Forschung

International diversity in drug metabolism and transport, pharmacogenetics

Pavez Loriè E, Baatout S, Choukér A, Buchheim JI, Baselet B, Dello Russo C, Wotring V, Monici M, Morbidelli L, Gagliardi D, Stingl JC, Surdo L, Yip VLM. The Future of Personalized Medicine in Space: From Observations to Countermeasures. Front Bioeng Biotechnol. 2021 Dec 13;9:739747. doi: 10.3389/fbioe.2021.739747. PMID: 34966726; PMCID: PMC8710508.

Rodeiro Guerra I, Herrea J, Cuétara E, Garrido G, Reyes E, Martínez I, Pérez CL, Fernández G, Hernández-Balmaseda I, Delgado R, Stingl JC, Berghe WV. Prevalence of ABCB1 3435C>T polymorphism in the Cuban population. Drug Metab Pers Ther. 2021 Dec 6. doi: 10.1515/dmpt-2020-0156. Epub ahead of print. PMID: 34860473.

Mutiti CS, Kapungu NN, Kanji CR, Stadler N, Stingl J, Nhachi C, Hakim J, Masimirembwa C, Thelingwani RS. Clinically relevant enantiomer specific R- and S-praziquantel pharmacokinetic drug-drug interactions with efavirenz and ritonavir. Pharmacol Res Perspect. 2021 May;9(3):e00769. doi: 10.1002/prp2.769. PMID: 33929078; PMCID: PMC8085964.

Mufwambi W, Stingl J, Masimirembwa C, Manasa J, Nhachi C, Stadler N, Mwila C, Kalungia AC, Mukosha M, Mutiti CS, Kamoto A, Kaonga P, Godman B, Munkombwe D. Healthcare Professionals' Knowledge of Pharmacogenetics and Attitudes Towards Antimicrobial Utilization in Zambia: Implications for a Precision Medicine Approach to Reducing Antimicrobial Resistance. Front Pharmacol. 2021 Jan 12;11:551522. doi: 10.3389/fphar.2020.551522. PMID: 33510634; PMCID: PMC7835886.

New drug target/pharmacological research

Strieder T, Puelles VG, Vogt M, Buhl EM, Saritas T, Hausmann R, Sterzer V, Leuchtle K, Boor P, Floege J, Moeller MJ, Stamellou E. Effects of Perfusion Pressures on Podocyte Loss in the Isolated Perfused Mouse Kidney. Cell Physiol Biochem. 2021 Apr 14;55(S4):1-12. doi: 10.33594/000000355. PMID: 33851800.

Grohmann M, Schumacher M, Günther J, Singheiser SM, Nußbaum T, Wildner F, Gerevich Z, Jabs R, Hirnet D, Lohr C, Illes P, Schmalzing G, Franke H, Hausmann R. BAC transgenic mice to study the expression of P2X2 and P2Y1 receptors. Purinergic Signal. 2021 Sep;17(3):449-465. doi: 10.1007/s11302-021-09792-9. Epub 2021 May 28. PMID: 34050505; PMCID: PMC8410928.

Yang R, Li Z, Zou Y, Yang J, Li L, Xu X, Schmalzing G, Nie H, Li G, Liu S, Liang S, Xu C. Gallic Acid Alleviates Neuropathic Pain Behaviors in Rats by Inhibiting P2X7 Receptor-Mediated NF-κB/STAT3 Signaling Pathway. Front Pharmacol. 2021 Aug 25;12:680139. doi: 10.3389/fphar.2021.680139. PMID: 34512324; PMCID: PMC8423904.

Shi L, Sun M, Ren X, Li Z, Yang R, Xu X, Li L, Li G, Liu S, Schmalzing G, Nie H, Li G, Liang S. LncRNA UC.360+ shRNA Improves Diabetic Cardiac Sympathetic Dysfunction Mediated by the P2X4 Receptor in the Stellate Ganglion. ACS Chem Neurosci. 2021 Apr 7;12(7):1210-1218. doi: 10.1021/acschemneuro.1c00050. Epub 2021 Mar 18. PMID: 33733741.

Illes P, Müller CE, Jacobson KA, Grutter T, Nicke A, Fountain SJ, Kennedy C, Schmalzing G, Jarvis MF, Stojilkovic SS, King BF, Di Virgilio F. Update of P2X receptor properties and their pharmacology: IUPHAR Review 30. Br J Pharmacol. 2021 Feb;178(3):489-514. doi: 10.1111/bph.15299. Epub 2020 Dec 21. PMID: 33125712; PMCID: PMC8199792.

