LaBooratory of Nephropathology

Group leader

Prof. Peter Boor, PhD
Institute of Pathology
Pauwelsstraße 30
52074 Aachen

Phone: 0241 80-89288
Fax: 0241 80-82446
pboorukaachende

We are a team of young researchers aiming to understand how kidney diseases develop and how we could diagnose and treat them.

The main focus of our laboratory is on chronic kidney disease (CKD), the common end-point of virtually all renal diseases (progressive but also acute). CKD reached world-wide pandemic proportions with up to 10% of world population being affected. Patients with CKD show high risk of mortality and morbidity with survival rates in end-stage kidney disease comparable to many malignancies.

We focus on the underlying pathological process of CKD, renal fibrosis. Progressive renal fibrosis leads to loss of function and the need for renal replacement therapy (dialyses or renal transplantation). At the moment we still lack both, sensitive diagnostic options as well as effective treatment therapies.

  

Left and middle picture depict the histological appearance of renal fibrosis in patients with advanced kidney disease showing marked deposition of extracellular matrix, vascular sclerosis and associated tubular atrophy and chronic inflammatory infiltrates. For comparison, at the right, a normal kidney parenchyme is shown with only small focus of interstitial fibrosis and tubular atrophy, a normal finding in aged kidneys.

In our previous and undergoing projects we work on identification of new markers, mechanisms and potential targets for therapeutic interventions for renal fibrosis, e.g. the growth factor PDGF (Platelet-Derived Growth Factor), nuclear transcription factor PPAR-α (Peroxisome Proliferator-activated Receptor), the receptor for anaphylatoxin C5a, the immune regulator MIF (Macrophage Migration Inhibitory Factor) or cytoskeletal components keratins. Apart from renal fibrosis, we are also interested in mechanisms and interventional possibilities for treatment of primary renal diseases including glomerulonephritides or acute kidney injury.

Our group established a wide range of tools that allows us to comprehensively analyze renal pathological alterations. We continually extend our “toolbox” including new in vitro methodologies, new models of kidney diseases and in vivo lineage tracing and imaging.

 

Murine kidneys showing collagen (in green) in normal healthy kidney (left) and exagerated deposition in fibrotic kidney (right).

 

 

Scanning electron microscopy shows a glomerulus  (left) and a normal appearing proximal tubule cross-section (right).

 

We are also very much opened for collaborative projects and work closely with many institutes within the faculty, mainly the department of nephrology, as well as outside of Aachen and Germany.

Are you interested in knowing more about our projects, methods, models and tools? Please contact us at pboorukaachende!

Group leader

Prof. Peter Boor, PhD
pboorukaachende

Postdocs

Dr. rer. nat. Eva Miriam Buhl
ebuhlukaachende

Dr. rer. nat. Sonja Djudjaj
sdjudjajukaachende

Dr. rer. nat. Katinka Karenberg
kkarenbergukaachende

Dr. rer. nat. Barbara Mara Klinkhammer
bklinkhammerukaachende

Julia Peusquens, M.Sc.
jpeusquensukaachende

Dr. med. Claudia Seikrit
cseikrit@ukaachen.de

Evelyn Wing Yin Tai, PhD
wtaiukaachende

Dickson Wong, PhD
dwongukaachende

Doctoral students & Master students

Roman David ‎Bülow, cand. med. 
roman.buelowrwth-aachende

Patrick Droste, cand. med. 
patrick.drosterwth-aachende

Katja Ermert, M.Sc. 
kermertukaachende

Ting Jia, MD
tjiaukaachende

Verena Kos, B.Sc.
verena.kosrwth-aachende

Sophie Reichelt, cand. med. 
sophie.reicheltrwth-aachende

Paula Tyra, cand. med. 
paula.tyrarwth-aachende

Tong Xu, MD
txuukaachende

Burcu Yesilyurt, M.Sc.
yburcuukaachende

Li Zhang, MD
lzhangukaachende

Technical assistance & HIWIs

Jana Baues
jbauesukaachende

Louisa Böttcher
loboettcherukaachende

Christina Gianussis
cgianussisukaachende

Lena Hahnfeld
lena.hahnfeldrwth-aachende

Michelle Lukasik
michelle.lukasikrwth-aachende

Simon Otten
sotten1ukaachende

Marie Cherelle Timm
mtimmukaachende

Jessica Wackernagel
jwackernagelukaachende

Felicitas Weiß
felicitas.weissrwth-aachende

Past team members

Janka Babickova, PhD

Oliver Backhaus, M.Sc.

Arpit Bajpai, M.Sc.

Carla Lea Frömbling

Claudia Gavranic

Julia Grafe

Anna Hübbers, B.Sc.

Jan Hübbers, B.Sc.

Stanislovas S. Jankauskas, PhD

Ole Kläner, M.Sc.

Felicitas Klein

Eva Lausberg, B.Sc.

Thomas Look

Michael Bernd Marder, M.Sc.

Fabienne Valerie Mieling, B.Sc.

Kathrin Neidig

Nina Nothofer, B.Sc.

Christian Olszewski, B.Sc.

Mario Papasotiriou, MD, PhD

Qinxue Sun, MD

Alexandra Wagnerová, Ing.

Michael Wolf

Group photo 2014

We have several ongoing projects and applications from highly motivated and qualified students are always welcome. Time frames or work packages for master thesis or medical doctoral thesis can be set individually. We offer a great scientific environment in a young team with many exciting questions.

If you would like to participate or try the work in our lab please contact Peter Boor or simply come to our scientific meeting (every monday at 17.00 in the Institute of Pathology, C2-C3, E-2).

A) Original articles

2019

Mitochondria Permeability Transition versus Necroptosis in Oxalate-Induced AKI.
Mulay SR, Honarpisheh MM, Foresto-Neto O, Shi C, Desai J, Zhao ZB, Marschner JA, Popper B, Buhl EM, Boor P, Linkermann A, Liapis H, Bilyy R, Herrmann M, Romagnani P, Belevich I, Jokitalo E, Becker JU, Anders HJ.
J Am Soc Nephrol. 2019 Oct;30(10):1857-1869. doi: 10.1681/ASN.2018121218. Epub 2019 Jul 11.

Influence of Vitamin C on Antioxidant Capacity of In Vitro Perfused Porcine Kidneys.
Bleilevens C, Doorschodt BM, Fechter T, Grzanna T, Theißen A, Liehn EA, Breuer T, Tolba RH, Rossaint R, Stoppe C, Boor P, Hill A, Fabry G.
Nutrients. 2019 Aug 1;11(8). pii: E1774. doi: 10.3390/nu11081774.

Cold Preflush of Porcine Kidney Grafts Prior to Normothermic Machine Perfusion Aggravates Ischemia Reperfusion Injury.
Fabry G, Doorschodt BM, Grzanna T, Boor P, Elliott A, Stollenwerk A, Tolba RH, Rossaint R, Bleilevens C.
Sci Rep. 2019 Sep 25;9(1):13897. doi: 10.1038/s41598-019-50101-7.

Hypothermic Oxygenated Machine Perfusion of Extended Criteria Kidney Allografts from Brain Dead Donors: Protocol for a Prospective Pilot Study.
Meister FA, Czigany Z, Bednarsch J, Böcker J, Amygdalos I, Morales Santana DA, Rietzler K, Moeller M, Tolba R, Boor P, Rohlfs W, Neumann UP, Lurje G.
JMIR Res Protoc. 2019 Oct 14;8(10):e14622. doi: 10.2196/14622.

