A molecule labeled “Phentolamine” is highlighted and appears to interact with the structure. The labels include “D3 P1”, “F1760”, ‘I1756’ and “T1709”.
Phentolamine Helps End Local Anesthesia but Also Blocks Sodium Channels

Phentolamine is a commonly used drug in clinical practice, above all to lower blood pressure through vasodilation. This vasodilatory effect leads to a faster local elimination of injected substances.…

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Potrait picture of woman, she stands there with ams crossed, smiling at the camera.
The Central Ethics Commission for Stem Cell Research (ZES) of the Federal Republic of Germany appoints Univ.-Prof. Dr. Lampert as a member

At the beginning of December, Prof. Dr. Lampert was appointed by the Federal Government of the Federal Republic of Germany to the ZES, which reviews research proposals from scientists in Germany who…

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Two people are standing in an interior with large windows in the background. One of the people is holding a guitar over their head while the other stands next to them.
Congratulations to Dr. med. Björn Heinrichs!

We congratulate Dr. Björn Heinrichs on his successfully completed medical doctorate with the title "Contribution of the voltage-gated sodium channels Nav1.7 and Nav1.8 to the pathophysiology of pain…

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The figure shows two diagrams of molecular structures with a graph in between. At the top is a cluster of blue molecules surrounded by red and black molecules; at the bottom is a similar blue cluster, this time with green and black molecules. The graph in between represents “Distance” on the x-axis and “Probability” on the y-axis, with two curves: ‘Before’ (red) and “After” (black).
Cholesterol depletion increases sodium currents mediated by Nav1.7

Cholesterol is a crucial component of cellular membranes. In our latest study in cooperation with Giulia Rossetti, we explored the impact of cholesterol depletion on Nav1.7, a key ion channel found…

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Two people are standing on a balcony or terrace with a cityscape in the background. One person is wearing a gown and a doctor's hat and holding a bouquet of flowers, the other is dressed casually.
Congratulations to Dr Claudia Trinler

We are very happy to congratulate Dr. Claudia Trinler on her successfully completed medical doctorate with the title "Characterization of a co-culture system of human induced pluripotent stem…

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The figure consists of two main areas, labeled (a) and (b): (a) shows two heatmaps with a color scale from blue to yellow, representing different dates. The left heatmap is labeled “Before”, the right one “After”, both with numerically labeled axes. (b) contains three elements: a line diagram with a blue curve and red markers, an enlarged detailed view of a section of this curve to the right of it and a black arrow pointing from the diagram to the detailed view. Translated with DeepL.com (free version)
Botulinum toxin alleviates pain independently of sodium channels

Botulinum toxin is not only a very dangerous neurotoxin, but also a frequently used drug in various medical fields. Apart from its muscle relaxant effect, the toxin has recently been used more and…

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A person stands in a lecture hall with green rows of seats and holds a crumpled sheet of paper in both hands.
New spokesperson for translational neurosciences

Prof. Angelika Lampert is the new spokesperson for the Translational Neurosciences research focus at the Faculty of Medicine at RWTH Aachen University. The head of the Institute of Neurophysiology…

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The illustration shows a microscopic image of a cell with structures highlighted in color: the cell body is shown in green, the cell membrane and other structures are marked in red, and a blue area inside presumably indicates the cell nucleus or an organelle. An arrow marks a specific location in the cell, which is also highlighted with another arrow in the enlarged overview at the bottom left. The scale is 5 µm, the labels “G” and “d49” are at the top of the image
Patient derived neurons express Nav1.7

We use induced pluripotent stem cells to produce nerve cells from chronic pain patients. Thereby, we focus on the voltage-gated sodium channel Nav1.7, as it has been associated with pain. In order to…

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The illustration consists of four areas: At the top left and right are two diagrams labeled “Before” and “After”, each with axes for voltage (‘V’) and current (“I”). At the bottom left is an image of a circuit board with black lines and dots on a gray background. The bottom right shows an image with coloured dots on a dark background, presumably a data visualization or analysis.
Validation of stem cell-derived sensory neurons for modelling genetic pain disorders

Stem cells, such as induced pluripotent stem cells (iPSC), can be used to generate human sensory neurons. They offer an attractive humanized model system to study pathophysiological mechanisms of…

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Two people are standing to the left and right of a vertical banner. Several logos and the words “MVA - Mathematics and Visualization in Applications” and other smaller texts can be seen on the banner.
Worldwide Sodium Channel Conference 2024

At the end of January, a unique conference took place in Grindelwald in Switzerland. For three days, over one hundred scientists from 19 countries gathered to discuss and present novel insights within…

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People in disco
Night of the Profs: Angelika Lampert DJs at the Apollo

On Friday, October 13, 2023, the guests at the Apollo experienced a unique night when professors from Aachen's RWTH university took over the DJ booth. Among them was Prof. Dr. med. Angelika Lampert…

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