Publikationen
2024
Martins Costa, A., Halfwerk, F., Thiel, J. N., Wiegmann, B., Neidlin, M., & Arens, J. (2024). Influence of utilizing hemodialysis membranes outside-in on solute clearance and filtration efficiency–One step towards a novel combined lung and kidney support device. Journal of Membrane Science, 122575.
2023
Strudthoff LJ, Hesselmann F, Clauser JC, Arens J. Refurbishment of Extracorporeal Life Support Oxygenators in the Context of In Vitro Testing. ASAIO J. 2023 Jun 13. doi: 10.1097/MAT.0000000000001999. Epub ahead of print. PMID: 37314830.
Strudthoff LJ, Focke J, Hesselmann F, Kaesler A, Martins Costa A, Schlanstein PC, Schmitz-Rode T, Steinseifer U, Steuer NB, Wiegmann B, Arens J, Jansen SV. Novel Size-Variable Dedicated Rodent Oxygenator for ECLS Animal Models-Introduction of the "RatOx" Oxygenator and Preliminary In Vitro Results. Micromachines (Basel). 2023 Mar 31;14(4):800. doi: 10.3390/mi14040800. PMID: 37421033; PMCID: PMC10144398.
Frank R. Halfwerk, Wytze C. Duinmeijer, Renard Haumann, Jutta Arens . International Journal of Healthcare Simulation: Defining low- and high-fidelity simulation in systematic reviews: the case of heart auscultation simulators. DOI: 10.54531/fpkb4904
A. Martins Costa, F. Halfwerk, J.-N. Thiel, B. Wiegmann, M. Neidlin, J. Arens, Effect of hollow fiber configuration and replacement on the gas exchange performance of artificial membrane lungs, Journal of Membrane Science (2023), doi: https://doi.org/10.1016/j.memsci.2023.121742
Türkmen, M.; Lauwigi, T.; Fechter, T.; Gries, F.; Fischbach, A.; Gries, T.; Rossaint, R.; Bleilevens, C.; Winnersbach, P. Bioimpedance Analysis as Early Predictor for Clot Formation Inside a Blood-Perfused Test Chamber: Proof of Concept Using an In Vitro Test-Circuit. Biosensors 2023, 13, 394.
Almesto Alabdullh, H.; Pflaum, M.; Mälzer, M.; Kipp, M.; Naghilouy-Hidaji, H.; Adam, D.; Kühn, C.; Natanov, R.; Niehaus, A.; Haverich, A.; Wiegmann B; (2023). Biohybrid Lung Development: Towards Complete Endothelialization of an Assembled Extracorporeal Membrane Oxygenator. Bioengineering 2023, 10, 72. https://doi.org/10.3390/bioengineering10010072
Hosseinnejad A, Ludwig N, Mersmann S, Winnerbach P, Bleilevens C, Rossaint R, Rossaint J, Singh S. Bioactive Nanogels Mimicking the Antithrombogenic Nitric Oxide-Release Function of the Endothelium. Small. 2023 Jan 12:e2205185. doi: 10.1002/smll.202205185. Epub ahead of print. PMID: 36635040.
2022
Martins Costa, A. F. , Halfwerk, F. R., Wiegmann, B., Neidlin, M. , & Arens, J. (2022). Trends, Advantages and Disadvantages in Combined Extracorporeal Lung and Kidney Support From a Technical Point of View. Frontiers in Medical Technology, 4, [909990]. https://doi.org/10.3389/fmedt.2022.909990
Hesselmann, F., Halwes, M., Bongartz, P. , Wessling, M., Cornelissen, C., Schmitz-Rode, T., Steinseifer, U., Jansen, S. V. , & Arens, J. (2022). TPMS-based membrane lung with locally-modified permeabilities for optimal flow distribution. Scientific reports, 12(1), [7160]. https://doi.org/10.1038/s41598-022-11175-y
Strudthoff, L., Lüken, H., Jansen, S. V., Petran, J., Schlanstein, P. C., Schraven, L., Schürmann, B. J., Steuer, N., Wagner, G., Schmitz-Rode, T., Steinseifer, U. , Arens, J., & Kopp, R. (2022). In Vitro and In Vivo Feasibility Study for a Portable VV-ECMO and ECCO2R System. Membranes, 12(2), [133]. https://doi.org/10.3390/membranes12020133
