In our colaborative project, we aim to investigate the qualitative and quantitative difference of fibrosis and inflammatory cell infiltration in various human kidney disease.
Background and research contents
The number of patients with end stage renal disease (ESRD) is increasing worldwide. Chronic kidney disease (CKD) is a progressive disease, which results in ESRD and cardiovascular morbidity and mortality. Irrespective of the etiology, the pathology of CKD is characterized by renal fibrosis and inflammatory cell infiltration. However, the mechanism and heterogeneity of these conditions remains elusive, and their variations depending on the gender, age, and etiology have not been determined yet.
In this study, we aim to investigate the differences in fibrosis and inflammatory cell infiltration in various human kidney diseases in collaboration project with Kyoto University, Department of Nephrology, Japan (Prof. Motoko Yanagita; http://www.med.kyoto-u.ac.jp/en/organization-staff/research/doctoral_course/r-038/).
In this project we also analyze surgically resected human kidney samples from our institute.
Ethics and private information handling
This research project is in accordance with the Declaration of Helsinki. The donated samples are utilized in an anonymous manner, and we take particular care to protect personal information. If the donors hope to opt out from this research project, the donors never suffer unreasonable disadvantages. If the donors hope to understand this project more precisely, it’s possible to tell and show the research plan and, in that case, please send e-mail to Peter Boor (pboorukaachende).
As this research project yields valuable findings, we will publish the results in international journals. In this case, the personal information about the donors will never be open.