Veröffentlichungen von Prof. Erik Biessen in den letzten 5 Jahren:

  1. Kerkhofs D, Helgers R, Hermes D, Steinbusch HPJ, Van Essen H, Leenders P, Prickaerts J, Staals J, Biessen EA, Van Oostenbrugge RJ and Foulquier S. Amlodipine limits microglia activation and cognitive dysfunction in aged hypertensive mice. J Hypertens. 2023.
     
  2. Ruder AV, Temmerman L, van Dommelen JMA, Nagenborg J, Lu C, Sluimer JC, Goossens P and Biessen EAL. Culture density influences the functional phenotype of human macrophages. Front Immunol. 2023;14:1078591.
     
  3. Skenteris NT, Hemme E, Delfos L, Karadimou G, Karlof E, Lengquist M, Kronqvist M, Zhang X, Maegdefessel L, Schurgers LJ, Arnardottir H, Biessen EAL, Bot I and Matic L. Mast cells participate in smooth muscle cell reprogramming and atherosclerotic plaque calcification. Vascul Pharmacol. 2023;150:107167.
     
  4. van der Vorst EPC, Maas SL, Theodorou K, Peters LJF, Jin H, Rademakers T, Gijbels MJ, Rousch M, Jansen Y, Weber C, Lehrke M, Lebherz C, Yildiz D, Ludwig A, Bentzon JF, Biessen EAL and Donners M. Endothelial ADAM10 controls cellular response to oxLDL and its deficiency exacerbates atherosclerosis with intraplaque hemorrhage and neovascularization in mice. Front Cardiovasc Med. 2023;10:974918.
     
  5. van Kuijk K, McCracken IR, Tillie R, Asselberghs SEJ, Kheder DA, Muitjens S, Jin H, Taylor RS, Wichers Schreur R, Kuppe C, Dobie R, Ramachandran P, Gijbels MJ, Temmerman L, Kirkwoord PM, Luyten J, Li Y, Noels H, Goossens P, Wilson-Kanamori JR, Schurgers LJ, Shen YH, Mees BME, Biessen EAL, Henderson NC, Kramann R, Baker AH and Sluimer JC. Human and murine fibroblast single cell transcriptomics reveals fibroblast clusters are differentially affected by ageing, and serum cholesterol. Cardiovasc Res. 2023.
     
  6. Fontaine MAC, Jin H, Gagliardi M, Rousch M, Wijnands E, Stoll M, Li X, Schurgers L, Reutelingsperger C, Schalkwijk C, van den Akker NMS, Molin DGM, Gullestad L, Eritsland J, Hoffman P, Skjelland M, Andersen GO, Aukrust P, Karel J, Smirnov E, Halvorsen B, Temmerman L and Biessen EAL. Blood Milieu in Acute Myocardial Infarction Reprograms Human Macrophages for Trauma Repair. Adv Sci (Weinh). 2023;10:e2203053.
     
  7. Segers FME, Ruder AV, Westra MM, Lammers T, Dadfar SM, Roemhild K, Lam TS, Kooi ME, Cleutjens K, Verheyen FK, Schurink GWH, Haenen GR, van Berkel TJC, Bot I, Halvorsen B, Sluimer JC and Biessen EAL. Magnetic resonance imaging contrast-enhancement with superparamagnetic iron oxide nanoparticles amplifies macrophage foam cell apoptosis in human and murine atherosclerosis. Cardiovasc Res. 2023;118:3346-3359.
     
  8. Ruder AV, Wetzels SMW, Temmerman L, Biessen EAL and Goossens P. Monocyte Heterogeneity in Cardiovascular Disease. Cardiovasc Res. 2023.
     
  9. Lu C, Donners M, Karel J, de Boer H, van Zonneveld AJ, den Ruijter H, Jukema JW, Kraaijeveld A, Kuiper J, Pasterkamp G, Cavill R, Perales-Paton J, Ferrannini E, Goossens P and Biessen EAL. Sex-specific differences in cytokine signaling pathways in circulating monocytes of cardiovascular disease patients. Atherosclerosis. 2023.
     
  10. Wieland EB, Kempen L, Lu C, Donners M, Biessen EAL and Goossens P. Protocol for multispectral imaging on cryosections to map myeloid cell heterogeneity in its spatial context. STAR Protoc. 2023;4:102601.

