Welcome to the Clavel lab at the Institute of Medical Microbiology, RWTH University Hospital, Aachen
The main focus of our research is the study of intestinal microbiomes (the communities of microorganisms, their genomes, and surrounding environmental factors in the gut). Because intestinal microorganisms have a major impact on the physiology of their host, it is important to investigate and understand their diversity and functions. We focus primarily on the human, pig, and mouse gut microbiomes because of their relevance for health-related issues. In particular, we are interested in describing the taxonomic diversity and evolution of gut bacteria thanks to the use of culture-based and sequencing approaches. The use of isolates under standardized conditions in the lab helps us understanding the ecology of microbes in the intestine. Moreover, we look at specific functions of microbes involved in interactions with the host and nutritional factors, including the conversion of cholesterol-derived substrates and associated impact on gut and liver physiology as well as metabolic responses.