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Claudia Trinler and Corinna Rösseler win poster price at Europhysiology in London

Congratulations to Corinna Rösseler and Claudia Trinler who both won a poster prize at the Europhysiology-meeting in September 2018 in London. Corinna Rösseler received a prize for her poster…

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Annual Retreat of the Institute of Physiology

Today the Institute of Physiology had for the fourth time its annual retreat – for the third time at Youth Hostel Aachen. Even if the location does not seem to be very fancy (it is better than it…

Loss-of-function of a voltage-gated sodium channel can lead to gain-of-pain

In a current project, we examined the effect of a previously described voltage-gated sodium channel mutation that has been identified in a patient suffering from the chronic pain syndrome small fiber…

Stefan Gründer was elected to Vice-President of the German Physiological Society

At the general meeting of the German Physiological Society (DPG) at the Europhysiology meeting in London, Stefan Gründer was elected to Vice-President of the DPG. His term starts on 1st of January…

Dr. Lilia Leisle comes from Cornell University to work at the Institute of Physiology

On August 1 2018, Dr. Lilia Leisle starts at the Institute of Physiology in the Gründer group. After finishing her thesis at the Max-Delbrück-Center for Molecular Medicine in Berlin, she moved for six…

Putative binding site of RFamide-neuropeptides on ASIC3 identified

RFamid-neuropeptides are important modulators of Acid-sensing ion channels (ASICs), in particular of ASIC3. By slowing desensitization of ASIC3, they strongly increase the excitatory current, which…

The sodium channel Nav1.7 is mechanically stabilized by its β-subunit

Voltage-gated sodium channels (Navs) not only respond to changes in membrane potential, but are also modified by mechanical stress in the cell membrane. In a living organism, mechanical influences are…

The opioid oxycodone inhibits the sodium channel of cardiomyocytes

Opioids are often the last resort for pain relief in patients that suffer from severe acute or chronic pain. Unfortunately, opioids can cause addiction and they have recently become notorious for…

Characterisation of a Wamid-activated ion channel in a marine annelid

Neuropeptides are structurally diverse and broadly distributed in the animal kingdom. Typically, they activate G protein-coupled receptors. But we also know a few ion channels that are directly…

Inhalational anesthetics accelerate desensitization of Acid-Sensing Ion Channels

Acid-sensing ion channels (ASICs) are proton-gated ion channels with important physiological functions. Inhibiting ASICs has neuroprotective effects, for example during ischemic stroke. Because…

Daniel Barth comes from New Zealand to join the Institute of Physiology as a Post-Doc

We welcome Daniel S. Barth as a new Post-Doc at the Institute of Physiology in the Lückhoff group. Dr. Barth successfully completed his Ph.D. thesis in August 2017 at the Institute of Physiology,…

Modulation of DEG/ENaCs by Amphiphiles Suggests Sensitivity to Membrane Alterations

The bile acid-sensitive ion channel BASIC is modulated by a variety of different amphiphilic substances, which modify the biophysical properties of the surrounding membrane. The precise mechanism…