  1. Wollenhaupt J, Frisch J, Harlacher E, Wong DWL, Jin H, Schulte C, Vondenhoff S, Moellmann J, Klinkhammer BM, Zhang L, Baleanu-Curaj A, Liehn EA, Speer T, Kazakov A, Werner C, van der Vorst EPC, Selejan SR, Hohl M, Bohm M, Kramann R, Biessen EAL, Lehrke M, Marx N, Jankowski J, Maack C, Boor P, Prates Roma L and Noels H. Pro-oxidative priming but maintained cardiac function in a broad spectrum of murine models of chronic kidney disease. Redox Biol. 2022;56:102459.
     
  2. Waring OJ, Skenteris NT, Biessen EAL and Donners M. Two-faced Janus: the dual role of macrophages in atherosclerotic calcification. Cardiovasc Res. 2022;118:2768-2777.
     
  3. van Kuijk K, Demandt JAF, Perales-Paton J, Theelen TL, Kuppe C, Marsch E, de Bruijn J, Jin H, Gijbels MJ, Matic L, Mees BME, Reutelingsperger CPM, Hedin U, Biessen EAL, Carmeliet P, Baker AH, Kramann RK, Schurgers LJ, Saez-Rodriguez J and Sluimer JC. Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signalling. Cardiovasc Res. 2022;118:1232-1246.
     
  4. van Dierendonck X, Vrieling F, Smeehuijzen L, Deng L, Boogaard JP, Croes CA, Temmerman L, Wetzels S, Biessen E, Kersten S and Stienstra R. Triglyceride breakdown from lipid droplets regulates the inflammatory response in macrophages. Proc Natl Acad Sci U S A. 2022;119:e2114739119.
     
  5. Segers FME, Ruder AV, Westra MM, Lammers T, Dadfar SM, Roemhild K, Lam TS, Eline Kooi M, Cleutjens K, Verheyen FK, Schurink GWH, Haenen GR, van Berkel TJC, Bot I, Halvorsen B, Sluimer JC and Biessen EAL. MRI Contrast-enhancement with superparamagnetic iron oxide nanoparticles amplify macrophage foam cell apoptosis in human and murine atherosclerosis. Cardiovasc Res. 2022.

  6. Peters LJF, Baaten C, Maas SL, Lu C, Nagy M, Jooss NJ, Bidzhekov K, Santovito D, Moreno-Andres D, Jankowski J, Biessen EAL, Doring Y, Heemskerk JWM, Weber C, Kuijpers MJE and van der Vorst EPC. MicroRNA-26b Attenuates Platelet Adhesion and Aggregation in Mice. Biomedicines. 2022;10.

  7. Madrigal-Matute J, de Bruijn J, van Kuijk K, Riascos-Bernal DF, Diaz A, Tasset I, Martin-Segura A, Gijbels MJJ, Sander B, Kaushik S, Biessen EAL, Tiano S, Bourdenx M, Krause GJ, McCracken I, Baker AH, Jin H, Sibinga NES, Bravo-Cordero JJ, Macian F, Singh R, Rensen PCN, Berbee JFP, Pasterkamp G, Sluimer JC and Cuervo AM. Protective role of chaperone-mediated autophagy against atherosclerosis. Proc Natl Acad Sci U S A. 2022;119:e2121133119.

  8. Kip AM, Grootjans J, Manca M, Hadfoune M, Boonen B, Derikx JPM, Biessen EAL, Olde Damink SWM, Dejong CHC, Buurman WA and Lenaerts K. Temporal Transcript Profiling Identifies a Role for Unfolded Protein Stress in Human Gut Ischemia-Reperfusion Injury. Cell Mol Gastroenterol Hepatol. 2022;13:681-694.

  9. Goossens P, Lu C, Cao J, Gijbels MJ, Karel JMH, Wijnands E, Claes BSR, Fazzi GE, Hendriks TFE, Wouters K, Smirnov E, van Zandvoort MJM, Balluff B, Cuypers E, Donners M, Heeren RMA and Biessen EAL. Integrating multiplex immunofluorescent and mass spectrometry imaging to map myeloid heterogeneity in its metabolic and cellular context. Cell Metab. 2022;34:1214-1225 e6.

  10. Fontaine MAC, Jin H, Gagliardi M, Rousch M, Wijnands E, Stoll M, Li X, Schurgers L, Reutelingsperger C, Schalkwijk C, van den Akker NMS, Molin DGM, Gullestad L, Eritsland J, Hoffman P, Skjelland M, Andersen GO, Aukrust P, Karel J, Smirnov E, Halvorsen B, Temmerman L and Biessen EAL. Blood Milieu in Acute Myocardial Infarction Reprograms Human Macrophages for Trauma Repair. Adv Sci (Weinh). 2022:e2203053.

