Veröffentlichungen von Dr. Emiel van der Vorst in den letzten 5 Jahren:

  1. van der Vorst, E. P. C., Daissormont, I., Aslani, M., Seijkens, T., Wijnands, E., Lutgens, E., Duchene, J., Santovito, D., Doring, Y., Halvorsen, B., Aukrust, P., Weber, C., Hopken, U. E. & Biessen, E. A. L. Interruption of the CXCL13/CXCR5 Chemokine Axis Enhances Plasma IgM Levels and Attenuates Atherosclerosis Development. Thromb Haemost 120, 344-347, doi:10.1055/s-0039-3400746 (2020).
     
  2. van der Vorst, E. P. C., Biessen, E. A. L. & Donners, M. Letter by van der Vorst et al Regarding Article, "Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques". Arterioscler Thromb Vasc Biol 40, e31-e32, doi:10.1161/ATVBAHA.119.313725 (2020).
     
  3. Tilstam, P. V., Soppert, J., Hemmers, C., Harlacher, E., Doring, Y., van der Vorst, E. P. C., Schulte, C., Alampour-Rajabi, S., Theelen, W., Asare, Y., de Winther, M. P. J., Lawrence, T., Bernhagen, J., Schober, A., Zernecke, A., Jankowski, J., Weber, C. & Noels, H. Non-activatable mutant of inhibitor of kappa B kinase alpha (IKKalpha) exerts vascular site-specific effects on atherosclerosis in Apoe-deficient mice. Atherosclerosis 292, 23-30, doi:10.1016/j.atherosclerosis.2019.10.023 (2020).
     
  4. Doring, Y., Jansen, Y., Cimen, I., Aslani, M., Gencer, S., Peters, L. J., Duchene, J., Weber, C. & van der Vorst, E. V. B-Cell Specific CXCR4 Protects Against Atherosclerosis Development and Increases Plasma IgM Levels. Circ Res, doi:10.1161/CIRCRESAHA.119.316142 (2020).
     
  5. van der Vorst, E. P. C. & Weber, C. Novel Features of Monocytes and Macrophages in Cardiovascular Biology and Disease. Arterioscler Thromb Vasc Biol 39, e30-e37, doi:10.1161/ATVBAHA.118.312002 (2019).
     
  6. van der Vorst, E. P. C., Peters, L. J. F., Muller, M., Gencer, S., Yan, Y., Weber, C. & Doring, Y. G-Protein Coupled Receptor Targeting on Myeloid Cells in Atherosclerosis. Front Pharmacol 10, 531, doi:10.3389/fphar.2019.00531 (2019).
     
  7. van der Vorst, E. P. C., Mandl, M., Muller, M., Neideck, C., Jansen, Y., Hristov, M., Gencer, S., Peters, L. J. F., Meiler, S., Feld, M., Geiselhoringer, A. L., de Jong, R. J., Ohnmacht, C., Noels, H., Soehnlein, O., Drechsler, M., Weber, C. & Doring, Y. Hematopoietic ChemR23 (Chemerin Receptor 23) Fuels Atherosclerosis by Sustaining an M1 Macrophage-Phenotype and Guidance of Plasmacytoid Dendritic Cells to Murine Lesions-Brief Report. Arterioscler Thromb Vasc Biol 39, 685-693, doi:10.1161/ATVBAHA.119.312386 (2019).
     
  8. van der Vorst, E. P. C. & Donners, M. ADAM8 in the cardiovascular system: An innocent bystander with clinical use? Atherosclerosis 286, 147-149, doi:10.1016/j.atherosclerosis.2019.04.205 (2019).
     
  9. Van der Vorst, E. P. C. & Biessen, E. A. L. Unwrapped and uNCORked: PPAR-gamma repression in atherosclerosis. Eur Heart J, doi:10.1093/eurheartj/ehz770 (2019).
     
  10. Kiouptsi, K., Jackel, S., Pontarollo, G., Grill, A., Kuijpers, M. J. E., Wilms, E., Weber, C., Sommer, F., Nagy, M., Neideck, C., Jansen, Y., Ascher, S., Formes, H., Karwot, C., Bayer, F., Kollar, B., Subramaniam, S., Molitor, M., Wenzel, P., Rosenstiel, P., Todorov, H., Gerber, S., Walter, U., Jurk, K., Heemskerk, J. W. M., van der Vorst, E. P. C., Doring, Y. & Reinhardt, C. The Microbiota Promotes Arterial Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice. mBio 10, doi:10.1128/mBio.02298-19 (2019).
     
  11. Gencer, S., van der Vorst, E. P. C., Aslani, M., Weber, C., Doring, Y. & Duchene, J. Atypical Chemokine Receptors in Cardiovascular Disease. Thromb Haemost 119, 534-541, doi:10.1055/s-0038-1676988 (2019).
     
  12. Doring, Y., van der Vorst, E. P. C., Duchene, J., Jansen, Y., Gencer, S., Bidzhekov, K., Atzler, D., Santovito, D., Rader, D. J., Saleheen, D. & Weber, C. CXCL12 Derived From Endothelial Cells Promotes Atherosclerosis to Drive Coronary Artery Disease. Circulation 139, 1338-1340, doi:10.1161/CIRCULATIONAHA.118.037953 (2019).
     
