Message archive

Functional characterisation of Acid-Sensing Ion Channels in Glioblastoma stem cell lines

Typically, the micro-environment of a tumour has a slightly acidic pH. Acid-sensing ion channels (ASICs), therefore, could have an important influence on tumor cells. In our most recent study, which…

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Two prizes at the 6th Symposium of the Young Physiologists in Jena

Sarah Thull was awarded a poster prize at the 6th Symposium of the Young Physiologists, which took place in Jena from 28-29 September for her poster entitled „Deltamethrin uncovers additional…

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Elucidation how the antiprotozoal drug diminazene inhibits ASICs and molecular identification of its binding site on ASICs

Activation of Acid-sensing ion channels (ASICs) contributes, among others, to neurodegeneration after ischemic stroke and pathological pain, for example neuropathic pain. Due to their…

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Annual Retreat of the Institute of Physiology

Today the Institute of Physiology had for the third time its annual retreat – again at Youth Hostel Aachen. The 30 participants were well entertained by exciting presentations and lively discussions.…

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Bacterial ion channel helps understand sodium channel gating

The bacterial ion channel NaChBac was the first voltage-gated sodium channel to be chrystalized. In our recent publication, we employed 3D structural holmology modelling to identify a highly…

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Our fomer scientist Martin Hampl successfully finished his PhD thesis

On 24th of July 2017 our former PhD student Martin Hampl sucessfully defended his dissertation entitled " Einfluss der β4 Untereinheit auf Toxikologie und Schalteigenschaften von spannungsgesteuerten…

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New insights into the gating mechanism of a species variant of the TRPM2 ion channel using the Ca2+ channel modulator 2-APB

2-Aminoethyldiphenylborinate (2-APB) is described as a modulator of both intracellular Ca2+ channels (IP3 receptor) and Ca2+ channels of the plasma membrane (Orai, TRP channels). Its effect can be…

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Daniel Löhrer successfully finished his PhD thesis

Today our former PhD student Daniel Löhrer successfully defended his dissertation entitled “Proteinbiochemische und elektrophysiologische Charakterisierung des bile acid-sensitve ion channels BASIC“.…

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LaborJournal berichtet über Veröffentlichung des Instituts für Physiologie

In seiner neuesten Ausgabe berichtet das LaborJournal in der Rubrik Journal Club über die letzte Veröffentlichung des Instituts für Physiologie, die in PNAS erschienen ist und die Identifizierung…

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Identification of a cono-RFamide that targets ASIC3 and enhances muscle pain

“Marine cone snails provide one of the highest toxin-diversities among venomous animals, the conotoxins, which often target ion channels. In addition, cone snail venoms contain short conopeptides, the…

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Paper in PNAS published

Today a paper of the institute of physiology has been published online in the renowned journal PNAS (USA). This paper reports the isolation of a short peptide from a cone snail venom, which targets…

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Axel Schmidt receives Best Poster award

Today, our scientist Axel Schmidt received the Best Poster award in the session Ion Channels III at the 96th Annual Meeting of the German Physiological Society in Greifswald. His Poster was entitled…

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