  11. Christ A, Goossens PG, Wijnands E, Jin H, Legein B, Oth T, Isaacs A, Stoll M, Vanderlocht J, Lutgens E, Daemen M, Zenke M and Biessen EAL. Low Density Lipoprotein Exposure of Plasmacytoid Dendritic Cells Blunts Toll-like Receptor 7/9 Signaling via NUR77. Biomedicines. 2022;10.

  12. Basso PJ, Rocha CRR, Biessen EAL, der Pluijm IV, Menck CFM and Camara NOS. Editorial: DNA repair and immune response. Front Immunol. 2022;13:1034689.


Stand: Feb 2023

  1. Schumacher D, Liehn EA, Singh A, Curaj A, Wijnands E, Lira SA, Tacke F, Jankowski J, Biessen EAL and van der Vorst EPC. CCR6 Deficiency Increases Infarct Size after Murine Acute Myocardial Infarction. Biomedicines. 2021;9.
     
  2. Kip AM, Grootjans J, Manca M, Hadfoune M, Boonen B, Derikx JPM, Biessen EAL, Olde Damink SWM, Dejong CHC, Buurman WA and Lenaerts K. Temporal Transcript Profiling Identifies a Role for Unfolded Protein Stress in Human Gut Ischemia-Reperfusion Injury. Cell Mol Gastroenterol Hepatol. 2021.
     
  3. Jin H, Mees BME, Biessen EAL and Sluimer JC. Transcriptional Sex Dimorphism in Human Atherosclerosis Relates to Plaque Type. Circ Res. 2021;129:1175-1177.
     
  4. Merlin J, Ivanov S, Dumont A, Sergushichev A, Gall J, Stunault M, Ayrault M, Vaillant N, Castiglione A, Swain A, Orange F, Gallerand A, Berton T, Martin JC, Carobbio S, Masson J, Gaisler-Salomon I, Maechler P, Rayport S, Sluimer JC, Biessen EAL, Guinamard RR, Gautier EL, Thorp EB, Artyomov MN and Yvan-Charvet L. Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation. Nat Metab. 2021;3:1313-1326.
     
  5. Biessen EAL and Van Berkel TJC. N-Acetyl Galactosamine Targeting: Paving the Way for Clinical Application of Nucleotide Medicines in Cardiovascular Diseases. Arterioscler Thromb Vasc Biol. 2021;41:2855-2865.
     
  6. Waring OJ, Skenteris NT, Biessen EAL and Donners M. Two-faced Janus: The dual role of macrophages in atherosclerotic calcification. Cardiovasc Res. 2021.
     
  7. Jaminon AMG, Akbulut AC, Rapp N, Kramann R, Biessen EAL, Temmerman L, Mees B, Brandenburg V, Dzhanaev R, Jahnen-Dechent W, Floege J, Uitto J, Reutelingsperger CP and Schurgers LJ. Development of the BioHybrid Assay: Combining Primary Human Vascular Smooth Muscle Cells and Blood to Measure Vascular Calcification Propensity. Cells. 2021;10.
     
  8. Tillie R, Theelen TL, van Kuijk K, Temmerman L, de Bruijn J, Gijbels M, Betsholtz C, Biessen EAL and Sluimer JC. A Switch from Cell-Associated to Soluble PDGF-B Protects against Atherosclerosis, despite Driving Extramedullary Hematopoiesis. Cells. 2021;10.
     
  9. Wauters L, Slaets H, De Paepe K, Ceulemans M, Wetzels S, Geboers K, Toth J, Thys W, Dybajlo R, Walgraeve D, Biessen E, Verbeke K, Tack J, Van de Wiele T, Hellings N and Vanuytsel T. Efficacy and safety of spore-forming probiotics in the treatment of functional dyspepsia: a pilot randomised, double-blind, placebo-controlled trial. Lancet Gastroenterol Hepatol. 2021;6:784-792.
     