Steuer, N. B., Schlanstein, P. C., Hannig, A., Sibirtsev, S., Jupke, A., Schmitz-Rode, T., Kopp, R., Steinseifer, U., Wagner, G. , & Arens, J. (2022). Extracorporeal Hyperoxygenation Therapy (EHT) for Carbon Monoxide Poisoning: In-Vitro Proof of Principle. Membranes, 12(1), [56]. https://doi.org/10.3390/membranes12010056
Clauser, J. C., Maas, J., Mager, I. , Halfwerk, F. R. , & Arens, J. (2022). The porcine abattoir blood model—: Evaluation of platelet function for in‐vitro hemocompatibility investigations. Artificial organs, 46(5), 922-931. https://doi.org/10.1111/aor.14146
Hesselmann, F., Arnemann, D., Bongartz, P. , Wessling, M., Cornelissen, C., Schmitz-Rode, T., Steinseifer, U., Jansen, S. V. , & Arens, J. (2022). Three‐dimensional Membranes for Artificial Lungs: Comparison of Flow‐Induced Hemolysis. Artificial organs, 46(3), 412-426. https://doi.org/10.1111/aor.14081
Kaesler, A., Rudawski, F. L., Zander, M. O., Hesselmann, F., Pinar, I., Schmitz-Rode, T. , Arens, J., Steinseifer, U., & Clauser, J. (2022). In-Vitro Visualization of Thrombus Growth in Artificial Lungs Using Real-Time X-Ray Imaging: A Feasibility Study. Cardiovascular engineering and technology, 13(2), 318–330. https://doi.org/10.1007/s13239-021-00579-y
Fischbach, A., Wiegand, S. B., Zazzeron, L., Traeger, L., di Fenza, R., Bagchi, A., Farinelli, W. A., Franco, W., Korupolu, S. , Arens, J., Grassi, L., Zadek, F., Bloch, D. B., Anderson, R. R., & Zapol, W. M. (2022). Veno‐venous extracorporeal blood phototherapy increases the rate of carbon monoxide (CO) elimination in CO‐poisoned pigs. Lasers in surgery and medicine, 54(2), 256-267. https://doi.org/10.1002/lsm.23462
Hesselmann, F., Focke, J. M., Schlanstein, P. C., Steuer, N., Reinartz, S. D., Schmitz-Rode, T., Steinseifer, U., Jansen, S. V. , & Arens, J. (2022). Introducing 3D-potting: a novel production process for artificial membrane lungs with superior blood flow design. Bio-Design and Manufacturing, 5, 141-152. https://doi.org/10.1007/s42242-021-00139-2
Martins Costa, A. F. , Halfwerk, F. R. , Arens, J., Wiegmann, B., Neidlin, M., & Thiel, J-N. (2022). Analysis of fibre configurations and specifications for the development of a novel, highly integrated artificial device combining pulmonary and renal support. Abstract from 10th EuroELSO 2022, London, United Kingdom.
Martins Costa, A. F. , Halfwerk, F. R., Wiegmann, B., Thiel, J-N., Neidlin, M. , & Arens, J. (2022). PULM6: Evaluating The Influence Of Fibre Replacement And Configuration For The Development Of A Novel Artificial Lung Integrating Oxygenation And Hemofiltration Membrane Fibre Layers In A Single Device. ASAIO Journal, 68(Issue Supplement 2), 87-87. https://doi.org/10.1097/01.mat.0000841192.81813.75
Quandt, J.; Garay-Sarmiento M., Witzdam, L.; Englert, J.; Rutsch, Y.; Stöcker, C.; Grottke, O.; Rodriguez-Emmenegger, C.* (2022): Interactive Hemocompatible Nanocoating to Prevent Surface‐Induced Coagulation in Medical Devices. Adv. Mater. Interfaces, doi: 10.1002/admi.202201055.
Riedelova, Z.; de los Santos Pereira, A.; Svoboda, J.; Pop-Georgievski, O.; Majek, P.; Pečánková, K.; Dyčka, F.; Rodriguez-Emmenegger, C.; Riedel, T.* (2022): The Relation Between Protein Adsorption and Hemocompatibility of Antifouling Polymer Brushes. Macromolecular Bioscience, doi: 10.1002/mabi.202200247
Towards Biohybrid Lung Development: Establishment of a Porcine In Vitro Model.
