Publications

  1. Strietz J, Stepputtis SS, Follo M, Bronsert P, Stickeler E, Maurer J. Human Primary Breast Cancer Stem Cells Are Characterized by Epithelial-Mesenchymal Plasticity. Int J Mol Sci. 2021 Feb 11;22(4):1808. doi: 10.3390/ijms22041808.
  2. Dhamija S, Yang CM, Seiler J, Myacheva K, Caudron-Herger M, Wieland A, Abdelkarim M, Sharma Y, Riester M, Groß M, Maurer J, Diederichs S. A pan-cancer analysis reveals nonstop extension mutations causing SMAD4 tumour suppressor degradation. Nat Cell Biol. 2020 Aug;22(8):999-1010. doi: 10.1038/s41556-020-0551-7. Epub 2020 Jul 27. PMID: 32719554
  3. Heesch A, Maurer J, Stickeler E, Beheshti M, Mottaghy FM, Morgenroth A. Development of Radiotracers for Breast Cancer-The Tumor Microenvironment as an Emerging Target. Cells. 2020 Oct 21;9(10):2334. doi: 10.3390/cells9102334. PMID: 33096754 Free PMC article. Review.
  4. Wittenborn J, Weikert L, Hangarter B, Stickeler E, Maurer J. The use of micro RNA in the early detection of cervical intraepithelial neoplasia. Carcinogenesis. 2020 Dec 31;41(12):1781-1789. doi: 10.1093/carcin/bgaa046. PMID: 32417880
  5. Rose M, Maurer A, Wirtz J, Bleilevens A, Waldmann T, Wenz M, Eyll M, Geelvink M, Gereitzig M, Rüchel N, Denecke B, Eltze E, Herrmann E, Toma M, Horst D, Grimm T, Denzinger S, Ecke T, Vögeli TA, Knuechel R, Maurer J, Gaisa NT. EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer. Oncogene. 2020 Oct;39(44):6856-6870. doi: 10.1038/s41388-020-01465-y. Epub 2020 Sep 25. PMID: 32978523 Free PMC article.
  6. Jäger R, Maurer J & Schorle H. (2003) Conditional Immortalization of Mouse Neural Crest Stem Cells. Eur J Cell Biol; Abstracts Suppl. 53, Vol.82.
  7. Jäger R and Maurer J, Jacob A, Schorle H. (2004) Cell type-specific conditional regulation of the c-myc protooncogene by combining Cre/loxP recombination and tamoxifen-mediated activation. Genesis; 38(3): 145-50.
  8. Maurer J, Fuchs S, Jäger R, Kurz B, Sommer L, Schorle H. (2007) Establishment and analysis of a neural crest stem cell line (JoMa1) using conditional transgenesis. Differentiation; 75(7): 580-591.
  9. Maurer J, Nelson B, Ceceña G, Bajpai R, Mercola M, Terskikh A and Oshima RG. (2008) Contrasting expression of keratins in mouse and human embryonic stem cells. PlosOne; 3(10):e3451.
  10. Curchoe CL and Maurer J, McKeown SJ, Cattarossi G, Cimadamore F, Nilbratt M, Snyder EY, Bronner-Fraser M, Terskikh AV. Early Acquisition of Neural Crest Competence During hESCs Neuralization, PLoS ONE: Research Article, published 09 Nov 201010.1371/journal.pone.0013890
  11. Castro DJ, Maurer J, Hebbard, L., & Oshima, R. G (2013). ROCK1 inhibition promotes the self-renewal of a novel mouse mammary cancer stem cell. Stem Cells 2013 Jan;31(1):12-22. doi: 10.1002/stem.1224.
  12. Graupner O, Maurer J, Lecker L, Klein B, Karim-Payab S, Stickeler E, Enzensberger C (2023). Serologische microRNA als potenzieller Biomarker bei Schwangerschaften mit später fetaler Wachstumsrestriktion, Ultraschall in der Medizin-European Journal of Ultrasound 44, S14-S14.
  13. Strietz J, Stepputtis SS, Preca BT, Vannier C, Kim MM, Castro DJ, Au Q, Boerries M, Busch H, Aza-Blanc P, Heynen-Genel S, Bronsert P, Kuster B, Stickeler E, Brabletz T, Oshima RG, Maurer J. ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer. Oncotarget. 2016 Dec 13;7(50):83278-83293. doi: 10.18632/oncotarget.13086.