  10. Jin H, Goossens P, Juhasz P, Eijgelaar W, Manca M, Karel JMH, Smirnov E, Sikkink C, Mees BME, Waring O, van Kuijk K, Fazzi GE, Gijbels MJJ, Kutmon M, Evelo CTA, Hedin U, Daemen M, Sluimer JC, Matic L and Biessen EAL. Integrative multiomics analysis of human atherosclerosis reveals a serum response factor-driven network associated with intraplaque hemorrhage. Clin Transl Med. 2021;11:e458.
     
  11. Seime T, Akbulut AC, Liljeqvist ML, Siika A, Jin H, Winski G, van Gorp RH, Karlof E, Lengquist M, Buckler AJ, Kronqvist M, Waring OJ, Lindeman JHN, Biessen EAL, Maegdefessel L, Razuvaev A, Schurgers LJ, Hedin U and Matic L. Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification. Cells. 2021;10.
     
  12. Demandt JAF, van Kuijk K, Theelen TL, Marsch E, Heffron SP, Fisher EA, Carmeliet P, Biessen EAL and Sluimer JC. Whole-Body Prolyl Hydroxylase Domain (PHD) 3 Deficiency Increased Plasma Lipids and Hematocrit Without Impacting Plaque Size in Low-Density Lipoprotein Receptor Knockout Mice. Front Cell Dev Biol. 2021;9:664258.
     
  13. Sundararaman SS, Peters LJF, Jansen Y, Gencer S, Yan Y, Nazir S, Bonnin Marquez A, Kahles F, Lehrke M, Biessen EAL, Jankowski J, Weber C, Doring Y and van der Vorst EPC. Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe(-/-) mice. Sci Rep. 2021;11:10409.
     
  14. van Kuijk K, Demandt JAF, Perales-Paton J, Theelen TL, Kuppe C, Marsch E, de Bruijn J, Jin H, Gijbels MJ, Matic L, Mees BME, Reutelingsperger CPM, Hedin U, Biessen EAL, Carmeliet P, Baker AH, Kramann RK, Schurgers LJ, Saez-Rodriguez J and Sluimer JC. DEFICIENCY OF MYELOID PHD PROTEINS AGGRAVATES ATHEROGENESIS VIA MACROPHAGE APOPTOSIS AND PARACRINE FIBROTIC SIGNALING: Atherogenic effects of myeloid PHD knockdown. Cardiovasc Res. 2021.
     
  15. Saar-Kovrov V, Zidek W, Orth-Alampour S, Fliser D, Jankowski V, Biessen EAL and Jankowski J. Reduction of protein-bound uraemic toxins in plasma of chronic renal failure patients: A systematic review. J Intern Med. 2021;290:499-526.
     
  16. Quiles-Jimenez A, Gregersen I, Segers FM, Skarpengland T, Kroustallaki P, Yang K, Kong XY, Lauritzen KH, Olsen MB, Karlsen TR, Nyman TA, Sagen EL, Bjerkeli V, Suganthan R, Nygard S, Scheffler K, Prins J, Van der Veer E, Ogaard JD, Floisand Y, Jorgensen HF, Holven KB, Biessen EA, Nilsen H, Dahl TB, Holm S, Bennett MR, Aukrust P, Bjoras M and Halvorsen B. DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development. Atherosclerosis. 2021;324:123-132.
     
  17. Sluimer JC and Biessen EAL. Arterial lymphangiogenesis ReSPONDINg 2 a new cue: the R-spondin2/LRG4 axis limits VEGFR3-mediated lymphangiogenesis and reverse cholesterol transport. Cardiovasc Res. 2021;117:1417-1419.
     
  18. Demandt JAF, Dubois LJ, van Kuijk K, Zatovicova M, Jin H, Parkkila S, van der Laan SW, Jelenska L, Mees BME, Reutelingsperger CPM, Cleutjens K, van der Kallen CJH, Schalkwijk CG, van Greevenbroek MMJ, Biessen EAL, Pasterkamp G, Pastorekova S, Stehouwer CDA and Sluimer JC. The hypoxia-sensor carbonic anhydrase IX affects macrophage metabolism, but is not a suitable biomarker for human cardiovascular disease. Sci Rep. 2021;11:425.
  1. Zhang H, Bredewold EOW, Vreeken D, Duijs J, de Boer HC, Kraaijeveld AO, Jukema JW, Pijls NH, Waltenberger J, Biessen EAL, van der Veer EP, van Zonneveld AJ and van Gils JM. Prediction Power on Cardiovascular Disease of Neuroimmune Guidance Cues Expression by Peripheral Blood Monocytes Determined by Machine-Learning Methods. Int J Mol Sci. 2020;21.
     