  13. van der Vorst, E. P. C., Weber, C. & Donners, M. A Disintegrin and Metalloproteases (ADAMs) in Cardiovascular, Metabolic and Inflammatory Diseases: Aspects for Theranostic Approaches. Thromb Haemost 118, 1167-1175, doi:10.1055/s-0038-1660479 (2018).
     
  14. van der Vorst, E. P. C. & Weber, C. Metabolomic profiling of atherosclerotic plaques: towards improved cardiovascular risk stratification. Eur Heart J 39, 2311-2313, doi:10.1093/eurheartj/ehy117 (2018).
     
  15. van der Vorst, E. P. C. & Doring, Y. Resistin keeps its Janus face. Int J Cardiol 272, 47-48, doi:10.1016/j.ijcard.2018.08.071 (2018).
     
  16. van der Vorst, E. P. C., de Jong, R. J. & Donners, M. Message in a Microbottle: Modulation of Vascular Inflammation and Atherosclerosis by Extracellular Vesicles. Front Cardiovasc Med 5, 2, doi:10.3389/fcvm.2018.00002 (2018).
     
  17. Rinne, P., Guillamat-Prats, R., Rami, M., Bindila, L., Ring, L., Lyytikainen, L. P., Raitoharju, E., Oksala, N., Lehtimaki, T., Weber, C., van der Vorst, E. P. C. & Steffens, S. Palmitoylethanolamide Promotes a Proresolving Macrophage Phenotype and Attenuates Atherosclerotic Plaque Formation. Arterioscler Thromb Vasc Biol 38, 2562-2575, doi:10.1161/ATVBAHA.118.311185 (2018).
     
  18. Merckelbach, S., van der Vorst, E. P. C., Kallmayer, M., Rischpler, C., Burgkart, R., Doring, Y., de Borst, G. J., Schwaiger, M., Eckstein, H. H., Weber, C. & Pelisek, J. Expression and Cellular Localization of CXCR4 and CXCL12 in Human Carotid Atherosclerotic Plaques. Thromb Haemost 118, 195-206, doi:10.1160/TH17-04-0271 (2018).
     
  19. Doring, Y. & van der Vorst, E. P. C. Gouty Offense in Patients With Obstructive Coronary Artery Disease Despite State-of-the-Art Therapy. J Am Heart Assoc 7, e010322, doi:10.1161/JAHA.118.010322 (2018).
     
  20. Weber, C., Badimon, L., Mach, F. & van der Vorst, E. P. C. Therapeutic strategies for atherosclerosis and atherothrombosis: Past, present and future. Thromb Haemost 117, 1258-1264, doi:10.1160/TH16-10-0814 (2017).
     
  21. van der Vorst, E. P. C., Theodorou, K., Wu, Y., Hoeksema, M. A., Goossens, P., Bursill, C. A., Aliyev, T., Huitema, L. F. A., Tas, S. W., Wolfs, I. M. J., Kuijpers, M. J. E., Gijbels, M. J., Schalkwijk, C. G., Koonen, D. P. Y., Abdollahi-Roodsaz, S., McDaniels, K., Wang, C. C., Leitges, M., Lawrence, T., Plat, J., Van Eck, M., Rye, K. A., Touqui, L., de Winther, M. P. J., Biessen, E. A. L. & Donners, M. High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-kappaB/STAT1-IRF1 Signaling. Cell Metab 25, 197-207, doi:10.1016/j.cmet.2016.10.013 (2017).
     
  22. van der Vorst, E. P. C., Theodorou, K., Biessen, E. A. L. & Donners, M. HDL and macrophages: explaining the clinical failures and advancing HDL-based therapeutics in cardiovascular diseases? Expert Rev Cardiovasc Ther 15, 343-344, doi:10.1080/14779072.2017.1313115 (2017).
     
  23. van der Vorst, E. P. C., Theodorou, K., Biessen, E. A. L. & Donners, M. Disease- or Storage-Associated Structural Modifications Are Unlikely to Explain HDL Pro-inflammatory Effects on Macrophages. Cell Metab 26, 4-5, doi:10.1016/j.cmet.2017.05.017 (2017).
     
  24. van der Vorst, E. P. C., Maas, S. L., Ortega-Gomez, A., Hameleers, J. M. M., Bianchini, M., Asare, Y., Soehnlein, O., Doring, Y., Weber, C. & Megens, R. T. A. Functional ex-vivo Imaging of Arterial Cellular Recruitment and Lipid Extravasation. Bio Protoc 7, doi:10.21769/BioProtoc.2344 (2017).
     
  25. van der Vorst, E. P., Zhao, Z., Rami, M., Holdt, L. M., Teupser, D., Steffens, S. & Weber, C. Contrasting effects of myeloid and endothelial ADAM17 on atherosclerosis development. Thromb Haemost 117, 644-646, doi:10.1160/TH16-09-0674 (2017).
     