  14. Preca BT, Bajdak K, Mock K, Lehmann W, Sundararajan V, Bronsert P, Matzge-Ogi A, Orian-Rousseau V, Brabletz S, Brabletz T, Maurer J, Stemmler MP. A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer. Oncotarget. 2017 Feb 14;8(7):11530-11543. doi: 10.18632/oncotarget.14563.
  15. Metzger E, Stepputtis SS, Strietz J, Preca BT, Urban S, Willmann D, Allen A, Zenk F, Iovino N, Bronsert P, Proske A, Follo M, Boerries M, Stickeler E, Xu J, Wallace MB, Stafford J, Kanouni T, Maurer J and Schüle R. KDM4 inhibition targets breast cancer stem cells. Cancer Research (2017), Published OnlineFirst September 7, 2017 doi: 10.1158/0008-5472.CAN-17-1754
  16. Jolly MK, Preca B, Tripathi SC, Jia D, George JT, Hanash SM, Brabletz T,   Stemmler MP, Maurer J and Levine H. Interconnected feedback loops among ESRP1, HAS2, and CD44 regulate epithelial-mesenchymal plasticity in cancer. APL Bioeng. 2018 Sep; 2(3): 031908. Published online 2018 Aug 22. doi: 10.1063/1.5024874
  17. Li X, Strietz J, Bleilevens A, Stickeler E, Maurer J. Chemotherapeutic Stress Influences Epithelial–Mesenchymal Transition and Stemness in Cancer Stem Cells of Triple-Negative Breast Cancer. Int. J. Mol. Sci. 2020, 21, 404. doi: 10.3390/ijms21020404
  18. Wittenborn J, Weikert L, Hangarter B, Stickeler E, Maurer J. The use of miRNA in the early detection of cervical intraepithelial neoplasia. Carcinogenesis. 2020 May 17. pii: bgaa046. doi: 10.1093/carcin/bgaa046.
  19. Strietz J, Stepputtis SS, Follo M, Bronsert P, Stickeler E, Maurer J. Human Primary Breast Cancer Stem Cells Are Characterized by Epithelial-Mesenchymal Plasticity. Int J Mol Sci. 2021 Feb 11;22(4):1808. doi: 10.3390/ijms22041808.
  20. Narasimhan H, Ferraro F, Bleilevens A, Weiskirchen R, Stickeler E, Maurer J. Tumor Necrosis Factor-α (TNFα) Stimulate Triple-Negative Breast Cancer Stem Cells to Promote Intratumoral Invasion and Neovasculogenesis in the Liver of a Xenograft Model. Biology 2022, 11(10), 1481; doi: 10.3390/biology11101481 PMID: 36290384
  21. IRAK2 Downregulation in Triple-Negative Breast Cancer Cells Decreases Cellular Growth In Vitro and Delays Tumour Progression in Murine Models. Ferraro F, Steinle A, Narasimhan H, Bleilevens A, Stolzenberg PM, Braunschweig T, Stickeler E, Maurer J. Int J Mol Sci. 2023 Jan 28;24(3):2520. doi: 10.3390/ijms24032520. PMID: 36768848
  22. Kupec T, Bleilevens A, Klein B, Hansen T, Najjari L, Wittenborn J, Stickeler E, Maurer J. Comparison of Serum and Urine as Sources of miRNA Markers for the Detection of Ovarian Cancer. Biomedicines. 2023;11(9):2508. doi.org/10.3390/biomedicines11092508
  23. Wittenborn J, Flasshove EM, Kupec T, Najjari L, Stickeler E, Maurer J. A Glimmer of Hope for Patients with a T3 Transformation Zone: miRNAs Are Potential Biomarkers for Cervical Dysplasia. Diagnostics (Basel). 2023 Dec 5;13(24):3599. doi: 10.3390/diagnostics13243599. PMID: 38132183; PMCID: PMC10742976.
  24. Hermann R, Poppe L, Pilbak S, Boden C, Maurer J, Weber S, Lerchl A. (2005) Predicted 3D-structure of melanopsin, the non-rod, non-cone photopigment of the mammalian circadian clock, from Djungarian hamsters (Phodopus sungorus). Neurosci Lett; 376(2): 76-80.
  25. Kretz M, Eckardt D, Krüger O, Kim JS, Maurer J, Theis M, Schorle H, Willecke K. (2006) Normal embryonic development and cardiac morphogenesis in mice with Wnt1-Cre mediated deletion of connexin43. Genesis; 44(6): 269-276.