  2. van Geffen JP, Swieringa F, van Kuijk K, Tullemans BME, Solari FA, Peng B, Clemetson KJ, Farndale RW, Dubois LJ, Sickmann A, Zahedi RP, Ahrends R, Biessen EAL, Sluimer JC, Heemskerk JWM and Kuijpers MJE. Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome. Sci Rep. 2020;10:21407.
     
  3. van der Vorst EPC, Daissormont I, Aslani M, Seijkens T, Wijnands E, Lutgens E, Duchene J, Santovito D, Doring Y, Halvorsen B, Aukrust P, Weber C, Hopken UE and Biessen EAL. Interruption of the CXCL13/CXCR5 Chemokine Axis Enhances Plasma IgM Levels and Attenuates Atherosclerosis Development. Thromb Haemost. 2020;120:344-347.
     
  4. van der Vorst EPC, Biessen EAL and Donners M. Letter by van der Vorst et al Regarding Article, "Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques". Arterioscler Thromb Vasc Biol. 2020;40:e31-e32.
     
  5. Peters LJF, Floege J, Biessen EAL, Jankowski J and van der Vorst EPC. MicroRNAs in Chronic Kidney Disease: Four Candidates for Clinical Application. Int J Mol Sci. 2020;21.
     
  6. Peters LJF, Biessen EAL, Hohl M, Weber C, van der Vorst EPC and Santovito D. Small Things Matter: Relevance of MicroRNAs in Cardiovascular Disease. Front Physiol. 2020;11:793.
     
  7. Kerkhofs D, van Hagen BT, Milanova IV, Schell KJ, van Essen H, Wijnands E, Goossens P, Blankesteijn WM, Unger T, Prickaerts J, Biessen EA, van Oostenbrugge RJ and Foulquier S. Pharmacological depletion of microglia and perivascular macrophages prevents Vascular Cognitive Impairment in Ang II-induced hypertension. Theranostics. 2020;10:9512-9527.
     
  8. Hung J, Scanlon JP, Mahmoud AD, Rodor J, Ballantyne M, Fontaine MAC, Temmerman L, Kaczynski J, Connor KL, Bhushan R, Biessen EAL, Newby DE, Sluimer JC and Baker AH. Novel Plaque Enriched Long Noncoding RNA in Atherosclerotic Macrophage Regulation (PELATON). Arterioscler Thromb Vasc Biol. 2020;40:697-713.
     
  9. Giamouridis D, Gao MH, Lai NC, Guo T, Miyanohara A, Blankesteijn WM, Biessen EAL and Hammond HK. Urocortin 2 Gene Transfer Improves Heart Function in Aged Mice. Mol Ther. 2020;28:180-188.
     
  10. Furmanik M, Chatrou M, van Gorp R, Akbulut A, Willems B, Schmidt H, van Eys G, Bochaton-Piallat ML, Proudfoot D, Biessen E, Hedin U, Perisic L, Mees B, Shanahan C, Reutelingsperger C and Schurgers L. Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification. Circ Res. 2020;127:911-927.
     
  11. Chteinberg E, Wetzels S, Gerritsen W, Temmerman L, van den Oord J, Biessen E, Kurz AK, Winnepenninckx V, Zenke M, Speel EJ and Zur Hausen A. Navitoclax combined with Alpelisib effectively inhibits Merkel cell carcinoma cell growth in vitro. Ther Adv Med Oncol. 2020;12:1758835920975621.
     
  12. Cao J, Goossens P, Martin-Lorenzo M, Dewez F, Claes BSR, Biessen EAL, Heeren RMA and Balluff B. Atheroma-Specific Lipids in ldlr(-/-) and apoe(-/-) Mice Using 2D and 3D Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging. J Am Soc Mass Spectrom. 2020;31:1825-1832.
  1. Van der Vorst, E. P. C. & Biessen, E. A. L. Unwrapped and uNCORked: PPAR-gamma repression in atherosclerosis. Eur Heart J, doi:10.1093/eurheartj/ehz770 (2019).
     
  2. Montserrat-de la Paz, S., Naranjo, M. C., Millan-Linares, M. C., Lopez, S., Abia, R., Biessen, E. A. L., Muriana, F. J. G. & Bermudez, B. Monounsaturated Fatty Acids in a High-Fat Diet and Niacin Protect from White Fat Dysfunction in the Metabolic Syndrome. Mol Nutr Food Res 63, e1900425, doi:10.1002/mnfr.201900425 (2019).
     