CYP2B6

Eum S, Sayre F, Lee AM, Stingl JC, Bishop JR. Association of CYP2B6 genetic polymorphisms with bupropion and hydroxybupropion exposure: A systematic review and meta-analysis. Pharmacotherapy. 2021 Nov 9. doi: 10.1002/phar.2644. Epub ahead of print. PMID: 34752647.

Langmia IM, Just KS, Yamoune S, Brockmöller J, Masimirembwa C, Stingl JC. CYP2B6 Functional Variability in Drug Metabolism and Exposure Across Populations-Implication for Drug Safety, Dosing, and Individualized Therapy. Front Genet. 2021 Jul 12;12:692234. doi: 10.3389/fgene.2021.692234. PMID: 34322158; PMCID: PMC8313315.

Personalized drug safety/Clinical pharmacogenetic research

Yamoune S, Wintz K, Niederau C, Craveiro RB, Wolf M, Stingl J. Role of cytochrome P450 2C8 genetic polymorphism and epoxygenase uncoupling in periodontal remodelling affecting orthodontic treatment. Basic Clin Pharmacol Toxicol. 2021 Nov 5. doi: 10.1111/bcpt.13681. Epub ahead of print. PMID: 34740282.

Just KS, Scholl C, Boehme M, Kastenmüller K, Just JM, Bleckwenn M, Holdenrieder S, Meier F, Weckbecker K, Stingl JC. Individualized versus Standardized Risk Assessment in Patients at High Risk for Adverse Drug Reactions (The IDrug Randomized Controlled Trial)-Never Change a Running System?

Pharmaceuticals (Basel). 2021 Oct 18;14(10):1056. doi: 10.3390/ph14101056. PMID: 34681280; PMCID: PMC8538435.

Just KS, Dormann H, Freitag M, Schurig M, Böhme M, Steffens M, Scholl C, Seufferlein T, Graeff I, Schwab M, Stingl JC. CYP2D6 in the Brain: Potential Impact on Adverse Drug Reactions in the Central Nervous System-Results From the ADRED Study. Front Pharmacol. 2021 May 7;12:624104. doi: 10.3389/fphar.2021.624104. PMID: 34025403; PMCID: PMC8138470.

Just KS, Tittel SR, Bollheimer C, Naudorf M, Laubner K, Zimny S, Zeyfang A, Hummel M, Stingl JC, Holl RW. Hypoglycemia in Older Adults: Time Trends and Treatment Differences in Patients Aged ≥75 Years With Type 2 Diabetes. J Am Med Dir Assoc. 2021 Sep;22(9):1898-1905.e1. doi: 10.1016/j.jamda.2021.05.006. Epub 2021 Jun 1. PMID: 34087226.

Just KS, Dallmeier D, Böhme M, Steffens M, Braisch U, Denkinger MD, Rothenbacher D, Stingl JC; ActiFE Study Group. Fall-Associated Drugs in Community-Dwelling Older Adults: Results from the ActiFE Ulm Study. J Am Med Dir Assoc. 2021 Oct;22(10):2177-2183.e10. doi: 10.1016/j.jamda.2020.12.032. Epub 2021 Jan 29. PMID: 33516672.

de Vries FM, Stingl JC, Breteler MMB. Polypharmacy, potentially inappropriate medication and pharmacogenomics drug exposure in the Rhineland Study. Br J Clin Pharmacol. 2021 Jul;87(7):2732-2756. doi: 10.1111/bcp.14671. Epub 2021 Feb 5. PMID: 33232531.

Alaeddin N, Stingl JC, Breteler MMB, de Vries FM. Validation of Self-Reported Medication Use Applying Untargeted Mass Spectrometry-Based Metabolomics Techniques in the Rhineland Study. Br J Clin Pharmacol. 2021 Dec 14. doi: 10.1111/bcp.15175. Epub ahead of print. PMID: 34907581.

Kemski S, Molitor V, Steffens M, Nümm TJ, Herrmann N, Hornung T, Bieber T, Schumann C, Kächele V, Seufferlein T, Heinemann V, Scholl C, Stingl JC. Association between miRNA signatures in serum samples from epidermal growth factor inhibitor treated patients and skin toxicity. Oncotarget. 2021 May 11;12(10):982-995. doi: 10.18632/oncotarget.27953. PMID: 34012511; PMCID: PMC8121613.