Cre recombinase toxicity in podocytes, a novel genetic model for FSGS in adolescent mice.
Frahsek M, Schulte K, Chia-Gil A, Djudjaj S, Schueler H, Leuchtle K, Smeets B, Dijkman H, Floege J, Moeller MJ. 
Am J Physiol Renal Physiol. 2019 Oct 7. doi: 10.1152/ajprenal.00573.2018. [Epub ahead of print]

CNN cascades for segmenting sparse objects in gigapixel whole slide images.
Gadermayr M, Dombrowski AK, Klinkhammer BM, Boor P, Merhof D.
Comput Med Imaging Graph. 2019 Jan;71:40-48. doi: 10.1016/j.compmedimag.2018.11.002. Epub 2018 Nov 16.

Generative Adversarial Networks for Facilitating Stain-Independent Supervised & Unsupervised Segmentation: A Study on Kidney Histology.
Gadermayr M, Gupta L, Appel V, Boor P, Klinkhammer BM, Merhof D.
IEEE Trans Med Imaging. 2019 Feb 14. doi: 10.1109/TMI.2019.2899364. [Epub ahead of print]

Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats.
Klein S, Frohn F, Magdaleno F, Reker-Smit C, Schierwagen R, Schierwagen I, Uschner FE, van Dijk F, Fürst DO, Djudjaj S, Boor P, Poelstra K, Beljaars L, Trebicka J.
Sci Rep. 2019 Feb 19;9(1):2256. doi: 10.1038/s41598-019-38678-5.

Novel parietal epithelial cell subpopulations contribute to focal segmental glomerulosclerosis and glomerular tip lesions.
Kuppe C, Leuchtle K, Wagner A, Kabgani N, Saritas T, Puelles VG, Smeets B, Hakroush S, van der Vlag J, Boor P, Schiffer M, Gröne HJ, Fogo A, Floege J, Moeller MJ.
Kidney Int. 2019 Feb 27. pii: S0085-2538(19)30186-3. doi: 10.1016/j.kint.2019.01.037. [Epub ahead of print]

Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury.
Poluzzi C, Nastase MV, Zeng-Brouwers J, Roedig H, Hsieh LT, Michaelis JB, Buhl EM, Rezende F, Manavski Y, Bleich A, Boor P, Brandes RP, Pfeilschifter J, Stelzer EHK, Münch C, Dikic I, Brandts C, Iozzo RV, Wygrecka M, Schaefer L.
Kidney Int. 2019 Mar;95(3):540-562. doi: 10.1016/j.kint.2018.10.037. Epub 2019 Jan 31.

Novel 3D analysis using optical tissue clearing documents the evolution of murine rapidly progressive glomerulonephritis.
Puelles VG, Fleck D, Ortz L, Papadouri S, Strieder T, Böhner AMC, van der Wolde JW, Vogt M, Saritas T, Kuppe C, Fuss A, Menzel S, Klinkhammer BM, Müller-Newen G, Heymann F, Decker L, Braun F, Kretz O, Huber TB, Susaki EA, Ueda HR, Boor P, Floege J, Kramann R, Kurts C, Bertram JF, Spehr M, Nikolic-Paterson DJ, Moeller MJ.
Kidney Int. 2019 Mar 15. pii: S0085-2538(19)30318-7. doi: 10.1016/j.kint.2019.02.034. [Epub ahead of print]

Elastin imaging enables noninvasive staging and treatment monitoring of kidney fibrosis.
Sun Q, Baues M, Klinkhammer BM, Ehling J, Djudjaj S, Drude NI, Daniel C, Amann K, Kramann R, Kim H, Saez-Rodriguez J, Weiskirchen R, Onthank DC, Botnar RM, Kiessling F, Floege J, Lammers T, Boor P.
Sci Transl Med. 2019 Apr 3;11(486). pii: eaat4865. doi: 10.1126/scitranslmed.aat4865.

Identification of platelet-derived growth factor C as a mediator of both renal fibrosis and hypertension.
van Roeyen CRC, Martin IV, Drescher A, Schuett KA, Hermert D, Raffetseder U, Otten S, Buhl EM, Braun GS, Kuppe C, Liehn E, Boor P, Weiskirchen R, Eriksson U, Gross O, Eitner F, Floege J, Ostendorf T.
Kidney Int. 2019 May;95(5):1103-1119. doi: 10.1016/j.kint.2018.11.031. Epub 2019 Feb 28.

Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer.
Kather JN, Pearson AT, Halama N, Jäger D, Krause J, Loosen SH, Marx A, Boor P, Tacke F, Neumann UP, Grabsch HI, Yoshikawa T, Brenner H, Chang-Claude J, Hoffmeister M, Trautwein C, Luedde T.
Nat Med. 2019 Jun 3. doi: 10.1038/s41591-019-0462-y. [Epub ahead of print]

2018

The Long Pentraxin PTX3 Is an Endogenous Inhibitor of Hyperoxaluria-Related Nephrocalcinosis and Chronic Kidney Disease.
Marschner JA, Mulay SR, Steiger S, Anguiano L, Zhao Z, Boor P, Rahimi K, Inforzato A, Garlanda C, Mantovani A, Anders HJ.
Front Immunol. 2018 Sep 25;9:2173. doi: 10.3389/fimmu.2018.02173. eCollection 2018.

Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury.
Gross A, Pack LAP, Schacht GM, Kant S, Ungewiss H, Meir M, Schlegel N, Preisinger C, Boor P, Guldiken N, Krusche CA, Sellge G, Trautwein C, Waschke J, Heuser A, Leube RE, Strnad P.
Mucosal Immunol. 2018 Nov;11(6):1630-1639. doi: 10.1038/s41385-018-0062-z. Epub 2018 Aug 16.

Glucagon-Like Peptide 1 and Its Cleavage Products Are Renoprotective in Murine Diabetic Nephropathy.
Moellmann J, Klinkhammer BM, Onstein J, Stöhr R, Jankowski V, Jankowski J, Lebherz C, Tacke F, Marx N, Boor P, Lehrke M.
Diabetes. 2018 Nov;67(11):2410-2419. doi: 10.2337/db17-1212. Epub 2018 Aug 13.

Cellular Origin and Functional Relevance of Collagen I Production in the Kidney.
Buchtler S, Grill A, Hofmarksrichter S, Stöckert P, Schiechl-Brachner G, Rodriguez Gomez M, Neumayer S, Schmidbauer K, Talke Y, Klinkhammer BM, Boor P, Medvinsky A, Renner K, Castrop H, Mack M.
J Am Soc Nephrol. 2018 Jul;29(7):1859-1873. doi: 10.1681/ASN.2018020138. Epub 2018 May 18.

HIF stabilization inhibits renal epithelial cell migration and is associated with cytoskeletal alterations.
Müller S, Djudjaj S, Lange J, Iacovescu M, Goppelt-Struebe M, Boor P.
Sci Rep. 2018 Jun 22;8(1):9497. doi: 10.1038/s41598-018-27918-9.

Oxidative stress in the brain caused by acute kidney injury.
Kovalčíková A, Gyurászová M, Vavrincová-Yaghi D, Vavrinec P, Tóthová Ľ, Boor P, Šebeková K, Celec P.
Metab Brain Dis. 2018 Jun;33(3):961-967. doi: 10.1007/s11011-018-0204-8. Epub 2018 Mar 7.

The protective role of macrophage migration inhibitory factor in acute kidney injury after cardiac surgery.
Stoppe C, Averdunk L, Goetzenich A, Soppert J, Marlier A, Kraemer S, Vieten J, Coburn M, Kowark A, Kim BS, Marx G, Rex S, Ochi A, Leng L, Moeckel G, Linkermann A, El Bounkari O, Zarbock A, Bernhagen J, Djudjaj S, Bucala R, Boor P.
Sci Transl Med. 2018 May 16;10(441). pii: eaan4886. doi: 10.1126/scitranslmed.aan4886.

2017 

Urinary endotrophin predicts disease progression in patients with chronic kidney disease.
Rasmussen DGK, Fenton A, Jesky M, Ferro C, Boor P, Tepel M, Karsdal MA, Genovese F, Cockwell P.
Sci Rep. 2017 Dec 11;7(1):17328. doi: 10.1038/s41598-017-17470-3.