  26. Bohrer, A. M., Schramm, A., Maurer, J., Schorle, H., Astrahantseff, K., Eggert, A., & Schulte, J. H. (2008, May). JoMa1-a model to analyze neural crest stem cells in-vitro. In Klinische Pädiatrie (Vol. 220, No. 3, pp. 199-199
  27. Cabral-Teixeira J, Talsky K, Zhang L, Maurer J, Tsuda M, Chao YS, Prigozhina N, Price J, Snyder E, Mercola M, Ruoslahti E, West MD, Larocca D (2008) Targeting nanoparticle probes to differentiating stem cells. NSTI-Nanotech 2008, ISBN 978-1-4200-8504-4 (Vol.2, pp. 430-433)
  28. Bohrer, A. M., E. Mahlow, Maurer J, H. Schorle, A. Schramm, A. Eggert, and J. H. Schulte. "N-myc induces transformation of neural crest stem cells in vitro and in vivo." Klinische Pädiatrie 221, no. 03 (2009): A5.
  29. Schulte J, Bohrer A, Mahlow E, Maurer J, Schorle H, De Preter K, Vandesompele, J, Speleman F, Schlierf S, Pajtler K, Schramm A, Eggert A (2009). Modeling neuroblastomagenesis from neural crest stem cells in vitro and in vivo. Pediatric Blood &Cancer (Vol. 53, pp. 703–704). Hoboken: WILEY-LISS
  30. Hebbard L, Maurer J, Amber M, Lesperance J, Hassell JA, Oshima RG, Terskikh A. (2010) MELK is Upregulated and Required in Mammary Tumor Initiating Cells In Vivo.Cancer Research 2010 Sep 22.
  31. Pajtler, K., Bohrer, A., Maurer, J., Schorle, H., Schramm, A., Eggert, A., Schulte, J. H., Production of Chick Embryo Extract for the Cultivation of Murine Neural Crest Stem Cells www.jove.com/details.stp doi: 10.3791/2380. J Vis Exp. 45 (2010).
  32. Lindner, S., Schulte, J. H., Bohrer, A., Maurer, J., DePreter, K., Lefever, S. & Schramm, A. (2011). Neuroblastoma develops from neural crest stem cells. Klinische Pädiatrie, 223(03),  A21.
  33. Steinmetz N.F., Maurer J., Sheng H., Bensussan A., Maricic I., Kumar V., Braciak T.A. Two Domains of Vimentin Are Expressed on the Surface of Lymph Node, Bone and Brain Metastatic Prostate Cancer Lines along with the Putative Stem Cell Marker Proteins CD44 and CD133. Cancers. 2011; 3(3):2870-2885.
  34. Murphy DA, Diaz B, Bromann PA, Tsai JH, Kawakami Y, Maurer J, Stewart RA, Izpisúa-Belmonte JC, Courtneidge SA (2011) A Src-Tks5 Pathway Is Required for Neural Crest Cell Migration during Embryonic Development. PLoS ONE 6(7): e22499. doi:10.1371/journal.pone.0022499
  35. Schulte JS, Lindner S, Bohrer A, Maurer J, DePreter K, Lefever S, Heukamp L, Schulte S, Molenaar J, Versteeg R, Thor T, Kunkele A, Vandesompele J, Speleman F, Schorle H, Eggert A, Schramm A. MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells. Oncogene. 2013 Feb 21;32(8):1059-65. doi: 10.1038/onc.2012.106. Epub 2012 Apr 9.
  36. Preca BT, Bajdak K, Mock K, Sundararajan V, Pfannstiel J, Maurer J, Wellner U, Hopt UT, Brummer T, Brabletz S, et al. A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells. Int J Cancer. 2015 Dec 1;137(11):2566-77. doi: 10.1002/ijc.29642. Epub 2015 Jun 30.
  37. Enderle-Ammour K; Bader M; Ahrens TD; Franke KU; Timme S; Csanadi A; Hoeppner J; Kulemann B; Maurer J; Reiss CP; Schilling O; Keck T; Brabletz T; Stickeler E; Werner M; Wellner UF; Bronsert P. Form Follows Function - Morphological and Immunohistological Insights Into EMT Characteristics of Tumorbuds. Tumour Biol. 2017 May;39(5):1010428317705501. doi: 10.1177/1010428317705501.