  3. Korporaal, S. J. A., Molenaar, T. J. M., Lutters, B. C. H., Meurs, I., Drost-Verhoef, S., Kuiper, J., van Berkel, T. J. C. & Biessen, E. A. L. Peptide Antagonists for P-selectin Discriminate between Sulfatide-Dependent Platelet Aggregation and PSGL-1-Mediated Cell Adhesion. J Clin Med 8, doi:10.3390/jcm8081266 (2019).
     
  4. Giamouridis, D., Gao, M. H., Lai, N. C., Tan, Z., Kim, Y. C., Guo, T., Miyanohara, A., Blankesteijn, M. W., Biessen, E. A. L. & Hammond, H. K. Urocortin 3 Gene Transfer Increases Function of the Failing Murine Heart. Hum Gene Ther 30, 10-20, doi:10.1089/hum.2018.103 (2019).
     
  5. Fontaine, M. A. C., Westra, M. M., Bot, I., Jin, H., Franssen, A., Bot, M., de Jager, S. C. A., Dzhagalov, I., He, Y. W., van Vlijmen, B. J. M., Gijbels, M. J. J., Reutelingsperger, C. P., van Berkel, T. J. C., Sluimer, J. C., Temmerman, L. & Biessen, E. A. L. Low human and murine Mcl-1 expression leads to a pro-apoptotic plaque phenotype enriched in giant-cells. Sci Rep 9, 14547, doi:10.1038/s41598-019-51020-3 (2019).
     
  6. Donners, M. & Biessen, E. A. L. SCRIBbling the role of endothelial polarity in atherosclerosis. Cardiovasc Res 115, 1937-1939, doi:10.1093/cvr/cvz171 (2019).
  1. Wetzels, S., Bijnen, M., Wijnands, E., Biessen, E. A. L., Schalkwijk, C. G. & Wouters, K. Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry. J Vis Exp, doi:10.3791/57319 (2018).
     
  2. Maracle, C. X., Agca, R., Helder, B., Meeuwsen, J. A. L., Niessen, H. W. M., Biessen, E. A. L., de Winther, M. P. J., de Jager, S. C. A., Nurmohamed, M. T. & Tas, S. W. Noncanonical NF-kappaB signaling in microvessels of atherosclerotic lesions is associated with inflammation, atheromatous plaque morphology and myocardial infarction. Atherosclerosis 270, 33-41, doi:10.1016/j.atherosclerosis.2018.01.032 (2018).
     
  3. Giamouridis, D., Gao, M. H., Lai, N. C., Tan, Z., Kim, Y. C., Guo, T., Miyanohara, A., Blankesteijn, W. M., Biessen, E. & Hammond, H. K. Effects of Urocortin 2 Versus Urocortin 3 Gene Transfer on Left Ventricular Function and Glucose Disposal. JACC Basic Transl Sci 3, 249-264, doi:10.1016/j.jacbts.2017.12.004 (2018).
     
  4. Bouthoorn, S., Gohar, A., Valstar, G., den Ruijter, H. M., Reitsma, J. B., Hoes, A. W., Rutten, F. H. & Queen of Hearts, C. Prevalence of left ventricular systolic dysfunction and heart failure with reduced ejection fraction in men and women with type 2 diabetes mellitus: a systematic review and meta-analysis. Cardiovasc Diabetol 17, 58, doi:10.1186/s12933-018-0690-3 (2018).
     
  5. Bijnen, M., Josefs, T., Cuijpers, I., Maalsen, C. J., van de Gaar, J., Vroomen, M., Wijnands, E., Rensen, S. S., Greve, J. W. M., Hofker, M. H., Biessen, E. A. L., Stehouwer, C. D. A., Schalkwijk, C. G. & Wouters, K. Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice. Gut 67, 1317-1327, doi:10.1136/gutjnl-2016-313654 (2018).
     