Phagocytosis of environmental or metabolic crystalline particles induces cytotoxicity by triggering necroptosis across a broad range of particle size and shape.
Honarpisheh M, Foresto-Neto O, Desai J, Steiger S, Gómez LA, Popper B, Boor P, Anders HJ, Mulay SR.
Sci Rep. 2017 Nov 14;7(1):15523. doi: 10.1038/s41598-017-15804-9.

Particles of different sizes and shapes induce neutrophil necroptosis followed by the release of neutrophil extracellular trap-like chromatin.
Desai J, Foresto-Neto O, Honarpisheh M, Steiger S, Nakazawa D, Popper B, Buhl EM, Boor P, Mulay SR, Anders HJ.
Sci Rep. 2017 Nov 3;7(1):15003. doi: 10.1038/s41598-017-15106-0.

Post-weaning epiphysiolysis causes distal femur dysplasia and foreshortened hindlimbs in fetuin-A-deficient mice.
Brylka LJ, Köppert S, Babler A, Kratz B, Denecke B, Yorgan TA, Etich J, Costa IG, Brachvogel B, Boor P, Schinke T, Jahnen-Dechent W.
PLoS One. 2017 Oct 31;12(10):e0187030. doi: 10.1371/journal.pone.0187030. eCollection 2017.

Segmenting renal whole slide images virtually without training data. 
Gadermayr M, Eschweiler D, Jeevanesan A, Klinkhammer BM, Boor P, Merhof D.
Comput Biol Med. 2017 Nov 1;90:88-97. doi: 10.1016/j.compbiomed.2017.09.014. Epub 2017 Sep 23.

Complement C5a receptors C5L2 and C5aR in renal fibrosis. 
Martin IV, Bohner A, Boor P, Shagdarsuren E, Raffetseder U, Lammert F, Floege J, Ostendorf T, Weber SN.
Am J Physiol Renal Physiol. 2017 Sep 13:ajprenal.00060.2017. doi: 10.1152/ajprenal.00060.2017. [Epub ahead of print]

Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations. 
Kim-Hellmuth S, Bechheim M, Pütz B, Mohammadi P, Nédélec Y, Giangreco N, Becker J, Kaiser V, Fricker N, Beier E, Boor P, Castel SE, Nöthen MM, Barreiro LB, Pickrell JK, Müller-Myhsok B, Lappalainen T, Schumacher J, Hornung V.
Nat Commun. 2017 Aug 16;8(1):266. doi: 10.1038/s41467-017-00366-1.

Macrophage Migration Inhibitory Factor Limits Renal Inflammation and Fibrosis by Counteracting Tubular Cell Cycle Arrest.
Djudjaj S, Martin IV, Buhl EM, Nothofer NJ, Leng L, Piecychna M, Floege J, Bernhagen J, Bucala R, Boor P.
J Am Soc Nephrol. 2017 Dec;28(12):3590-3604. doi: 10.1681/ASN.2017020190. Epub 2017 Aug 11.

Renal function following xenon anesthesia for partial nephrectomy-An explorative analysis of a randomized controlled study. 
Stevanovic A, Schaefer P, Coburn M, Rossaint R, Stoppe C, Boor P, Pfister D, Heidenreich A, Christ H, Hellmich M, Fahlenkamp AV.
PLoS One. 2017 Jul 18;12(7):e0181022. doi: 10.1371/journal.pone.0181022. eCollection 2017.

YB-1 orchestrates onset and resolution of renal inflammation via IL10 gene regulation.
Wang J, Djudjaj S, Gibbert L, Lennartz V, Breitkopf DM, Rauen T, Hermert D, Martin IV, Boor P, Braun GS, Floege J, Ostendorf T, Raffetseder U.
J Cell Mol Med. 2017 Dec;21(12):3494-3505. doi: 10.1111/jcmm.13260. Epub 2017 Jun 30.

Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence From Mouse and Human Studies.
Döring Y, Noels H, van der Vorst EPC, Neideck C, Egea V, Drechsler M, Mandl M, Pawig L, Jansen Y, Schröder K, Bidzhekov K, Megens RTA, Theelen W, Klinkhammer BM, Boor P, Schurgers L, van Gorp R, Ries C, Kusters PJH, van der Wal A, Hackeng TM, Gäbel G, Brandes RP, Soehnlein O, Lutgens E, Vestweber D, Teupser D, Holdt LM, Rader DJ, Saleheen D, Weber C.
Circulation. 2017 Jul 25;136(4):388-403. doi: 10.1161/CIRCULATIONAHA.117.027646. Epub 2017 Apr 27.

Murine CD103+ dendritic cells protect against steatosis progression towards steatohepatitis. 
Heier EC, Meier A, Julich-Haertel H, Djudjaj S, Rau M, Tschernig T, Geier A, Boor P, Lammert F, Lukacs-Kornek V. J Hepatol. 2017 Jan 18. pii: S0168-8278(17)30012-0. doi: 10.1016/j.jhep.2017.01.008.

Clot Structure: A Potent Mortality Risk Factor in Patients on Hemodialysis. 
Schuett K, Savvaidis A, Maxeiner S, Lysaja K, Jankowski V, Schirmer SH, Dimkovic N, Boor P, Kaesler N, Dekker FW, Floege J, Marx N, Schlieper G. J Am Soc Nephrol. 2017 Jan 5. pii: ASN.2016030336. doi: 10.1681/ASN.2016030336. [Epub ahead of print]

Regardless of etiology, progressive renal disease causes ultrastructural and functional alterations of peritubular capillaries. 
Bábíčková J, Klinkhammer BM, Buhl EM, Djudjaj S, Hoss M, Heymann F, Tacke F, Floege J, Becker JU, Boor P. Kidney Int. 2017 Jan;91(1):70-85. doi: 10.1016/j.kint.2016.07.038.

2016

Contrast-enhanced CT imaging in patients with chronic kidney disease. 
von Stillfried S, Apitzsch JC, Ehling J, Penzkofer T, Mahnken AH, Knüchel R, Floege J, Boor P. Angiogenesis. 2016 Oct;19(4):525-35. doi: 10.1007/s10456-016-9524-7.

Keratin 23 is a stress-inducible marker of mouse and human ductular reaction in liver disease. 
Guldiken N, Kobazi Ensari G, Lahiri P, Couchy G, Preisinger C, Liedtke C, Zimmermann HW, Ziol M, Boor P, Zucman-Rossi J, Trautwein C, Strnad P. J Hepatol. 2016 Sep;65(3):552-9. doi: 10.1016/j.jhep.2016.04.024.

Comparison of Aerobic Preservation by Venous Systemic Oxygen Persufflation or Oxygenated Machine Perfusion of Warm-Ischemia-Damaged Porcine Kidneys.  
Kalenski J, Mancina E, Paschenda P, Beckers C, Bleilevens C, Tóthová Ľ, Boor P, Gross D, Tolba RH, Doorschodt BM. Eur Surg Res. 2016;57(1-2):10-21. doi: 10.1159/000444851.

An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice.
Ludwig-Portugall I, Bartok E, Dhana E, Evers BD, Primiano MJ, Hall JP, Franklin BS, Knolle PA, Hornung V, Hartmann G, Boor P, Latz E, Kurts C. Kidney Int. 2016 Sep;90(3):525-39. doi: 10.1016/j.kint.2016.03.035.

CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10-Producing Regulatory T Cells.
Evers BD, Engel DR, Böhner AM, Tittel AP, Krause TA, Heuser C, Garbi N, Kastenmüller W, Mack M, Tiegs G, Panzer U, Boor P, Ludwig-Portugall I, Kurts C.
J Am Soc Nephrol. 2016 Apr 1. pii: ASN.2015080873. [Epub ahead of print]

Keratins are novel markers of renal epithelial cell injury.
Djudjaj S, Papasotiriou M, Bülow RD, Wagnerova A, Lindenmeyer MT, Cohen CD, Strnad P, Goumenos DS, Floege J, Boor P.
Kidney Int. 2016 Apr;89(4):792-808. doi: 10.1016/j.kint.2015.10.015. Epub 2016 Feb 6.