Schlör S, Pflaum M, Höffler K, Kühn C, Haverich A, Wiegmann B. Membranes (Basel). 2022 Jul 3;12(7):687. doi: 10.3390/membranes12070687. PMID: 35877890
Trends, Advantages and Disadvantages in Combined Extracorporeal Lung and Kidney Support From a Technical Point of View. Martins Costa A, Halfwerk F, Wiegmann B, Neidlin M, Arens J. Front Med Technol. 2022 Jun 21;4:909990. doi: 10.3389/fmedt.2022.909990. eCollection 2022. PMID: 35800469 Free PMC article. Review.
Winnersbach, P., Hosseinnejad, A., Breuer, T., Fechter, T., Jakob, F., Schwaneberg, U., Rossaint, R., Bleilevens, C., Singh, S., Endogenous Nitric Oxide-Releasing Microgel Coating Prevents Clot Formation on Oxygenator Fibers Exposed to In Vitro Blood Flow. Membranes, 12(1), 73. https://doi.org/10.3390/membranes12010073
Winnersbach, P., Rossaint, J., Buhl, E. M., Singh, S., Lölsberg, J., Wessling, M., Rossaint, R., & Bleilevens, C. (2022). Platelet count reduction during in vitro membrane oxygenation affects platelet activation, neutrophil extracellular trap formation and clot stability, but does not prevent clotting. Perfusion, 37(2), 134–143. https://doi.org/10.1177/0267659121989231
Hosseinnejad, A., Fischer, T., Jain, P., Bleilevens, C., Jakob, F., Schwaneberg, U., Rossaint, R., & Singh, S. (2021). Enzyme mimetic microgel coating for endogenous nitric oxide mediated inhibition of platelet activation. Journal of colloid and interface science, 601, 604–616. https://doi.org/10.1016/j.jcis.2021.05.143
2021
Riedel, T.;* de los Santos Pereira, A.; Táborská, J.; Riedelová, Z.; Pop-Georgievski, O.; Májek, P.; Pečánková, K.; Rodriguez-Emmenegger, C. (2021): Complement activation dramatically accelerates blood plasma fouling on antifouling poly(2-Hydroxyethyl Methacrylate) brush surfaces. | Macromolecular Bioscience, DOI: 10.1002/mabi.202100460.
Sales, M., Clauser, J. C., Schmitz-Rode, T., Linde, T., Mager, I., Maas, J., Steinseifer, U., Autschbach, R., Zayat, R. , Arens, J., & Schnoering, H. (2021). Exploration of appropriate anticoagulant reagents and reliability of porcine blood for in vitro evaluation of thrombogenicity. International Journal of Clinical and Experimental Medicine, 14(9), 2333-2342.
Hosseinnejad, A.; Fischer, T.; Jain, P.; Bleilevens, C.; Jakob, F.; Schwaneberg, U.; Rossaint, R.; Singh, S., Enzyme mimetic microgel coating for endogenous nitric oxide mediated inhibition of platelet activation. Journal of Colloid and Interface Science 2021.
Jain, P.; Nishiguchi, A.; Linz, G.; Wessling, M.; Ludwig, A.; Rossaint, R.; Möller, M.; Singh, S., Reconstruction of Ultra-thin Alveolar-capillary Basement Membrane Mimics. Advanced Biology 2021,n/a (n/a), 2000427.
Obstals, F.; Witzdam, L.; Garay-Sarmiento, M.; Kostina, N. Y.; Quandt, J.; Rossaint, R.; Singh, S.; Grottke, O.; Rodriguez-Emmenegger, C., Improving Hemocompatibility: How Can Smart Surfaces Direct Blood To Fight against Thrombi. ACS Applied Materials & Interfaces 2021,13 (10), 11696-11707.
Striebel, J.; Vorobii, M.; Kumar, R.; Liu, H.-Y.; Yang, B.; Weishaupt, C.; Rodriguez-Emmenegger, C.; Fuchs, H.; Hirtz, M.; Riehemann, K., Controlled Surface Adhesion of Macrophages via Patterned Antifouling Polymer Brushes. Advanced NanoBiomed Research 2021,1 (1), 2000029.
Hosseinnejad, A., Fischer, T., Jain, P., Bleilevens, C., Jakob, F., Schwaneberg, U., Rossaint, R., & Singh, S. (2021). Enzyme mimetic microgel coating for endogenous nitric oxide mediated inhibition of platelet activation. Journal of colloid and interface science, 601, 604–616. https://doi.org/10.1016/j.jcis.2021.05.143
Hosseinnejad, A., Ludwig, N., Wienkamp, A. K., Rimal, R., Bleilevens, C., Rossaint, R., Rossaint, J., & Singh, S. (2021). DNase I functional microgels for neutrophil extracellular trap disruption. Biomaterials science, 10(1), 85–99. https://doi.org/10.1039/d1bm01591e
Jain, P.; Nishiguchi, A.; Linz, G.; Wessling, M.; Ludwig, A.; Rossaint, R.; Möller, M.; Singh, S., Reconstruction of Ultra-thin Alveolar-capillary Basement Membrane Mimics. Advanced Biology 2021,n/a (n/a), 2000427.