  38. Allam A, Thomsen AR, Gothwal M, Saha D, Maurer J, Brunner TB. Pancreatic stellate cells in pancreatic cancer: In focus. Pancreatology. 2017 May 27. pii: S1424-3903(17)30485-4. doi: 10.1016/j.pan.2017.05.390. [Epub ahead of print] Review.
  39. Seidl, M, Bader M, Vaihinger A, Wellner UF, Todorova R, Herde B, Schrenk K, Maurer J, Schilling O, Erbes T, Fisch P, Pfeiffer J, Hoffmann L, Franke K, Werner M and Bronsert P. Morphology of Immunomodulation in Breast Cancer Tumor Draining Lymph Nodes Depends on Stage and Intrinsic Subtype. Scientific Reports. 2018;8(1):5321.
  40. Hillebrand LE, Wickberg SM, Gomez-Auli A, Follo M, Maurer J, Busch H, Boerries M, Reinheckel T. MMP14 empowers tumor-initiating breast cancer cells under hypoxic nutrient-depleted conditions. FASEB J. 2018 Dec 6:fj201801127R. doi: 10.1096/fj.201801127R. [Epub ahead of print]
  41. Oria VO, Lopatta P, Schmitz T, Preca BT, Nyström A, Conrad C, Bartsch JW, Kulemann B, Hoeppner J, Maurer J, Bronsert P, Schilling O. ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma. Mol Oncol. 2018 Dec 17. doi: 10.1002/1878-0261.12426. [Epub ahead of print]
  42. Metzger E, Wang S, Urban S, Willmann D, Schmidt A, Offermann A, Allen A, Sum M, Obier N, Cottard F, Ulferts S, Preca BT, Hermann B, Maurer J, Greschik H, Hornung V, Einsle O, Perner S, Imhof A, Jung M, Schüle R. KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells. Nat Struct Mol Biol. 2019 May;26(5):361-371. doi: 10.1038/s41594-019-0219-9. Epub 2019 May 6.
  43. Dhamija S, Yang CM, Seiler J, Myacheva K, Caudron-Herger M, Wieland A, Abdelkarim M, Sharma Y, Riester M, Groß M, Maurer J, Diederichs S. A pan-cancer analysis reveals nonstop extension mutations causing SMAD4 tumour suppressor degradation. Nat Cell Biol. 2020;22(8):999-1010. doi:10.1038/s41556-020-0551-7
  44. Rose M, Maurer A, Wirtz J, Bleilevens A, Waldmann T, Wenz M, Eyll M, Geelvink M, Gereitzig M, Rüchel N, Denecke B, Eltze E, Herrmann E, Toma M, Horst D, Grimm T, Denzinger S, Ecke T, Vögeli TA, Knuechel R, Maurer J, Gaisa NT. EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer. Oncogene. 2020 Oct;39(44):6856-6870. doi: 10.1038/s41388-020-01465-y. Epub 2020 Sep 25. Erratum in: Oncogene. 2021 Feb;40(7):1390.
  45. Heesch A, Maurer J, Stickeler E, Beheshti M, Mottaghy FM, Morgenroth A. Development of Radiotracers for Breast Cancer-The Tumor Microenvironment as an Emerging Target. Cells. 2020 Oct 21;9(10):2334. doi: 10.3390/cells9102334.
  46. Laine A, Nagelli SG, Farrington C, Butt U, Cvrljevic AN, Vainonen JP, Feringa FM, Grönroos TJ, Gautam P, Khan S, Sihto H, Qiao X, Pavic K, Connolly DC, Kronqvist P, Elo LL, Maurer J, Wennerberg K, Medema RH, Joensuu H, Peuhu E, de Visser K, Narla G, Westermarck J. CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis. Cancer Res. 2021 Aug 15;81(16):4319-4331. doi: 10.1158/0008-5472.CAN-20-3651. Epub 2021 Jun 18. PMID: 34145035; PMCID: PMC8373817.
  47. Meng J, Peng J, Feng J, Maurer J, Li X, Li Y, Yao S, Chu R, Pan X, Li J, Zhang T, Liu L, Zhang Q, Yuan Z, Bu H, Song K, Kong B. Niraparib exhibits a synergistic anti-tumor effect with PD-L1 blockade by inducing an immune response in ovarian cancer. J Transl Med. 2021 Oct 7;19(1):415. doi: 10.1186/s12967-021-03073-0.
  48. Dornhof J, Kieninger J, Muralidharan H, Maurer J, Urban GA, Weltin A. Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures. Lab Chip. 2021 Dec 1. doi: 10.1039/d1lc00689d.