The role of PDGF-D in healthy and fibrotic kidneys.
Buhl EM, Djudjaj S, Babickova J, Klinkhammer BM, Folestad E, Borkham-Kamphorst E, Weiskirchen R, Hudkins K, Alpers CE, Eriksson U, Floege J, Boor P.
Kidney Int. 2016 Apr;89(4):848-61. doi: 10.1016/j.kint.2015.12.037. Epub 2016 Feb 18.

2015

Improved preservation of warm ischemia-damaged porcine kidneys after cold storage in Ecosol, a novel preservation solution.
Kalenski J, Mancina E, Paschenda P, Beckers C, Bleilevens C, Tóthová Ľ, Boor P, Doorschodt BM, Tolba RH.
Ann Transplant. 2015 Apr 27;20:233-42. doi: 10.12659/AOT.892823.
Related citations

IL-6 Trans-Signaling Drives Murine Crescentic GN.
Braun GS, Nagayama Y, Maruta Y, Heymann F, van Roeyen CR, Klinkhammer BM, Boor P, Villa L, Salant DJ, Raffetseder U, Rose-John S, Ostendorf T, Floege J.
J Am Soc Nephrol. 2015 Jun 3. pii: ASN.2014111147. [Epub ahead of print]
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Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74.
Djudjaj S, Lue H, Rong S, Papasotiriou M, Klinkhammer BM, Zok S, Klaener O, Braun GS, Lindenmeyer MT, Cohen CD, Bucala R, Tittel AP, Kurts C, Moeller MJ, Floege J, Ostendorf T, Bernhagen J, Boor P.
J Am Soc Nephrol. 2015 Oct 9. pii: ASN.2015020149. [Epub ahead of print]

Quantitative Micro-Computed Tomography Imaging of Vascular Dysfunction in Progressive Kidney Diseases.
Ehling J, Bábíčková J, Gremse F, Klinkhammer BM, Baetke S, Knuechel R, Kiessling F, Floege J, Lammers T, Boor P.
J Am Soc Nephrol. 2015 Jul 20. pii: ASN.2015020204. [Epub ahead of print]
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Role of Platelet-Derived Growth Factor-CC in Capillary Rarefaction in Renal Fibrosis.
Boor P, Bábíčková J, Steegh F, Hautvast P, Martin IV, Djudjaj S, Nakagawa T, Ehling J, Gremse F, Bücher E, Eriksson U, van Roeyen CR, Eitner F, Lammers T, Floege J, Peutz-Kootstra CJ, Ostendorf T.
Am J Pathol. 2015 Aug;185(8):2132-42. doi: 10.1016/j.ajpath.2015.04.022.
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Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis.
Schierwagen R, Maybüchen L, Zimmer S, Hittatiya K, Bäck C, Klein S, Uschner FE, Reul W, Boor P, Nickenig G, Strassburg CP, Trautwein C, Plat J, Lütjohann D, Sauerbruch T, Tacke F, Trebicka J.
Sci Rep. 2015 Aug 11;5:12931. doi: 10.1038/srep12931.
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Turnover of type III collagen reflects disease severity and is associated with progression and microinflammation in patients with IgA nephropathy.
Genovese F, Boor P, Papasotiriou M, Leeming DJ, Karsdal MA, Floege J.
Nephrol Dial Transplant. 2015 Aug 26. pii: gfv301. [Epub ahead of print]
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Common histological patterns in glomerular epithelial cells in secondary focal segmental glomerulosclerosis.
Kuppe C, Gröne HJ, Ostendorf T, van Kuppevelt TH, Boor P, Floege J, Smeets B, Moeller MJ.
Kidney Int. 2015 Apr 8. doi: 10.1038/ki.2015.116. [Epub ahead of print]
PMID: 25853334
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Serum and urine markers of collagen degradation reflect renal fibrosis in experimental kidney diseases.
Papasotiriou M, Genovese F, Klinkhammer BM, Kunter U, Nielsen SH, Karsdal MA, Floege J, Boor P.
Nephrol Dial Transplant. 2015 Mar 16. pii: gfv063. [Epub ahead of print]
PMID: 25784725
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If you lose your nerves, at least you will not get kidney fibrosis!
Boor P, Papasotiriou ME.
Kidney Int. 2015 Feb;87(2):275-7. doi: 10.1038/ki.2014.327.
PMID: 25635720
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Diffusion-weighted MRI does not reflect kidney fibrosis in a rat model of fibrosis.
Boor P, Perkuhn M, Weibrecht M, Zok S, Martin IV, Gieseke J, Schoth F, Ostendorf T, Kuhl C, Floege J.
J Magn Reson Imaging. 2015 Jan 28. doi: 10.1002/jmri.24853. [Epub ahead of print]
PMID: 25630829
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Epiplakin attenuates experimental mouse liver injury by chaperoning keratin reorganization.
Szabo S, Wögenstein KL, Österreicher CH, Guldiken N, Chen Y, Doler C, Wiche G, Boor P, Haybaeck J, Strnad P, Fuchs P.
J Hepatol. 2015 Jan 21. pii: S0168-8278(15)00012-4. doi: 10.1016/j.jhep.2015.01.007. [Epub ahead of print]
PMID: 25617501 Free Article
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CX3CR1 reduces kidney fibrosis by inhibiting local proliferation of profibrotic macrophages.
Engel DR, Krause TA, Snelgrove SL, Thiebes S, Hickey MJ, Boor P, Kitching AR, Kurts C.
J Immunol. 2015 Feb 15;194(4):1628-38. doi: 10.4049/jimmunol.1402149. Epub 2015 Jan 16.
PMID: 25595779
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Determination of the preferred conditions for the isolated perfusion of porcine kidneys.
Mancina E, Kalenski J, Paschenda P, Beckers C, Bleilevens C, Boor P, Doorschodt BM, Tolba RH.
Eur Surg Res. 2015;54(1-2):44-54. doi: 10.1159/000366155. Epub 2014 Oct 21.
PMID: 25341590
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2014

Gp130 dependent signaling in the podocyte.
Nagayama Y, Braun GS, Jakobs CM, Maruta Y, van Roeyen CR, Klinkhammer BM, Boor P, Villa L, Raffetseder U, Trautwein C, Görtz D, Müller-Newen G, Ostendorf T, Floege J.
Am J Physiol Renal Physiol. 2014 Jun 4. pii: ajprenal.00620.2013. [Epub ahead of print]
PMID: 24899055 [PubMed - as supplied by publisher]
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Select item 24850012

