In a paper just published in *Nature Communications*, Nour demonstrates the ability of the Salmonella virulence factor SopB to inhibit the early response of the intestinal epithelium to an invasive Salmonella infection. Nour demonstrates that SopB inhibits the early release of TNF and IL-18 by interacting with Adam17 and inhibiting secretory autophagy. This reduces the resulting inflammatory response and damage to the intestinal epithelium.
The work was carried out in the Hornef research group in close collaboration with Stefan Düsterhöft and Andreas Ludwig from the Institute for Molecular Pharmacology, and Joel Sekrig and Marlene Birk from the Institute of Medical Microbiology at Uniklinik RWTH Aachen, Isabel Karkossa, Kristin Schubert and Martin von Bergen from the Helmholtz Institute for Environmental Research in Leipzig, Michael Vocur and Tom Lüdde from Düsseldorf University Hospital, and Jörg Deiwick and Michael Hensel from the University of Osnabrück.
The manuscript can be downloaded open access under: https://pubmed.ncbi.nlm.nih.gov/42409845/