Obstals, F.; Witzdam, L.; Garay-Sarmiento, M.; Kostina, N. Y.; Quandt, J.; Rossaint, R.; Singh, S.; Grottke, O.; Rodriguez-Emmenegger, C., Improving Hemocompatibility: How Can Smart Surfaces Direct Blood To Fight against Thrombi. ACS Applied Materials & Interfaces 2021,13 (10), 11696-11707.
Striebel, J.; Vorobii, M.; Kumar, R.; Liu, H.-Y.; Yang, B.; Weishaupt, C.; Rodriguez-Emmenegger, C.; Fuchs, H.; Hirtz, M.; Riehemann, K., Controlled Surface Adhesion of Macrophages via Patterned Antifouling Polymer Brushes. Advanced NanoBiomed Research 2021,1 (1), 2000029.
Winnersbach, P.; Rossaint, J.; Buhl, E. M.; Singh, S.; Lölsberg, J.; Wessling, M.; Rossaint, R.; Bleilevens, C., Platelet count reduction during in vitro membrane oxygenation affects platelet activation, neutrophil extracellular trap formation and clot stability, but does not prevent clotting. Perfusion 2021, 267659121989231.
Dipresa D, Kalozoumis P, Pflaum M, Peredo A, Wiegmann B, Haverich A, Korossis S, Haemodynamic Assessment of Hollow-Fibre Membrane Oxygenators using Heterogeneous Computational Fluid Dynamics Models. J Biomech Eng.2021 Jan 19. doi: 10.1115/1.4049808.
Pflaum M, Jurmann S, Katsirntaki K, Mälzer M, Haverich A, Wiegmann B. Towards Biohybrid Lung Development-Fibronectin-Coating Bestows Hemocompatibility of Gas Exchange Hollow Fiber Membranes by Improving Flow-Resistant Endothelialization. Membranes (Basel).2021 Dec 27;12(1):35. doi: 10.3390/membranes12010035. PMID: 35054561.
Pflaum M, Dahlmann J, Engels L, Naghilouy-Hidaji H, Adam D, Zöllner J, Otto A, Schmeckebier S, Martin U, Haverich A, Olmer R, Wiegmann B. Towards Biohybrid Lung: Induced Pluripotent Stem Cell derived Endothelial Cells as Clinically Relevant Cell Source for Biologization. Micromachines (Basel). 2021 Aug 19;12(8):981. doi: 10.3390/mi12080981. PMID: 34442603.
2020
Alves, P.; Gomes, L. C.; Rodríguez-Emmenegger, C.; Mergulhão, F. J., Efficacy of A Poly(MeOEGMA) Brush on the Prevention of Escherichia coli Biofilm Formation and Susceptibility. Antibiotics (Basel, Switzerland) 2020,9 (5).
Alves, P.; Gomes, L. C.; Vorobii, M.; Rodriguez-Emmenegger, C.; Mergulhao, F. J., The potential advantages of using a poly(HPMA) brush in urinary catheters: effects on biofilm cells and architecture. Colloids and Surfaces B-Biointerfaces 2020,191.
Arens, J.; Grottke, O.; Haverich, A.; Maier, L. S.; Schmitz-Rode, T.; Steinseifer, U.; Wendel, H. P.; Rossaint, R., Toward a Long-Term Artificial Lung. Asaio j 2020.
Kotlarek, D.; Curti, F.; Vorobii, M.; Corradini, R.; Careri, M.; Knoll, W.; Rodriguez-Emmenegger, C.; Dostalek, J., Surface plasmon resonance-based aptasensor for direct monitoring of thrombin in a minimally processed human blood. Sensors and Actuators B-Chemical 2020,320.
Petran, J.; Muelly, T.; Dembinski, R.; Steuer, N.; Arens, J.; Marx, G.; Kopp, R., Validation of RESP and PRESERVE score for ARDS patients with pumpless extracorporeal lung assist (pECLA). Bmc Anesthesiology 2020,20 (1).