Weber-Lassalle K, Ernst C, Reuss A, Möllenhoff K, Baumann K, Jackisch C, Hauke J, Dietrich D, Borde J, Park-Simon TW, Hanker L, Prieske K, Schmidt S, Weber-Lassalle N, Pohl-Rescigno E, Kommoss S, Marmé F, Heitz F, Stingl JC, Schmutzler RK, Harter P, Hahnen E. Clonal Hematopoiesis-Associated Gene Mutations in a Clinical Cohort of 448 Patients with Ovarian Cancer. J Natl Cancer Inst. 2021 Dec 28:djab231. doi: 10.1093/jnci/djab231. Epub ahead of print. PMID: 34963005.

Imaging and data research

Stingl JC, Scholl C, Bosch JE, Viviani R. Genetic polymorphism of CYP2C19 and subcortical variability in the human adult brain. Transl Psychiatry. 2021 Sep 8;11(1):467. doi: 10.1038/s41398-021-01591-5. PMID: 34497262; PMCID: PMC8426391.

Molecular modeling and physiology

Kostritskii AY, Machtens JP. Molecular mechanisms of ion conduction and ion selectivity in TMEM16 lipid scramblases. Nat Commun. 2021 May 14;12(1):2826. doi: 10.1038/s41467-021-22724-w. PMID: 33990555; PMCID: PMC8121942.

Kostritskii AY, Alleva C, Cönen S, Machtens JP. g_elpot: A Tool for Quantifying Biomolecular Electrostatics from Molecular Dynamics Trajectories. J Chem Theory Comput. 2021 May 11;17(5):3157-3167. doi: 10.1021/acs.jctc.0c01246. Epub 2021 Apr 29. PMID: 33914551.

Alleva C, Machtens JP, Kortzak D, Weyand I, Fahlke C. Molecular Basis of Coupled Transport and Anion Conduction in Excitatory Amino Acid Transporters. Neurochem Res. 2021 Feb 15. doi: 10.1007/s11064-021-03252-x. Epub ahead of print. PMID: 33587237.

Pharmaceutical Research

Puengel T, Weber B, Wirtz TH, Buendgens L, Loosen SH, Geisler L, Özdirik B, Karim H, Abu Jhaisha S, Brozat JF, Hohlstein P, Eisert A, Yagmur E, Trautwein C, Tacke F, Koch A. Low Serum Levels of Soluble Receptor Activator of Nuclear Factor κ B Ligand (sRANKL) Are Associated with Metabolic Dysregulation and Predict Long-Term Mortality in Critically Ill Patients. Diagnostics 2022, 12, 62. doi.org/10.3390/diagnostics12010062

Koeck JA, Mastragelopoulos N, Just KS, Eisert A. The prevalence of 'triple whammy' prescriptions in surgical inpatients and associated pharmacist recommendations. Pharmazie. 2021 Jul 1;76(7):317-327. doi: 10.1691/ph.2021.1323. PMID: 34256894.

Koeck JA, Young NJ, Kontny U, Orlikowsky T, Bassler D, Eisert A. Interventions to Reduce Medication Dispensing, Administration, and Monitoring Errors in Pediatric Professional Healthcare Settings: A Systematic Review. Front Pediatr. 2021 May 26;9:633064. doi: 0.3389/fped.2021.633064. PMID: 34123962; PMCID: PMC8187621.

Koeck JA, Young NJ, Kontny U, Orlikowsky T, Bassler D, Eisert A. Interventions to Reduce Pediatric Prescribing Errors in Professional Healthcare Settings: A Systematic Review of the Last Decade. Paediatr Drugs. 2021 May;23(3):223-240. doi: 10.1007/s40272-021-00450-6. Epub 2021 May 7. PMID: 33959936.

Eisert A, Lanckohr C, Frey J, Frey O, Wicha SG, Horn D, Ellger B, Schuerholz T, Marx G, Simon TP. Comparison of two empirical prolonged infusion dosing regimens for meropenem in patients with septic shock: A two-center pilot study. Int J Antimicrob Agents. 2021 Mar;57(3):106289. doi: 10.1016/j.ijantimicag.2021.106289. Epub 2021 Jan 27. PMID: 33515688.