  6. Bijnen, M., Beelen, N., Wetzels, S., Gaar, J. V., Vroomen, M., Wijnands, E., Scheijen, J. L., van de Waarenburg, M. P. H., Gijbels, M. J., Cleutjens, J. P., Biessen, E. A. L., Stehouwer, C. D. A., Schalkwijk, C. G. & Wouters, K. RAGE deficiency does not affect non-alcoholic steatohepatitis and atherosclerosis in Western type diet-fed Ldlr(-/-) mice. Sci Rep 8, 15256, doi:10.1038/s41598-018-33661-y (2018).
  1. Wouters, K., Gaens, K., Bijnen, M., Verboven, K., Jocken, J., Wetzels, S., Wijnands, E., Hansen, D., van Greevenbroek, M., Duijvestijn, A., Biessen, E. A., Blaak, E. E., Stehouwer, C. D. & Schalkwijk, C. G. Circulating classical monocytes are associated with CD11c(+) macrophages in human visceral adipose tissue. Sci Rep 7, 42665, doi:10.1038/srep42665 (2017).
     
  2. Winkels, H., Meiler, S., Smeets, E., Lievens, D., Engel, D., Spitz, C., Burger, C., Rinne, P., Beckers, L., Dandl, A., Reim, S., Ahmadsei, M., Van den Bossche, J., Holdt, L. M., Megens, R. T., Schmitt, M., de Winther, M., Biessen, E. A., Borst, J., Faussner, A., Weber, C., Lutgens, E. & Gerdes, N. CD70 limits atherosclerosis and promotes macrophage function. Thromb Haemost 117, 164-175, doi:10.1160/TH16-04-0318 (2017).
     
  3. Winkels, H., Meiler, S., Lievens, D., Engel, D., Spitz, C., Burger, C., Beckers, L., Dandl, A., Reim, S., Ahmadsei, M., Hartwig, H., Holdt, L. M., Hristov, M., Megens, R. T. A., Schmitt, M. M., Biessen, E. A., Borst, J., Faussner, A., Weber, C., Lutgens, E. & Gerdes, N. CD27 co-stimulation increases the abundance of regulatory T cells and reduces atherosclerosis in hyperlipidaemic mice. Eur Heart J 38, 3590-3599, doi:10.1093/eurheartj/ehx517 (2017).
     
  4. van der Vorst, E. P. C., Theodorou, K., Wu, Y., Hoeksema, M. A., Goossens, P., Bursill, C. A., Aliyev, T., Huitema, L. F. A., Tas, S. W., Wolfs, I. M. J., Kuijpers, M. J. E., Gijbels, M. J., Schalkwijk, C. G., Koonen, D. P. Y., Abdollahi-Roodsaz, S., McDaniels, K., Wang, C. C., Leitges, M., Lawrence, T., Plat, J., Van Eck, M., Rye, K. A., Touqui, L., de Winther, M. P. J., Biessen, E. A. L. & Donners, M. High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-kappaB/STAT1-IRF1 Signaling. Cell Metab 25, 197-207, doi:10.1016/j.cmet.2016.10.013 (2017).
     
  5. van der Vorst, E. P. C., Theodorou, K., Biessen, E. A. L. & Donners, M. HDL and macrophages: explaining the clinical failures and advancing HDL-based therapeutics in cardiovascular diseases? Expert Rev Cardiovasc Ther 15, 343-344, doi:10.1080/14779072.2017.1313115 (2017).
     
  6. van der Vorst, E. P. C., Theodorou, K., Biessen, E. A. L. & Donners, M. Disease- or Storage-Associated Structural Modifications Are Unlikely to Explain HDL Pro-inflammatory Effects on Macrophages. Cell Metab 26, 4-5, doi:10.1016/j.cmet.2017.05.017 (2017).
     
  7. Theodorou, K., van der Vorst, E. P. C., Gijbels, M. J., Wolfs, I. M. J., Jeurissen, M., Theelen, T. L., Sluimer, J. C., Wijnands, E., Cleutjens, J. P., Li, Y., Jansen, Y., Weber, C., Ludwig, A., Bentzon, J. F., Bartsch, J. W., Biessen, E. A. L. & Donners, M. Whole body and hematopoietic ADAM8 deficiency does not influence advanced atherosclerotic lesion development, despite its association with human plaque progression. Sci Rep 7, 11670, doi:10.1038/s41598-017-10549-x (2017).
     
  8. Temmerman, L., Westra, M. M., Bot, I., van Vlijmen, B. J. M., van Bree, N., Bot, M., Habets, K. L. L., Keulers, T. G. H., van der Vlag, J., Cotter, T. G., van Berkel, T. J. C. & Biessen, E. A. L. Leukocyte Bim deficiency does not impact atherogenesis in ldlr (-/-) mice, despite a pronounced induction of autoimmune inflammation. Sci Rep 7, 3086, doi:10.1038/s41598-017-02771-4 (2017).
     