Comprehensive assessment of nephrotoxicity of intravenously administered sodium-oleate-coated ultrasmall superparamagnetic iron oxide (USPIO) and titanium dioxide (TiO2) nanoparticles in rats
Šebekova K, Dušinska M, Simon Klenovics K, Kollarova R, Kebis A, Staruchova M, Vlkova B, Boor P, Celec P, Hodosy J, Beňo M, Tulinska J, Pribojova J, Bilaničova D, Pojana G, Marcomini A, Volkovova K: . Nanotoxicol 2014, 8:142-57.   
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Origin of Parietal Podocytes in Atubular Glomeruli Mapped by Lineage Tracing
Schulte K, Berger K, Boor P, Jirak P, Gelman IH, Arkill KP, Neal CR, Kriz W, Floege J, Smeets B, Moeller MJ . J Am Soc Nephrol 2014, 25:129-41.
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The Regenerative Potential of Parietal Epithelial Cells in Adult Mice
Berger K, Schulte K, Boor P, Kuppe C, van Kuppevelt TH, Floege J, Smeets B, Moeller MJ.. J Am Soc Nephrol. 2014, in print
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Mesenchymal stem cells from CKD donors exhibit premature senescence and loss of regenerative potential
Klinkhammer BM, Kramann R, Mallau M, Makowska A, van Roeyen CRC, Rong S, Buecher EB, Boor P, Stuettgen E, Otten S, Floege J, Kunter U: . PLoS ONE 2014, in print
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Determination of the Preferred Conditions for the Isolated Perfusion of Porcine Kidneys. Mancina E, Kalenski J, Paschenda P, Beckers C, Bleilevens C, Boor P, Doorschodt BM, Tolba RH. Eur Surg Res. 2014 Oct 21;54(1-2):44-54. [Epub ahead of print] PMID: 25341590 [PubMed - as supplied by publisher]
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Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes. Kim S, Becker J, Bechheim M, Kaiser V, Noursadeghi M, Fricker N, Beier E, Klaschik S, Boor P, Hess T, Hofmann A, Holdenrieder S, Wendland JR, Fröhlich H, Hartmann G, Nöthen MM, Müller-Myhsok B, Pütz B, Hornung V, Schumacher J. Nat Commun. 2014 Oct 20;5:5236. doi: 10.1038/ncomms6236. PMID: 25327457 [PubMed - in process]
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Detection of Activated Parietal Epithelial Cells on the Glomerular Tuft Distinguishes Early Focal Segmental Glomerulosclerosis from Minimal Change Disease. Smeets B, Stucker F, Wetzels J, Brocheriou I, Ronco P, Gröne HJ, D'Agati V, Fogo AB, van Kuppevelt TH, Fischer HP, Boor P, Floege J, Ostendorf T, Moeller MJ. Am J Pathol. 2014 Oct 7. pii: S0002-9440(14)00492-1. doi: 10.1016/j.ajpath.2014.08.007. [Epub ahead of print]
PMID: 25307344 [PubMed - as supplied by publisher]
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Epiplakin deficiency aggravates murine caerulein-induced acute pancreatitis and favors the formation of acinar keratin granules. Wögenstein KL, Szabo S, Lunova M, Wiche G, Haybaeck J, Strnad P, Boor P, Wagner M, Fuchs P.
PLoS One. 2014 Sep 18;9(9):e108323. doi: 10.1371/journal.pone.0108323. eCollection 2014. PMID: 25232867 [PubMed - in process] Free PMC Article
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Platelet Derived Growth Factors (PDGFs) in Glomerular and Tubulointerstitial Fibrosis. Ostendorf T, Boor P, van Roeyen CRC, Floege J
Kidney Int Suppl 2014, in print
Boor P, Ostendorf T, Floege J: PDGF and the progression of renal disease. Nephrol Dial Transplat 2014, 29 Suppl 1:i45-i54.
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Genovese F, Manresa AA, Leeming DJ, Karsdal MA, Boor P: The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis?
Fibrogenesis Tissue Repair. 2014 Mar 28;7(1):4. doi: 10.1186/1755-1536-7-4. PMID: 24678881 [PubMed] Free PMC Article; Related citations Select item 24667162
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2013

Cold shock Y-box protein-1 proteolysis autoregulates its transcriptional activities. van Roeyen CR, Scurt FG, Brandt S, Kuhl VA, Martinkus S, Djudjaj S, Raffetseder U, Royer HD, Stefanidis I, Dunn SE, Dooley S, Weng H, Fischer T, Lindquist JA, Mertens PR.  Cell Commun Signal. 2013, 11:63. 
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Proximal tubular cells contain a phenotypically distinct, scattered cell population involved in tubular regeneration. Smeets B, Boor P, Dijkman H, Sharma SV, Jirak P, Khera S, Mooren F, Berger K, Bornemann J, Gelman IH, Floege J, van der Vlag J, Wetzels JFM, Moeller MJ:  J Pathol 2013, 229: 645-59. 
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Platelet-Derived Growth Factor (PDGF)-C neutralization reveals differential roles of PDGF-receptors in liver and renal fibrosis. Martin IV, Borkham-Kamphorst E, Zok S, van Roeyen CRC, Eriksson U, Boor P, Hiththetiya K, Fischer HP, Wasmuth HE, Weiskirchen R, Eitner F, Floege J, Ostendorf T: Am J Pathol 2013, 182: 107-17. 
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Late angiotensin II receptor blockade in progressive rat mesangioproliferative glomerulonephritis: new insights into mechanisms Villa L, Boor P, Konieczny A, Kunter U, van Roeyen CRC, Denecke B, Gan L, Neusser MA and Cohen CD for the ERCB-Consortium, Eitner F, Scholl T, Ostendorf T, Floege J: , J Pathol 2013, 229:672-84. 
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Biological Responses to PDGF-AA Versus PDGF-CC in Renal Fibroblasts.
Seikrit C, Henkel C, van Roeyen CRC, Bokemeyer D, Eitner F, Martin IV, Boor P, Ruth Knüchel, Meyer HE, Müller-Newen G, Eriksson U, Floege J, Ostendorf T:  Nephrol Dial Transplant 2013, 28:889-900. 
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Growth arrest-specific protein 1 is a novel endogenous inhibitor of glomerular cell activation and proliferation. van Roeyen CRC, Zok S, Pruessmeyer J, Boor P, Fleckenstein S, Ostendorf T, Ludwig A, Floege J  Kidney Int 2013, 83: 251-63.
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Advanced glycation end products in infant formulas do not contribute to insulin resistance associated with their consumption.
Klenovics KS, Boor P, Somoza V, Celec P, Fogliano V, Šebeková K  PLoS ONE 2013, 8:e53056. 
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Albumin is recycled from the primary urine by tubular transcytosis.
Tenten T, Menzel S, Kunter U, Sicking EM, van Roeyen CVR, Sanden SK, Kaldenbach M, Boor P, Fuss A, Uhlig S, Lanzmich R, Dijkman H, Grepl M, Wild K, Kriz W, Smeets B, Floege J, Moeller MJ:  J Am Soc Nephrol 2013, 24:1966-1980. 
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Raffetseder U: YB-1 is an early and central mediator of bacterial and sterile inflammation in vivo. Hanssen L, Alidousty C, Djudjaj S, Frye BC, Rauen T, Boor P, Mertens PR, van Roeyen CR, Tacke F, Heymann F, Tittel AP, Koch A, Floege J, Ostendorf T,  J Immunol 2013, J Immunol 2013, 191:2604-2613. 
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Warfarin Induces Cardiovascular Damage in Mice. Krüger T, Oelenberg S, Kaesler N, Schurgers LJ, van de Sandt A, Boor P, Schlieper GR, Brandenburg VM, Fekete BC, Veulemans V, Ketteler M, Vermeer C, Jahnen-Dechent W, Floege J, Westenfeld R  ATVB 2013, 33:2618-2624.
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In vivo phage display – A discovery tool in molecular biomedicine.
Bábíčková J, Tóthová Ľ, Boor P, Celec P:  Biotechnol Adv 2013, 31:1247-1259