  49. Sankaranarayanan RA, Peil J, Vogg ATJ, Bolm C, Terhorst S, Classen A, Bauwens M, Maurer J, Mottaghy F, Morgenroth A. Auger Emitter Conjugated PARP Inhibitor for Therapy in Triple Negative Breast Cancers: A Comparative In-Vitro Study. Cancers (Basel). 2022 Jan 4;14(1):230. doi: 10.3390/cancers14010230. PMID: 35008392.
  50. Jain S, Hu C, Kluza J, Ke W, Tian G, Giurgiu M, Bleilevens A, Campos AR, Charbono A, Stickeler E, Maurer J, Holinski-Feder E, Vaisburg A, Bureik M, Luo G, Marchetti P, Cheng Y, Wolf DA. Metabolic targeting of cancer by a ubiquinone uncompetitive inhibitor of mitochondrial complex I. Cell Chem Biol. 2022 Mar 17;29(3):436-450.e15. doi: 10.1016/j.chembiol.2021.11.002. Epub 2021 Nov 30. PMID: 34852219
  51. Kupec T, Bleilevens A, Iborra S, Najjari L, Wittenborn J, Maurer J, Stickeler E. Stability of circulating microRNAs in serum. PLoS One. 2022 Aug 31;17(8):e0268958. doi: 10.1371/journal.pone.0268958. eCollection 2022. PMID: 36044434
  52. Ambur Sankaranarayana R, Florea A, Allekotte S, Vogg ATJ, Maurer J, Schäfer L, Bolm C, Terhorst S, Classen A, Bauwens M, Morgenroth A, Mottaghy FM. PARP targeted Auger emitter therapy with [125I]PARPi-01 for triple-negative breast cancer. EJNMMI Res. 2022 Sep 14;12(1):60. doi: 10.1186/s13550-022-00932-9. PMID: 36104637
  53. Lüchtenborg AM, Metzger P, Cosenza Contreras M, Oria V, Biniossek ML, Lindner F, Fröhlich K, Malyi A, Erbes T, Gensch N, Maurer J, Thomsen A, Boerries M, Schilling O, Werner M, Bronsert P. Krüppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer. Breast Cancer Res. 2022 Oct 3;24(1):65. doi: 10.1186/s13058-022-01562-8. PMID: 36192788
  54. The Potential of PSMA as a Vascular Target in TNBC. Heesch A, Ortmanns L, Maurer J, Stickeler E, Sahnoun SEM, Mottaghy FM, Morgenroth A. Cells. 2023 Feb 8;12(4):551. doi: 10.3390/cells12040551.PMID: 36831218
  55. Karge A, Enzensberger C, Stickeler E, Maurer J, Kuschel B, Pecks U, Graupner O (3/2023) Bedeutung der Molekularpathologie in der Geburtshilfe–Plazenta im Fokus Die Gynäkologie 56 (3), 191-199
  56. Raute K, Strietz J, Parigiani MA, Andrieux G, Thomas OS, Kistner KM, Zintchenko M, Aichele P, Hofmann M, Zhou H, Weber W, Boerries M, Swamy M, Maurer J, Minguet S. Breast Cancer Stem Cell-Derived Tumors Escape from γδ T-cell Immunosurveillance In Vivo by Modulating γδ T-cell Ligands.Cancer Immunol Res. 2023 May 4;:OF1-OF20. PMID: 37139603
  57. Kamin H, Nolte L, Bleilevens A, Stickeler E, Heinemann D, Maurer J, Johannsmeier S, Ripken T. Imaging and quantification of the tumor microenvironment of triple negative breast cancer using TPEF and scanning laser optical tomography. Biomed Opt Express. 2023 Aug 10;14(9):4579-4593. doi: 10.1364/BOE.494181. PMID: 37791264; PMCID: PMC10545185.
  58. De Lorenzi F, Hansen N, Theek B, Daware R, Motta A, Breuel S, Nasehi R, Baumeister J, Schöneberg J, Stojanović N, von Stillfried S, Vogt M, Müller-Newen G, Maurer J, Sofias AM, Lammers T, Fischer H, Kiessling F. Engineering Mesoscopic 3D Tumor Models with a Self-Organizing Vascularized Matrix. Adv Mater. 2023 Oct 22:e2303196. doi: 10.1002/adma.202303196. Epub ahead of print. PMID: 37865947.