Masur S, Eisert A, Freitag M. Metformin-Therapie bei operativen Eingriffen und Gabe jodhaltiger Kontrastmittel [Metformin Therapy During Surgical Interventions and Iodinated Contrast Agent Use]. Dtsch Med Wochenschr. 2021 Jan;146(2):121-127. German. doi: 10.1055/a-1241-2407. Epub 2021 Jan 19. PMID: 33465808.

Conceptual papers, regulatory science

Huber C, Friede T, Stingl J, Benda N. Classification of Companion Diagnostics: A New Framework for Biomarker-Driven Patient Selection. Ther Innov Regul Sci. 2021 Nov 28. doi: 10.1007/s43441-021-00352-2. Epub ahead of print. PMID: 34841493.

Dubrall D, Leitzen S, Toni I, Stingl J, Schulz M, Schmid M, Neubert A, Sachs B. Descriptive analysis of adverse drug reaction reports in children and adolescents from Germany: frequently reported reactions and suspected drugs. BMC Pharmacol Toxicol. 2021 Oct 7;22(1):56. doi: 10.1186/s40360-021-00520-y. PMID: 34620231; PMCID: PMC8499510.

Leitzen S, Dubrall D, Toni I, Stingl J, Schulz M, Schmid M, Neubert A, Sachs B. Analysis of the reporting of adverse drug reactions in children and adolescents in Germany in the time period from 2000 to 2019. PLoS One. 2021 Mar 3;16(3):e0247446. doi: 10.1371/journal.pone.0247446. PMID: 33657139; PMCID: PMC7928460.

Schoretsanitis G, Westin AA, Stingl JC, Deligiannidis KM, Paulzen M, Spigset O. Antidepressant transfer into amniotic fluid, umbilical cord blood & breast milk: A systematic review & combined analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Apr 20;107:110228. doi: 10.1016/j.pnpbp.2020.110228. Epub 2021 Jan 2. PMID: 33358964; PMCID: PMC7882033.

Eap CB, Gründer G, Baumann P, Ansermot N, Conca A, Corruble E, Crettol S, Dahl ML, de Leon J, Greiner C, Howes O, Kim E, Lanzenberger R, Meyer JH, Moessner R, Mulder H, Müller DJ, Reis M, Riederer P, Ruhe HG, Spigset O, Spina E, Stegman B, Steimer W, Stingl J, Suzen S, Uchida H, Unterecker S, Vandenberghe F, Hiemke C. Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants. World J Biol Psychiatry. 2021 Oct;22(8):561-628. doi: 10.1080/15622975.2021.1878427. Epub 2021 May 12. PMID: 33977870.

Hausmann R, Franke H, Schmalzing G. How Prof. Burnstock's enthusiasm supported P2 receptor research in Germany. Purinergic Signal. 2021 Mar;17(1):139-140. doi: 10.1007/s11302-021-09768-9. Epub 2021 Feb 4. PMID: 33543379; PMCID: PMC7954914.

Covid-19-related or antiviral pharmacological issues

Hein S, Herrlein ML, Mhedhbi I, Bender D, Haberger V, Benz N, Eisert J, Stingl J, Dreher M, Oberle D, Schulze J, Mache C, Budt M, Hildt C, Wolff T, Hildt E. Analysis of BNT162b2- and CVnCoV-elicited sera and of convalescent sera toward SARS-CoV-2 viruses. Allergy. 2021 Nov 25. doi: 10.1111/all.15189. Epub ahead of print. PMID: 34820854.

Hein S, Benz NI, Eisert J, Herrlein ML, Oberle D, Dreher M, Stingl JC, Hildt C, Hildt E. Comirnaty-Elicited and Convalescent Sera Recognize Different Spike Epitopes. Vaccines (Basel). 2021 Dec 1;9(12):1419. doi: 10.3390/vaccines9121419. PMID: 34960165; PMCID: PMC8708883.