  26. Theodorou, K., van der Vorst, E. P. C., Gijbels, M. J., Wolfs, I. M. J., Jeurissen, M., Theelen, T. L., Sluimer, J. C., Wijnands, E., Cleutjens, J. P., Li, Y., Jansen, Y., Weber, C., Ludwig, A., Bentzon, J. F., Bartsch, J. W., Biessen, E. A. L. & Donners, M. Whole body and hematopoietic ADAM8 deficiency does not influence advanced atherosclerotic lesion development, despite its association with human plaque progression. Sci Rep 7, 11670, doi:10.1038/s41598-017-10549-x (2017).
     
  27. Rinne, P., Rami, M., Nuutinen, S., Santovito, D., van der Vorst, E. P. C., Guillamat-Prats, R., Lyytikainen, L. P., Raitoharju, E., Oksala, N., Ring, L., Cai, M., Hruby, V. J., Lehtimaki, T., Weber, C. & Steffens, S. Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages. Circulation 136, 83-97, doi:10.1161/CIRCULATIONAHA.116.025889 (2017).
     
  28. Rademakers, T., van der Vorst, E. P., Daissormont, I. T., Otten, J. J., Theodorou, K., Theelen, T. L., Gijbels, M., Anisimov, A., Nurmi, H., Lindeman, J. H., Schober, A., Heeneman, S., Alitalo, K. & Biessen, E. A. Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis. Sci Rep 7, 45263, doi:10.1038/srep45263 (2017).
     
  29. Hyafil, F., Pelisek, J., Laitinen, I., Schottelius, M., Mohring, M., Doring, Y., van der Vorst, E. P., Kallmayer, M., Steiger, K., Poschenrieder, A., Notni, J., Fischer, J., Baumgartner, C., Rischpler, C., Nekolla, S. G., Weber, C., Eckstein, H. H., Wester, H. J. & Schwaiger, M. Imaging the Cytokine Receptor CXCR4 in Atherosclerotic Plaques with the Radiotracer (68)Ga-Pentixafor for PET. J Nucl Med 58, 499-506, doi:10.2967/jnumed.116.179663 (2017).
     
  30. Doring, Y., Noels, H., van der Vorst, E. P. C., Neideck, C., Egea, V., Drechsler, M., Mandl, M., Pawig, L., Jansen, Y., Schroder, K., Bidzhekov, K., Megens, R. T. A., Theelen, W., Klinkhammer, B. M., Boor, P., Schurgers, L., van Gorp, R., Ries, C., Kusters, P. J. H., van der Wal, A., Hackeng, T. M., Gabel, G., Brandes, R. P., Soehnlein, O., Lutgens, E., Vestweber, D., Teupser, D., Holdt, L. M., Rader, D. J., Saleheen, D. & Weber, C. Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence From Mouse and Human Studies. Circulation 136, 388-403, doi:10.1161/CIRCULATIONAHA.117.027646 (2017).
     
  31. Chubanov, V., Ferioli, S., Wisnowsky, A., Simmons, D. G., Leitzinger, C., Einer, C., Jonas, W., Shymkiv, Y., Bartsch, H., Braun, A., Akdogan, B., Mittermeier, L., Sytik, L., Torben, F., Jurinovic, V., van der Vorst, E. P., Weber, C., Yildirim, O. A., Sotlar, K., Schurmann, A., Zierler, S., Zischka, H., Ryazanov, A. G. & Gudermann, T. Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Elife 5, doi:10.7554/eLife.20914 (2016).
     
  32. van der Vorst, E. P., Jeurissen, M., Wolfs, I. M., Keijbeck, A., Theodorou, K., Wijnands, E., Schurgers, L., Weber, S., Gijbels, M. J., Hamers, A. A., Dreymueller, D., Rose-John, S., de Winther, M. P., Ludwig, A., Saftig, P., Biessen, E. A. & Donners, M. M. Myeloid A disintegrin and metalloproteinase domain 10 deficiency modulates atherosclerotic plaque composition by shifting the balance from inflammation toward fibrosis. Am J Pathol 185, 1145-1155, doi:10.1016/j.ajpath.2014.11.028 (2015).
     
  33. van der Vorst, E. P., Doring, Y. & Weber, C. Chemokines and their receptors in Atherosclerosis. J Mol Med (Berl) 93, 963-971, doi:10.1007/s00109-015-1317-8 (2015).
     
  34. van der Vorst, E. P., Doring, Y. & Weber, C. MIF and CXCL12 in Cardiovascular Diseases: Functional Differences and Similarities. Front Immunol 6, 373, doi:10.3389/fimmu.2015.00373 (2015).
     
  35. van der Vorst, E. P., Doring, Y. & Weber, C. Chemokines. Arterioscler Thromb Vasc Biol 35, e52-56, doi:10.1161/ATVBAHA.115.306359 (2015).
     
  36. Kusters, D. H., Chatrou, M. L., Willems, B. A., De Saint-Hubert, M., Bauwens, M., van der Vorst, E., Bena, S., Biessen, E. A., Perretti, M., Schurgers, L. J. & Reutelingsperger, C. P. Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet. PLoS One 10, e0130484, doi:10.1371/journal.pone.0130484 (2015).