Steuer, N. B.; Hugenroth, K.; Beck, T.; Spillner, J.; Kopp, R.; Reinartz, S.; Schmitz-Rode, T.; Steinseifer, U.; Wagner, G.; Arens, J., Long-Term Venovenous Connection for Extracorporeal Carbon Dioxide Removal (ECCO2R)-Numerical Investigation of the Connection to the Common Iliac Veins. Cardiovasc Eng Tech 2020,11 (4), 362-380.
Pflaum M, Merhej H, Peredo A, Wiegmann B, Wolkers W, Haverich A, Korossis S. Hypothermic preservation of endothelialized gas exchange membranes; Artif Organs. 2020 Jul 15. doi: 10.1111/aor.13776.
2019
Vorobii, M.; Kostina, N. Y.; Rahimi, K.; Grama, S.; Soder, D.; Pop-Georgievski, O.; Sturcova, A.; Horak, D.; Grottke, O.; Singh, S.; Rodriguez-Emmenegger, C., Antifouling Microparticles To Scavenge Lipopolysaccharide from Human Blood Plasma. Biomacromolecules 2019,20 (2), 959-968.
Dedisch, S.; Obstals, F.; de los Santos Pereira, A.; Bruns, M.; Jakob, F.; Schwaneberg, U.; Rodriguez-Emmenegger, C., Turning a Killing Mechanism into an Adhesion and Antifouling Advantage. Advanced Materials Interfaces 2019,6 (18), 1900847.
Fischer, T.; Moller, M.; Singh, S., Approach to Obtain Electrospun Hydrophilic Fibers and Prevent Fiber Necking. Macromolecular Materials and Engineering 2019,304 (12).
Korossis, S. In Chapter 1 Structure-Function Relationship of Heart Valves in Health and Disease, 2019.
Kotlarek, D.; Vorobii, M.; Ogieglo, W.; Knoll, W.; Rodriguez-Emmenegger, C.; Dostálek, J., Compact Grating-Coupled Biosensor for the Analysis of Thrombin. ACS Sensors 2019,4 (8), 2109-2116.
1Kotlarek, D.; Vorobii, M.; Ogieglo, W.; Knoll, W.; Rodriguez-Emmenegger, C.; Dostalek, J., Compact Grating-Coupled Biosensor for the Analysis of Thrombin. Acs Sensors 2019,4 (8), 2109-2116.
Walter, M.; Eisenbrand, S.; Kopp, R.; Leonhardt, S., Hardware-in-the-Loop Test Bench for Artificial Lungs. In Xiv Russian-Germany Conference on Biomedical Engineering, Potrakhov, N. N.; Gryaznov, A. Y.; Kostrin, D. K., Eds. 2019; Vol. 2140.
2018
Bleilevens, C.; Lölsberg, J.; Cinar, A.; Knoben, M.; Grottke, O.; Rossaint, R.; Wessling, M., Microfluidic cell sorting: Towards improved biocompatibility of extracorporeal lung assist devices. Sci Rep 2018,8 (1), 8031.
Lopez-Mila, B.; Alves, P.; Riedel, T.; Dittrich, B.; Mergulhão, F.; Rodriguez-Emmenegger, C., Effect of shear stress on the reduction of bacterial adhesion to antifouling polymers. Bioinspir Biomim 2018,13 (6), 065001.
Obstals, F.; Vorobii, M.; Riedel, T.; de Los Santos Pereira, A.; Bruns, M.; Singh, S.; Rodriguez-Emmenegger, C., Improving Hemocompatibility of Membranes for Extracorporeal Membrane Oxygenators by Grafting Nonthrombogenic Polymer Brushes. Macromol Biosci 2018,18 (3).
Olmer, R.; Engels, L.; Usman, A.; Menke, S.; Malik, M. N. H.; Pessler, F.; Göhring, G.; Bornhorst, D.; Bolten, S.; Abdelilah-Seyfried, S.; Scheper, T.; Kempf, H.; Zweigerdt, R.; Martin, U., Differentiation of Human Pluripotent Stem Cells into Functional Endothelial Cells in Scalable Suspension Culture. Stem Cell Reports 2018,10 (5), 1657-1672.
Zwirner U, Höffler K, Pflaum M, Korossis S, Haverich A, Wiegmann B. Identifying an optimal seeding protocol and endothelial cell substrate for biohybrid lung development. J Tissue Eng Regen Med.2018 Dec;12(12):2319-2330. doi: 10.1002/term.2764. Epub 2018 Dec 10. PMID: 30362254.