Warnat-Herresthal S, Schultze H, Shastry KL, Manamohan S, Mukherjee S, Garg V, Sarveswara R, Händler K, Pickkers P, Aziz NA, Ktena S, Tran F, Bitzer M, Ossowski S, Casadei N, Herr C, Petersheim D, Behrends U, Kern F, Fehlmann T, Schommers P, Lehmann C, Augustin M, Rybniker J, Altmüller J, Mishra N, Bernardes JP, Krämer B, Bonaguro L, Schulte-Schrepping J, De Domenico E, Siever C, Kraut M, Desai M, Monnet B, Saridaki M, Siegel CM, Drews A, Nuesch-Germano M, Theis H, Heyckendorf J, Schreiber S, Kim-Hellmuth S; COVID-19 Aachen Study (COVAS), Nattermann J, Skowasch D, Kurth I, Keller A, Bals R, Nürnberg P, Rieß O, Rosenstiel P, Netea MG, Theis F, Mukherjee S, Backes M, Aschenbrenner AC, Ulas T; Deutsche COVID-19 Omics Initiative (DeCOI), Breteler MMB, Giamarellos-Bourboulis EJ, Kox M, Becker M, Cheran S, Woodacre MS, Goh EL, Schultze JL. Swarm Learning for decentralized and confidential clinical machine learning. Nature. 2021 Jun;594(7862):265-270. doi: 10.1038/s41586-021-03583-3. Epub 2021 May 26. PMID: 34040261; PMCID: PMC8189907.

Glitscher M, Martín DH, Woytinek K, Schmidt B, Tabari D, Scholl C, Stingl JC, Seelow E, Choi M, Hildt E. Targeting Cholesterol Metabolism as Efficient Antiviral Strategy Against the Hepatitis E Virus. Cell Mol Gastroenterol Hepatol. 2021;12(1):159-180. doi: 10.1016/j.jcmgh.2021.02.002. Epub 2021 Feb 15. PMID: 33601063; PMCID: PMC8099564.

Stingl, JC. Antidepressant drug treatment protecting from COVID-19: one more piece in the repurposing puzzle. BJPsych Open. 2021 Dec 20;8(1):e20. doi: 10.1192/bjo.2021.1075.

Viviani R, Dommes L, Bosch J, Steffens M, Paul A, Schneider KL, Stingl JC, Beschoner P. Signals of anticipation of reward and of mean reward rates in the human brain. Sci Rep. 2020;10(1): 4287. doi: 10.1038/s41598-020-61257-y. PMCID: PMC7062891.

Pharmacovigilance/Therapeutic drug monitoring/Pharmacokinetics

Schoretsanitis G, Spigset O, Stingl JC, Deligiannidis KM, Paulzen M, Westin AA. The impact of pregnancy on the pharmacokinetics of antidepressants: a systematic critical review and meta-analysis. Expert Opin Drug Metab Toxicol. 2020 May;16(5): 431-440. doi: 10.1080/17425255.2020.1750598. PMCID: PMC7323120.

Paulzen M, Schoretsanitis G, Gründer G, Franz C, Stingl JC, Augustin M. Pregnancy exposure to venlafaxine-Therapeutic drug monitoring in maternal blood, amniotic fluid and umbilical cord blood and obstetrical outcomes. J Affect Disord. 2020;266: 578-584.

Dubrall D, Schmid M, Stingl JC, Sachs B. Angioedemas associated with renin-angiotensin system blocking drugs: Comparative analysis of spontaneous adverse drug reaction reports. PLoS ONE. 2020;15(3): e0230632. doi: 10.1371/journal.pone.0230632. PMCID: PMC7098604.

International diversity in drug metabolism and transport, pharmacogenetics

Mufwambi W, Stingl JC, Masimirembwa C, Manasa J, Nhachi C, Stadler N, Mwila C, Kalungia AC, Mukosha M, Mutiti CS, Kamoto A, Kaonga P, Godman B, Munkombwe D. Healthcare Professionals' Knowledge of Pharmacogenetics and Attitudes Towards Antimicrobial Utilization in Zambia: Implications for a Precision Medicine Approach to Reducing Antimicrobial Resistance.  Front Pharmacol. 2020;11: 551522. doi: 10.3389/fphar.2020.551522. PMCID: PMC7835886.

Tabari D, Scholl C, Steffens M, Weickhardt S, Elgner F, Bender D, Herrlein ML, Sabino C, Semkova V, Peitz M, Till A, Brüstle O, Hildt E, Stingl JC. Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures. Viruses. 2020 Nov;12(11): 1219. doi: 10.3390/v12111219. PMCID: PMC7693339.

New drug target/pharmacological research

Rühlmann AH, Körner J, Hausmann R, Bebrivenski N, Neuhof C, Detro-Dassen S, Hautvast P, Benasolo CA, Meents J, Machtens JP, Schmalzing G, Lampert A.  Uncoupling sodium channel dimers restores the phenotype of a pain-linked Na 1.7 channel mutation. Br J Pharmacol. 2020 Oct;177(19): 4481-4496. doi: 10.1111/bph.15196. PMCID: PMC7484505.