  9. Rademakers, T., van der Vorst, E. P., Daissormont, I. T., Otten, J. J., Theodorou, K., Theelen, T. L., Gijbels, M., Anisimov, A., Nurmi, H., Lindeman, J. H., Schober, A., Heeneman, S., Alitalo, K. & Biessen, E. A. Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis. Sci Rep 7, 45263, doi:10.1038/srep45263 (2017).
     
  10. Nagenborg, J., Goossens, P., Biessen, E. A. L. & Donners, M. Heterogeneity of atherosclerotic plaque macrophage origin, phenotype and functions: Implications for treatment. Eur J Pharmacol 816, 14-24, doi:10.1016/j.ejphar.2017.10.005 (2017).
     
  11. Maffia, P., Doring, Y., Biessen, E. A. & Mallat, Z. Commentary: Indoleamine 2,3-Dioxygenase-Expressing Aortic Plasmacytoid Dendritic Cells Protect against Atherosclerosis by Induction of Regulatory T Cells. Front Immunol 8, 140, doi:10.3389/fimmu.2017.00140 (2017).
     
  12. Kusters, P., Seijkens, T., Burger, C., Legein, B., Winkels, H., Gijbels, M., Barthels, C., Bennett, R., Beckers, L., Atzler, D., Biessen, E., Brocker, T., Weber, C., Gerdes, N. & Lutgens, E. Constitutive CD40 Signaling in Dendritic Cells Limits Atherosclerosis by Provoking Inflammatory Bowel Disease and Ensuing Cholesterol Malabsorption. Am J Pathol 187, 2912-2919, doi:10.1016/j.ajpath.2017.08.016 (2017).
     
  13. Haitjema, S., Meddens, C. A., van der Laan, S. W., Kofink, D., Harakalova, M., Tragante, V., Foroughi Asl, H., van Setten, J., Brandt, M. M., Bis, J. C., O'Donnell, C., Cheng, C., Hoefer, I. E., Waltenberger, J., Biessen, E., Jukema, J. W., Doevendans, P. A., Nieuwenhuis, E. E., Erdmann, J., Bjorkegren, J. L., Pasterkamp, G., Asselbergs, F. W., den Ruijter, H. M. & Mokry, M. Additional Candidate Genes for Human Atherosclerotic Disease Identified Through Annotation Based on Chromatin Organization. Circ Cardiovasc Genet 10, doi:10.1161/CIRCGENETICS.116.001664 (2017).
     
  14. Gajjala, P. R., Jankowski, V., Heinze, G., Bilo, G., Zanchetti, A., Noels, H., Liehn, E., Perco, P., Schulz, A., Delles, C., Kork, F., Biessen, E., Narkiewicz, K., Kawecka-Jaszcz, K., Floege, J., Soranna, D., Zidek, W. & Jankowski, J. Proteomic-Biostatistic Integrated Approach for Finding the Underlying Molecular Determinants of Hypertension in Human Plasma. Hypertension 70, 412-419, doi:10.1161/HYPERTENSIONAHA.116.08906 (2017).
     
  15. Bucerius, J., Barthel, H., Tiepolt, S., Werner, P., Sluimer, J. C., Wildberger, J. E., Patt, M., Hesse, S., Gertz, H. J., Biessen, E. A. L., Mottaghy, F. M. & Sabri, O. Feasibility of in vivo (18)F-florbetaben PET/MR imaging of human carotid amyloid-beta. Eur J Nucl Med Mol Imaging 44, 1119-1128, doi:10.1007/s00259-017-3651-2 (2017).
     
  16. Biessen, E. A. L. & Wouters, K. Macrophage complexity in human atherosclerosis: opportunities for treatment? Curr Opin Lipidol 28, 419-426, doi:10.1097/MOL.0000000000000447 (2017).
     
  17. Bermudez, B., Dahl, T. B., Medina, I., Groeneweg, M., Holm, S., Montserrat-de la Paz, S., Rousch, M., Otten, J., Herias, V., Varela, L. M., Ranheim, T., Yndestad, A., Ortega-Gomez, A., Abia, R., Nagy, L., Aukrust, P., Muriana, F. J. G., Halvorsen, B. & Biessen, E. A. L. Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPARgamma-Dependent Monocyte Differentiation and Function. Arterioscler Thromb Vasc Biol 37, 1157-1167, doi:10.1161/ATVBAHA.116.308187 (2017).