2012

Behaviour and hormonal status in healthy rats on a diet rich in Maillard reaction products with or without solvent extractable aroma compounds. Sebekova K, Klenovics KS, Boor P, Celec P, Behuliak M, Schieberle P, Heidland A, Palkovits M, Somoza V:  Physiol Behav 2012, 105(3):693-701. 
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Primary cultures of glomerular parietal epithelial cells or podocytes with proven origin. Kabgani N, Grigoleit T, Schulte K, Sechi A, Sauer-Lehnen S, Tag C, Boor P, Kuppe C, Warsow G, Schordan S, Mostertz J, Chilukoti R, Homuth G, Endlich N, Tacke F, Weiskirchen R, Fuellen G, Endlich K, Floege J, Smeets B, Moeller MJ:  PLoS ONE 2012, 7: e34907. 
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A novel, dual role of CCN3 in experimental glomerulonephritis: pro-angiogenic and anti-mesangioproliferative effects. van Roeyen CRC*, Boor P*, Borkham-Kamphorst E, Rong S, Kunter U, Martin IV, Kaitovic A, Fleckenstein S, Perbal B, Weiskirchen R, Ostendorf T, Floege J:  Am J Pathol 2012, 180:1979-1990. 
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Notch-3 receptor activation drives inflammation and fibrosis following tubulointerstitial kidney injury. Djudjaj S, Chatziantoniou C, Raffetseder U, Guerrot D, Dussaule JC, Boor P, Kerroch M, Hanssen L, Brandt S, Dittrich A, Ostendorf T, Floege J, Zhu C, Lindenmeyer M, Cohen CD, Mertens PR:  J Pathol 2012, 228:286-299.
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Cold shock Y-box protein-1 participates in signaling circuits with auto-regulatory activities. Brandt S, Raffetseder U, Djudjaj S, Schreiter A, Kadereit B, Michele M, Pabst M, Zhu C, Mertens PR.  Eur J Cell Biol. 2012, 91:464-71. 
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Boor P: EP4 - a new piece in the fibrotic puzzle. Kidney Int 2012, 82:132–135 [editorial]. 
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The renal (myo-)fibroblast: a heterogenous group of cells.
Boor P, Floege J  Nephrol Dial Transplant 2012, 27:3027–3036.
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New approaches in progressive kidney diseases. Boor P,  Pathologe 2012, 33:296–301. [German]
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2011

Notch3 is essential for regulation of the renal vascular tone. Hypertension. Boulos N, Helle F, Dussaule JC, Placier S, Milliez P, Djudjaj S, Guerrot D, Joutel A, Ronco P, Boffa JJ, Chatziantoniou C.  2011, 57:1176-82.    
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Extracellular YB-1 blockade in experimental nephritis up-regulates Notch-3 receptor expression and signalling. RaffetsederU, Rauen T, Boor P, Ostendorf T, Hanssen L, Floege J, En-Nia A, Djudjaj S, Frye BC, Mertens PR:  Nephron Exp Nephrol 2011, 118:e100-e108. 
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Effects and mechanisms of angiotensin II receptor blockade with telmisartan in a normotensive model of mesangioproliferative nephritis. Villa L, Boor P, Konieczny A, Kunter U, van Roeyen CRC, Denecke B, Gan L, Kupper MB, Eitner F, Ostendorf T, Floege J  Nephrol Dial Transplant 2011, 26: 3131-43. 
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Bactofection with Toll-like receptor 4 in a murine model of urinary tract infection. Tóthová Ľ, Hodosy J, Kamodyová N, Janega P, Slobodníková L, Liptáková A, Boor P, Celec P, Curr Microbiol 2011, 62(6):1739-42.  
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Y-box binding protein-1 mediates profibrotic effects of calcineurin inhibitors in the kidney. Hanssen L, Frye BC, Ostendorf T, Alidousty C, Djudjaj S, Boor P, Rauen T, Floege J, Mertens PR, Raffetseder U,  J Immunol 2011, 187:298-308.Ä
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Metabolic syndrome is inversely related to soluble receptor for advanced glycation end products: a study in mother-infant pairs. Klenovicsová K, Boor P, Hrachová J, Furková K, Šebeková K, Biopolym Cell 2011, 27: 132-140. 
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Peroxisome proliferator-activated receptor-α agonist BAY PP1 attenuates renal fibrosis in rats. Boor P, Celec P, Martin IV, Villa L, Hodosy R, Klenovicsová K, Esposito C, Schäfer S, Albrecht-Küpper B, Ostendorf T, Ostendorf T, Heidland A, Šebeková K,  Kidney Int 2011, 80: 1182–1197. 
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Induction of Progressive Glomerulonephritis via Podocyte-specific Overexpression of Platelet-derived Growth Factor (PDGF) van Roeyen CRC, Eitner F, Boor P, Moeller MJ, Raffetseder U, Hanssen L, Bücher E, Villa L, Banas M, Hudkins KL, Alpers CE, Ostendorf T, Floege J,  –D. Kidney Int 2011, 80: 1292-1305.
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Growth Factors in Renal Fibrosis. Boor P, Floege J:  Clin Exp Pharmacol Physiol 2011, 38:391-400. 
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Renal fibrosis – novel insights into mechanisms and therapeutic targets. Boor P, Ostendorf T, Floege J,  Nat Rev Nephrol 2010; 6:643-656. 
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Models of IgA nephropathy. Eitner F, Boor P, Floege J  Drug Discov Today Dis Model 2010, 7:21-26.

2010

Association of biochemical parameters and RAGE gene polymorphisms in healthy infants and their mothers. Boor P, Celec P, Klenovicsová K, Vlková B, Szemes T, Minárik G, Turňa J, Šebeková K,  Clin Chim Acta 2010; 411:1034-1040. 
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PDGF-CC accelerates glomerular capillary repair in experimental glomerulonephritis. Boor P, van Roeyen CRC, Kunter U, Villa L, Bücher E, Hohenstein B, Hugo CP, Eriksson U, Satchell SC, Mathieson PW, Eitner F, Floege J, Ostendorf T:  Am J Pathol 2010; 177:58-69. 
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2009

Nuclear detection of Y-box protein-1 (YB-1) closely associates with progesterone receptor negativity and is a strong adverse survival factor in human breast cancer. Dahl E, En-Nia A, Wiesmann F, Krings R, Djudjaj S, Breuer E, Fuchs T, Wild PJ, Hartmann A, Dunn SE, Mertens PR.  BMC Cancer. 2009, 9:410. 
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YB-1 acts as a ligand for Notch-3 receptors and modulates receptor activation. Rauen T, Raffetseder U, Frye BC, Djudjaj S, Mühlenberg PJ, Eitner F, Lendahl U, Bernhagen J, Dooley S, Mertens PR.  J Biol Chem. 2009, 284:26928-40.  
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Y-box protein-1 is actively secreted through a non-classical pathway and acts as an extracellular mitogen. Frye BC, Halfter S, Djudjaj S, Muehlenberg P, Weber S, Raffetseder U, En-Nia A, Knott H, Baron JM, Dooley S, Bernhagen J, Mertens PR.EMBO Rep. 2009, 10:783-9 
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Differential regulation of chemokine CCL5 expression in monocytes/macrophages and renal cells by Y-box protein-1. Raffetseder U, Rauen T, Djudjaj S, Kretzler M, En-Nia A, Tacke F, Zimmermann HW, Nelson PJ, Frye BC, Floege J, Stefanidis I, Weber C, Mertens PR.  Kidney Int. 2009, 75: 185-96. 
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Late blockade of the renin-angiotensin system in the obese zucker rat – functional and partial morphological regression of renal injury. Šebeková K, Lill M, Boor P, Heidland A, Amann K,  Am J Nephrol 2009, 29:164-170. 
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Neuronal activation in the central nervous system during different forms of acute renal failure in rats. Palkovits M, Šebekova K, Gallatz K, Šebekova K Jr, Boor P, Klassen A, Bahner U, Heidland A:  Neuroscience 2009, 159:862-882.
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Patients with IgA nephropathy exhibit high systemic PDGF-DD levels. Boor P, Eitner F, Cohen CD, Lindenmeyer MT, for the ERCB-Consortium, Mertens PR, Ostendorf T, Floege J:  Nephrol Dial Transplant 2009; 24:2755-2762. 
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Renal, vascular and cardiac fibrosis in rats exposed to passive smoking and industrial dust fiber amosite. Boor P, Casper S, Celec P, Beňo M, Hurbánková M, Heidland A, Amann K, Šebeková K. J Cel Mol Med 2009, 13:4484-4491. 
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Polyclonal IgG ameliorates the course of progressive mesangioproliferative glomerulonephritis in rats. Boor P, Kunter U.  Kidney Blood Pres Res 2009; 32:169-174. 
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Effects of Regular Moderate Exercise on Early Diabetic nephropathy in Obese Zucker Rats. Boor P, Celec P, Behuliak M, Grančič P, Kebis A, Kukan M, Pronajová N, Liptaj T, Ostendorf T, Šebeková K.  Metabolism 2009; 58:1669-1677. 
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2008