Thull S, Neacsu C, O'Reilly AO, Bothe S, Hausmann R, Huth T, Meents J, Lampert A. Dataset of electrophysiological patch-clamp recordings of the effect of the compounds deltamethrin, ATx-II and ß4-peptide on human cardiac Nav1.5 sodium channel gating properties. Data Brief. 2020 Aug;31: 105844.  doi: 10.1016/j.dib.2020.105844. PMCID: PMC7329930                .

Richter K, Ogiemwonyi-Schaefer R, Wilker S, Chaveiro AI, Agné A, Hecker M, Reichert M, Amati AL, Schlüter KD, Manzini I, Schmalzing G, McIntosh JM, Padberg W, Grau V, Hecker A. Amyloid Beta Peptide (Aß_1-42) Reverses the Cholinergic Control of Monocytic IL-1ß Release. J Clin Med. 2020 Sep; 9(9): 2887. doi: 10.3390/jcm9092887. PMCID: PMC7564705.

Trang M, Schmalzing G, Müller CE, Markwardt F. Dissection of P2X4 and P2X7 Receptor Current Components in BV-2 Microglia. Int J Mol Sci. 2020 Nov;21(22). doi: 10.3390/ijms21228489. PMCID: PMC7696836.

Thull S, Neacsu C, O'Reilly AO, Bothe S, Hausmann R, Huth T, Meents J, Lampert A. Mechanism underlying hooked resurgent-like tail currents induced by an insecticide in human cardiac Nav1.5.  Toxicol Appl Pharmacol. 2020;397: 115010.

Personalized drug safety/Clinical pharmacogenetic research

van der Wouden CH, Böhringer S, Cecchin E, Cheung KC, Dávila-Fajardo CL, Deneer VHM, Dolzan V, Ingelman-Sundberg M, Jönsson S, Karlsson MO, Kriek M, Mitropoulou C, Patrinos GP, Pirmohamed M, Rial-Sebbag E, Samwald M, Schwab M, Steinberger D, Stingl JC, Sunder-Plassmann G, Toffoli G, Turner RM, van Rhenen MH, van Zwet E, Swen JJ, Guchelaar HJ, Ubiquitous Pharmacogenomics Consortium. Generating evidence for precision medicine: considerations made by the Ubiquitous Pharmacogenomics Consortium when designing and operationalizing the PREPARE study.  Pharmacogenet Genomics. 2020 Aug;30(6): 131-144. doi: 10.1097/FPC.0000000000000405. PMCID: PMC7331826.

Gaebler AJ, Schneider KL, Stingl JC, Paulzen M. Subtherapeutic bupropion and hydroxybupropion serum concentrations in a patient with CYP2C19*1/*17 genotype suggesting a rapid metabolizer status. Pharmacogenomics J. 2020;20(6): 840-844.

Barakat AK, Scholl C, Steffens M, Brandenburg K, Ising M, Lucae S, Holsboer F, Laje G, Kalayda GV, Jaehde U, Stingl JC. Citalopram-induced pathways regulation and tentative treatment-outcome-predicting biomarkers in lymphoblastoid cell lines from depression patients. Transl Psychiatry. 2020;10(1): 210. doi: 10.1038/s41398-020-00900-8. PMCID: PMC7329820.

Viviani R, Messina I, Bosch JE, Dommes L, Paul A, Schneider KL, Scholl C, Stingl JC. Effects of genetic variability of CYP2D6 on neural substrates of sustained attention during on-task activity. Transl Psychiatry. 2020;10(1): 338. doi: 10.1038/s41398-020-01020-z. PMCID: PMC7539151.

Dubrall D, Just KS, Schmid M, Stingl JC, Sachs B.  Adverse drug reactions in older adults: a retrospective comparative analysis of spontaneous reports to the German Federal Institute for Drugs and Medical Devices. BMC Pharmacol Toxicol. 2020;21(1): 25. doi: 10.1186/s40360-020-0392-9. PMCID: PMC7092423.