The selective TP receptor antagonist, S18886 (terutroban), attenuates renal damage in the double transgenic rat model of hypertension. Šebeková K, Ramuscak A, Boor P, Heidland A, Amann K.  Am J Nephrol 2008; 28:47-53. 
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CCN3 is a novel, endogenous, and PDGF-regulated inhibitor of glomerular cell proliferation. van Roeyen CRC, Eitner F, Scholl T, Boor P, Kunter U, Planque N, Groene HJ, Bleau AM, Perbal B, Ostendorf T, Floege J.  Kidney Int 2008; 73:86-94. 
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PDGF-C acts as a potent pro-inflammatory cytokine that mediates renal interstitial fibrosis in vivo. Eitner F, Bücher E, van Roeyen C, Kunter U, Song R, Seikrit C, Villa L, Boor P, Bäckström G, Eriksson U, Östman A, Floege J, Ostendorf T. J Am Soc Nephrol 2008; 19:281-289.
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2007

PDGF-D inhibition by CR002 ameliorates tubulointerstitial fibrosis following experimental glomerulonephritis. BBoor P, Konieczny A, Villa L, Kunter U, van Roeyen CRC, LaRochelle WJ, Smithson G, Arrol S, Ostendorf T, Floege J. Nephrol Dial Translant 2007; 22:1323-31.
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Complement C5 Mediates Experimental Tubulointerstitial Fibrosis. Boor P, Konieczny A, Villa L, Schult A, Bücher E, Rong S, Kunter U, van Roeyen C.R.C, Polakowski T, Hawlisch H, Hillebrandt S, Lammert F, Eitner F, Floege J, Ostendorf T.  J Am Soc Nephrol 2007; 18:1508-1515. 
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Mesenchymal Stem Cells Prevent Progressive Experimental Renal Failure but Maldifferentiate into Glomerular Adipocytes. Kunter U, Rong S, Boor P, Eitner F, Müller-Newen G, Djuric Z, van Roeyen CRC, Konieczny A, Ostendorf T, Villa L, Milovanceva-Popovska M, Kerjaschki D, Floege J.  J Am Soc Nephrol 2007; 18:1754-1764. 
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The MAP Kinase Erk Regulates Renal Activity of Cyclin Dependent Kinase 2 in Experimental Glomerulonephritis. Bokemeyer D, Panek D, Kitahara M, Trzaskos JM, Müller CE, Hockemeyer J, Kunter U, Boor P, Floege J, Kramer HJ, Ostendorf T:  Nephrol Dial Transplant 2007; 22:3431-3441. 
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Genomic Damage and Malignancy in End-Stage Renal Failure: Do AGEs Contribute? Šebeková K, Wagner Z, Schupp N, Boor P.  Kidney Blood Press Res 2007; 30:56-66. 
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The Role of PDGF-D in Mesangioproliferative Glomerulonephritis. Floege J, van Roeyen C, Boor P, Ostendorf T.  Contrib Nephrol 2007; 157:153-158. 
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Treatment Targets in Renal Fibrosis. Boor P, Sebekova K, Ostendorf T, Floege J.  Nephrol Dial Transplant 2007; 22:3391-407. 
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Role of T cells and dendritic cells in glomerular immunopathology. Kurts C, Heymann F, Lukacs-Kornek V, Boor P, Floege J.  Semin Immunopathol 2007; 29:317-335.
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B) Review articles

2019

Evolving complexity of MIF signaling.
Jankauskas SS, Wong DWL, Bucala R, Djudjaj S, Boor P.
Cell Signal. 2019 May;57:76-88. doi: 10.1016/j.cellsig.2019.01.006. Epub 2019 Jan 23. Review.

Extracellular Matrix in Kidney Fibrosis: More Than Just a Scaffold.
Bülow RD, Boor P.
J Histochem Cytochem. 2019 May 22:22155419849388. doi: 10.1369/0022155419849388. [Epub ahead of print]

2018

[MIF in kidney diseases : A story of Dr. Jekyll and Mr. Hyde (German version)].
Boor P.
Pathologe. 2018 Dec;39(Suppl 2):177-184. doi: 10.1007/s00292-018-0535-6. German.

[What is certain in the treatment of glomerulonephritis?]
Floege J, Boor P, Moeller MJ.
Internist (Berl). 2018 Dec;59(12):1268-1278. doi: 10.1007/s00108-018-0500-8. Review. German.

Diffusion-weighted magnetic resonance imaging to assess diffuse renal pathology: a systematic review and statement paper.
Caroli A, Schneider M, Friedli I, Ljimani A, De Seigneux S, Boor P, Gullapudi L, Kazmi I, Mendichovszky IA, Notohamiprodjo M, Selby NM, Thoeny HC, Grenier N, Vallée JP.
Nephrol Dial Transplant. 2018 Sep 1;33(suppl_2):ii29-ii40. doi: 10.1093/ndt/gfy163.

Magnetic resonance imaging T1- and T2-mapping to assess renal structure and function: a systematic review and statement paper.
Wolf M, de Boer A, Sharma K, Boor P, Leiner T, Sunder-Plassmann G, Moser E, Caroli A, Jerome NP.
Nephrol Dial Transplant. 2018 Sep 1;33(suppl_2):ii41-ii50. doi: 10.1093/ndt/gfy198.

Magnetic resonance imaging biomarkers for chronic kidney disease: a position paper from the European Cooperation in Science and Technology Action PARENCHIMA.
Selby NM, Blankestijn PJ, Boor P, Combe C, Eckardt KU, Eikefjord E, Garcia-Fernandez N, Golay X, Gordon I, Grenier N, Hockings PD, Jensen JD, Joles JA, Kalra PA, Krämer BK, Mark PB, Mendichovszky IA, Nikolic O, Odudu A, Ong ACM, Ortiz A, Pruijm M, Remuzzi G, Rørvik J, de Seigneux S, Simms RJ, Slatinska J, Summers P, Taal MW, Thoeny HC, Vallée JP, Wolf M, Caroli A, Sourbron S.
Nephrol Dial Transplant. 2018 Sep 1;33(suppl_2):ii4-ii14. doi: 10.1093/ndt/gfy152.

Cellular and molecular mechanisms of kidney fibrosis.
Djudjaj S, Boor P.
Mol Aspects Med. 2018 Jun 22. pii: S0098-2997(18)30040-2. doi: 10.1016/j.mam.2018.06.002. [Epub ahead of print] Review.

The new SFB/TRR219 Research Centre.
Noels H, Boor P, Goettsch C, Hohl M, Jahnen-Dechent W, Jankowski V, Kindermann I, Kramann R, Lehrke M, Linz D, Maack C, Niemeyer B, Roma LP, Schuett K, Speer T, Wagenpfeil S, Werner C, Zewinger S, Böhm M, Marx N, Floege J, Fliser D, Jankowski J.
Eur Heart J. 2018 Mar 21;39(12):975-977. doi: 10.1093/eurheartj/ehy083. No abstract available.

Cell-free DNA: the role in pathophysiology and as a biomarker in kidney diseases.
Celec P, Vlková B, Lauková L, Bábíčková J, Boor P.
Expert Rev Mol Med. 2018 Jan 18;20:e1. doi: 10.1017/erm.2017.12.

2017

PDGF in organ fibrosis. 
Klinkhammer BM, Floege J, Boor P.
Mol Aspects Med. 2017 Nov 21. pii: S0098-2997(17)30127-9. doi: 10.1016/j.mam.2017.11.008. [Epub ahead of print] Review.

Fibrosis imaging: Current concepts and future directions. 
Baues M, Dasgupta A, Ehling J, Prakash J, Boor P, Tacke F, Kiessling F, Lammers T.
Adv Drug Deliv Rev. 2017 Nov 1;121:9-26. doi: 10.1016/j.addr.2017.10.013. Epub 2017 Nov 20. Review.

Treatment of Renal Fibrosis-Turning Challenges into Opportunities. 
Klinkhammer BM, Goldschmeding R, Floege J, Boor P. Adv Chronic Kidney Dis. 2017 Mar;24(2):117-129. doi: 10.1053/j.ackd.2016.11.002.

2016

Salivary markers of kidney function - Potentials and limitations.
Celec P, Tóthová Ľ, Šebeková K, Podracká Ľ, Boor P.
Clin Chim Acta. 2016 Jan 30;453:28-37. doi: 10.1016/j.cca.2015.11.028. Epub 2015 Nov 26. Review.

Biomarkers: Albuminuria - a marker of systemic microvascular function.
Boor P. Nat Rev Nephrol. 2016 Aug;12(8):449-50. doi: 10.1038/nrneph.2016.82.

2015

Platelet-derived growth factors (PDGFs) in glomerular and tubulointerstitial fibrosis.
Ostendorf T, Boor P, van Roeyen CR, Floege J.
Kidney Int Suppl (2011). 2014 Nov;4(1):65-69. Review.
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Renal allograft fibrosis: biology and therapeutic targets.
Boor P, Floege J.
Am J Transplant. 2015 Apr;15(4):863-86. doi: 10.1111/ajt.13180. Epub 2015 Feb 17.
PMID: 25691290
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Keratins in health and disease.
Toivola DM, Boor P, Alam C, Strnad P.
Curr Opin Cell Biol. 2015 Feb;32C:73-81. doi: 10.1016/j.ceb.2014.12.008. Epub 2015 Jan 17. Review.
PMID: 25599598
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Select item 25595779

2014    

Platelet Derived Growth Factors (PDGFs) in Glomerular and Tubulointerstitial Fibrosis. Ostendorf T, Boor P, van Roeyen CRC, Floege J.  Kidney Int Suppl 2014, in print
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PDGF and the progression of renal disease. Boor P, Ostendorf T, Floege J:  Nephrol Dial Transplat 2014, 29 Suppl 1:i45-i54.
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The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis?
Genovese F, Manresa AA, Leeming DJ, Karsdal MA, Boor P. Fibrogenesis Tissue Repair. 2014 Mar 28;7(1):4. doi: 10.1186/1755-1536-7-4. PMID: 24678881 [PubMed] Free PMC Article; Select item 24667162 
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2013    

In vivo phage display – A discovery tool in molecular biomedicine. Bábíčková J, Tóthová Ľ, Boor P, Celec P:  Biotechnol Adv 2013, 31:1247-1259
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2012    

Cold shock Y-box protein-1 participates in signaling circuits with auto-regulatory activities. Brandt S, Raffetseder U, Djudjaj S, Schreiter A, Kadereit B, Michele M, Pabst M, Zhu C, Mertens PR.  Eur J Cell Biol. 2012, 91:464-71. 
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EP4 - a new piece in the fibrotic puzzle. Boor P.  Kidney Int 2012, 82:132–135 [editorial]. 
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The renal (myo-)fibroblast: a heterogenous group of cells. Boor P, Floege J:  Nephrol Dial Transplant 2012, 27:3027–3036. 
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New approaches in progressive kidney diseases. Boor P:  Pathologe 2012, 33:296–301. [German]
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2011    

Growth Factors in Renal Fibrosis. Boor P, Floege J.  Clin Exp Pharmacol Physiol 2011, 38:391-400. 
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Renal fibrosis – novel insights into mechanisms and therapeutic targets. Boor P, Ostendorf T, Floege J.  Nat Rev Nephrol 2010; 6:643-656. 
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Models of IgA nephropathy. Eitner F, Boor P, Floege J:  Drug Discov Today Dis Model 2010, 7:21-26.

2007    

Genomic Damage and Malignancy in End-Stage Renal Failure: Do AGEs Contribute? Šebeková K, Wagner Z, Schupp N, Boor P.  Kidney Blood Press Res 2007; 30:56-66. 
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The Role of PDGF-D in Mesangioproliferative Glomerulonephritis. Floege J, van Roeyen C, Boor P, Ostendorf T.  Contrib Nephrol 2007; 157:153-158. 
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Treatment Targets in Renal Fibrosis. Boor P, Sebekova K, Ostendorf T, Floege J.  Nephrol Dial Transplant 2007; 22:3391-407.
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Role of T cells and dendritic cells in glomerular immunopathology. Kurts C, Heymann F, Lukacs-Kornek V, Boor P, Floege J. Semin Immunopathol 2007; 29:317-335.
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  • University of Bonn, Germany
  • LMU, University of Munich, Germany
  • University of Regensburg, GermanyUniversity of Cologne, Germany
  • INSERM, Paris, France
  • OMRF, Oklahoma Medical Research Foundation, Oklahoma, USA
  • University of Kyoto, Japan

Renal Molecular Pathologist Network (REMAP) is the first official European Renal Molecular Pathology training course realized by the cooperation of 6 different European Universities and a company specialized in e-learning and content management. It is funded by the Erasmus+ Programme of the European Union.

REMAP aims at training new professionals who will be able to provide renal biopsy services, molecular diagnostics as well as outstanding nephropathologic support: the renal molecular pathologist. “We are delighted to have been successful in Erasmus+ and we are getting to the heart of the project activities”, said the project coordinator Prof. Loreto Gesualdo.“ The students from all Europe will benefit from the project since the lessons will be released in open educational resources at the end of the project.”

REMAP involves six academic partners namely Università degli Studi di Bari Aldo Moro (IT),University of Cyprus (CY), Uniklinik RWTH Aachen (D), Academic Medical Centre of University of Amsterdam (NL), Charles University in Prague (CZ) and the Instituto de Investigacion Sanitaria de la Fundacion Jimenez Diaz (ES) with specialized expertise in nephrology, telepathology or molecular diagnosis, that will be supported by an ICT company (GRIFO Multimedia -IT) specialized in e-learning to develop an innovative multidisciplinary training course.

In the next three years, REMAP project will train twelve young European students from six different countries who will interact to each other, benefiting of this highly specialized course. The students will have the chance to put in practice their knowledge in the best clinical centres in Europe in order to gain also dynamic and interdisciplinary work experience. The result of the project will see the students returning with new skills and highly professional qualifications.

The local coordinators are Univ.-Prof. Dr. med. Jürgen Floege from the Medical Clinic II (Nephrology) and Ass.-Prof. Dr. med. Peter Boor, Ph.D. from the Institute of Pathology.

For more information about REMAP, please visit www.remapnet.eu or contact inforemapneteu.

We receive research funding from several sources:

  1. Interdisciplinary Center for Clinical Research (IZKF) and Medical Faculty of RWTH University, Aachen, Germany
  2. German Research Foundation (Deutsche Forschungsgemeinschaft – DFG)
  3. Else-Kröner Fresenius Stiftung (EKFS)
  4. SFB/TRR57 consortium “Mechanisms of organ fibrosis” (www.sfbtrr57.de) of the German Research Foundation and
    SFB/TRR219 consortium “Mechanisms of Cardiovascular Complications in Chronic Kidney Disease” (www.sfb-trr219.de) of the German Research Foundation 
  5. BMBF consortium STOP FSGS (Bundesministerium für Bildung und Forschung)
  6. Intramural grants (Start)