Huebner T, Steffens M, Linder R, Fracowiak J, Langner D, Garling M, Falkenberg F, Roethlein C, Gomm W, Haenisch B, Stingl JC. Influence of metabolic profiles on the safety of drug therapy in routine care in Germany: protocol of the cohort study EMPAR. BMJ Open. 2020;10(4): e032624. doi: 10.1136/bmjopen-2019-032624. PMCID: PMC7213853.

Just KS, Dormann H, Schurig M, Böhme M, Steffens M, Plank-Kiegele B, Ettrich K, Seufferlein T, Gräff I, Igel S, Schricker S, Jaeger SU, Schwab M, Stingl JC.  The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study. Br J Clin Pharmacol. 2020 Nov;86(11): 2144-2154. doi: 10.1111/bcp.14304. PMCID: PMC7576634.

Weber S, Lampert A, Stingl JC, Peuckmann-Post V, Hiddemann S, Elsner F, Neuner I, Rolke R.     [Basic Knowledge of Drug Pain Therapy in the Palliative Situation].  Dtsch Med Wochenschr. 2020;145(13): 917-925. doi: 10.1055/a-1016-9941. PMID: 32615607  

Just KS, Dormann H, Böhme M, Schurig M, Schneider KL, Steffens M, Dunow S, Plank-Kiegele B, Ettrich K, Seufferlein T, Gräff I, Igel S, Schricker S, Jaeger SU, Schwab M, Stingl JC. Personalising drug safety-results from the multi-centre prospective observational study on Adverse Drug Reactions in Emergency Departments (ADRED). Eur J Clin Pharmacol. 2020;76(3): 439-448.

Just KS, Dormann H, Schurig M, Böhme M, Fracowiak J, Steffens M, Scholl C, Seufferlein T, Gräff I, Schwab M, Stingl JC. Adverse Drug Reactions in the Emergency Department: Is There a Role for Pharmacogenomic Profiles at Risk? -Results from the ADRED Study.  J Clin Med. 2020 Jun; 9(6): 1801. doi: 10.3390/jcm9061801. PMCID: PMC7355597.

Stingl JC, Just KS, Schurig M, Böhme M, Steffens M, Schwab M, Seufferlein T, Dormann H. Prevalence of Psychotropic Drugs in Cases of Severe Adverse Drug Reactions Leading to Unplanned Emergency Visits in General Hospitals. Pharmacopsychiatry. 2020;53(3): 133-137.

Molecular modeling and physiology

Alberione MP, Moeller R, Kirui J, Ginkel C, Doepke M, Ströh LJ, Machtens JP, Pietschmann T, Gerold G. Single-nucleotide variants in human CD81 influence hepatitis C virus infection of hepatoma cells. Med Microbiol Immunol (Berl). 2020;209(4): 499-514. doi: 10.1007/s00430-020-00675-1. PMCID: PMC7176029.

Alleva C, Kovalev K, Astashkin R, Berndt MI, Baeken C, Balandin T, Gordeliy V, Fahlke C, Machtens JP. Na-dependent gate dynamics and electrostatic attraction ensure substrate coupling in glutamate transporters. Sci Adv. 2020 Nov;6(47).  doi: 10.1126/sciadv.aba9854. PMCID: PMC7673805.

Pharmaceutical Research

Wirtz TH, Buendgens L, Weiskirchen R, Loosen SH, Haehnsen N, Puengel T, Abu Jhaisha S, Brozat JF, Hohlstein P, Koek G, Eisert A, Mohr R, Roderburg C, Luedde T, Trautwein C, Tacke F, Koch A. Association of Serum Calprotectin Concentrations with Mortality in Critically Ill and Septic Patients. Diagnostics (Basel). 2020 Nov;10(11). doi: 10.3390/diagnostics10110990. PMCID: PMC7700375.

Amkreutz J, Lenssen R, Marx G, Deisz R, Eisert A. Medication safety in a German telemedicine centre: Implementation of a telepharmaceutical expert consultation in addition to existing tele-intensive care unit services.  J Telemed Telecare. 2020;26(1-2): 105-112.

Buendgens L, Yagmur E, Ginsberg A, Weiskirchen R, Wirtz T, Jhaisha SA, Eisert A, Luedde T, Trautwein C, Tacke F, Koch A. Midregional Proadrenomedullin (MRproADM) Serum Levels in Critically Ill Patients Are Associated with Short-Term and Overall Mortality during a Two-Year Follow-Up. Mediators Inflamm. 2020;2020: 7184803. doi: 10.1155/2020/7184803. PMCID: PMC7428945.